• Journal of Sensor Science and Technology
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• v.30 no.2
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• pp.109-113
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• 2021

In this study, an automated culture media replacement system was developed to analyze changes in the contraction characteristics of cardiomyocytes according to the state of the culture media. For the long-term storage of culture media, a Peltier refrigerator with a temperature of 5 to 8℃ was provided and a pH of 7.4 was maintained. The cell culture media of the cardiomyocytes was continuously replaced using interlocking pumps at a flow rate of 0.83 μl/h. The cardiomyocytes in which the culture media was replaced automatically demonstrated lower heartbeats per minute compared to samples in which there was no replacement. However, these cardiomyocytes moved more uniformly and produced greater displacement in one heartbeat cycle. It was observed that the sarcomere length of the cardiomyocytes increased due to the automated culture media replacement system. These cardiomyocytes were found to demonstrate better maturation compared to the control group. The maturation of cardiomyocytes was verified through staining images. The proposed automated culture media replacement system generates a uniform heart rate and improvements in contraction force. Based on the study, patient-specific drug toxicity assessments can be conducted using differentiated cardiomyocytes in induced pluripotent stem cells.

• Journal of the Korean Data and Information Science Society
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• v.22 no.4
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• pp.775-784
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• 2011

In this paper, we consider the periodic preventive maintenance model for repairable system following the expiration of non-renewing free replacement-repair warranty (NFRRW). Under this preventive maintenance model, we derive the expressions for the expected cycle length, the expected total cost and the expected cost rate per unit time. Also, we determine the optimal preventive maintenance period and the optimal preventive maintenance number by minimizing the expected cost rate per unit time. Finally, the optimal periodic preventive maintenance policy is given for Weibull distribution case.

• The Journal of Korean Physical Therapy
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• v.36 no.1
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• pp.27-32
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• 2024

Purpose: This study was conducted to verify the effect of applying a pressure biofeedback unit on walking ability and knee joint function while performing knee joint extensor strengthening exercises using resistance exercise equipment in total knee replacement (TKR) patients. Methods: This study was conducted on twelve patients receiving rehabilitation treatment after being admitted to a rehabilitation hospital post-TKR. Of these, six were allocated to a feedback group with a pressure biofeedback unit, and the other 6 were allocated to a control group without a pressure biofeedback unit. The subjects performed an exercise program for 45 minutes per session, five times a week, for two weeks. Walking ability and knee joint function were evaluated and analyzed before and after exercise. Results: The feedback group showed significantly better improvements in walking speed, gait cycle, step length on the non-operation side, time on the foot on the operation side, K-WOMAC stiffness, and K-WOMAC function than the control group (p<0.05). Conclusion: When strengthening the knee joint extensor muscles using resistance exercise equipment in TKR patients, the provision of a pressure biofeedback unit was found to improve walking ability and knee joint function by inducing concentric-eccentric contraction of the knee joint extensor muscles. Therefore, the study shows that exercise based on the provision of a pressure biofeedback unit should be considered when strengthening knee joint extensor muscles to improve the walking ability and knee joint function of TKR patients in clinical practice.

• Computational Structural Engineering : An International Journal
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• v.1 no.1
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• pp.59-69
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• 2001

This study is intended to propose a systematic approach for reliability-based assessment of life cycle cost (LCC) effectiveness and economic efficiency for cost-effective seismic upgrading of existing bridges. The LCC function is expressed as the sum of the upgrading cost and all the discounted life cycle damage costs, which is formulated as a function of the Park-Ang damage index and structural damage probability. The damage costs are expressed in terms of direct damage costs such as repair/replacement costs, human losses and property damage costs, and indirect damage costs such as road user costs and indirect regional economic losses. For dealing with a variety of uncertainties associated with earthquake loads and capacities, a simulation-based reliability approach is used. The SMART-DRAIN-2DX, which is a modified version of the well-known DRAIN-2DX, is extended by incor-porating LCC analysis based on the LCC function developed in the study. Economic efficiencies for optimal seismic upgradings of the continuous PC segmental bridges are assessed using the proposed LCC functions and benefit-cost ratio.

• Journal of Electrical Engineering and Technology
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• v.13 no.4
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• pp.1631-1637
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• 2018

Electric utilities has been considered the necessity to introduce asset management of electric power facilities in order to reduce maintenance cost of existing facilities and to maximize profit. This paper aims to provide data that can helpful to make profitable decision in terms of power transformers which have a significant part in the power system. Therefore, this study is modeling input cost for power transformer during its entire life and also the life cycle cost (LCC) technique is applied. In particular, the variation of transformer state related with maintenance and the variation of the EUAC curve based on cost and effect of maintenance is examined. In this study, the trend of the equivalent uniform annual cost (EUAC) according to maintenance cycle and cost of equipment is analyzed. In line with that, sensitivity analysis influenced by the changes of other cost factors was performed.

• The Transactions of the Korea Information Processing Society
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• v.6 no.5
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• pp.1189-1202
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• 1999

As compared with VOD data, NOD article data has the following characteristics: it is created at any time, has a short life cycle, is selected as not one article but several articles by a user, and has high access locality in time. Because of these intrinsic features, user access patterns of NOD article data are different from those of VOD. Thus, building NOD system using the existing techniques of VOD system leads to poor performance. In this paper, we analysis the log file of a currently running electronic newspaper, show that the popularity distribution of NOD articles is different from Zipf distribution of VOD data, and suggest a new popularity model of NOD article data MS-Zipf(Multi-Selection Zipf) distribution and its approximate solution. Also we present a life cycle model of NOD article data, which shows changes of popularity over time. Using this life cycle model, we develop LLBF (Largest Life-cycle Based Frequency) prefetching algorithm and analysis he performance by simulation. The developed LLBF algorithm supports the similar level in hit-ratio to the other prefetching algorithms such as LRU(Least Recently Used) etc, while decreasing the number of data replacement in article prefetching and reducing the overhead of the prefetching in system performance. Using the accurate user access patterns of NOD article data, we could analysis correctly the performance of NOD server system and develop the efficient policies in the implementation of NOD server system.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.30-40
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• 2007

The demand for light-rail construction projects has recently been increasing, and they are mostly supervised by private construction companies. Therefore, a private construction company that aim to raise gains from the operation of the facilities during the contract period greater than what they invested should b able to accurately calculate the costs from the aspect of Life Cycle Cost (LCC). In particular, a light-rail transit bridge that has a heavier portion from the aspect of the cost of light-rail transit construction requires a more accurate calculation method than the conventional LCC calculation method. For this, an LCC analysis model was developed and a cost breakdown structure was suggested based on literature review. The construction costs by shape of the upper part of a light-rail transit were calculated based on the cost breakdown system presented in this paper, and the cost generation cycle and cost unit price were collected and analyzed based on records on maintenance costs, rehabilitation and replacement. In addition, after forming some hypotheses in order to perform the LCC analysis, economic evaluation was conducted from the aspect of the LCC by using performance data by item.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.1189-1194
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• 2009

A gutter-shaped U grating is a facility that is installed at the sides of a road to provide pedestrians with a rainwater-free road. The previous studies on this facility focused mainly on the progress of the efforts that are being made to improve its performance and interception efficiency so as to prevent damages in regional areas due to the heavy rains caused by climate change. The studies on its maintenance, however, are still inadequate. Therefore, this study was conducted to analyze and compare the life cycle costs and performance evaluations of the steel and magic gratings, which are installed in apartments. The results of the study show that the replacement period and rate of gratings differ depending on where they are installed. The initial capital investment cost of a magic grating installed at a road where many vehicles pass is quite high, but in terms of its maintenance and entire-life-cycle costs, its total expenses are lower than those of a steel grating. The results of this study are expected to serve as preliminary data for the selection of an adequate grating that is suitable for particular places in the design phase of construction projects.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.51 no.2
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• pp.62-67
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• 2002

This paper provides the results of accelerated aging test of 18kV ZnO lightning arresters to investigate the leakage current characteristics. It was impossible to establish the replacement criterion for field operating lightning arrester because conventional aging test was only focused on the aging of ZnO elements. In general, it is possible to replace the aged arresters before the failure in the field using the leakage current measurement because it must be increased by the aging. But we can not use the method because we don't know the characteristics of the installed lightning arresters. Therefore in this paper we applied operating voltage and accelerating cycle which consists of temperature and humidity to the arresters. Then we measured the variation of total and resistive leakage current and found out the characteristics of the acted lightning arresters.

• IE interfaces
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• v.6 no.2
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• pp.37-51
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• 1993

This paper studies the economic replacement method for production facilities which requires huge investment but are necessary for higher productivity and competability of products. That is, the general models for the decision of economic life of properties which minimizes the total costs throughout the usage life(Life cycle costs) are generated. Main factors which make influences for the decision of econmic life can be divided by three. These are the change of salvage value, repair and maintenance costs, and availability of production facilities with the passage of usage time. In this paper, the real world data for these three factors are collected and analyzed for the extraction of representative standard forms with the passage of time. And general models for economic replacement methods and optimal usage terms are presented through tables with the combination of the standard forms of these three main factors.