• Title/Summary/Keyword: release behavior

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Comparison of Measured and Predicted $^3H$ Concentrations in Environmental Media around the Wolsung Site for the Validation of INDAC Code (주면피폭선량 평가코드(INDAC)의 검증을 위한 월성원전 주면 삼중수소 농도 실측치와 예측치의 비교 평가)

  • Jang, Si-Young;Kim, Chang-Kyu;Rho, Byung-Hwan
    • Journal of Radiation Protection and Research
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    • v.25 no.2
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    • pp.75-80
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    • 2000
  • The predicted results of INDAC code were compared with measured $^3H$ concentrations in air and pine-needle around the Wolsung site. The optimal sets of input data to INDAC were in addition selected by comparing the measured values with the predicted values of INDAC based on various conditions such as the release modes of effluents into the environment, the classification of wind classes, and the consideration of terrain. The predicted $^3H$ concentrations in air and pine-needle were shown to have good agreement with measured values, although there are some limitations such as uncertainties in measured values, complex topology around the site, and the land-sea breeze effects. The assumption on the $^3H$ behavior in vegetables or plants that the ratio of $^3H$ concentration in plant water to $^3H$ concentration in atmospheric water is 1/2 was shown to be conservative in terms of the audit calculation performed by the regulator. It was also found that data sets based on mixed mode and no terrain data were not appropriate for the audit calculation ensuring the compliance with regulations. Thus, if the mixed mode is considered as the release mode of effluents into the environment, meteorological data measured at 58 m height and terrain data should be used to evaluate the atmospheric dispersion factor.

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Effect of Cosurfactants on the Release Behavior of Zaltoprofen-loaded PLGA Microspheres in In Vitro : Preparation and Characterization (보조계면활성제 첨가에 따른 잘토프로펜을 함유한 PLGA 미립구의 생체외 방출 거동: 제조 및 특성)

  • Eom, Shin;Yoo, Seok-Cheol;Kim, Yong-Ki;Lee, Young-Hyun;Lee, Eun-Yong;Yu, Hyeon;Lee, Dong-Won;Khang, Gil-Son
    • Polymer(Korea)
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    • v.34 no.4
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    • pp.333-340
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    • 2010
  • Zaltoprofen, a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID), is known to have powerful inhibitory effects on acute, subacute and chronic inflammation. We developed poly(lactide-co-glycolide)(PLGA) microspheres loaded with zaltoprofen for sustained controlled delivery using an oil-water solvent evaporation methods by varying PLGA molecular weight and cosurfactant contents. Physicochemical properties and morphology of zaltoprofen-loaded PLGA microspheres were investigated by scanning electron microscope, X-ray diffraction and differential scanning calorimeter. The size of microspheres increased with the molecular weight of PLGA and the content of cosurfactants. The increase of PLGA molecular weight and cosurfactant content decreased the porosity of microspheres, subsequently resulting in the slow drug release. The results demonstrated that the adjustment of PLGA molecular weight and the cosurfactant content allowed us to control the drug release profiles of drug-loaded microspheres.

Three Stage Performances and Herding of Domestic and Foreign Films in the Korean Market (한국 시장에서 상영한 한국영화와 외국영화의 3단계 성과와 군집행동(Herding behavior)현상의 분석)

  • Hahn, Minhi;Kang, Hyunmo;Kim, Dae-Seung
    • Asia Marketing Journal
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    • v.11 no.4
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    • pp.21-48
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    • 2010
  • This article analyzes film performances in the Korean movie market utilizing three-stage models that incorporate available information in three different stages of the movie life cycle, i.e., at the time of its release, at the end of the first week, and at the end of its life cycle. Based on the premise that the performance of a movie is affected principally by factors of scale, evaluation, and competition, we attempted to ascertain the effects on these factors on performances, and how they differ in different stages. Also, by analyzing domestic and foreign movies released in Korea separately, we were able to compare the different effects of the three factors on the performances of the two categories of movies. Additionally, our movie performance models incorporated herding behavior among the customers. Our results demonstrate that herding is prominently observed after the first week only for domestic movies. In general, the scale factor has been shown to be most important for movie performances in all stages. For foreign films, it is particularly critical for the first week and total performances. Whereas the evaluation factor influences domestic film performance more strongly at the screen choice stage, it affects the performance of foreign films more strongly in the later stages of the life cycle. As compared to foreign films, domestic film performance appears to be more sensitive to the competition factor. We also discuss the effects of covariates such as genre and symbolicity on movie performance.

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Leaching Behavior of Arsenic and Heavy-Metals and Treatment Effects of Steel Refining Slag in a Reducing Environment of Paddy Soil (논토양의 환원환경에서 비소 및 중금속의 용출특성과 제강슬래그의 처리효과)

  • Yun, Sung-wook;Yu, Chan;Yoon, Yong-Cheol;Kang, Dong-Hyeon;Lee, Si-Young;Son, Jinkwan;Kim, Dong-Hyeon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.58 no.3
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    • pp.29-38
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    • 2016
  • There have been only a few studies focused on the stabilization of metal (loid)s in anaerobic soils such as paddy soils. In this study, laboratory-scale column tests were conducted to artificially manipulate anoxic conditions in submerged paddy fields and we observed the release behavior of As, Cd, Pb, and Zn, as well as to examine the stabilization effect of steel refining slag (SRS) on the metal(loid)s. The leachate samples were collected and chemical parameters were monitored during the test period. Results suggest that anoxic conditions were developed during submersion, and that As or heavy metals (particularly Cd) fractions bound to ferrous (Fe) /manganese (Mn) oxides were easily dissociated. Moreover, As is also reduced by itself to a trivalent form with higher mobility in the reducing environment of rice paddy soil. However, it was also shown that SRS significantly decreased the dissolution of Zn, Pb, Cd, and As in the the leachates; their removal rates in the SRS-treated soil were 66 %, 45 %, 24 %, and 84 %, respectively, of those in the control soil.

An Experimental Study on the Fracture Energy of Steel Fiber Reinforced Concrete Structures by the Effects of Fiber Contents (강섬유 혼입량에 의한 강섬유보강콘크리트의 파괴에너지에 관한 실험적 연구)

  • 장동일;채원규;정원우;손영환
    • Magazine of the Korea Concrete Institute
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    • v.3 no.4
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    • pp.79-88
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    • 1991
  • In this study, fracture tests were carried out in order to investigate the fracture behavior of SFRC(Steel Fiber Peinforced Concrete) with initial cracks. The relationships between loading. strain, mld-span deflections and CMOD(Crack Mouth Opening Displacement) of the beams were observed under the three point loading system. The effect of the fiber content and the initial crack ratio on the concrete fracture behavior were studied and the fracture toughness, the critical energy release ratio and the fracture energy were also calcul ated from the test results. From the test results, it was known that when the fiber contents are between 0.5% and 1.0%, and 1.5% the average fracture energy of SFRC specimens is about 7~10 times. and about 15 times better than that of the plam concrete specimens respectively.ively.

A Basic Study of the Behavior Characteristics of Diesel Spray and Natural-gas Jet (디젤 분무와 천연 가스 분류의 거동 특성에 관한 기초 연구)

  • Yeom, J.K.;Kim, M.C.
    • Journal of Power System Engineering
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    • v.13 no.6
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    • pp.13-21
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    • 2009
  • This basic study is required to examine spray or jet behavior depending on fuel phase. In this study, analyses of diesel fuel(n-Tridecane, $C_{13}H_{28}$) spray and natural gas fuel(Methane, $CH_4$) jet under high temperature and pressure are performed by a general-purpose program, ANSYS CFX release 11.0, and the results of these are compared with experimental results of diesel fuel spray using the exciplex fluorescence method. The simulation results of diesel spray is analyzed by using the combination of Large-Eddy Simulation(LES) and Lagrangian Particle Tracking(LPT) and of a natural gas jet is analyzed by using Multi-Component Model(MCM). There are two study variables considered, that is, ambient pressure and injection pressure. In a macroscopic analysis, the higher ambient pressure is, the shorter spray or jet tip penetration is at each time after start of injection. And the higher injection pressure is, the longer spray or jet tip penetration is at each time after start of injection. When liquid fuel is injected, droplets of the fuel need some time to evaporate. However, when natural gas fuel is injected, the fuel does not need time to evaporate. Gas fuel consists of minute particles. Therefore, the gas fuel is mixed with the ambient gas more quickly at the initial time of injection than the liquid fuel is done. The experimental results also validate the usefulness of this analysis.

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A Numerical Analysis on the Freeze Coating of a Non-Isothermal Flat Plate with a Binary Alloy (비등온 평판의 이성분 합금 냉각코팅에 관한 수치해석)

  • Nam, Jin-Hyeon;Kim, Chan-Jung
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.24 no.11
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    • pp.1437-1446
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    • 2000
  • A numerical analysis on the freeze coating process of a non-isothermal finite dimensional plate with a binary alloy is performed to investigate the growth and decay behavior of the solid and the mushy layer of the freeze coat and a complete procedure to calculate the process is obtained in this study. The continuously varying solid and mushy layers are immobilized by a coordinate transform and the resulting governing differential equations are solved by a finite difference technique. To account for the latent heat release and property change during solidification, proper phase change models are adopted. And the convection in the liquid melt is modeled as an appropriate heat transfer boundary condition at the liquid/mushy interface. The present results are compared with analytic solutions derived for the freeze coating of infinite dimensional plates and the discrepancy is found to be less than 0.5 percent in relative magnitude for all simulation cases. In addition the conservation of thermal energy is checked. The results show that the freeze coat grows proportional to the 1.2 square of axial position as predicted by analytic solutions ar first. But after the short period of initial growth, the growth rate of the freeze coat gradually decreases and finally the freeze coat starts to decay. The effects of various non-dimensional processing parameters on the behavior of freeze coat are also investigated.

Tapentadol: Can It Kill Two Birds with One Stone without Breaking Windows?

  • Chang, Eun Jung;Choi, Eun Ji;Kim, Kyung Hoon
    • The Korean Journal of Pain
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    • v.29 no.3
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    • pp.153-157
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    • 2016
  • Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

Release of Organic Matter and Behavior of Nitrogen in the Degradation of Sewage Sludge Using Ultrasound (초음파를 이용한 하수 슬러지 분해에서 유기물 방출과 질소 거동)

  • Yoon, Yong-Soo;Kang, Gwang-Nam;Choi, Suk-Soon
    • Journal of the Korea Organic Resources Recycling Association
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    • v.10 no.4
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    • pp.75-80
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    • 2002
  • The sewage sludge with concentrated MLSS, ranging from 5967 to 8400mg/L was degraded by ultrasound. In this study, ultrasound treatment was used to investigate the behavior characterization of SBOD, sludge biodegradation, C/N ratio, TN, turbidity and sludge morphology. From the experimental results of C/N ratio change and TN removal, the optimal irradiation time was found to be 10 minutes. The results showed the relative index of sludge biodegradation(SBOD/TCOD) was enhanced to 0.76 from the initial value of 0.013 at the 5967mg/L MLSS, during the 60minutes treatment. Throughout this research, the results provide useful engineering reference data for reuse of sewage sludge using ultrasound.

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Computational Study on Unsteady Mechanism of Spinning Detonations

  • Matsuo, Akiko;Sugiyama, Yuta
    • 한국전산유체공학회:학술대회논문집
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    • 2008.03a
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    • pp.367-373
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    • 2008
  • Spinning detonations propagating in a circular tube were numerically investigated with a one-step irreversible reaction model governed by Arrhenius kinetics. Activation energy is used as parameter as 10, 20, 27 and 35, and the specific heat ratio and the heat release are fixed as 1.2 and 50. The time evolution of the simulation results was utilized to reveal the propagation mechanism of single-headed spinning detonation. The track angle of soot record on the tube wall was numerically reproduced with various levels of activation energy, and the simulated unique angle was the same as that of the previous reports. The maximum pressure histories of the shock front on the tube wall showed stable pitch at Ea=10, periodical unstable pitch at Ea=20 and 27 and unstable pitch consisting of stable, periodical unstable and weak modes at Ea=35, respectively. In the weak mode, there is no Mach leg on the shock front, where the pressure level is much lower than the other modes. The shock front shapes and the pressure profiles on the tube wall clarified the mechanisms of these stable and unstable modes. In the stable pitch at Ea=10, the maximum pressure history on the tube wall remained nearly constant, and the steady single Mach leg on the shock front rotated at a constant speed. The high and low frequency pressure oscillations appeared in the periodical unstable pitch at Ea=20 and 27 of the maximum pressure history. The high frequency was one cycle of a self-induced oscillation by generation and decay in complex Mach interaction due to the variation in intensity of the transverse wave behind the shock front. Eventually, sequential high frequency oscillations formed the low frequency behavior because the frequency behavior was not always the same for each cycle. In unstable pitch at Ea=35, there are stable, periodical unstable and weak modes in one cycle of the low frequency oscillation in the maximum pressure history, and the pressure amplitude of low frequency was much larger than the others. The pressure peak appeared after weak mode, and the stable, periodical unstable and weak modes were sequentially observed with pressure decay. A series of simulations of spinning detonations clarified that the unsteady mechanism behind the shock front depending on the activation energy.

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