• Journal of Microbiology and Biotechnology
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• 제27권2호
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• pp.380-387
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• 2017

The foamy viruses are currently considered essential for development as vectors for gene delivery. Previous studies demonstrated that prototype foamy virus (PFV) can infect and replicate prevalently in a variety of cell types for its exclusive replication strategy. However, the virus-host interaction, especially PFV-transportin3 (TNPO3), is still poorly understood. In our investigation of the role of TNPO3 in PFV infection, we found lower virus production in TNPO3 knockdown (KD) cells compared with wild-type 293T cells. PCR analysis revealed that viral DNAs were mostly altered to circular forms: both 1-long terminal repeat (1-LTR) and 2-LTR in TNPO3 KD cells. We therefore suggest that TNPO3 is required for successful PFV replication, at least at/after the nuclear entry step of viral DNA. These findings highlight the obscure mysteries of PFV-host interaction and the requirement of TNPO3 for productive infection of PFV in 293T cells.

• The Journal of Korean Physical Therapy
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• 제17권1호
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• pp.108-122
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• 2005

The gait training strategy in very important things for central nervous system(CNS) injury patients. There are many method and strategy for regaining of the gait who had CNS injury. A human being has central pattern generator(CPG) is spinal CPG for locomotion. It is a neural network which make the cyclical patterns and rhythmical activities for walking. Sensory input from loading and hip position is essential for CPG stimulation that makes the central neural rhythm and pattern generating structure. From sensory input, the proprioceptive information facilitate proximal muscles that controlled in voluntarily from cortical level and visual and / or acoustical information facilitate distal muscles that controlled voluntarily from subcortical level. Gait training method can classify that is functional level and structural level. Functional level includ level surface gait, going up and down the stair. It is important to facilitate a guide tempo in order to activate the central pattern generators. During the functional test or functional activities, can point out the poor period in gait that have to be facilitate in structural level. There are many access methods with patient position and potentiality. The methods are using of rhythmic initiation, replication and combination of isotonic with standing position. Clinically using it on weight transfer onto the stance leg, loading response, loading response and pre-swing, terminal stance, up and downwards stairs.

• Natural Product Sciences
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• 제26권4호
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• pp.340-344
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• 2020

A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher's method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 μM.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2006년도 한국컴퓨터종합학술대회 논문집 Vol.33 No.1 (D)
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• pp.271-273
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• 2006

초기의 비구조적인 피어-투-피어 방식은 플러딩(flooding) 방식의 검색 기법을 사용하는데, 이 기법은 통신비용이 매우 많이 소요되어 비효율적이다. 따라서 효율적인 검색 기법으로 임의 경로(random walk) 검색 방식이 제안되었다. 이 검색 기법은 메시지가 임의로 노드를 이동하기 때문에, 검색의 성공률이 낮다. 이를 보완하기 위하여 효율적인 복제기법이 요구된다. 현재 나와 있는 복제 기법은 여러 방법이 있으나, 모두 통신에 고비용을 요구한다. 따라서 복제 기법에서는 통신비용을 최소화하는 효율적인 복제 기법이 필요하다. 본 논문에서는 캐시를 사용하여 직접적인 데이터 통신비용을 최대로 줄이는 한편, 복제를 질의가 많이 도착하는 곳에 위치시켜 검색률의 저하를 막고, 잘못된 캐시 관리 기법을 통해 동적인 환경에서도 잘못된 캐시로 인한 검색의 실패를 최소할 수 있는 기법을 제안한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권2호
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• pp.63-73
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• 2012

Development of antiviral resistance to lamivudine is the most important factor for the treatment failure. It is necessary to establish proper guidelines to overcome drug resistance for children with chronic hepatitis B. Primary treatment with lamivudine should be considered if patients are in immune-clearance phase and have persistently elevated ALT levels more than twice the upper limit of normal value. Before initiating the therapy, careful consideration of the patient's status is required to exclude abnormal liver function tests due to other causes. The treatment option should be carefully decided to suppress the viral replication effectively. To obtain good compliance, clinicians should educate patients and their parents. Appropriate monitoring for virologic breakthrough and genotypic resistance is important in deciding to change the treatment plan. Sequential monotherapy should be avoided and a combination of drugs in other categories is recommended. New antiviral agents, such as entecavir and tenofovir, which have high potency and high genetic barrier, are soon expected to be available for use with children.

• 정보기술과데이타베이스저널
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• 제3권2호
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• pp.3-24
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• 1996

In this paper a data replicator scheme with a distributed join architecture is suggested with its cost functions and the performance results. The contribution of this scheme is not only minimizing the number of base relation locks in distributed database tables but also reducing the remote transmission amount remarkably, which will be able to embellish the distributed databse system practical. The differential files that are derived from the active log of the DBMS are mainly forcing the scheme to reduce the number of base relation locks. The amount of transportation between relevant sites could be curtailed by the tuple reduction procedures. Then we prescribe an algorithm of data replicator with its cost function and show the performance results compared with the semi-join scheme in their distributed environments.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2005년도 한국컴퓨터종합학술대회 논문집 Vol.32 No.1 (A)
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• pp.586-588
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• 2005

P2P (Peer-to-peer) 파일 공유 시스템에서 컨텐츠의 복제는 Hot Spot의 방지와 가용성의 보장, 검색 속도의 향상을 위해 사용되고 있다. 컨텐츠의 복제본의 수(공간 효율성)와 검색 성능은 일종의 trade-off로써 이 논문에서는 가능한 검색 성능을 향상시키면서 적절한 양의 복제본의 수를 유지하는 방법인 SRoD 알고리즘을 제안한다. SRoD는 DHT 기반 파일공유시스템에서 전반적으로 간단하게 접목하여 사용할 수 있다는 장점을 가지고 있다. 이러한 특징은 P2P가 추구하는 자율성과 평등성을 보장하기 위한 것이다. 본 논문에서는 SRoD 알고리즘을 설명하고 이것의 장점과 보완해야 할 점에 대해 논하게 될 것이다.

• Journal of Genetic Medicine
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• 제10권1호
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• pp.20-26
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• 2013

Mitochondrion is an intracellular organelle with its own genome. Its function in cellular metabolism is indispensable that mitochondrial dysfunction gives rise to multisystemic failure. The manifestation is most prominent with tissues of high energy demand such as muscle and nerve. Mitochondrial myopathies occur not only by mutations in mitochondrial genome, but also by defects in nuclear genes or secondarily by toxic insult on mitochondrial replication. Currently curative treatment modality does not exist and symptomatic treatment remains mainstay. Administration of L-arginine holds great promise according to the recent reports. Advances in mitochondrial RNA import might enable a new therapeutic strategy.

• Journal of Electrical Engineering and Technology
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• 제8권3호
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• pp.649-657
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• 2013

DTN flooding based routing protocol replicate the message copy to increase the delivery like hood that overloads the network resources. The probabilistic routing protocols reduce replication cost by forwarding the message to a node that holds high predictability value to meet its destination. However, the network traffic converges to high probable nodes and produce congestion that triggers the drop of previously stored messages. In this paper, we have proposed a routing protocol called as Connection frequency Buffer Aware Routing Protocol (CFBARP) that uses an adaptive method to maintain the information about the available buffer space at the receiver before message transmission. Furthermore, a frequency based method has been employed to determine the connection recurrence among nodes. The proposed strategy has performed well in terms of reducing message drop, message relay while increases the delivery probability.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 1999년도 가을 학술발표논문집 Vol.26 No.2 (3)
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• pp.250-252
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• 1999

모빌 컴퓨팅에서는 모빌 호스트의 위치와 상태관리를 위하여 디폴트 서버기법이 널리 사용되는데, 모빌 호스트로 전송되는 데이터는 먼저 디폴트 서버로 보내진 후 다시 모빌 호스트가 위치하는 로칼 서버로 전송된다. 디폴트 서버기법에 기반을 둔 SDN(single Default Notification)기법에서는 클라이언트가 모빌 호스트와의 연결요청을 하면 쿼리 서버를 통해 해당 디폴트 서버에 모빌 호스트의 위치 및 상태를 문의한 후 통신이 이뤄진다. 그러나 쿼리 횟수가 많고 디폴트 서버와의 거리가 멀거나 기지국의 수가 많을 경우 디폴트 서버와의 통신 오버헤드가 커지며, 디폴트 서버에 결함이 발생할 경우 해당 모델 호스트와의 연결이 불가능해진다. 본 논문에서는 위와 같은 문제점을 해결하기 위해 디폴트 서버와의 통신 비용을 줄이기 위한 디폴트 서버 중첩 기법을 제안한다.