• Title/Summary/Keyword: replication process

Search Result 219, Processing Time 0.033 seconds

Fabrication of Non Viral Vector for Drug and Gene Delivery using Particle Replication In Non-Wetting Templates (PRINT) Technique (Particle Replication In Non-Wetting Templates (PRINT) 방법을 이용한 약물 및 유전자 전달체의 제작)

  • Park, Ji-Young;Gratton, Stephanie;Benjamin, Maynor;Lim, Jomg Sung;Desimone, Joseph
    • Korean Chemical Engineering Research
    • /
    • v.45 no.5
    • /
    • pp.493-499
    • /
    • 2007
  • Polymeric hydrogel particles were fabricated to demonstrate the scale-up possibilities with the Particle Replication In Non-wetting Templates (PRINT) process. A permanently etched, specifically designed master was made on a silicon wafer using conventional photolithography, then reactive ion etching. The master and substrate were used repeatedly to make a large number of identical elastomeric perfluoropolyethers (PFPE) replica molds. The PFPE replica molds were used to fabricate and harvest individual, monodisperse micron-sized particles using the PRINT process. A water-soluble polymer adhesive was used as a sacrificial layer for harvesting particles. Particles were composed of biodegradable poly (ethylene glycol) diacrylate (PEG-diA), and aminoethylacrylate (AEM) and 2-acryloxyethyltrimethyl ammonium chloride (AETMAC) were added to them for improving the uptake of the cells. This study suggested PRINT used to produce the uniformed and shape specific biodegradable polymer is the effective technique for the non viral vector for the drug and the gene delivery.

Management of Database Replication in Main Memory DBMS ALTIBASE$^{TM}$ for High Availability (고가용성을 위한 주기억장치 DBMS ALTIBASE$^{TM}$의 이중화 관리 기법)

  • Lee Kyu Woong
    • Journal of Internet Computing and Services
    • /
    • v.6 no.1
    • /
    • pp.73-84
    • /
    • 2005
  • ALTIBASE/sup TM/ is the relational main-memory DBMS in which a main memory is primarily used as the main storage device. We present the database replication strategies and techniques of the ALTIBASETM system in order to meet the requirement of high availability and efficient transaction processing. Our process architecture for replication management and its communication model are proposed, and database replication protocols are also described. We show the experimental result of transaction processing rate with various DBMS parameters and overall performance of database replication system as compared to standalone system.

  • PDF

Proposition for Conservation of Traditional Costumes -Mainly on the Replication of Milchanggun's Jobok (복식유물의 보존을 위한 제안 -밀창군 조복의 복제를 중심으로-)

  • Chae Ok-Ja;Park Chi-Sun;Park Sung-Sil
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.30 no.6 s.154
    • /
    • pp.859-869
    • /
    • 2006
  • We proposed that the replicas be made as an alternative to achieve such reciprocal goals as the safe preservation of traditional costume relics and socio-educational realizations through exhibitions, etc., A replication was categorized for its purpose into a restoral replication: a work based on the historical research of color and shapes as they were originally made and a current state replication : a production based on a minute record of the relics as they are excavated. Then, we reported the reproduction process from the excavation to the exhibition on the excavated traditional costumes of Milchanggun's Jobok. The purpose of a replication of relics is to record the relics experiencing the change resulted from the inevitable degeneration over time as organic cultural assets together with the substitution exhibition of relics and academic researches and so on.

Fabrication of Ni master for the replication of planar optical devices by LIGA process (LIGA 공정을 이용한 평면형 광소자용 Ni 마스터 제작)

  • Kim, Jin-Tae;Jeong, Myung-Yung
    • Proceedings of the KSME Conference
    • /
    • 2003.04a
    • /
    • pp.945-949
    • /
    • 2003
  • LIGA(Lithographie Galvanoformung Abformung), a fabrication method for the production of microstructrues with a high aspect ratio, is now playing an important role in a fabrication of polymeric optical waveguide device as the replication processes have been developed such as hot embossing and injection molding. The present report deals with the fabrication of Ni master used for the replication of multi-mode polymeric optical waveguide. With the basic technological features in the sequence of the LIGA technique, we fabricated Ni master with 12 channel microstructures of $100\;{\times}\;100{\mu}m\;^2{\times}\;60mm$, and achieved an accuracy of ${\pm}1\;{\mu}m$. Manufactured polymeric optical wavegude with the same using hot embossing process has also the same accuracy and approved its mass production capability.

  • PDF

Fabrication and Properties of Ni and Ni-W Electroplated Molds Using LIGA-like Process for Replication of Micro Components (LIGA-like 공정을 이용한 마이크로 부품 복제용 Ni과 Ni-W 금형 제조 및 특성)

  • Hwang, W.S.;Park, J.S.;Kang, Y.C.;Cho, J.W.;Park, S.S.;Lee, I.G.;Kang, S.G.
    • Korean Journal of Materials Research
    • /
    • v.13 no.1
    • /
    • pp.6-10
    • /
    • 2003
  • Electroplated Ni and Ni-W micro-molds using LIGA-like process for replication of micro-components such as microfluidic parts and micro optical parts have been investigated. In general, it is hard to produce micro-parts using conventional mechanical processes. Micro-mold formed by LIGA-like process could fabricate micro-parts with high aspect ratio. In this paper, fabrication and properties of electroplated Ni molds with varying applied current types as well as those of Ni-W molds were investigated. Ni molds fabricated under pulse-reverse current showed the highest hardness value of about 160 Hv. Ni-W molds showed the hardness of about 500 Hv which was much harder than that of Ni electroplated molds. The above results suggested that high quality micro-molds could be fabricated by using Ni electroplating of pulse-reverse type for core molds and sequential Ni-W alloys coating.

Development of UV imprinting process for micro lens array of image sensor (UV 임프린트를 이용한 이미지 센서용 마이크로 렌즈 어레이 성형 공정 개발)

  • Lim, Ji-Seok;Kim, Seok-Min;Jeong, Gi-Bong;Kim, Hong-Min;Kang, Shin-Il
    • 정보저장시스템학회:학술대회논문집
    • /
    • 2005.10a
    • /
    • pp.17-21
    • /
    • 2005
  • High-density image sensors have microlens array to improve photosensitivity. It is conventionally fabricated by reflow process. The reflow process has some weak points. UV imprinting process can be proposed as an alternative process to integrate microlens array on photodiodes. In this study, the UV imprionting process to integrate microlens array on image sensor was developed using W transparent flexible mold and simulated image sensor substrate. The UV transparent flexible mold was fabricated by replicating master pattern using siliconacrylate photopolymer. The releasing property and shape accuacy of siliconacrylate mold was analysed. After UV imprinting process, replication quality and align accuracy was analysed.

  • PDF

Development of UV imprinting process for micro lens array of image sensor (UV 임프린트를 이용한 이미지 센서용 마이크로 렌즈 어레이 성형 공정 개발)

  • Lim, Ji-Seok;Kim, Seok-Min;Jeong, Gi-Bong;Kim, Hong-Min;Kang, Shin-Il
    • Transactions of the Society of Information Storage Systems
    • /
    • v.2 no.2
    • /
    • pp.91-95
    • /
    • 2006
  • High-density image sensors rave microlens array to improve photosensitivity. It is conventionally fabricated by reflow process. The reflow process has some weak points. UV imprinting process can be proposed as an alternative process to integrate microlens array on photodiodes. In this study, the UV imprionting process to integrate microlens array on image sensor was developed using UV transparent flexible mold and simulated image sensor substrate. The UV transparent flexible mold was fabricated by replicating master pattern using siliconacrylate photopolymer. The releasing property and shape accuacy of siliconacrylate mold was analysed. After UV imprinting process, replication quality and align accuracy was analysed.

  • PDF

Fabrication of Metallic Nano-filter Using UV-Imprinting Process (UV 임프린팅 공정을 이용한 금속막 필터제작)

  • Noh Cheol Yong;Lee Namseok;Lim Jiseok;Kim Seok-min;Kang Shinill
    • Proceedings of the Korean Society for Technology of Plasticity Conference
    • /
    • 2005.05a
    • /
    • pp.237-240
    • /
    • 2005
  • The demand of micro electrical mechanical system (MEMS) bio/chemical sensor is rapidly increasing. To prevent the contamination of sensing area, a filtration system is required in on-chip total analyzing MEMS bio/chemical sensor. A nano-filter was mainly applied in some application detecting submicron feature size bio/chemical products such as bacteria, fungi and so on. We suggested a simple nano-filter fabrication process based on replication process. The mother pattern was fabricated by holographic lithography and reactive ion etching process, and the replication process was carried out using polymer mold and UV-imprinting process. Finally the nano-filter is obtained after removing the replicated part of metal deposited replica. In this study, as a practical example of the suggested process, a nano-dot array was replicated to fabricate nano-filter fur bacteria sensor application.

  • PDF

Fabrication of the Micro-structured DVD-RAM Substrates (미세 형상을 갖는 DVD-RAM 기판의 성형에 관한 연구)

  • 문수동
    • Proceedings of the Korean Society for Technology of Plasticity Conference
    • /
    • 2000.04a
    • /
    • pp.167-170
    • /
    • 2000
  • Recently the sub-micron structured substrates of 0.74 ${mu}ell$ track pitch and 800 $\AA$groove depth are required for DVD-RAM and the track pitch is expected to be narrower as the need for the information storage density is getting higher. For the accurate replication of the land-groove structure in the stamper to the plastic substrates it is important to control the injection -compression molding process such that the integrity of the replication for the land-groove structure is maximized. in the present study polycarbonate substrates were fabricated by injection comression molding and the land-groove structure regarded as one of mold temperature and the compression pressure on the integrity of the replication were examined experimentally. An efficient design methodology using the response surface method (RSM) the central composite design(CCD) technique and the analysis-of-variance (ANOVA) was developed to obtain the optimum processing conditions which maximize the integrity of the replication with a limited number of experiments.

  • PDF

Fabrication of Microlens Array by UV-molding (UV 성형을 통한 마이크로 렌즈 어레이의 제작)

  • 김석민;임지석;강신일;전병희
    • Transactions of Materials Processing
    • /
    • v.13 no.3
    • /
    • pp.236-241
    • /
    • 2004
  • UV-molded microlens arrays with high replication quality were fabricated using a parametric design method. It is important to maximize the replication quality, because one can obtain the replicated micro-optical components with desired properties by accurate control of the shape. In the present study, nickel mold inserts for microlens arrays with lenses having diameters between $3\mu\textrm{m}$ and $230\mu\textrm{m}$ were fabricated by electroforming process. An UV-molding system was designed and constructed, a simple technique to avoid micro-air bubbles was first suggested, and the effects of the compression pressure and UV-curing dose on the replication quality of UV-molded microlens arrays with a diameter of $14\mu\textrm{m}$ were examined experimentally. Finally, geometrical and optical properties of the replicated microlens arrays were measured and analyzed.