• Title/Summary/Keyword: releasing

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Clinical application of gonadotropin-releasing hormone analogs in children and adolescents

  • Kim, Ho-Seong
    • Clinical and Experimental Pediatrics
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    • v.53 no.3
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    • pp.294-299
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    • 2010
  • Although the increasing incidence of central precocious puberty (CPP) in Korea has recently raised public concerns about health and growth problems, there are many areas of uncertainty regarding the pathogenesis, diagnosis, and management of CPP. In this paper, we review the definition of precocity, the assessment of CPP, and the hormonal abnormalities that support the diagnosis. In addition, we review the practical guidelines regarding the clinical use of gonadotropin-releasing hormone analogs in children with CPP. Indications for treatment, determination of dosage, monitoring during treatment, and discontinuation of therapy are discussed.

Aspects of the word-final stop releasing in reading the English isolated words enumerated (영어 나열형 고립 단에 읽기에서 어말 폐쇄음의 파열 양상)

  • Rhee Seok-Chae;Kang Sooha;Park Jihyun;Hwang Sunmin
    • MALSORI
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    • no.46
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    • pp.13-24
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    • 2003
  • This experimental study shows that, in reading of the English isolated words that are enumerated, the releasing of the word-final stop is employed for signaling enumeration in company with the well-known intonational pattern for it. Furthermore, this study tries to find the aspects of the releasing of the stops in the word-final positions, focusing on the association of the stop releasing/nonreleasing with i) the POA (Place of Articulation) distinction of the word-final stop, ii) the various qualities of the vowel before the final stop, and iii) the voice distinction of the stop in the word-final position.

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A Case of Pregnancy Using Recombinant Follicle Stimulating Hormone and Gonadotropin Releasing Hormone Antagonist (유전자 재조합 난포자극호르몬과 성선자극호르몬 분비호르몬 길항제를 이용한 임신 1례)

  • Nam, Yoon-Sung;Kim, Nam-Keun;Kim, Eun-Kyung;Chung, Hyung-Min;Cha, Kwang-Yul
    • Clinical and Experimental Reproductive Medicine
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    • v.28 no.1
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    • pp.73-77
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    • 2001
  • Objective: To report the pregnancy which was made by in vitro fertilization using recombinant follicle stimulating hormone and gonadotropin releasing hormone antagonist. Material and Method: Case report. Results: Six oocytes were retrieved and all were fertilized by intracytoplasmic sperm injection. Six embryos were transferred and the pregnancy was confirmed. Conclusion: It is envisaged that the availability of recombinant gonadotropins and gonadotropin releasing hormone antagonists will ultimately lead to shorter, cheaper and safer treatments, using reduced dosages.

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Protein-Protein Interaction Analysis of Corticotropin - Releasing Hormone Receptor 1 with Corticotropin-Releasing Hormone and Sauvagine

  • Nagarajan, Santhosh Kumar
    • Journal of Integrative Natural Science
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    • v.11 no.2
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    • pp.101-106
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    • 2018
  • Corticotropin - releasing hormone receptor 1 (CRHR1) forms an integral part of the pathophysiology of disorders like post-traumatic stress disorder, stress, anxiety, addiction, and depression. Hence it is essential to look for new, potent and structure-specific inhibitors of CRHR1. We have analysed the protein-protein interaction complexes of the CRHR1 receptor with its native ligand CRF and full agonist Sauvagine. The structure of Sauvagine was predicted using homology modelling. We have identified that the residues TYR253, ASP254, GLU256, GLY265, ARG1014 and LY1060 are important in the formation of protein-protein complex formation. Future studies on these residues could throw light on the crucial structural features required for the formation of CRHR1-inhibitor complex and in studies that try to solve the structural complexities of CRHR1.

Application of chitosan resin formulae as a sustained-releasing form adjuvant (키토산 resin formulae의 서방효과(sustained-releasing effect) 보조제로서의 활용)

  • Kim, Sang-Uk;Kang, Mun-Il;Lee, Jae-Il;Kim, Tae-Jung
    • Korean Journal of Veterinary Service
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    • v.33 no.2
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    • pp.173-176
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    • 2010
  • Here, we report the suitability of using a resin-type chitosan formulae as a sustained-releasing form adjuvant in comparison with commercially well-known Freund's adjuvants. To induce the immunological responses, N-terminal region of Pasteurella multocida toxin was used as an antigen, which was found to be protective immunogen against P. multocida infection. Mice immunized with chitosan resin formulae showed statistically significant antibody induction (P<0.001) as much as that of Freund’s adjuvants. As a result, the resin-type sustained-releasing form chitosan formulae is thought to be a good candidate for a new type adjuvant.

Aspects of the word-final stop releasing and its phonetic correlates in reading the English isolated words enumerated (영어 나열형 고립 단어 읽기에서 어말 폐쇄음의 파열 양상 및 그 음성적 상관성)

  • Rhee Seok-Chae;Kang Sooha;Park Jihyun;Hwang Sunmin
    • Proceedings of the KSPS conference
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    • 2003.05a
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    • pp.61-68
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    • 2003
  • This experimental research shows that, in reading of the English isolated words that are enumerated, the releasing of the word-final stop is employed for signaling enumeration in company with the well-known intonational pattern for it. Furthermore, this study tries to find the conceivable phonetic correlates of the releasing of the stop in word-final position, focusing on the association of the stop releasing/nonreleasing with i) the POA (Place of Articulation) distinction of the word-final stop, ii) the various qualities of the preceding vowel placed before the final stop, and iii) the voice distinction of the stop in the word-final position.

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Control of Prestressing Forces in a Splicing Method using the Partial Post-tensioning and Releasing Procedure (부분 긴장과 해제를 이용한 연속화 과정에서의 긴장력 조절)

  • 이환우;김광양
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.15 no.2
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    • pp.251-259
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    • 2002
  • A new splicing technique by the secondary moment which is intentionally induced by the tensioning effect of continuous tendons and the releasing effect of temporary beam tendons was developed. The tensioning and releasing works are essential and the decisions of the magnitude and order about them may be important engineering problems in this technique. In this paper, it was studied lot the practically optimum procedure of the tensioning and releasing works. As the result, it is concluded that the gradual progress through the three stages is reasonable for the procedure and the tensioning work have to precede the releasing work. Additionally, the magnitude of preceding tensioning force should be obtained by the sensitivity analysis and the minimum limit is more critical than the minimum limit.

Preparation of Calcium Peroxide Originated from Oyster Shell Powder and Oxygen Releasing Ability (패각 분말기반 과산화칼슘 제조와 산소 유리 특성)

  • Yoo, Gilsun;An, Jieun;Cho, Daechul;Kwon, Sung Hyun
    • Journal of Environmental Science International
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    • v.27 no.9
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    • pp.763-770
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    • 2018
  • Bioremediation in situ is heavily dependent on the oxygenic environment which would privide the dwelling microorganism with sufficient oxygen. The situation could be easily resolved with supply of an Oxygen Releasing Compound (ORC). In this paper we prepared that sort of material out of oyster shell powder (mostly calcium carbonate) that prevails every shore areas of the country. We used two different oxidizing methods in the first step of the whole manufacturing process-conventional heating in a furnace and an ultrasound generator to obtain calcium oxide. Then that calcium oxide was further oxidized into calcium peroxide which may release oxygen under a moisturized condition. The oxygen releasing experiments were run to test the performance of our products, and to determine the gas kinetics during the experiments. Interestingly, calcium peroxide derived from ultrasound treatment was much more energy-effective as ORC than that from furnace heating although the heat derived process was better than that of ultrasound in terms of oxygen content and its releasing rate. We also found that most of the data collected from the gas releasing experiments fairly supported an ordinary $1^{st}$ order kinetics to oxygen concentration, which shaped a sharp discharge of oxygen at the very early moment of each test.

Characterization of Mold Releasing Agent Obtained from Carbon Black Suspension in Natural Polymer Solution (카본 블랙과 천연 고분자를 이용하여 제조한 금속 주조용 이형제의 특성)

  • Lee, Soo;Jin, Seok-Hwan;Park, Jung-Hyun
    • Journal of the Korean Applied Science and Technology
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    • v.29 no.1
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    • pp.13-18
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    • 2012
  • A die casting mold releasing agent was prepared from aqueous mixture of powdery carbon black and water soluble natural polymeric materials such as xanthan gum(X-gum) and carboxymethyl cellulose(CMC), which were used as thickening agent as well as curing agent with aldehydes. The suitable concentration of natural polymers for stable dispersion of carbon black in water was 0.25 wt% of X-gum or 1.0 wt% of CMC. When CMC was used less than 1 wt%, the final carbon black disperion showed a rapid phase separation. The adhesion of carbon black releasing agent on glass plate was improved with the amount of crosslinking agent, glutaraldehyde and chain extender, oligosaccharide. However, the affinity of carbon black releasing agent prepared with X-gum was stronger than that with CMC on glass plate. The final carbon black mold releasing agents prepared under our mixing conditions can be applied to the production of castings of high quality with good workability and without worthening evironmental situations.

Kinematic Analysis of Double Backward Somersault on the Parallel Bars (평행봉 2회전 뒤돌아 무릎 구부려 내리기 동작의 운동학적 분석)

  • Lee, Jong-Hun;Lee, Yong-Sik
    • Korean Journal of Applied Biomechanics
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    • v.14 no.1
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    • pp.27-40
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    • 2004
  • The purpose of this study was to provide basic data for improving athletic performances by analyzing the kinematic variables of the Double Backward Somersault on the Parallel Bars through the 3D motion analysis. The subjects in this study were 5 male gymnasts who were ranked as national athletes. The results are as follows. 1. A total time(Mean Time) of performance showed $2.72{\pm}0.82\;sec$. and flight time to landing after releasing was 0.87sec.(mean). In order to perform better stable flying movement, the flight time should be increased. 2. In the change of velocity of the center of mass, when the increasing ascension velocity of the upper point was high, the position in the top point was high on releasing. 3. In the position variable of the center of mass, the mean of upper-bottom position in horizontal posture was $242.1{\pm}6.5cm$, $232.8{\pm}6.4cm$ in releasing, and $265.0{\pm}5.6cm$ in the highest point. This result is explained that the position of center of mass can be raised by using elastic power when wrist raised the bar in the releasing movement. 4. The angle of shoulder joint was $271.1{\pm}14.0$. Such a big angle influences a negative effect on the releasing velocity, because trunk is not a position in the enough vertical direction. 5. The ankle of hip joint in hand-standing was $191.1{\pm}5.9$, $118.8{\pm}5.3$ in releasing, and $122.3{\pm}5.3$ in taking on. Therefore, the result suggests that trunk should be straightly raised in taking on.