• Journal of Digital Contents Society
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• v.18 no.7
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• pp.1293-1301
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• 2017

Recent changes in social structure, such as nuclear family and personalization, are leading to personal and social problems, which may cause various problems due to negative emotional amplification. The absence of a family member who gives a sense of psychological stability in the past can be considered as a representative cause of the emotional difficulties of modern people. This personal and social problem is solved through the empathic interaction of the companion robot communication with users in daily life. In this study, we developed sophisticated empathic interaction design through prototyping of emotional robots. As a result, it was confirmed that the face interaction greatly affects the emotional interaction of the emotional robot and the interaction of the robot improves the emotional sense of the robot. This study has the theoretical and practical significance in that the emotional robot is made more sophisticated interaction and the guideline of the sympathetic interaction design is presented based on the experimental results.

• The Plant Pathology Journal
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• v.36 no.4
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• pp.314-322
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• 2020

Interplay between histone acetylation and deacetylation is one of the key components in epigenetic regulation of transcription. Here we report the requirement of MoHDA1-mediated histone deacetylation during asexual development and pathogenesis for the rice blast fungus, Magnaporthe oryzae. Structural similarity and phylogenetic analysis suggested that MoHDA1 is an ortholog of Saccharomyces cerevisiae Hda1, which is a representative member of class II histone deacetylases. Targeted deletion of MoHDA1 caused a little decrease in radial growth and large reduction in asexual sporulation. Comparison of acetylation levels for H3K9 and H3K14 showed that lack of MoHDA1 gene led to significant increase in H3K9 and H3K14 acetylation level, compared to the wild-type and complementation strain, confirming that it is a bona fide histone deacetylase. Expression analysis on some of the key genes involved in asexual reproduction under sporulation-promoting condition showed almost no differences among strains, except for MoCON6 gene, which was up-regulated more than 6-fold in the mutant than wild-type. Although the deletion mutant displayed little defects in germination and subsequent appressorium formation, the mutant was compromised in its ability to cause disease. Wound-inoculation showed that the mutant is impaired in invasive growth as well. We found that the mutant was defective in appressorium-mediated penetration of host, but did not lose the ability to grow on the media containing H₂O₂. Taken together, our data suggest that MoHDA1-dependent histone deacetylation is important for efficient asexual development and infection of host plants in M. oryzae.

• Journal of Science Education
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• v.41 no.2
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• pp.267-280
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• 2017

The purpose of this study is to review the foundation of the representative early scientific societies and their major activities. The documents, books, and literature related to this study were collected through internet websites (e.g., google scholar, wikipedia) and analyzed by the qualitative content analysis method. The result of this study shows that requirement for the necessary resources to acquire or to prepare the instruments for the experiment is significantly increased with the rising importance of the experiments to conduct the scientific methods. As a consequence, scientists faced urgent necessities to conduct scientific experiments with cooperation and exchange of the newest information by establishing a community beyond the independent and individual research activity. Establishment of the scientific societies is the result of these necessities. At the beginning of the scientific societies, the resources are provided by either wealthy patron or member contribution or public through foundation of government organization. This study provides the implications for future scientific societies.

• Korean Journal of Pharmacognosy
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• v.40 no.1
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• pp.59-64
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• 2009

Atopic dermatitis, caused by immune hyper-responsiveness, is wide spread in humans as well as in the dogs, especially in industrialized condition. Pet dogs are generally exposed to the same environment as their owners, and a significant portion of these animals are also known to suffer from this allergic disease. However, diagnosis and treatment methods of atopic dermatitis in animals have not been well established. We explored the possibility of using recently developed PG102 for the treatment of atopic dermatitis in the canine population. PG102 is a water soluble extract prepared from Actinidia arguta, and has been shown to produce significant therapeutic effect in variable allergy animal models. After oral administration of PG102 at a dose of 12.5 mg/kg daily for 4 weeks, severity of disease was greatly improved. IgE is one of representative members used to diagnose allergic diseases in humans. However, it is not well established whether there is any correlation between the serum level of IgE and atopic dermatitis. Our data indicated that dogs diagnosed to have atopic dermatitis contained higher level of serum IgE than the normal dogs and that treatment of dogs with PG102 significantly lowered the serum level of IgE. Taken together, this study demonstrated that PG102 treatment yielded significant amelioration of canine atopic dermatitis and down-regulation of serum IgE and that the serum level of IgE can be used as a convenient member for diagnosis of atopic dermatitis in dogs.

• Journal of the Korean Chemical Society
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• v.40 no.7
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• pp.526-530
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• 1996

3-(N-Alkylamino)-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxides have been prepared by the treatment of 3-imino-1,2,5-thiadiazolidine 1,1-dioxides with alkylamines. The selected spectral properties of these heterocycles are detailed, as well as an X-ray crystallographic structure of a representative member of these compounds. 3-(N-Benzylamino)-4,5-dihydro-4-(4'-methoxyphenyl)-1,2,5-thiadiazole 1,1-dioxide crystallyzes in space group $P2_1a$, monoclinic, with $a=22.512(3)(1)\AA$, $b=9.831(2)\AA$, $c=7.194(4)\AA$, $\beta=96.65(2)$, and Z=4.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.3
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• pp.102-113
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• 2017

A new index for the buckling strength of non-structured plates is proposed. The external work or the deformation energy caused by the external loads or the boundary displacement controled by a load parameter is calculated along an equilibrium path of the member under consideration. If the second variation of the energy with respect to the parameter loses its positiveness, it defined as the limit of the stability. In contrast to the current method given in codes where the stability limit is evaluated by using only representative internal forces, the evaluation of the stability limit is always consistent even with the change of the distribution of the internal forces on the boundary. If the elasticity is concerned, the result from this proposed approach becomes identical to that from the classical methods.

• Toxicological Research
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• v.28 no.4
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• pp.255-262
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• 2012

Inflammation is the immune system's response to infection and injury-related disorders, and is related to pro-inflammatory factors (NO, $PGE_2$, cytokines, etc.) produced by inflammatory cells. Atopic dermatitis (AD) is a representative inflammatory skin disease that is characterized by increasing serum levels of inflammatory chemokines, including macrophage-derived chemokine (MDC). Carpinus tschonoskii is a member of the genus Carpinus. We investigated the anti-inflammatory activity of C. tschonoskii by studying the effects of various solvent fractions prepared from its leaves on inflammatory mediators in HaCaT and RAW264.7 cells. We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-${\gamma}$ signaling pathway. In addition, the chloroform fraction significantly suppressed the expression of inflammatory factors induced by lipopolysaccharide stimulation, except COX-2 and TNF-${\alpha}$. These results suggest that the chloroform fraction of C. tschonoskii leaves may include a component with potential anti-inflammatory activity.

• The Korean Journal of Archival Studies
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• no.68
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• pp.243-279
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• 2021

Rep. Roh Hoe-chan is a representative politician in Korean progressive politics. From the labor movement to the workers' political organization movement, they devoted themselves to the movement to build a progressive party. As a member of the 17th, 19th, and 20th National Assembly, he carried out legislative activities. The record he left is the record of the political power of workers, the record of the progressive party, and the record of a politician who suffers and practices. Also, as the son of a displaced person, as a student activist suffering from the restoration period, it is also a record of a human being of cultural literacy who played the cello. Archivist's basic research is expected to play a role in creating a virtuous cycle of archive management by structuring the archive and presenting various access points to various users, allowing more diverse research and use in the future.

• International journal of steel structures
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• v.18 no.5
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• pp.1525-1540
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• 2018

A test rig with multi-functional purposes was specifically designed and manufactured to study the behavior of multi-planar welded tubular joints subjected to multi-planar concurrent axial loading. An experimental investigation was conducted on full-scale welded tubular joints with each consisting of one chord and eight braces under monotonic loading conditions. Two pairs or four representative specimens (two specimens for each joint type) were tested, in which each pair was reinforced with two kinds of different internal stiffeners at the intersections between the chords using welded rectangular hollow steel sections (RHSSs) and the braces using rolled circular hollow steel sections (CHSSs) and welded RHSSs. The effects of different internal stiffeners at the chord-brace intersection on the load capacity of joints under concurrent multi-planar axial compression/tension are discussed. The test results of joint strengths, failure modes, and load-stress curves are presented. Finite element analyses were performed to verify the experimental results. The study results show that the two different joint types with the internal stiffeners at the chord-brace intersection under axial compression/tension significantly increase the corresponding ultimate strength to far exceed the usual design strength. The load carrying capacity of welded tubular joints decreases with a higher degree of the manufacturing imperfection in individual braces at the tubular joints. Furthermore, the interaction effect of the concurrent axial loading applied at the welded tubular joint on member stress is apparent.

• Korean Journal of Legislative Studies
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• v.24 no.2
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• pp.101-134
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• 2018

This study examines the effects of members' legislative performance on their renominations in the $19^{th}$ Korean National Assembly. We measure how many bills each member has proposed and passed in the Assembly. In addition, we also include rate of passing bills as an indicator of legislative performance. Particularly, we analyze 320 members in total, and 270 members who got in on the competition for nomination separately. The empirical findings of our study show that, firstly, among the total members in the Assembly, as they propose bills more and pass bills fewer, they are more likely to be renominated in the very next election. However, this is a result of different types of members rather than legislative performance. Secondly, among the members who actually competed for renomination, the legislative performance of members can not affect their renomination. Therefore, we argue that it is necessary to stipulate nominations criteria and transform top-down nomination method to bottom-up one in order to raise responsiveness and enhance representative democracy.