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Blood Pressure Reduction of SHR Treated with EA-contaning Lentinus edodes Mycelial Solid Culture Extract (Eritadenine 함유 표고버섯균사체 고체배양 효소추출물(EA-LEMSCEE)의 spontaneous hypertension rat 혈압감소)

  • Moon, Yeon-Kyu;Jung, Jae Eun;Cho, Bok-Im;Heo, Jeong-Doo;Choi, Jungil;Kim, Jeong Ok;Ha, Yeong Lae
    • Journal of Life Science
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    • v.28 no.2
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    • pp.187-194
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    • 2018
  • Eritadenine (EA), derived from Lentinus edodes (LE), reduced low-density lipoprotein (LDL), triglyceride (TG), and phospholipids in bloods, and fatty acid depositions in animals and humans. Previously, we reported that EA inhibited angiotensin-converting enzyme (ACE) activity in vitro. Now, we report that EA reduced blood pressures in spontaneous hypertension rats (SHR). EA-containing LE mycelial culture enzyme extract (EA-LEMSCEE) was prepared from LE mycelial solid cultures and the hot-water extract of LE fruit bodies. Both EA and EA-LEMSCEE inhibited ACE activity in immortalized human umbilical endothelial cells (EA.hy926). EA-LEMSCEE treatments (7.5 mg/kg, 22.5 mg/kg) significantly reduced systolic and diastolic blood pressure in SHR. At five weeks of treatment, EA-LEMSCEE treatment significantly reduced systolic and diastolic blood pressure, similar to the positive control (captopril, CP; 4 mg/kg) treatment. In addition, the LEMSCEE without EA decreased systolic and diastolic blood pressures compared to the control, but not significant. EA-LEMSCEE decreased renin and ACE activities, and angiotensin II (Ang II) contents in SHR compared to the control. After five weeks of treatment, the effect of EA-LEMCEE was similar to that of CP. These results indicate that EA and EA-LEMSCEE reduce blood pressure by inhibiting the renin and ACE activity of SHR. Furthermore, these results imply that EA or EA-LEMSCEE could be used as an antihypertension agent in humans.

A Case Study of Japanese Local Self-Governments Universal Design Policy (일본 자치체의 유니버설디자인 정책 사례연구)

  • Lee, Ho-Soong
    • Archives of design research
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    • v.19 no.1 s.63
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    • pp.27-38
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    • 2006
  • Recently, in each local self-governments Japan, the importation of universal design policy is actively being expanded as a plan to maximize living satisfaction of.citizens within the region. This research investigates the background on how the local self-governments ended up importing the universal design administrative policy, investigates the policies which each self governing bodies have been promoting and presents necessary stipulations following those policies. When we sum up the necessity of promoting universal design by local self-governments, although the we carry various problems in the promoting process in the settlement of provincial era and promoting substantiality of it, we can point out the low birth rate phenomenon, progression of aged people's society, diversification of values as a result of social and economic maturity, etc. as social and economic background. For people's values, as they escape from the economic they attach great importance to economic supremacy, they respect culture, environment, etc. with higher level than economic aspect and the improvement of life's quality is becoming important. Meanwhile, the universal design which is known to many users as a usable design concept as reach to a point where it is getting attention as a basic concept of 21st century design. Today, each of local self-governments in Japan are making various efforts for unperturbed importation and application of universal design to local communities through homepage, universal design guideline or report, various workshops, etc. Especially, there are universal design policies of public areas, facilities, manufacture of other products and information for the contents of the policy. The enforcement of universal design policy puts importance in 1) the process of planning, alteration, policy scheme and decision making 2) the process of policy's enforcement 3) the probation process of all processes and I could find out that equal participation of roles by local citizens, citizen's organizations, companies with the administration hasn't been adopted for each of these processes.

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Geology and Ore Deposits in the Haman-Kunbuk Copper District (함안군북지구(咸安郡北地區)의 지질(地質)과 동광상(銅鑛床))

  • Moon, Chung Uk;Kim, Myung Whan;Lee, Ji Hern;Choi, Chung Jung
    • Economic and Environmental Geology
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    • v.3 no.2
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    • pp.55-73
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    • 1970
  • The district investigated covers the central and southern portions of the Uiryong Quadrangle amounting to $40km^2$ in area and is bounded approximately by geographical coordinates of $128^{\circ}$ 28' $40^{{\prime}{\prime}}{\sim}128^{\circ}$ 24' 25"E in longitude and $35^{\circ}10{\prime}{\sim}35^{\circ}14^{\prime}06^{{\prime}{\prime}}N$ in latitude. The purpose of this investigation was to provide basic information in drawing up a comprehensive development plan of the copper ore deposits known to exist in the HamanKumbuk district with special emphasis given to the ascertainment of geological and paragenetic characteristics. The area consists chiefly of shale, sandy shale and chert, all belong to Kyongsang System of Cretaceous age. Intruded into these rocks are andesite, granodiorite, basic dikes, and acidic dikes. The mineralization which took place in the area, consists of mostly fissure-filling vein deposits, numbering several tens, with varying magnitudes. The fissures and shear zones created in rocks, such as chert and granodiorite, hosted the deposition of mineralizing vapors and/or hydrothermal solutions along their openings. The strike lengths of these veins vary from 50 to 600 meters in extension and 0.1 to 3 meters in width. Although the degree of fluctuation in width is great, it averages 0.3m. The stuctural patterns, which apparently affected the deposition of veins, are fissure patterns, trend NS to $N30^{\circ}W$, and steep-pitching tension fractures as well as normal fault pattern. Ore minerals associated with vein matters are primarily chalcopyrite and small amounts of scheelite, cobaltiferous arsenopyrite, and gold and silver intimately associated with sulphide minerals. Associated with these ore mineral are pyrite, pyrrhotite, magnetite, specularite and arsenopyrite. Gangue minerals noted are quartz, calcite, chlorite, tourmaline and hornblende. In terms of the compositions of associated minerals, the vein deposits in the district could be grouped under the following four categories: 1. Pyrrhoitite, Arsenopyrite, Gold and Silver Bearing Copper Vein (Type I) 2. Calcite-Scheelite-Copper Vein (Type II) 3. Magnetite-Pyrite-Copper Vein (Type III) 4. Tourmaline Copper Vein (Type IV) Of the four types, the first and the fourth are presently yielding relatively higher grades: of copper ores and concentrates. The estimated ore reserves total some 222,000 metric tons with the following breakdown in terms of metal contents: Name of Mines Au(g/t) Ag(g/t) Cu(%) Reserves(M/T) Kunbuk 15.92 78.69 6,074 60.498 Cheil Kunbuk - - 1.040 60,847 Haman - - 2.688 101,204 222,549 As rehabilitation of old workings and/or exploration of veins at depth proceed, additional estimation of ore reserves may become apparent and necessary. With regard to the problem of beneficiation and upgrading of low-grade ores in the district, it would be advisable to make decisions on location, treating capacity and mill flowsheet after sufficient amount of exploration is completed as suggested in the report.

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Analysis of Formaldehyde in Fisheries Products (수산물 중 포름알데히드 함량분석)

  • Kim, Hyun-Ah;Jang, Jin-Wook;Kim, Do-Hyeong;Lee, Hwee-Jae;Lee, Soo-Min;Chang, Ho-Won;Lee, Kwang-Soo;Lee, Chang-Hee;Jang, Young-Mi;Kang, Chan-Soon
    • Korean Journal of Food Science and Technology
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    • v.43 no.1
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    • pp.17-22
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    • 2011
  • In this study, formaldehyde in various fisheries products was previously derivatized with acetylacetone and subsequently analyzed by using HPLC-PDA. The formaldehyde contents ranged from 0.07 to 73.74 mg/kg. The compound was significantly higher in both mollusks (0.34-12.38 mg/kg) and crustaceans (0.09-73.74 mg/kg) than in fish (0.07-3.35 mg/kg) and shellfish (0.50-3.90 mg/kg). This difference was due to storage time and temperature. In general, fish and shellfish are sold live or in refrigerated form with shorter a shelf-life, but mollusks and crustaceans are distributed in cold or frozen systems with a longer shelf-life. Using food intake data from a report of the National Health and Nutrition Survey, the daily human exposure level to formaldehyde was 0.58% of the ADI. The results from this study might provide fundamental information to confirm naturally-originating or fraudulent formaldehyde treatment in fisheries products.

Consumers Perceptions on Sodium Saccharin in Social Media (소셜미디어 분석을 통한 삭카린나트륨 소비자 인식 조사)

  • Lee, Sooyeon;Lee, Wonsung;Moon, Il-Chul;Kwon, Hoonjeong
    • Journal of Food Hygiene and Safety
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    • v.30 no.4
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    • pp.329-342
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    • 2015
  • The purpose of this study was to investigate consumers' perceptions of sodium saccharin in social media. Data was collected from Naver blogs and Naver web communities (Korean representative portal web-site), and media reports including comment sections on a Yonhap news website (Korean largest news agency). The results from Naver blogs and Naver web communities showed that it was primarily mentioned 'sodium saccharin-no added' products, properties of sodium saccharin, and methods of reducing sodium saccharin in food. When media reported the expansion of food categories permitted to use sodium saccharin, search volume for sodium saccharin has increased in both PC and mobile search engines. Also, it was mainly commented about distrust of government, criticism of food product price, and distrust of food companies below the news on the news site. The label of sodium saccharin-no added products in market emphasized "no added-sodium saccharin". These results suggest that consumers are interested in sodium saccharin and especially when media reported the expansion of food categories permitted to use it. Consumers were able to search various information on sodium saccharin except safety or acceptable daily intake through social media. Therefore media or competent authority should report item on sodium saccharin with information including safety or acceptable daily intake based on scientific background and reference or experts' interview for consumers to get reliable information.

Antitumor Activity of Methylene Chloride Fraction from Angelica Keiskei Through Induction of Apoptosis in Human Prostate Carcinoma DU145 Cells (전립선 암세포주 DU145의 세포고사 유도를 통한 신선초 (Angelica keiskei) 메틸렌 클로라이드 추출물의 항암효과)

  • Kang, Yoon-Mook;Kim, Sung-Moo;Kim, Hyun-Jung;Park, Kyung-Ran;Shim, Bum-Sang;Kim, Sung-Hoon;Choi, Seung-Hoon;Ahn, Kyoo-Seok;Ahn, Kwang-Seok
    • Journal of Korean Traditional Oncology
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    • v.15 no.1
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    • pp.19-27
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    • 2010
  • The roots and leaves of Angelica keiskei (AK) have been used for the treatment of various diseases including coronary heartdisease, hypertension, and cancer in the Korean folk medicine. However, the mechanism by which methylenechloride fraction (MF) from AK exerts anti-tumorigenic activity in human prostate cancer cells has not been fully understood. In the present study, we report the MF exerted the highest cytotoxicity against prostate cancer DU145 cells compared with other fractions. Especially, MF caused the accumulation of sub-G1 DNA contents of cell cycle and increased annexin V-positive apoptotic bodies and DNA fragmentation. MF down-regulated several proliferative (Cyclin D1) and anti-apoptotic (Bcl-xl, Bcl-2, IAP-1/2, and survivin)gene products in these cells. Hence, MF induced apoptosis through the caspase-3 activation in DU145 cells. We further confirmed that caspase-3 plays an importance role in MF-induced apoptosis in DU145 cells by using caspase-3 inhibitor. Additionally, we observed that MF potentiated Dox-induced apoptosis in DU145 cells. Taken together, our data demonstrate the evidence that MF induces apoptosis depend on caspase-3 activation of and overcomes resistance to chemotherapy in human prostate cancer cells.

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A Top-Down Approach to the Hardware Design Education Focusing on the Logic Design Courses (하드웨어 설계 교육에서의 TOP-DOWN 접근방법 : 논리설계 과목을 중심으로)

  • Yi Kang;Jung Kyeong-Hoon;Han Youn-Sik
    • Journal of Engineering Education Research
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    • v.6 no.2
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    • pp.22-29
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    • 2003
  • The ultimate goal of a hardware design course is to equip the students with the system design ability. However, the majority of the current structures of the design courses are focused on the understanding of the operational principles of each device which is used later as a building block for the design of a system. The shortcomings of this approach are, first, that it is very hard to keep the students motivated to the end of the course where system design concepts are dealt, and, second, the students do not have enough experience of the system design which is usually required in the field. As an alternative to solve these problems, it is necessary to reverse the order of contents of the course. Namely we introduce the high level of the abstract concept of the system design in the very beginning of the course and later by lowering the level of abstraction to the operational principle of the internal devices. In this paper, we propose a new top-down methodology for the introductory hardware design course of logic design, where the design expression and verification in the system-level are introduced first and then detail knowledge on each device is introduced later. Also, we report a case result from a student's working group as part of an extracurricular education in order to verify the validity of our proposed approach

An Analysis of News Report Characteristics on Archives & Records Management for the Press in Korea: Based on 1999~2018 News Big Data (뉴스 빅데이터를 이용한 우리나라 언론의 기록관리 분야 보도 특성 분석: 1999~2018 뉴스를 중심으로)

  • Han, Seunghee
    • Journal of the Korean Society for information Management
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    • v.35 no.3
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    • pp.41-75
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    • 2018
  • The purpose of this study is to analyze the characteristics of Korean media on the topic of archives & records management based on time-series analysis. In this study, from January, 1999 to June, 2018, 4,680 news articles on archives & records management topics were extracted from BigKinds. In order to examine the characteristics of the media coverage on the archives & records management topic, this study was analyzed to the difference of the press coverage by period, subject, and type of the media. In addition, this study was conducted word-frequency based content analysis and semantic network analysis to investigate the content characteristics of media on the subject. Based on these results, this study was analyzed to the differences of media coverage by period, subject, and type of media. As a result, the news in the field of records management showed that there was a difference in the amount of news coverage and news contents by period, subject, and type of media. The amount of news coverage began to increase after the Presidential Records Management Act was enacted in 2007, and the largest amount of news was reported in 2013. Daily newspapers and financial newspapers reported the largest amount of news. As a result of analyzing news reports, during the first 10 years after 1999, news topics were formed around the issues arising from the application and diffusion process of the concept of archives & records management. However, since the enactment of the Presidential Records Management Act, archives & records management has become a major factor in political and social issues, and a large amount of political and social news has been reported.

Prebiotic Properties of Levan in Rats

  • Jang, Ki-Hyo;Kang, Soon-Ah;Cho, Yun-Hi;Kim, Yun-Young;Lee, Yun-Jung;Hong, Kyung-Hee;Seong, Kyung-Hwa;Kim, So-Hye;Kim, Chul-Ho;Rhee, Sang-Ki;Ha, Sang-Do;Choue, Ryo-Won
    • Journal of Microbiology and Biotechnology
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    • v.13 no.3
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    • pp.348-353
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    • 2003
  • Generally, two different types of fructose polymer are found in nature. One is inulin, whose fructosyl residues are linked mainly by a ${\beta}-(2,1)-linkage$, while the other is high-molecular-weight levan, whose fructosyl residues are linked mainly by a ${\beta}-(2,6)-linkage$. In contrast to the extensive studies on the prebiotic properties of inulin, there has been no report on the effect of levan on the large bowel microflora in viva. Therefore, to examine whether dietary levan can be used as a prebiotic, Sprague-Dawley male rats were fed one of two diets for 3 weeks: 1) basal diet plus sucrose; 2) basal diet plus 10% (wt/wt) levan. The cecal bowel mass, cecal and colon short-chain fatty acids (SCFAs), pH, and microflora were then compared. The intake of the levan-containing diet significantly increased the total cecal weight and wall weight. The analyses of the SCFAs in the cecal and colonic contents revealed that levan was converted into acetate, butyrate, and lactate, which resulted in acidic conditions. The intake of levan also significantly increased the total number of microorganisms by 5-fold and lactic acid-producing bacteria (LAB) 30-fold in the feces. Accordingly, the current work shows that levan can be used as a prebiotic for stimulating the growth of LAB in an animal model.

Purification, and Biochemical and Biophysical Characterization of Cellobiohydrolase I from Trichoderma harzianum IOC 3844

  • Colussi, Francieli;Serpa, Viviane;Da Silva Delabona, Priscila;Manzine, Livia Regina;Voltatodio, Maria Luiza;Alves, Renata;Mello, Bruno Luan;Nei, Pereira Jr.;Farinas, Cristiane Sanches;Golubev, Alexander M.;Santos, Maria Auxiliadora Morim;Polikarpov, Igor
    • Journal of Microbiology and Biotechnology
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    • v.21 no.8
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    • pp.808-817
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    • 2011
  • Because of its elevated cellulolytic activity, the filamentous fungus Trichoderma harzianum has a considerable potential in biomass hydrolysis applications. Trichoderma harzianum cellobiohydrolase I (ThCBHI), an exoglucanase, is an important enzyme in the process of cellulose degradation. Here, we report an easy single-step ion-exchange chromatographic method for purification of ThCBHI and its initial biophysical and biochemical characterization. The ThCBHI produced by induction with microcrystalline cellulose under submerged fermentation was purified on DEAE-Sephadex A-50 media and its identity was confirmed by mass spectrometry. The ThCBHI biochemical characterization showed that the protein has a molecular mass of 66 kDa and pI of 5.23. As confirmed by smallangle X-ray scattering (SAXS), both full-length ThCBHI and its catalytic core domain (CCD) obtained by digestion with papain are monomeric in solution. Secondary structure analysis of ThCBHI by circular dichroism revealed ${\alpha}$- helices and ${\beta}$-strands contents in the 28% and 38% range, respectively. The intrinsic fluorescence emission maximum of 337 nm was accounted for as different degrees of exposure of ThCBHI tryptophan residues to water. Moreover, ThCBHI displayed maximum activity at pH 5.0 and temperature of $50^{\circ}C$ with specific activities against Avicel and p-nitrophenyl-${\beta}$-D-cellobioside of 1.25 U/mg and 1.53 U/mg, respectively.