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http://dx.doi.org/10.7314/APJCP.2014.15.18.7737

The Neutrophil to Lymphocyte Ratio has a High Negative Predictive Value for Pathologic Complete Response in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy  

Eryilmaz, Melek Karakurt (Department of Medical Oncology, Akdeniz University School of Medicine)
Mutlu, Hasan (Department of Medical Oncology, Akdeniz University School of Medicine)
Salim, Derya Kivrak (Department of Medical Oncology, Akdeniz University School of Medicine)
Musri, Fatma Yalcin (Department of Medical Oncology, Akdeniz University School of Medicine)
Tural, Deniz (Department of Medical Oncology, Akdeniz University School of Medicine)
Coskun, Hasan Senol (Department of Medical Oncology, Akdeniz University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.18, 2014 , pp. 7737-7740 More about this Journal
Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values in locally advanced breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Materials and Methods: Datawere collected retrospectively from the Akdeniz University School of Medicine Database for locally advanced BC patients treated with NACT between January 2000-December 2013. Results: A total of 78 patients were analyzed. Sixteen (20%) patients achieved pCR. Estrogen receptor (ER) positivity was lower in pCR+ than pCR-cases (p=0.011). The median NLR values were similar in both arms. The optimum NLR cut-off point for BC patients with PCR+ was 2.33 (AUC:0.544, 95%CI [0.401-0.688], p=0.586) with sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 50%, 51,6%, 21,1%, and 80%, respectively. Conclusions: This study showed no relationship between the pCR and pretreatment NLR values. Because of a considerable high NPV, in the patients with higher NLR who had luminal type BC in which pCR is lower after NACT, such treatment may not be recommended.
Keywords
Breast cancer; neutrophil to lymphocyte ratio; pathologic complete response; neoadjuvant chemotherapy;
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