• Journal of the Korean Chemical Society
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• v.37 no.5
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• pp.527-536
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• 1993

The characteristics of the controlled drug release were studied for biodegradable transdermal drug delivery system. A biodegradable polymeric matrix was prepared from chitosan, silver sulfadiazine, and glycerine. The release behavior of silver sulfadiazine from chitosan matrix was consistent with the Higuchi's diffusion controlled model. The release time was delayed by increasing the content of silver sulfadiazine and thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant (K) of release rate was proportional to the content of drug or glycerine and the thickness of chitosan matrix. These results indicated that chitosan matrix shows some potential as a drug delivery system for transdermal therapeutic application.

• Journal of Korean Society for Atmospheric Environment
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• v.15 no.2
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• pp.151-158
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• 1999

Offsite consequences resulting form worst-case scenarios involving release of toxic substances in the Yochon area were estimated using the ALOHA(Areal Locations of Hazardous Atmospheres) model. Eight toxic substances, including NH3, were considered; five were toxic gases and three were toxic liquids at ambient temperature. For toxic gases, the entire quantity was assumed to be released at a constant rate during a 10-minute period. For toxic liquids, the entire quantity stored in the tank was assumed to be spilled and spread and spread instantaneously to form a pool with a depth of 1cm, and then evaporated over some period of time. Except for phosgene and toluene 2,4-diisocyanate, for which concentration levels corresponding to human health effects are very low, average distances of the area at risk of adverse health effects for a 1- tom release were predicted to be $2.3{\pm}1.1 km$ for the worst-case meteorological conditions and $0.93{\pm}0.69km$ under typical meteorological conditions of the Yochon are. Because a large number of people were predicted to be affected in the current analysis, refined analyses considering both realistic accident scenarios and topographic effects were warranted.

• KSBB Journal
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• v.11 no.6
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• pp.676-680
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• 1996

The characteristics of controlled drug release were studied for a biodegradable drug delivery system. A biodegradable chitosan matrix was prepared after swelling chitosan with 10%-acetic acid and adding sulfadiazine. The release behavior of sulfadiazine from the chitosan matrix was studied using the Higuchi's diffusion controlled model in phosphate buffer solutions of pH 7.4 and pH 1.2. The drug release time was delayed by increasing the content of sulfadiazine. The drug release at pH 7.4 was more delayed than that at pH 1.2. The reason is that chitosan has greater swelling abilities at low pH than at high pH. The apparent release rate constant(K) increased as the concentration of drug increased. In shoat, the formulation the biodegradable chitosan matrix to suppress the burst effect of drug release mechanism, which led to a sustained release pattern.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.2
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• pp.24-31
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• 2004

A cylindrical constant volume combustion bomb is used to investigate the combustion characteristics and to analyzer the heat quantity of inhomogeneous charge methane-air mixture. To analyze the heat quantity, some definitions including the CHR ratio, the UHC ratio and the HL ratio are needed and are calculated. It is shown that the effect of stratification is not significant in case of the overall excess air ratio of 1.1, mainly due to the higher heat loss and lower thermal efficiency compared to those of homogeneous condition. In the case of the overall excess air ratio of 1.4, as the initial charge pressure decreases, the CHR ratio has been decreased while the HL ratio has been increased, Generally, as the initial charge pressure increases, the amount of injection mixture has been decreased and has resulted in lower mean velocity and turbulence intensity for injection mixture. Also, the injected mixture is too rich to result in mixing deficiency in combustion chamber. From these results, it could be possible to acquire the improvement of thermal efficiency and the reduction of heat loss simultaneously through the 2-stage injection in CNG direct injection engine.

• Journal of Advanced Marine Engineering and Technology
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• v.24 no.4
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• pp.421-426
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• 2000

A study on the combustion and exhaust emissions characteristics of diesel engine with various suction air humidity is performed experimentally. In this paper, suction air humidity is changed from RH 50% to RH 90%, the experiments are performed at engine speed 1800rpm, and main measured parameters are cylinder pressure, fuel consumption rate, CO, HC, NOx and Soot emissions etc. Increase of suction air humidity from RH 50% to RH 90% does not effect specific fuel consumption, decreases maximum pressure in cylinder, ratio of maximum pressure rise and net heat release, and delays ignition timing. Also, that increases CO and HC emissions, decreases NOx emissions, but does not constant in changing tendency on emission.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.11
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• pp.1368-1375
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• 2004

Measurements of OH chemiluminescence in an atmospheric pressure, laboratory-scale dump combustor at equivalence ratios ranging from 0.63 to 0.89 were reported. The signal from the first electronically excited state of OH to ground state was detected through a band-pass filter with an ICCD. The objectives of this study are two: One is to see the effects of equivalence ratio on global heat release rate and local Rayleigh index distribution. To get the local Rayleigh index distribution, the line-of-sight images were inverted by tomographic method, such as Abel do-convolution. Another aim is to investigate the validity of using OH chemiluminescence acquired with an ICCD as a qualitative measure of local heat release. For constant inlet velocity and temperature, the overall intensities of OH emission acquired at different equivalence ratio showed periodic and higher value at high equivalence ratio. OH intensity averaged over one period of pressure increased exponentially with equivalence ratio. Local Rayleigh index distribution clearly showed the region of amplifying or damping the combustion instability as equivalence ratio increased. It could provide an information/insights on active control such as secondary fuel injection. Finally, local heat release rate derived from reconstructed OH images were presented fur typical locations.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.309-313
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• 1999

This study was prepared to develop the sustained release dosage form of phenylpropanolamine hydrochloride (PPA) by complexation with cation exchange resin(CER). The PPA-CER complex was confirmed by differential scanning calorimetry(DSC) thennogram, indicating a relative shift of an endometric peak of PPA to higher temperature. The loading efficiency was increased as the amount of PPA was increased as well as the time of fractional exchange was advanced as the temperatures were increased. Loading efficiency, fractional exchange, reaction rate constant and activation energy were highly dependent on the temperature and drug : resin ratio. The optimal ratio of PPA and resin was estimated to be 10: 10 for the sustained release.

• Journal of Adhesion and Interface
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• v.4 no.2
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• pp.1-9
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• 2003

Epoxy-amine liquid prepolymers are extensively applied onto metallic substrates and cured to obtain painted materials or bonded joint structures. Overall performances of such systems depend on the created interphase between the organic layer and the substrate. When epoxy-amine liquid mixtures are applied onto more or less hydrated metallic oxide layer, concomitant amine chemical sorption and hydroxide dissolution appear lending to the chelate formation. As soon as the chelate concentration is higher than the solubility product, these species crystallize as sharp needles. Moreover, intrinsic and thermal residual stresses are developed within painted or bonded systems. When residual stresses are higher than the organic layer/substrate adhesion, buckling, blistering, debonding may occur leading to a catastrophic drop of system performances. Practical adhesion can be evaluated with either ultimate parameters (Fmax or Dmax) or the critical strain energy release rate, using the three point flexure test (ISO 14679-1997). We observe that, for the same system, the ultimate load decreases while residual stresses increase when the liquid/solid time increases. Ultimate loads and residual stresses depend on the metallic surface treatment. For these systems, the critical strain energy release rate which takes into account the residual stress profile and the Young's modulus gradient remains quite constant whatever the metallic surface treatment was. These variations will be discussed and correlate to the formation mechanisms of the interphase.

• Archives of Pharmacal Research
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• v.19 no.1
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• pp.30-35
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• 1996

Poly(l-lactic acid)(PLLA) microspheres loaded with ampicillin sodium (AMP-Na_, .betha.-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) wre carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experimet. The release of ampicillin sodium was constant at a rate of 1.68 $mug/ml/day$ per 1 mg of microspheres for 18 days initial burst effect.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.6
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• pp.949-958
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• 2001

A semi-infinite interfacial crack propagated with constant velocity in two bonded anisotropic strips under out-of-plane clamped displacements is analyzed. Using Fourier integral transform the problem is formulated and the Wiener-Hopf equation is derived. By solving this equation the asymptotic stress and displacement fields near the crack tip are obtained, where the results get more general expressions applicable not only to isotropic/orthotropic materials but also to the extent of the anisotropic material having one plane of elastic symmetry for the interfacial crack. The dynamic stress intensity factor is obtained as a closed form, which is decreased as the velocity of crack propagation increases. The critical velocity where the stress intensity factor comes to zero is obtained, which agrees with the lower value between the critical values of parallel crack merged in the material 1 and 2 adjacent to the interface. Using the near tip fields of stresses and displacements, the dynamic energy release rate is also obtained as a form of the stress intensiy factor.