• The Journal of Korean Medicine
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• v.26 no.2 s.62
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• pp.152-165
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• 2005

Background: The use of herbal preparations as remedies for various medical conditions has continuously increased in Korea Large proportions of Korean patients use herbal medicinal products, folk remedies, and food supplements. However, studies on the safety of herbal products arc conducted on a less than sufficient basis even in the countries like Korea where herbal medicine is being used extensively. Some of the reports on the safety of herbs were done by the doctors of western medicine but lack of knowledge and misclassification led to misunderstandings. Objecitves: This study aims to review the recent evidences on hepatotoxic events associated with the use of herbal medicinal products, folk remedy, and food supplements. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Methods: Systematic literature searches were performed on MedRic and MEDLIS in Korea. Screening and selection of the articles and the extraction of data were performed independently by two of authors. There were no restrictions regarding the published date. In order to avoid bias, the articles written by medical doctors, not by oriental doctors were selected. 43 journals were chosen for the review. Results: Analyzing the number of journals, studies on the drug-induced liver injury were increased after the year 2000. The proportion of herbal and folk remedy associated hepatotoxic injuries in all drug-induced liver injury was $21.0\%-30.0\%$. But criterion for herbal medicine is rather vague and limited objective data hindered objectiveness. Few of single medicinal herbs and combination preparations were associated with hepatotoxic injuries. But because of lack of objectivity, further researches must be conducted to yield more concrete results. Conclusions: yield more concrete results. Incidence figures are largely unknown, and in most cases a causal attribution is not established. The challenge for the future is to systematically research this area, educate all parties involved, and minimize patient risks.

• Journal of Oriental Neuropsychiatry
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• v.35 no.1
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• pp.101-113
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• 2024

Objectives: The purpose of this scoping review is to suggest future treatment and research directions for adult ADHD by examining domestic trends in Korean research on adults with ADHD tendencies. Methods: The present review used Arksey and O'Malley's scoping review methodology. Eight domestic databases were used, and a search was conducted in July 2023 while targeting domestic papers that had been published within the last 20 years. Subject keywords included 'College student', 'Soldier', and 'Adult', and the subject-related terms that were searched for included 'ADHD'. Results: From 502 initially collected articles, 78 were ultimately selected for analysis in this work. Domestic research related to adult ADHD has been steadily conducted since 2000, and most such research has been done in psychology. Regarding the research participants, those in their 20s were the most common age group, and college students accounted for more than half of participants. In terms of study design, survey studies were the most common, while there was a lack of studies on intervention. The subject most closely dealt with in ADHD studies was interpersonal relationships, followed by depression and addiction. The main intervention used in this study was cognitive behavioral therapy, however it was limited in number. Conclusions: More multifaceted studies on adult ADHD need to be conducted using various research methodologies, and there is also a need for more studies using interventions. It is also important for such research to be expanded to broader geographic areas, ages, and occupations.

• Journal of Sasang Constitutional Medicine
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• v.28 no.1
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• pp.51-56
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• 2016

Objectives This study was to identify the types of errors in the statistical analysis and trends of previous reported papers that used various statistical techniques.Methods We have selected 118 original articles for statistical review from the OASIS(http://oasis.kiom.re.kr) and the Pubmed(http://www.pubmed.gov) in the field of Sasang constitutional medicine. Published year was restricted from 2011 to 2015.Results 1. The ANOVA(25.72%) was the statistic of choice overall, followed by the chi-square test(21.74%), regression analysis(14.13%), t-test(11.59%), and etc. 2. By examining the errors of the statistical methods, there were 42(59.2%) thesis with errors among 71 thesis using ANOVA, 19(31.7%) thesis among 60 thesis using chi-square test, and 35(89.7%) over 39 thesis using regression analysis.Conclusions To improve the quality of Sasang Constitution, the participation of statisticians in research design will reduce the significant errors in statistical interpretation of the results.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.8 no.1
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• pp.49-61
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• 2013

Objectives: The aim of this study was to analyse the domestic trends of Chuna treatments techniques in Korean literature. Methods: We searched the clinical trials on Chuna treatments through both electronic search(used keyword 'chuna') and hand search in 3 Korean web databases(OASIS, NDSL, RISS) and 4 related journals(The Journal of Korea CHUNA Manual Medicine for Spine & Nerves, Journal of Oriental Rehabilitation Medicine, The Journal of Korean Acupuncture & Moxibustion Society, Journal of Korean Medicine Society). All relevant clinical trials were selected and extracted to be analyzed according to their published year, journals, types of study, used techniques. Results: The number of the clinical studies tends to increase every year. The studies on Chuna treatments were mainly published in The Journal of Korea Chuna Manual Medicine for Spine & Nerves. In case of types of study, case reports and case series were predominant. The most frequently adopted techniques of Chuna in studies were flexion distraction technique for lumbar spine and JS supine position cervical spine distraction. Conclusions: Through the results of this study, we hope that the more qualitative education could be conducted by strengthening the techniques which often used. Also analysis of the reason of rarely used techniques should be conducted and the modification or developing techinques should be followed as a counter measures. As applying more rigorous methodology, more qualitative evidence based Chuna studies should be conducted in future clinical research.

• Journal of Society of Preventive Korean Medicine
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• v.21 no.3
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• pp.75-85
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• 2017

Objectives : The new health technology assessment (nHTA) involves evaluating the safety and efficacy of the new health technology under the Medical Services Act by the New Health Technology Assessment Project Division from 2007. The purpose of this study is to understand the status of applications and recent trends of the results, and suggest strategies for the development of new health technologies in Korean Medicine. Methods : We investigated and analyzed the results of evaluation of new health technology of whole conventional medical and the list of new health technologies in Korean Medicine provided by the New Health Technology Assessment Project Division from 2007 to 2016. Results : The number of applications for new health technology of Korean medicine was low as 41 items in the whole number of 2,013 items. The evaluation method of new health technologies in both, the whole medical and Korean medicine fields was the same, but the tendency in results was very different. Most of the new health technology items in Korean medicine were classified as existing technology (20 items), early stage technology (7 items), and Only 2 items were evaluated as research stage technology. Conclusions : In order to develop new health technology in the Korean medical field, we have made suggestions about the health technology assessment systems, R&D infrastructures, and corporation with conventional medicines.

• Journal of Korean Medicine for Obesity Research
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• v.11 no.2
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• pp.41-68
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• 2011

Objectives: After organizing segmentations related to obesity from classics and each studies, we would like to examine the value of wild ginseng, bovis calculus, ursi fel and moschus as a obesity medicine. Methods: We found out 4 drugs which are wild ginseng, bovis calculus, ursi fel and moschus from the classics, such as "Shin-Nong-Bon-Cho-Kyung", "Myoung-Eui-Byul-Lok", "Bon-Cho-Gang-Mok", "Bon-Cho-Jong-Shin", "Bon-Cho-Bi-Yo", "Bon-Cho-Gu-Jin" and "Deuk-Bae-Bon-Cho", we searched websites such as RISS, Korean traditional knowledge portal, the society of Korean medicine for obesity research, Korean pharmacopuncture institute, the Korean academy of oriental rehabilitation medicine and Korean acupuncture & moxibustion society as well. Results: 1. We couldn't find the contents related to the efficacy of improving obesity through wild ginseng, bovis calculus, ursi fel and moschus from the classics. 2. Wild ginseng had a study dealing with the efficacy of anticancer, obesity, toxicity, immunity, sulfation, diabetes, plasma proteins, depression, hypertension, endometriosis and hair loss. Especially among 6 studies related to obesity, apart from the study that treated extract of wild ginseng directly to the cell or oral administration to the animals, also have studies that had an efficacy of improving obesity through injecting pharmacopuncture to acupuncture point and vein, etc. 3. Bovis calculus had a study about efficacy related to arthritis, liver, inflammation of cornea, obesity, anticancer, immunity, antacid, heart, lumbar pain, hypertension, toxicity, a digestive organ and sasang constitution, especially in case of obesity, had each studies about oral administration of complex prescription and about cell unit experiment of pharmacopuncture. 4. Ursi fel had a study about efficacy related to liver, arthritis, inflammation of cornea, immunity, obesity, anticancer, antacid, lumbar pain, digestive organ, toxicity, cell protection, skin ailment, etc. Especially in case of obesity, had each studies about oral administration of animal experiment and about cell unit experiment of pharmacopuncture. 5. Moschus had a study about efficacy related to liver, the central nervous system, arthritis, inflammation of cornea, immunity, obesity, anticancer, hypertension, heart, lumbar pain, etc. Especially in case of obesity, had one study about oral administration of complex prescription. Conclusion: Through the result of probability as a obesity medicine of wild ginseng, bovis calculus, ursi fel and moschus, we could identify the possibility of each drug as a obesity medicine. Also in the future, it is considered that studies about one or complex prescription and pharmacopuncture as a obesity medicine will be needed.

• Korean Journal of Oriental Medicine
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• v.13 no.2 s.20
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• pp.113-120
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• 2007

Objectives : This study was conducted to collect the basic data for the developments of moxibustion related technique and the efficient promotion of moxibustion research. Methods : We have analysed the moxibustion associated patents application informations searching by WIPS company. We searched and analyzed the total of 1.770 data base from the year 1976 to July, 2006. Results : Korea is mostly superior compared to the others in number of domestic patents. Korean applicant was as frequent as 1066 subjects(80%) of nationality. The most common field of patents was 'moxibustion body' 587 subjects(26%), 'heating material' 495 subjects(23%), 'heating control' 96 subjects(4%). 'manufacture method' 78 subjects(3%), 'etc'(3%). The most common applicant of moxibustion patents was Yu Tae Woo(131subjects). Kim Geun Sik(50subjects), Most moxibustion material and device was wormwood, wormwood moxibustion device. Conclusion : Moxibustion technological development is being recognized as a core capability of competitive advantage for sustainable growth of international alternative medicine. We are in need of inspecting the patents. We will have to work up for strengthen the competitiveness of Korea moxibustion patents.

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.72-86
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• 2021

Objectives The aim of this study was to review the current clinical Sasang constitutions studies by using genetics and to provide basic data for developing in a better direction of research. Methods Research articles on genetics of the clinical Sasang constitutions studies were extracted from six databases. The articles were classified were published year, published journals, and the types of studies. Subjects of research and experimental methods for the genetic research were summarized. Results A total of 43 selected research articles were published from 1996 to 2020 and more than half of them were published in Journal of Sasang Constitutional Medicine and Journal of Korean Oriental Medicine. There were three main types of researches. The three types of researches were for investigating a genetic indicator for classification of Sasang constitutional type, confirming a relationship between pathological gene and Sasang constitutional type, and checking a hereditary of Sasang constitutional type. But these studies did not yield clear results illustrating a relationship between Genetics and Sasang Constitutional Medicine. Discussion In this study, the necessity of the follow up studies to demonstrate a relationship between Genetics and Sasang Constitutional Medicine was confirmed.

• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.251-263
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• 2019

Objectives: The purpose of this study was to review the clinical research trends in the treatment of post traumatic stress disorder (PTSD) in Korean medicine (KM). Methods: We searched MEDLINE, CENTRAL, EMBASE, Google Scholar and five Korean databases through May 2019, for studies on KM to treat PTSD. Clinical research that conducted KM treatment of PTSD patients were included. Two researchers independently conducted study selection and data extraction process. Results: Totally, eight studies were included in this review. Types of traumatic events that patients experienced included physical violence/threatening, traffic accidents, sexual violence and personal tragic events. KM interventions performed included acupuncture, moxibustion, herbal medicine, physical therapy, and KM-based psychotherapy. Treatment duration varied from two days to more than five months. Follow-up began at least one week to three months after the end of treatments. It was reported that the major psychological and/or somatic symptoms of PTSD, such as anxiety, depression, insomnia, and musculoskeletal pain, subjectively improved, as well as other objective outcomes: Impact Event Scale-Revised Korean version (IES-R-K), Beck's Depression Inventory (BDI), State-Trait Anxiety Inventory, Hwabyung Symptoms/characters, Electroencephalography (EEG) change, etc. Statistical studies were conducted in three studies only. Outcomes such as Visual Analogue Scale (VAS), BDI, and IES-R-K showed statistically significant improvement after KM treatments. There was no study reporting adverse events during or after the interventions. Conclusions: According to this review, diverse types of KM treatments have been used among PTSD patients in eight studies. The KM treatments effectively improved psychological and somatic symptoms of PTSD patients. However, the lack of high quality research as well as the lack of standardization of KM treatments for PTSD are limitations. Further methodologically robust clinical trials should be performed, and the standardization of KM treatments for PTSD should be sought.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.2
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• pp.43-55
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• 2020

Objectives : The general and specific characteristics inherited in Korean traditional medicine research is to be identified and on the basis of this, the role of researchers, research institutes and government organizations is to be presented. Method : Analysis data targeted 399 cases of traditional medicine researches out of 696 cases, excluding overlapped 297 cases, that are relevanttokey-words, 'Oriental Medicine' and 'Herbal Prescription' registered in the National Institutes of Health Clinical Research Information Service(CRIS) as of 31 December, 2019. Including the regulation of the Ministry of Food and Drug Safety, research fund supporting, type of mediation, targeting disease and so forth, frequency analysis was carried out in order to confirm the general and specific characteristics of traditional medicine. Results : As a result of analyzing the data, researches of medicines(herbal medicines) and mediation(acupuncture, moxibustion) and were identified as the most and in the case of the targeting disease, it appeared in the order of targeting the research on musculoskeletal system and the healthy person.