• Archives of Pharmacal Research
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• v.27 no.2
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• pp.239-245
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• 2004

KR-31543, (2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2 -methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran, is a new neuroprotective agent for preventing ischemia-reperfusion damage. This study was performed to identify the metabolic pathway of KR-31543 in human liver microsomes and to characterize cytochrome P450 (CYP) enzymes that are involved in the metabolism of KR-31543. Human liver microsomal incubation of KR-31543 in the presence of NADPH resulted in the formation of two metabolites, M1 and M2. M1 was identified as N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine on the basis of LC/MS/MS analysis with a synthesized authentic standard, and M2 was suggested to be hydroxy-KR-31543. Correlation analysis between the known CYP enzyme activities and the rates of the formation of M 1 and M2 in the 12 human liver microsomes have showed significant correlations with testosterone 6$\beta$-hydroxylase activity (a marker of CYP3A4). Ketoconazole, a selective inhibitor of CYP3A4, and anti-CYP3A4 monoclonal antibodies potently inhibited both N-hydrolysis and hydroxylation of KR-31543 in human liver microsomes. These results provide evidence that CYP3A4 is the major isozyme responsible for the metabolism of KR-31543 to M1 and M2.

• Journal of Radiation Industry
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• v.2 no.3
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• pp.141-148
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• 2008

Beta rays emitted from tritium in titanium tritide film were simulated with cathode rays of a scanning electron microscope to investigate the effect of beta rays from tritium on semiconductor devices. The cathode ray currents, which vary with the change of applied energy and beam spot size, were measured with Faraday cup. The current from the semiconductor device irradiated with cathode rays at various conditions was measured. The cathode ray current increased with the increase of spot size to a maximum then decreased when the spot sized increased further. The magnitude of current produced in the semiconductor device is proportional to the magnitude of cathode ray current. The magnitude of cathode ray current at each energy level was matched to the intensity of beta ray to simulate the tritium beta ray spectrum. Then the semiconductor characteristics were analyzed with I-V curves.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2004.08a
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• pp.163-166
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• 2004

Integrated Ship-Shore Information System makes use of advanced technology of marine mobile communication and extends the computer network of shipping company to ship. This system conveniently accomplishes the information exchange between company and ship, guarantees navigation safety and improves commercial performance. The framework of integrated ship-shore information system and the analysis of its function are provided in this paper. Meanwhile, the idea based on the specification of J2EE to build this system is put forward and the relevant technology is demonstrated.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.1
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• pp.49-52
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• 2019

• Journal of Navigation and Port Research
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• v.33 no.8
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• pp.595-602
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• 2009

The aim of this study is to identify the difference of the customer satisfaction before and after establishment of Busan Port Authority with focus on container terminals in Busan Port. As a result, the customer satisfaction varies according to customer types, and it has been changed followed by container port environment. Therefore suitable strategies have to establish, i.e. berth number for large shipping company, connectivity for feeder company, and activity of customer attraction for terminal operating company.

• Asia-Pacific Journal of Business
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• v.13 no.3
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• pp.329-341
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• 2022

Purpose - The purpose of this study was to investigate consistency in estimating the number of vacant jobs using the two business labor force survey with two different time points of survey. Design/methodology/approach - We studied the cause of the differences in estimating the number of vacant jobs between the monthly sample and the new sample in business labor force survey. Findings - To summarize our findings, As the size of the company increases, the number of vacant jobs in the company also increases, and the probability that the number of vacant jobs in the company is zero decreases. The monthly sample was assessed to have a higher likelihood that the number of vacant jobs in the company was zero and the number of vacant jobs was considerable compared to the local sample. Research implications or Originality - Because local survey sample companies tend to minimize the number of vacant jobs even when they reply under the same conditions, the estimation result of the number of vacant jobs in the current monthly survey differs significantly from the estimation result of the local survey. Divergent "degrees of knowledge of question items," survey methodologies, or investigators could be the causes of the various response trends.

• Corrosion Science and Technology
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• v.14 no.1
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• pp.12-18
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• 2015

Since the operation period of nuclear power plants has increased, the degradation of buried pipes gradually increases and recently it seems to be one of the emerging issues. Maintenance on buried pipes needs high quality of management system because outer surface of buried pipe contacts the various soils but inner surface reacts with various electrolytes of fluid. In the USA, USNRC and EPRI have tried to manage the degradation of buried pipes. However, there is little knowledge about the inspection procedure, test and manage program in the domestic nuclear power plants. This paper focuses on the development and build-up of real-time monitoring and control system of buried pipes. Pipes to be tested are tape-coated carbon steel pipe for primary component cooling water system, asphalt-coated cast iron pipe for fire protection system, and pre-stressed concrete cylinder pipe for sea water cooling system. A control system for cathodic protection was installed on each test pipe which has been monitored and controlled. For the calculation of protection range and optimization, computer simulation was performed using COMSOL Multiphysics (Altsoft co.).

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.426.2-426
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• 2001

• Proceedings of the Korean Society for Bio-Environment Control Conference
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• 2000.10a
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• pp.116-118
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• 2000

• Journal of the Korean Institute of Navigation
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• v.25 no.4
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• pp.487-512
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• 2001

In 1986, the People's Insurance Company of China(hereinafter called PICC) Hull Insurance Clauses, which were amended on the basis of the version 1972, were put into effect. Since PICC is the biggest state-owned insurance company in China, its hull insurance clauses have been used nationwide. In the clauses are included the following contents： scope of cover, exclusions, period of insurance, automatical termination of insurance, duty of assured, claim and indemnity, treatment of disputes and so on. However, this study is only limited to the legal interpretation of the most important clauses relating to indemnity of the insurer. The writers attempt to supply some basic materials necessary for the establishment and enforcement of the Korean hull insurance clauses.