• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.571-572
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• 2006

RTP (rapid thermal pressing), one of micro-pattern replication techniques like hot embossing, is focused on achieving shorter cycle time. DFSS(Design for Six Sigma) has been applied in order to enhance the completeness of the development process for RTP system. According to DIDOV roadmap, we derived design concepts and subsequently decided the main performances, design factors, and components for RTP system. In the design process of RTP system using finite element analysis, it was realized that its structural characteristics affect large area replicability. Optimizing structural design factors, based on CAE, it was checked out that its large area replicability could be improved in a virtual test. Finally, we have a plan to validate the large area replicability of the developed RTP system, by performing micro-pattern replication tests with polymeric sheets.

• Design & Manufacturing
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• 제2권1호
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• pp.45-50
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• 2008

Micro channel is to fabricate desired pattern on the polymer substrate by pressing the patterned mold against the substrate which is heated above the glass transition temperature, and it is a high throughput fabrication method for bio chip, optical microstructure, etc. due to the simultaneous large area patterning. However, the bad pattern fidelity in large area patterning is one of the obstacles to applying the hot embossing technology for mass production. In the present study, stamper of cross channel with width $100{\mu}m$ and height $50{\mu}m$ was manufactured using UV-LiGA process. Micro channel was manufactured using stamper manufactured in this study. Also replicability appliance was evaluated for micro channel and factors affected replicability were investigated using Taguchi method.

• 한국지리정보학회지
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• 제25권4호
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• pp.63-80
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• 2022

현실의 공간을 가상의 공간으로 구현하여 문제를 분석하고 예측하는 기술이 개발되면서, 복잡한 도시 내의 정밀한 공간정보를 취득하는 것이 중요해지고 있다. 본 연구는 복잡한 경관을 가진 도시지역을 대상으로 무인항공기를 통해 영상을 취득하고 고해상도 영상에 적합한 영상분류 기법인 객체기반 영상분석 기법과 의미론적 분할 기법을 적용하여 토지피복 분류를 수행하였다. 또한, 동일시기에 수집된 영상을 바탕으로 인공지능이 학습하지 않은 지역에 대해 각 인공지능 모형의 토지피복 분류 재현성을 확인하고자 하였다. 학습 지역을 대상으로 인공지능 모형을 학습하였을 때, 토지피복 분류 정확도가 OBIA-RF는 89.3%, OBIA-DNN은 85.0%, U-Net의 경우 95.3%로 분석되었다. 재현성을 평가하기 위해 검증 지역에 인공지능 모형을 적용하였을 때, OBIA-RF는 7%, OBIA-DNN은 2.1%, U-Net은 2.3%의 정확도가 감소하였다. 형태학적인 특성과 분광학적인 특성을 모두 고려한 U-Net이 토지피복 분류 정확도 및 재현성 평가에서 우수한 성능을 보이는 것으로 나타났다. 본 연구의 결과는 정밀한 공간정보가 중요해짐에 따라 기초자료 생성 방법으로써 도시환경 연구분야에 기여할 수 있을 것으로 판단된다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 추계학술대회 논문집
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• pp.195-196
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• 2009

• 한국정밀공학회지
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• 제23권8호
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• pp.178-184
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• 2006

Hot embossing is to fabricate desired pattern on the polymer substrate by pressing the patterned mold against the substrate which is heated above the glass transition temperature, and it is a high throughput fabrication method for bio chip, optical microstructure, etc. due to the simultaneous large area patterning. However, the bad pattern fidelity in large area patterning is one of the obstacles to applying the hot embossing technology for mass production. In the present study, PDMS pad was used as a cushion on the backside of the micro-patterned 4 inch Si mold to improve the pattern fidelity over the 4 inch PMMA sheet by increasing the conformal contact between the Si mold and the PMMA sheet. The pattern replicability improvement over 4 inch wafer scale was evaluated by comparing the replicated pattern height and depth for PDMS-cushioned Si mold against the rigid Si mold without PDMS cushion.

• 구강회복응용과학지
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• 제25권3호
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• pp.201-210
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• 2009

중심위는 교합적, 교정적, 보존적 관점에서 진단과 치료에 중요한 요소이며, 중심위에 대한 정의와 채득방법에 대하여서는 학자들마다 다양하게 주장하고 있다. 중심위를 채득하는 방법에는 여러 가지가 있고 임상적으로 가장 중요한 부분 중 하나가 재현성과 정확성을 확보하는 것이다. 이에 저자는 중심위 채득시 하악 과두의 운동접번축(kinematic axis)을 인식하는 Arcus $Digma^{(R)}$의 EPA test를 이용하여 중심위 채득 방법에 따른 재현성을 비교하였다. 구강 악안면계의 기능이상이 없으며 교합이 정상이고 치아의 교모 및 마모가 심하지 않은 성인 10명를 대상으로 5가지 중심위 채득 방법 (Self-guided method, Bimanual manipulation, Chin-point guidance, Leaf gauge method, Gothic arch tracer)에 따른 중심위의 재현성을 Arcus $Digma^{(R)}$를 이용하여 비교 연구한 결과 다음과 같은 결론을 얻었다. 첫째, 중심위 채득 방법에 따라 하악과두의 위치는 상이한 양상을 나타냈다. 둘째, 재현성은 bimanual manipulation이 가장 높게 나타났으며 다음으로 chin point guidance, Gothic arch tracer, leaf gauge를 이용한 방법 그리고 unguided method 순이었다. 셋째, 임상에서 양손조작법이나 chin-point guidance이 재현성면에서 비교적 매우 훌륭한 방법이라는 것을 미루어 알 수 있다.

• 한국해양환경ㆍ에너지학회지
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• 제14권2호
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• pp.93-106
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• 2011

본 연구는 mesocosm의 정의, 규모, 연구사례, 국내 외 연구동향, mesocosm 조성 시 일반적인 문제점, 해결방안을 거론하고, 끝으로 향후 발전방향을 제시하였다. 지면의 제약 때문에 주로 연성저질생태계(soft-bottom ecosystem)를 위한 mesocosm의 조성에 관련된 내용에 중점을 두었다. Mesocosm이란 규모적인 측면에서 "중형(1~1000 $m^3$)규모이며, 외부에서 먹이 공급 없이 스스로 유지가 가능하며, 환경의 일부 조건을 인위적으로 조절 가능한 인공생태계"를 말한다. 이러한 연구는 1960년대 중반부터 해양/담수생태계, 특히 해양식물플랑크톤이 주 연구 대상이었으나, 점차 확대되어, 최근에는 독성학, 육수학, 환경학, 환경공학, 지구화학 등 다양한 분야에서 흔히 사용하는 도구가 되었다. 과학적인 도구의 하나로서 mesocosm은 기본적으로, 1. 재현성(replicability), 2. 반복성(repeatability), 그리고 3.생태학적 현실성(ecological realism or accuracy)이 구비되어야 한다. 여기에 구체적으로 필요한 규모(scaling), 퇴적물과 해수의 조성, 광량, 난류(亂流), 물 교환율, 포식자 등 기술적인 문제에 대한 해결책을 상세히 언급하였다. Mesocosm이라는 과학적인 도구의 미래 발전 방향은 1. 다양한 통계기법을 통한 객관성의 확보, 2. 수치모델분야와 상호 보완하여 "생태계의 살아 움직이는 모델"로서 보다 더 광범위한 적용이 될 것이다. 앞으로 독성물질에 대한 생태계의 반응 및 독성물질의 거동과 지구온난화에 대한 생태계 및 지구환경의 반응 등을 예측하는데 mesocosm은 매우 유용한 도구가 될 것으로 확신한다.

• 보건교육건강증진학회지
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• 제31권4호
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• pp.63-72
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• 2014

Objectives: The current study reviews the implementation and evaluation of the Chronic Disease Self-Management Program (CDSMP) in the United States (U.S.) to illustrate the program's potential contribution to improving health among Korean adults with chronic conditions while saving healthcare costs. Methods: This study examines existing literature on the history, theoretical background, essential elements, and delivery outcomes of CDSMP with special focus on the successes and challenges to be faced in the implementation of CDSMP to Koreans with chronic conditions. Results: CDSMP is designed to empower people with chronic conditions to develop skills necessary for medical, social role, and emotional management of chronic conditions. Recent studies show the utility of CDSMP in achieving the Triple Aim health reform goals (i.e., better care, better health, better value). Lessons learned from the U.S. experience emphasize the importance of establishing evidence-based studies, collaborating with community partners, and diversifying funding sources to make CDSMP more sustainable. Conclusion: The current study demonstrates the replicability of CDSMP and potential for expansion in Korea. More concerted efforts among academia, government, and communities are needed to deliver CDSMP to Korean adults and identify its effectiveness within the Korean context in terms of meeting the Triple Aim goals of better care, better health, and better value.

• 대한의생명과학회지
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• 제29권3호
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• pp.144-151
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• 2023

A Pap smear is the most important screening test for the diagnosis of cervical cancer. However, subjective judgment by the operator cannot be excluded, and replicability may greatly be reduced if uncertain specimens are examined. Examiners often experience difficulties in differentiating atrophy with inflammatory changes and ASCUS when diagnosing squamous epithelial lesions from a pap smear. Reports often vary between cytologists and pathologists, and misdiagnosis may result in delayed follow-ups and advanced diseases. Hence, auxiliary examinations are necessary when confusing results between atrophy and ASCUS are obtained. The importance of p16^INK4a activation due to HPV infection, which is an important factor in the outbreak of cervical cancer, has been highlighted. Recent studies have reported that p16^INK4a immunocytochemical staining and HPV high-risk type tests using liquid-based cervical specimens are effective to detect the presence of lesions of grade HSIL or higher in patients with ASC-H. However, no research exists on the utility of HPV and p16^INK4a tests on the differential diagnosis of atrophy and ASCUS. This study focused on whether p16^INK4a immunocytochemical staining and HPV tests can help diagnose borderline lesions between atrophy and ASCUS. The results reported that p16^INK4a activation can significantly (P<0.001) differentiate atrophy from ASCUS in atrophic lesions infected with High risk-HPV. Therefore, it may be concluded that p16^INK4a immunocytochemical staining is an effective auxiliary test in lesions infected with HR-HPV when atrophic lesions are difficult to differentiate by morphology. Such results are expected to help decide on adequate follow-up and treatment.

• 한국환경과학회지
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• 제20권9호
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• pp.1087-1093
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• 2011

The mixotrophic marine ciliate Mesodinium rubrum possesses a highly modified algal endosymbiont as a nutrition source for the species. Accordingly, we assumed that the species can reflect the ecotoxicity on marine producer (as phytoplankton) and consumer (as zooplankton) both. A series of experiments were conducted to identify the potential of the species as a standard test species for marine ecotoxicological study. The comparison of species sensitivity on reference toxic materials was made using potassium dichromate for phytoplankton and copper chloride for zooplankton. The ciliate revealed the highest sensitivity on both reference materials among the seven test species including phytoplankton, benthic copepod and rotifer species. The toxicity end point of the species was 72hr-$EC_{50}$=1.52 mg/L (as potassium dichromate) estimated by population growth inhibition (PGI), which is more sensitive than the most sensitive phytoplankton Skeletonema costatum (72hr-$EC_{50}$=3.05 mg/L). As comparison to rotifer, it also revealed higher sensitivity on copper chloride; 72hr-$EC_{50}$=0.38 mg/L for ciliate and 48hr-$EC_{50}$=0.48 mg/L for rotifer. Also, the elutriate toxicity test of various ocean disposal wastes were conducted to identify the potential of ciliate toxicity test application using industrial waste sludges. The toxicity of leather processing waste sludge was highest on the ciliate, followed by dyeing waste sludge and dye production waste sludge as an increasing order of toxicity. 72h-$EC_{50}$ of ciliate PGI test was 1.83% and that of S. costatum 3.84% for leather waste sludge which showed highest toxicity. The toxicity test results also revealed that the highest sensitivity was observed on ciliate species on ocean disposed sludge wastes. Also, ciliate toxicity test well discriminated the degree of toxicity between sludge sources; 72h-$EC_{50}$ values were 1.83% for leather processing waste sludge, 16.75% for dye production waste sludge and 27.75% for textile production waste sludge. Even the laboratory culture methods of the species were not generally established yet, the species has high potential as the standard test species for marine toxicity test in terms of the dual reflection of phyto- and zooplankton toxicity from single test, sensitivity and test replicability.