• Advances in concrete construction
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• 제11권5호
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• pp.429-445
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• 2021

With regard to economic efficiency, composite fix beams are widely used to pass longitudinal shear forces across the interface. The current knowledge of the composite beam load-slip activity and shear capability are restricted to data from measurements of push-off. Modelling and analysis of the composite beams based on Euro-code 4 regarding to shear, bending, and deflection under differing loads were carried out using Finite Element through an efficient computer simulation and the final loading and sections capacity based on the failure modes was analysed. In bending, the section potential was increased by an improvement of the strength in both steel and concrete, but the flexural and compressive resistance growth is very weak (3.2% 3.1% and 3.0%), while the strength of the concrete has increased respectively from 25 N/mm² to 30, 35, and 40 N/mm² compared to the increment of steel strength by 27% and 21% when it was raised from 275 to 355 and 460 N/mm², respectively. It was found that the final flexural load capacity of fix beams was declined with increase in the fix beam span for both three steel strength. The shear capacity of sections was remained unchanged at constant steel strength and different length, but raised with final yield strength increment of steel sections by 29%, and 67% when it was raised from 275 N/mm² to 355 N/mm² and 460 N/mm², respectively.

• 한국안전학회지
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• 제36권2호
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• pp.10-17
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• 2021

This paper presents the robust design of each component used in the development of an induction bolt heating system for dismantling the high-temperature high-pressure casing heating bolts of turbines in power plants. The induction bolt heating system comprises seven assemblies, namely AC breaker, AC filter, inverter, transformer, work coil, cable, and CT/PT. For each of these assemblies, the various failure modes are identified by the failure mode and effects analysis (FMEA) method, and the causes and effects of these failure modes are presented. In addition, the risk priority numbers are deduced for the individual parts. To ensure robust design, the insulated-gate bipolar transistor (IGBT), switched-mode power supply (SMPS), C/T (adjusting current), capacitor, and coupling are selected. The IGBT is changed to a field-effect transistor (FET) to enhance the voltage applied to the induction heating system, and a dual-safety device is added to the SMPS. For C/T (adjusting current), the turns ratio is adjusted to ensure an appropriate amount of induced current. The capacitor is replaced by a product with heat resistance and durability; further, coupling with a water-resistant structure is improved such that the connecting parts are not easily destroyed. The ground connection is chosen for management priority.

• Journal of Information Technology Applications and Management
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• 제28권3호
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• pp.77-87
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• 2021

The color gray in the cinema expresses the private or public memory and oblivion in the reminiscence scenes. The aesthetic function and meaning of gray that interacts with other elements in cinematic time and space are expanded in various ways. This study was analyzed the cases in which gray was used as the main visual style by limiting the scope to Korean films. Based on the traditional cultural symbolic meaning of gray, I analyzed how it was applied and transformed in films, and interpreted the cultural-social meaning by the interaction between gray and other elements. In film history starting from monochrome, gray has been used as a visual device suitable for realizing cinematic or imaginary reality. Gray is adopted when dreams or recollections are visualized as imaginary reality, and it is used when dreamy imaginations of daydreaming are demonstrated. Gray, which reproduces the dreamlike reality of imagination, is the concrete and realistic way of expression. First, in Korean films, gray is a flashback visual device that recalls the past, and is an intermediary visual form that materializes the imaginary. In films such as Ode to My Father (2014), DongJu (2015), A Resistance(2019) and The Battle : Roar to Victory (2019), the gray of the past is a visual device for cultural memory that builds the homogeneity and identity of the group. In the era of hyper-visibility, gray in black and white images is intended to be clearly remembered by unfamiliarity rather than blurry oblivion by familiarity. Second, in genre films with disaster materials such as Train To Busan (2016) and Ashfall (2019), the grays of rain, fog, clouds, shadows and smoke highlight other elements, and the gray color causes anxiety and fear. In war films such as TaeGukGi: Brotherhood Of War (2003) and The Front Line (2011), gray shows a more intense brutality than the primary color. In sports films such as 4th Place (2015), Take Off (2009) and Forever The Moment (2007), gray expresses uncertainty and immaturity. Third, gray visualizes the historical memory of A Petal (1996), the oblivion in Oh! My Gran (2020) and Poetry (2010), and the reality of daydreaming Gagman (1988) and Dream (1990). At the boundary between imagination and reality, gray is a visual form of dreams, memories and forgetfulness.

• The Plant Pathology Journal
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• 제37권2호
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• pp.152-161
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• 2021

Sugar beet (Beta vulgaris L.) is known as a key product for agriculture in several countries across the world. Beet soil-borne virus (BSBV) triggers substantial economic damages to sugar beet by reducing the quantity of the yield and quality of the beet sugars. We conducted the present study to report the complete genome sequences of two BSBV isolates in Turkey for the first time. The genome organization was identical to those previously established BSBV isolates. The tripartite genome of BSBV-TR1 and -TR3 comprised a 5,835-nucleotide (nt) RNA1, a 3,454-nt RNA2, and a 3,005-nt RNA3 segment. According to sequence identity analyses, Turkish isolates were most closely related to the BSBV isolate reported from Iran (97.83-98.77% nt identity). The BSBV isolates worldwide (n = 9) were phylogenetically classified into five (RNA-coat protein read through gene [CPRT], TGB1, and TGB2 segments), four (RNA-rep), or three (TGB3) lineages. In genetic analysis, the TGB3 revealed more genetic variability (Pi = 0.034) compared with other regions. Population selection analysis revealed that most of the codons were generally under negative selection or neutral evolution in the BSBV isolates studied. However, positive selection was detected at codon 135 in the TGB1, which could be an adaptation in order to facilitate the movement and overcome the host plant resistance genes. We expect that the information on genome properties and genetic variability of BSBV, particularly in TGB3, TGB1, and CPRT genes, assist in developing effective control measures in order to prevent severe losses and make amendments in management strategies.

• 한국가금학회지
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• 제48권4호
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• pp.255-265
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• 2021

지구 온난화와 여름철 고온 환경은 육계의 성장 능력뿐만 아니라 동물복지에도 큰 영향을 미친다. 성장과 근육발달 중심으로 선발된 육계는 열 스트레스를 완화시키는 심장과 폐와 같은 핵심 장기들은 비례적으로 성장하지 못하여 급격한 환경 온도 변화에 대처하기가 어렵다. 환경 온도의 변화는 배아 발달 기간 및 부화 초기까지 근육생성에 큰 영향을 준다. 위성세포 또한 고온 스트레스에 매우 민감하다. 고온스트레스는 위성세포의 증식 및 분화 활동에 영향을 주고, 위성세포의 운명뿐만 아니라, 근육 성장 및 구조에 영향을 미친다. 부화 기간의 정교한 온도조절과 부화 초기 사육 환경 온도의 관리는 육계의 성장과 근육 발달, 그리고 동물복지를 결정하는 데 가장 중요한 핵심 요소이다.

• 한국초지조사료학회지
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• 제42권3호
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• pp.201-207
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• 2022

Fescues, which are widely cultivated as grasses and forages around the world, are often naturally infected with the endophyte, Epichloë. This fungus, transmitted through seeds, imparts resistance to drying and herbivorous insects in its host without causing any external damage, thereby contributing to the adaptation of the host to the environment and maintaining a symbiosis. However, some endophytes, such as E. coenophialum synthesize ergovaline or lolitrem B, which accumulate in the plant and impart anti-mammalian properties. For example, when livestock consume excessive amounts of grass containing toxic endophytes, problems associated with neuromuscular abnormalities, such as convulsions, paralysis, high fever, decreased milk production, reproductive disorders, and even death, can occur. Therefore, pre-inoculation with non-toxic endogenous fungi or management with endophyte-free grass is important in preventing damage to livestock and producing high-quality forage. To date, the diagnosis of endophytes has been mainly performed by observation under a microscope following staining, or by performing an immune blot assay using a monoclonal antibody. Recently, the polymerase chain reaction (PCR)-based molecular diagnostic method is gaining importance in the fields of agriculture, livestock, and healthcare given the method's advantages. These include faster results, with greater accuracy and sensitivity than those obtained using conventional diagnostic methods. For the diagnosis of endophytes, the nested PCR method is the only available option developed; however, it is limited by the fact that the level of toxic alkaloid synthesis cannot be estimated. Therefore, in this study, we aimed to develop a triplex real-time PCR diagnostic method that can determine the presence or absence of endophyte infection using DNA extracted from seeds within 1 h, while simultaneously detecting easD and LtmC genes, which are related to toxic alkaloid synthesis. This new method was then also applied to real field samples.

• 대한조현병학회지
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• 제23권1호
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• pp.8-14
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• 2020

Objectives: This study aimed to investigate suicidal behaviors and the related psychopathology across the different stages of schizophrenia. Methods: We recruited 131 patients with schizophrenia and categorized them into two groups, according to the duration of illness (DI) as follows: ≤10 years (n=39) and >10 years (n=92). Psychopathology and suicidality were assessed using the 18-item Brief Psychiatric Rating Scale (BPRS-18) and the suicidality module from the Mini-International Neuropsychiatric Interview, respectively. Results: One-quarter of the patients with a DI ≤10 years and nearly one-sixth of the patients with a DI >10 years experienced suicidal behaviors in the previous month. Suicidality scores were significantly associated with the "affect" factor scores of the BPRS-18 in patients with a DI ≤10 years (β=0.55, p=0.003) and with the "resistance" factor scores in patients with a DI of >10 years (β=0.29, p=0.006). Conclusion: The present study demonstrated that psychopathological factors were differentially associated with suicidality in patients with schizophrenia according to the illness stage. Our findings suggest that for effective suicide prevention, different approaches are required for the management of each stage of schizophrenia.

• 해양환경안전학회지
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• 제28권5호
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• pp.827-834
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• 2022

최근 무인선을 활용한 해양 조사가 주목을 받고 있으며, 특히 세일을 이용한 소형 무인 드론에 대한 연구가 고조되고 있다. 세일 드론의 용도는 해양 조사, 감시 및 오염방제 등을 들 수 있다. 따라서 본 연구에서는 트윈 세일을 채용한 드론에 대해 선속을 추정하는 방식을 이용하여 항주최적조건을 확인하고 세일드론의 운동성능 및 저항 등 초기설계단계에서 검토해야 할 성능에 대해서 고찰하고자 하였다. 그 결과, 트윈 세일 드론은 항해속도를 2.0 m/s 이하로 유지하는 편이 유리하며 복원성 또한 DNV에서 규정하는 조건을 충족시켰다. 또한, TWA 100°일 때 받음각 20°에서 최고속력은 1.69 m/s, TWA 100°일 때 받음각 25°에서 최고속력은 1.74 m/s를 보였다.

• Journal of Gastric Cancer
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• 제23권1호
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• pp.224-249
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• 2023

Gastric cancer is heterogeneous in morphology, biology, genomics, and treatment response. Alterations in human epidermal growth factor receptor 2 (HER2) overexpression, microsatellite instability (MSI) status, programmed death-ligand 1 (PD-L1) levels, and fibroblast growth factor receptor 2 (FGFR2) can be used as biomarkers. Since the combination of fluoropyrimidine/platinum plus trastuzumab that was investigated in the ToGA trial was approved as a standard of care in HER2-positive patients in 2010, no other agents showed efficacy in the first- (HELOISE, LOGiC, JACOB trials) and second- (TyTAN, GATSBY, T-ACT trials) line treatments. Despite the success in treating breast cancer, various anti-HER2 agents, including a monoclonal antibody (pertuzumab), an antibody-drug conjugate (ADC; trastuzumab emtansine [T-DM1]), and a small molecule (lapatinib) failed to translate into clinical benefits until the KEYNOTE-811 (first-line) and DESTINY-Gastri01 (≥second-line) trials were conducted. The incorporation of HER2-directed treatment with immune checkpoint inhibitors in the form of a monoclonal antibody or ADC is now approved as a standard treatment. Despite the promising results of new agents (engineered monoclonal antibodies, bi-specific antibodies, fusion proteins, and small molecules) in the early phase of development, the management of HER2-positive gastric cancer requires further optimization to achieve precision medicine with a chemotherapeutic backbone. Treatment resistance is a complex process that can be overcome using a combination of chemotherapy, targeted agents, and immune checkpoint inhibitors, including novel agents. HER2 status must be reassessed in patients undergoing anti-HER2 treatment with disease progression after the first-line treatment. As a general guideline, patients who need systemic treatment should receive chemotherapy plus targeted agents, anti-angiogenic agents, immune checkpoint inhibitors, or their combinations.

• Earthquakes and Structures
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• 제24권4호
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• pp.275-288
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• 2023

Based on the crucial role of high-speed railway bridges (HSRBs) in the safety of high-speed railway operations, it is an important approach to mitigate earthquake hazards by proceeding with seismic risk assessments in their whole life. Bridge seismic risk assessment, which usually evaluates the seismic performance of bridges from a probabilistic perspective, provides technical support for bridge risk management. The seismic performance of bridges is greatly affected by the degradation of material properties, therefore, material damage plays a nonnegligible role in the seismic risk assessment of the bridge. The effect of material damage is not considered in most current studies on seismic risk analysis of bridges, nevertheless. To fill the gap in this area, in this paper, a nonlinear dynamic time-history analysis has been carried out by establishing OpenSees finite element model, and a seismic vulnerability analysis is carried out based on the incremental dynamic analysis (IDA) method. On this basis, combined with the site risk analysis, the time-dependent seismic risk analysis of an offshore three-span HSRB in the whole life cycle has been conducted. The results showed that the seismic risk probabilities of both components and system of the bridge increase with the service time, and their seismic risk probabilities increase significantly in the last service period due to the degradation of the material strength, which demonstrates that the impact of durability damage should be considered when evaluating the seismic performance of bridges in the design and service period.