• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.571-572
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• 2006

RTP (rapid thermal pressing), one of micro-pattern replication techniques like hot embossing, is focused on achieving shorter cycle time. DFSS(Design for Six Sigma) has been applied in order to enhance the completeness of the development process for RTP system. According to DIDOV roadmap, we derived design concepts and subsequently decided the main performances, design factors, and components for RTP system. In the design process of RTP system using finite element analysis, it was realized that its structural characteristics affect large area replicability. Optimizing structural design factors, based on CAE, it was checked out that its large area replicability could be improved in a virtual test. Finally, we have a plan to validate the large area replicability of the developed RTP system, by performing micro-pattern replication tests with polymeric sheets.

• Design & Manufacturing
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• v.2 no.1
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• pp.45-50
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• 2008

Micro channel is to fabricate desired pattern on the polymer substrate by pressing the patterned mold against the substrate which is heated above the glass transition temperature, and it is a high throughput fabrication method for bio chip, optical microstructure, etc. due to the simultaneous large area patterning. However, the bad pattern fidelity in large area patterning is one of the obstacles to applying the hot embossing technology for mass production. In the present study, stamper of cross channel with width $100{\mu}m$ and height $50{\mu}m$ was manufactured using UV-LiGA process. Micro channel was manufactured using stamper manufactured in this study. Also replicability appliance was evaluated for micro channel and factors affected replicability were investigated using Taguchi method.

• Journal of the Korean Association of Geographic Information Studies
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• v.25 no.4
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• pp.63-80
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• 2022

As a technology to analyze and predict an issue has been developed by constructing real space into virtual space, it is becoming more important to acquire precise spatial information in complex cities. In this study, images were acquired using an unmanned aerial vehicle for urban area with complex landscapes, and land cover classification was performed object-based image analysis and semantic segmentation techniques, which were image classification technique suitable for high-resolution imagery. In addition, based on the imagery collected at the same time, the replicability of land cover classification of each artificial intelligence (AI) model was examined for areas that AI model did not learn. When the AI models are trained on the training site, the land cover classification accuracy is analyzed to be 89.3% for OBIA-RF, 85.0% for OBIA-DNN, and 95.3% for U-Net. When the AI models are applied to the replicability assessment site to evaluate replicability, the accuracy of OBIA-RF decreased by 7%, OBIA-DNN by 2.1% and U-Net by 2.3%. It is found that U-Net, which considers both morphological and spectroscopic characteristics, performs well in land cover classification accuracy and replicability evaluation. As precise spatial information becomes important, the results of this study are expected to contribute to urban environment research as a basic data generation method.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.10a
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• pp.195-196
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• 2009

• Journal of the Korean Society for Precision Engineering
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• v.23 no.8 s.185
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• pp.178-184
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• 2006

Hot embossing is to fabricate desired pattern on the polymer substrate by pressing the patterned mold against the substrate which is heated above the glass transition temperature, and it is a high throughput fabrication method for bio chip, optical microstructure, etc. due to the simultaneous large area patterning. However, the bad pattern fidelity in large area patterning is one of the obstacles to applying the hot embossing technology for mass production. In the present study, PDMS pad was used as a cushion on the backside of the micro-patterned 4 inch Si mold to improve the pattern fidelity over the 4 inch PMMA sheet by increasing the conformal contact between the Si mold and the PMMA sheet. The pattern replicability improvement over 4 inch wafer scale was evaluated by comparing the replicated pattern height and depth for PDMS-cushioned Si mold against the rigid Si mold without PDMS cushion.

• Journal of Dental Rehabilitation and Applied Science
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• v.25 no.3
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• pp.201-210
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• 2009

The purpose of this study was to compare the replicability of centric relation made by means of self guided method, bimanual manipulation, chin-point guidance, leaf gauge method, gothic arch tracing. The EPA test of Arcus $Digma^{(R)}$ was employed for examining the reproducibility of centric relation. 10 adults with normal occlusion were participated in this study. In this limitation of study, the following results were obtained; Condyle position was different depending on different methods of guiding centric relation. Left and right temporomandibular joints showed a little different degree of repeatability. Bimanual manipulation using anterior jig was the most replicable. Chin point guidance provided the second most repeatable method, and Gothic arch tracing showed the third, the leaf gauge was the forth, the self-guided method was the worst.

• Journal of the Korean Society for Marine Environment & Energy
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• v.14 no.2
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• pp.93-106
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• 2011

This review has dealt with definition, size, history, and status of mesocosm, and also discussed several problems and trouble shootings related to the building of mesocosm, and finally will suggest the future directions of this scientific tool. Due to the restriction of the space, the discussion mainly focused on "the mesocosm building for the soft-bottom ecosystem". The mesocosm is defined as "medium-sized, self-sustaining, and man-controllable ecosystem". This type of studies has already initiated since 1960, but nowadays it expands to the diverse fields of science and technologies, such as toxicology, limnology, environmental sciences and engineering, and even geochemistry. As a scientific tool, the mesocosm requires following aspects; replicability, repeatability, and ecological realism or accuracy. Several technical problems have to be solved for the perfect building of mesocosm. They are known as scaling, composition of seawater/sediment, light intensity, turbulence, hydraulic residence time, and top predator. These trouble shootings are provided at the discussion in detail. In the context, I expect two promising directions in the future; 1. Objectivity based on the diverse statistical methodologies, 2. "Living ecosystem modelling" coordinated with the mathematical modelling. With these, the mesocosm will be more powerful tool for the scientists and engineers to investigate the chemical and the ecological responses to the toxic materials and global climate changes.

• Korean Journal of Health Education and Promotion
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• v.31 no.4
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• pp.63-72
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• 2014

Objectives: The current study reviews the implementation and evaluation of the Chronic Disease Self-Management Program (CDSMP) in the United States (U.S.) to illustrate the program's potential contribution to improving health among Korean adults with chronic conditions while saving healthcare costs. Methods: This study examines existing literature on the history, theoretical background, essential elements, and delivery outcomes of CDSMP with special focus on the successes and challenges to be faced in the implementation of CDSMP to Koreans with chronic conditions. Results: CDSMP is designed to empower people with chronic conditions to develop skills necessary for medical, social role, and emotional management of chronic conditions. Recent studies show the utility of CDSMP in achieving the Triple Aim health reform goals (i.e., better care, better health, better value). Lessons learned from the U.S. experience emphasize the importance of establishing evidence-based studies, collaborating with community partners, and diversifying funding sources to make CDSMP more sustainable. Conclusion: The current study demonstrates the replicability of CDSMP and potential for expansion in Korea. More concerted efforts among academia, government, and communities are needed to deliver CDSMP to Korean adults and identify its effectiveness within the Korean context in terms of meeting the Triple Aim goals of better care, better health, and better value.

• Biomedical Science Letters
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• v.29 no.3
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• pp.144-151
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• 2023

A Pap smear is the most important screening test for the diagnosis of cervical cancer. However, subjective judgment by the operator cannot be excluded, and replicability may greatly be reduced if uncertain specimens are examined. Examiners often experience difficulties in differentiating atrophy with inflammatory changes and ASCUS when diagnosing squamous epithelial lesions from a pap smear. Reports often vary between cytologists and pathologists, and misdiagnosis may result in delayed follow-ups and advanced diseases. Hence, auxiliary examinations are necessary when confusing results between atrophy and ASCUS are obtained. The importance of p16^INK4a activation due to HPV infection, which is an important factor in the outbreak of cervical cancer, has been highlighted. Recent studies have reported that p16^INK4a immunocytochemical staining and HPV high-risk type tests using liquid-based cervical specimens are effective to detect the presence of lesions of grade HSIL or higher in patients with ASC-H. However, no research exists on the utility of HPV and p16^INK4a tests on the differential diagnosis of atrophy and ASCUS. This study focused on whether p16^INK4a immunocytochemical staining and HPV tests can help diagnose borderline lesions between atrophy and ASCUS. The results reported that p16^INK4a activation can significantly (P<0.001) differentiate atrophy from ASCUS in atrophic lesions infected with High risk-HPV. Therefore, it may be concluded that p16^INK4a immunocytochemical staining is an effective auxiliary test in lesions infected with HR-HPV when atrophic lesions are difficult to differentiate by morphology. Such results are expected to help decide on adequate follow-up and treatment.

• Journal of Environmental Science International
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• v.20 no.9
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• pp.1087-1093
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• 2011

The mixotrophic marine ciliate Mesodinium rubrum possesses a highly modified algal endosymbiont as a nutrition source for the species. Accordingly, we assumed that the species can reflect the ecotoxicity on marine producer (as phytoplankton) and consumer (as zooplankton) both. A series of experiments were conducted to identify the potential of the species as a standard test species for marine ecotoxicological study. The comparison of species sensitivity on reference toxic materials was made using potassium dichromate for phytoplankton and copper chloride for zooplankton. The ciliate revealed the highest sensitivity on both reference materials among the seven test species including phytoplankton, benthic copepod and rotifer species. The toxicity end point of the species was 72hr-$EC_{50}$=1.52 mg/L (as potassium dichromate) estimated by population growth inhibition (PGI), which is more sensitive than the most sensitive phytoplankton Skeletonema costatum (72hr-$EC_{50}$=3.05 mg/L). As comparison to rotifer, it also revealed higher sensitivity on copper chloride; 72hr-$EC_{50}$=0.38 mg/L for ciliate and 48hr-$EC_{50}$=0.48 mg/L for rotifer. Also, the elutriate toxicity test of various ocean disposal wastes were conducted to identify the potential of ciliate toxicity test application using industrial waste sludges. The toxicity of leather processing waste sludge was highest on the ciliate, followed by dyeing waste sludge and dye production waste sludge as an increasing order of toxicity. 72h-$EC_{50}$ of ciliate PGI test was 1.83% and that of S. costatum 3.84% for leather waste sludge which showed highest toxicity. The toxicity test results also revealed that the highest sensitivity was observed on ciliate species on ocean disposed sludge wastes. Also, ciliate toxicity test well discriminated the degree of toxicity between sludge sources; 72h-$EC_{50}$ values were 1.83% for leather processing waste sludge, 16.75% for dye production waste sludge and 27.75% for textile production waste sludge. Even the laboratory culture methods of the species were not generally established yet, the species has high potential as the standard test species for marine toxicity test in terms of the dual reflection of phyto- and zooplankton toxicity from single test, sensitivity and test replicability.