In Vitro Metabolism of a New Neuroprotective Agent, KR-31543 in the Human Liver Microsomes : Identification of Human Cytochrome P450
![]() ![]() |
Ji, Hye-Young
(Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University)
Lee, Seung-Seok (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) Yoo, Sung-Eun (Korea Research Institute of Chemical Technology) Kim, Hosoon (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lee, Dong-Ha (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lim, Hong (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lee, Hye-Suk (Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) |
1 | Baldwin, S. J., Bloomer, J. C., Smith, G. J., Ayrton, A. D., Clarke, S. E., and Chenery, R. J., Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica, 25, 261-270 (1995) DOI ScienceOn |
2 | Hong, K. W., Kim, K. Y., Lee, J. H., Shin, H. K., Kwak, Y. G., Kim, S. O., Lim, H., and Yoo, S. E., Neuroprotective effect of (2S,3S,4R)-N'-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N-benzyl-guanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther., 301, 210-216 (2002) DOI ScienceOn |
3 | Lee, M. H., Bae, S. K., Kim, E. J., Kim, Y. G., Kim, S. O., Lee, D. H., Lim, H., Yoo, S. E., and Lee, M. G., Dose-independent pharmacokinetics of a new neuroprotective agent for ischemia-reperfusion damage, KR-31543, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects. J. Pharm. Sci., 92, 190-201 (2003) DOI ScienceOn |
4 | Merry, C., Barry, M. G., Ryan, M., Tjia, J. F., Hennesy, M., Eagling, V.A, Mulcahy, F., and Back, D. J., Interaction of sildenafil and indinavir when co-administered to HIV-positive patients. AIDS, 13, F101-F107 (1999). DOI ScienceOn |
5 | Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., and Guengerich, F. P., Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther., 270, 414-423 (1994) |
6 | von Moltke, L. L., Greenblatt, D. J., Grassi, J. M., Granda, B. W, Duan, S. X., Fogelman, S. M., Daily, J. P, Harmatz, J. S., and Shader, R. I., Protease inhibitors as inhibitors of human cytochromes P450: High risk associated with ritonavir. J. Clin. Pharmacol., 38, 106-111 (1998) DOI ScienceOn |
7 | Wrighton, S. A., Brian, W. R., Sari, M. A., Iwasaki, M., Guengerich, F. P., Raucy, J. L., Molowa, D. T., and Vandenbranden, M., Studies on the expression and metabolic capabilities of human liver cytochrome P-450 IIIA4 (HLp 3). Mol. Pharmacol., 38, 207-213 (1990) PUBMED |
8 | Maurice, M., Pichard, L., and Daujat, M., Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. FASEB J., 6, 752-758 (1992) |
9 | Watkins, P. B., Wrighton, S. A., Mauel, P., Schuets, E. G., Mendezpicon, G., Parker, G. A., and Guzelian, P. S., Identification of an inducible form of cytochrome P-450 in human liver. Proc. Natl. Acad. Sci. USA, 82, 6310-6314 (1985) DOI ScienceOn |
10 | Kim, J., Ji, H. Y., Lee, S. S., Yoo, S. E., Kim. S. O., Lee, D. H., Lim, H., and Lee, H. S., Metabolism of a new neuroprotective agent for ischemia-reperfusion damage, KR-31543 in the rats using liquid chromatography/electrospray mass spectrometry. Arch. Pharm. Res., 25, 664-668 (2002) DOI ScienceOn |
11 | Yoo, S. E., Vi, K. Y., Lee, S., Suh, J., Kim, N., Lee, B. H., Seo, H. W., Kim, S. O., Lee, D. H., Lim, H. and Shin, H. S., A novel anti-ischemic ATP-sensitive potassium channel opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N'cyanoguanidine analogue. J. Med. Chem., 44, 4207-4215 (2001) DOI ScienceOn |
12 |
Wang, J. S., Wen, X., Backman, J. T., Taavitsainen, P., Neubonnen, P. J., and Kivisto, K. T., Midazolam |
13 | Otton, S. V., Crewe, H. K., Lennard, M. S., Tucker, G. T., and Woods, H. F., Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. J. Pharmacol. Exp. Therap., 247, 242-247 (1988) |
14 | Lillibridge, J. H., Liang, B. H., Kerr, B. M., Webber, S., Quart, B., Shetty, B., and Lee, C. A., Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate. Drug Metab. Disp., 26, 609-616 (1998) |
15 | Wrighton, S. A. and Ring B. J., Inhibition of human CYP3A catalyzed 1-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine and nizatidine. Pharm. Res., 11, 921-924 (1994) DOI ScienceOn |
16 | Bork, R. W., Muto, T., Beaune, P. H., Srivastava, P. K., Lloyd, R. S., and Guengerich, F. P., Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J. Biol. Chem., 264, 910-919 (1989) PUBMED |
17 | Sesardic, D., Boobis, A. R., and Murray, B. P., Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man. Br. J. Clin. Pharmacol., 29, 651-663 (1990) DOI PUBMED ScienceOn |
![]() |