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http://dx.doi.org/10.20307/nps.2020.26.4.340

Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.  

Kwon, Haeun (Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Kim, Jun Gu (College of Pharmacy, Chungbuk National University)
Oh, Jeong-Joo (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University)
Kim, Jae-Jin (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University)
Kim, Gyu-Hyeok (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University)
Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
Yim, Joung Han (Korea Polar Research Institute)
Lee, Dongho (Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Publication Information
Natural Product Sciences / v.26, no.4, 2020 , pp. 340-344 More about this Journal
Abstract
A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher's method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 μM.
Keywords
Pleosporales sp.; Chromone; Molecular Networking; Mosher's method; Nitric oxide production;
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Times Cited By KSCI : 2  (Citation Analysis)
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