• 한국건설관리학회논문집
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• 제9권4호
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• pp.182-192
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• 2008

BTL 사업은 공공시설물에서 민간의 자본과 기술력을 통해 높은 성과를 낼 것으로 기대되고 있지만, VE의 최적 설계안을 선정하고 건물의 유지관리 비용 예측에 사용되는 LCC 분석은 다수의 복잡한 문제점을 가지고 있어 제한적으로 적용되고 있다. 본 연구의 목적은 국내의 BTL 사업에서 LCC 분석의 문제점을 분석하고 그 해결방안을 제안하는 것이다. 이를 위해 BTL 사업에서 주요 사업대상인 교육시설을 중심으로 LCC 분석을 두 가지 수준(대안선정 LCC와 건축 LCC)으로 구분하고, 이들의 주요 특징을 고찰하였다. 그리고 6가지 측면(비용분류체계, 수선정보, 생애주기, 비용의 시간적 가치, 수선정보 데이터베이스, LCC 분석모델)에서 사례연구를 통해 4가지 주요 문제점과 해결방안을 도출하였다. 이 연구의 결과는 민간과 공공분야 참여주체들의 중장기적인 계획과 실행에 의해 해결될 수 있을 것이다.

• 한국시뮬레이션학회논문지
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• 제26권3호
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• pp.23-34
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• 2017

본 연구는 복수 품목을 정비하는 단일 정비부대의 정비 프로세스를 시뮬레이션으로 모델링하였다. 이를 통해 정비능력을 공유한 정비창이 최적 비용으로 구성품 가동률과 목표 가동율 등을 달성하는지를 분석할 수 있다. 구성품 가동률과 정비시간 등을 핵심 성과지표로 하여 육군 항공기 정비단 엔진 정비프로세스에 대한 시뮬레이션 모델을 구성하고 실증연구를 하였다. 영향요소의 식별을 위해 NOLH 실험설계법을 적용하여, 33가지 시나리오를 구성하고 다중회귀분석을 수행하였다. 이 비용분석 연구를 통해 정비 프로세스의 개선사항을 식별할 수 있었다. 본 연구는 시뮬레이션을 통해 복수품목을 정비하는 단일 정비부대의 비용대 효과 분석 모형을 제공했다는데 의의가 있다.

• 건축역사연구
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• 제16권3호
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• pp.39-56
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• 2007

This study is conservation works trend since 1900. Objects for study are National Treasures and Treasures in Buddhism, in wooden architecture. And researched about the factor of conservation works, roof and tile, painting and dissolution conservation works cycle by dissolution, timber change ratio. The factor of conservation works is the most, roof and tile. Conservation works cycle by dissolution is 12.8 years. Painting cycle is 16.3 years. There are two concepts of conservation works, that is restoration and preservation. There are many restoration before 1960's. To 1960's the preservation to be many to 1970's many Restoration. And since the end of 1970's is Preservation. These reasons are conservation works history of object, the rule for Heritage protection, people on works, and study of architecture. history.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 가을 학술발표회 논문집
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• pp.249-256
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• 1999

This study is intended to propose a systematic procedure for the development of the reliability-based seismic safety and cost-effective Performance criteria for design and upgrading of long span PC bridges. In the paper, a set of cost function models for life cycle cost analysis of bridges is proposed. The total life cycle cost functions consist of initial cost and direct/indirect damage costs considering repair/replacement costs, human losses and property damage costs, road user costs, and indirect regional economic losses. The damage costs are successfully expressed in terms of Park-Ang median global damage indices and damage probabilities. The proposed approach is successfully applied to model bridges in both regions of a moderate seismicity area like Seoul, Korea and a high one like Tokyo, Japan. It may be expected that the proposed approach can be effectively utilized for the development of cost-effective performance criteria for design and upgrading of various types of bridges as well as long span PC bridges.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2003년도 학술대회논문집
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• pp.81-86
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• 2003

최근 대형 전력시설물에 대한 VE 와 LCC 기법의 도입은 여러 가지 형태로 수행되고 있으며, 일반적으로 전력 시설물의 비용을 생각할 때 그 초기투자비만을 대상으로 평가하는 경향이 있으나, 시설물의 총 생애비용 (보전비, 수선비, 개선비, 운용비, 전력비등)을 동시에 고려하여야 한다. 본 연구에서는 간선설계에서 장거리 급전시 전압강하로 인한 동손비를 고려한 설계기법과 내구년한에 따른 총생애비용기법을 적용하여 타당성을 입증하였다.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.386-397
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• 2007

One major development in bridge life cycle cost analysis (LCCA) in recent years is to develop deterioration model for bridge components so that the times of repair/replacement throughout a component's life span can be properly determined. Taiwan also developed her own bridge LCCA model in 2003, integrating with the bridge inspection database in the local bridge management system (T-BMS). Under the framework of the local LCCA model, this study employs the reliability method in developing a deterioration model of bridge components. A component deteriorates through time in its reliability, which represents the probability of a component's condition index exceeds a user specified threshold. Model assumptions and rationale are described in the paper. The steps for applying the developed model are explained in detail. Results and findings are reported.

• The Journal of Advanced Prosthodontics
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• 제12권3호
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• pp.140-149
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• 2020

PURPOSE. This study evaluated the color stabilities of two computer-aided design and computer-aided manufacturing (CAD/CAM) blocks and a nanofill composite resin and the microtensile bond strength (µTBS) between the materials. MATERIALS AND METHODS. Twelve specimens of 4 mm height were prepared for both Lava Ultimate (L) and Vita Enamic (E) CAD/CAM blocks. Half of the specimens were thermocycled (10,000 cycle, 5° to 55℃) for each material. Both thermocycled and non-thermocycled specimens were surface treated with one of the three different methods (Er,Cr:YSGG laser, bur, or control). For each surface treatment group, one of the thermocycled and one of non-thermocycled specimens were restored using silane (Ceramic Primer II), universal adhesive (Single Bond Universal), and nanofill composite resin of 4-mm height (Filtek Ultimate). The other specimens were restored with the same procedure without using silane. For each group, 1 × 1 × 8 mm bar specimens were prepared using a microcutting device. Bar specimens were thermocycled (10,000 cycle, 5° to 55℃) and microtensile tests were performed. Staining of the materials in coffee solution was also compared using a spectrophotometer. Data were analyzed using one-way ANOVA, t-test and post-hoc Scheffe tests. RESULTS. µTBS were found similar between the thermocycled and non-thermocycled groups (P>.05). The highest µTBS (20.818 MPa) was found in the non-thermocycled, bur-ground, silane-applied E group. Silane increased µTBS at some E groups (P<.05). Composite resin specimens showed more staining than CAD/CAM blocks (P<.05). CONCLUSION. CAD/CAM blocks can be repaired with composite resins after proper surface treatments. Using silane is recommended in repair process. Color differences may be shown between CAD/CAM blocks and the nanofill composite after a certain time period.

• BMB Reports
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• 제41권3호
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• pp.230-235
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• 2008

LRP15 is a novel gene cloned from lymphocytic cells, and its function is still unknown. Bioinformatic data showed that LRP15 might be regulated by DNA methylation and had an important role in DNA repair. In this study, we investigate whether the expression of LRP15 is regulated by DNA methylation, and whether overexpression of LRP15 increases efficiency of DNA repair of UV-induced DNA damage in HeLa cells. The results showed (1) the promoter of LRP15 was hypermethylated in HeLa cells, resulting a silence of its expression. Gene expression was restored by a demethylating agent, 5-aza-2'-deoxycytidine, but not by a histone deacetylase inhibitor, trichostatin A; (2) overexpression of LRP15 inhibited HeLa cell proliferation, and the numbers of cells in the G2/M phase of the cell cycle in cells transfected with LRP15 increased about 10% compared with controls; (3) cyclin B1 level was much lower in cells overexpressing LRP15 than in control cells; and (4) after exposure to UV radiation, the LRP15-positive cells showed shorter comet tails compared with the LRP15-negative cells. From these results we conclude that the expression of LRP15 is controlled by methylation in its promoter in HeLa cells, and LRP15 confers resistance to UV damage and accelerates the DNA repair rate.

• 한국발생생물학회지:발생과생식
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• 제20권2호
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• pp.141-147
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• 2016

Rad51 is a key component of homologous recombination (HR) to repair DNA double-strand breaks and it forms Rad51 recombinase filaments of broken single-stranded DNA to promote HR. In addition to its role in DNA repair and cell cycle progression, Rad51 contributes to the reprogramming process during the generation of induced pluripotent stem cells. In light of this, we performed reprogramming experiments to examine the effect of co-expression of Rad51 and four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc, on the reprogramming efficiency. Co-expression of Rad51 significantly increased the numbers of alkaline phosphatase-positive colonies and embryonic stem cell-like colonies during the process of reprogramming. Co-expression ofRad51 significantly increased the expression of epithelial markers at an early stage of reprogramming compared with control cells. Phosphorylated histone H2AX (${\gamma}H2AX$), which initiates the DNA double-strand break repair system, was highly accumulated in reprogramming intermediates upon co-expression of Rad51. This study identified a novel role of Rad51 in enhancing the reprogramming efficiency, possibly by facilitating mesenchymal-to-epithelial transition and by regulating a DNA damage repair pathway during the early phase of the reprogramming process.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.338-351
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• 2003

UV radiation is the most dangerous stress factor among permanent environmental impacts on human skin. Consequences of UV exposure are aberrant tissue architecture, alterations in skin cells including functional changes. Nowadays new kinds of outdoor leisure-time activities and changing environmental conditions make the question of sun protection more important than ever. It is necessary to recognize that self-confident consumers do not consider to change their way of life, they demand modern solutions on the basis of new scientific developments. In the past one fundamental principle of cosmetics was the use of physical and organic filter systems against damaging UV-rays. Today new research results demonstrate that natural protecting cell mechanisms can be activated. Suitable biological actives strongly support the protection function not from the surface but from the inside of the cell. A soy seed preparation (SSP) was proven to stimulate natural skin protective functions. The major functions are an increased energy level and the prevention of DNA damage. These functions can I be defined as biological UV protection. The tumor suppressor protein p53 plays a key role in the regulation of DNA repair. p53 must be transferred into the phosphorylated form to work as transcription factor for genes which are regulating the cell cycle or organizing DNA repair. A pretreatment with SSP increases the phosphorylation rate of p53 of chronically UV-irradiated human keratinocytes significantly. According to the same test procedure SSP induces a dramatic increase in the expression of the tumor suppressor protein p14$^{ARF}$ that is supporting the p53 activity by blocking the antagonist of p53, the oncoprotein Mdm2. Mdm2, a ubiquitin E3-ligase, downregulates p53 and at the same time it prevents phosphorylation of p53. The positive influence of the tumor suppressor proteins explains the stimulation of DNA repair and prevention of sunburn cell formation by SSP, which was proven in cell culture experiments. In vivo the increased skin tolerance against UV irradiation by SSP could be confirmed too. We have assumed, that an increased repair potential provides full cell functionality.y.