• 한국가금학회지
• /
• 제40권3호
• /
• pp.277-281
• /
• 2013

The experiment was undertaken to see the effects of Bacillus sp. on the growth performance and disease resistance to Salmonella sp. infections. The use of probiotic microbes in poultry is commonly practiced. In this study, Bacillus subtilis was tested using a total of 120 chicks of age of 1 day after hatching. The growth traits examined were body weight gain and feed conversion rate. And also, the Salmonella resistance of Bacillus subtilis was tested after the chicks were orally administered with Salmonella pullorum by gavage force injections. The result showed that Bacillus subtilis yielded a high feed efficiency, consequently increased growth rate. For the effect of Bacillus subtilis on Salmonella infection, Bacillus subtilis significantly improved the resistance to Salmonella pullorum infection. Various clinical symptoms of Salmonella infection were highly decreased by addition of Bacillus sp.

• Journal of Microbiology and Biotechnology
• /
• 제17권2호
• /
• pp.280-286
• /
• 2007

We evaluated a commercial biopreparation of plant growth-promoting rhizobacteria (PGPR) strains Bacillus subtilis GB03 and B. amyloliquefaciens IN937a formulated with the carrier chitosan (Bio Yield) for its capacity to elicit growth promotion and induced systemic resistance against infection by Cucumber Mosaic Virus (CMV) and Pseudomonas syringae pv. tomato DC3000 in Arabidopsis thaliana. The biopreparation promoted plant growth of Arabidopsis hormonal mutants, which included auxin, gibberellic acid, ethylene, jasmonate, salicylic acid, and brassinosteroid insensitive lines as well as each wild-type. The biopreparation protected plants against CMV based on disease severity in wild-type plants. However, virus titre was not lower in control plants and those treated with biopreparation, suggesting that the biopreparation induced tolerance rather than resistance against CMV. Interestingly, the biopreparation induced resistance against CMV in NahG plants, as evidenced by both reduced disease severity and virus titer. The biopreparation also elicited induced resistance against P. syringae pv. tomato in the wild-type but not in NahG transgenic plants, which degrade endogenous salicylic acid, indicating the involvement of salicylic acid signaling. Our results indicate that some PGPR strains can elicit plant growth promotion by mechanisms that are different from known hormonal signaling pathways. In addition, the mechanism for elicitation of induced resistance by PGPR may be pathogen-dependent. Collectively, the two-Bacilli strain mixture can be utilized as a biological inoculant for both protection of plant against bacterial and viral pathogens and enhancement of plant growth.

• Clinical and Experimental Pediatrics
• /
• 제52권2호
• /
• pp.152-158
• /
• 2009

Reduced fetal growth is independently associated with increased risk of health problems in later life, particularly type 2 diabetes and cardiovascular diseases. Insulin resistance appears to be a key component underlying these metabolic complications. It is suggested that detrimental fetal environment may program insulin resistance syndrome. An insulin-resistant genotype may also result in both low birth weight and insulin resistance syndrome, and it is likely that the association of low birth weight with insulin resistance is the result of both genetic and environmental factors. Early postnatal rapid catch-up growth is closely related to risk for subsequent metabolic diseases. Fat mass is strikingly reduced in neonates born small for gestational age (SGA), and recent data suggest that insulin resistance seen in catch-up growth is related to the disproportionate catch-up in fat mass compared with lean mass. Endocrine disturbances are also recognized in SGA children, but overt clinical problems are infrequent in childhood. Cognitive impairment is reported in some children born SGA, especially those who do not show catch-up growth, in whom early neurodevelopmental evaluation is required. Breast feeding, also known to be protective against the long-term risk of obesity, may prevent some intellectual impairment in SGA children. Calorie-dense feeding does not seem to be appropriate in SGA infants. We must balance the positive effect of nutrition on neural development against rapid fat deposition and the future risk of insulin resistance.

• Tuberculosis and Respiratory Diseases
• /
• 제79권4호
• /
• pp.248-256
• /
• 2016

Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.

• 한국해양공학회지
• /
• 제13권2호통권32호
• /
• pp.58-65
• /
• 1999

The effect of specimen thickness on fatigue crack growth rate was studied. The objective of the present study is to investigate the effect of specimen thickness on the fatigue crack growth behavior at various stress intensity factor ranges and also the variation of material restance to fatigue crack growth. The fatigue crack growth resistance was treated as a spatial stochastic process, which varies randomly on the crack path, Compact tension specimens with a LT orientation for structural steel were used. All testing was done at a constant stress intensity level. The experimental data were analyzed for the size effect to determine the Weibull distributions of the material resistance.

• 한국해양공학회지
• /
• 제1권2호
• /
• pp.93-100
• /
• 1987

Corrosion fatigue cracking of the austenitic stainless steel(bese metal & heat affected zone by TIG weld) was studied experimentally under the environments of various specific resistance and air. The characteristics of corrosion fatigue crack growth rate and the environmental constants of paris' rule were investigated for SUS 304 weldments in the various specific resistance. The influences of stress intensity factor range and corrosion on the crack growth rate were compared. The characteristics of corrosion fatigue cracking for the weldments were inspected from mechanical, electrochemical and microstructural point of view. Main results obtained are as follows: 1) As the specific resistance decreases, the environmental constant C of paris'rule increases(hence the corrosion fatigue crack growth rate is rapid), but the environmental constant m decreases, so the effect of corrosion to the crack growth rate is more susceptible than thet of stress intensity factor range. 2) As the stress intensity factor range decreases, the corrosion fatigue crack growth rate of heat affected zone is more susceptible than that of the base metal. 3) The corrosion fatigue crack growth rate of the heat affected zone is more rapid than that of the base metal, because of the phenomenon of softening and the less noble potential coused by wedlding heat cycle. 4) The corrosion fatigue cracking of SUS 304 weldment appears transgranular fracture.

• 대한기계학회논문집A
• /
• 제29권9호
• /
• pp.1225-1234
• /
• 2005

Mode I stress intensity factor $(K_I)$ of Notched Ring Test(NRT) specimen for measuring slow crack growth resistance was found using finite-element method. The theoretical $K_I$ value of NRT was not available in any references and could not be solved analytically. At first, in order to verify the accuracy of the finite-element approach, published $K_I$ values of several cracks were calculated and compared with finite-element results. The results were in good agreement within inherent errors of theoretical $K_I$. Finally the mode I stress intensity factor of NRT was found using 2- and 3-dimensional finite-element methods and expressed as a function of the applied load. This enabled direct comparison of resistance to slow crack growth between NRT and Notched Pipe Test(NPT), which employ different loading regime.

• 동력기계공학회지
• /
• 제15권6호
• /
• pp.73-80
• /
• 2011

The experimental investigation focuses on an influence of artificial aging time in longitudinal butt welded Al 6013-T4 aluminum alloy on the fatigue crack growth resistance. The preferred welding processes for this alloy are frequently tungsten inert gas welding (TIG) process due to its comparatively easier applicability and better weldability than other gas metal arc welding. Fatigue crack growth tests were carried out on compact tension specimens (CT) in longitudinal butt TIG welded after T82 heat treatment was varied in three artificial aging times of 6 hours, 18 hours and 24 hours. Of the three artificial aging times, 24 hours of artificial aging time are offering better resistance against the growing fatigue cracks. The superior fatigue crack growth resistance preferred spatial variation of materials within each specimen in the Paris equation based on reliability theory and fatigue crack growth rate by crack length are found to be the reasons for superior fatigue resistance of 24 hours of artificial aging time was compared to other joints. The highest of crack propagation resistance occurs in artificial aging times of 24 hours due to the increase in grain size (fine grained microstructures).

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권10호
• /
• pp.4879-4881
• /
• 2012

Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage induced by ionizing radiation, and non-homologous end joining is the predominant pathway for repair of radiation-induced DSBs. Some cell signaling pathways that respond to normal growth factors are abnormally activated in human cancer. These pathways also invoke the cell survival mechanisms that lead to resistance to radiation. The molecular connection between the EGFR and its control over DNA repair capacity appears to be mediated by one or more signaling pathways downstream of this receptor. The purpose of this mini-review was not only to highlight the relation of the EGFR signal as a regulatory mechanism to DNA repair and radiation resistance, but also to provide clues to improving existing radiation resistance through novel therapies based on the above-mentioned mechanism.

• Journal of Welding and Joining
• /
• 제20권3호
• /
• pp.98-104
• /
• 2002

A study on microstructures of welds for Zircaloy-4 sheath end closure by the resistance upset welding methods was carried out. Two upset welding process variations such as magnetic farce and multi-impulse resistance welding were used. Grain size and microhardness across welds were analysed in terms of welding parameters. Magnetic farce resistance weld with one cycle of unbalanced mode has smaller upset length and $\alpha-grain$ size in heat affected zone than those of multi-impulse resistance weld because of lower heat input and shorter welding time. Heat affected zone formed by two upset resistance welding variations revealed fine Widmanstatten structure or martensitic ${\alpha}'$ structure due to the high heating rate and foster cooling rate. Magnetic force resistance welds showed recrystallized grains before grain growth, whereas multi-impulse resistance welds showed full grain growth.