• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.8 s.179
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• pp.2115-2122
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• 2000

The understanding of impact-induced delamination is important in safety and reliability of composite structure. In this study, a model for arrest toughness is proposed in consideration of fracture behavior of composite materials. Also, the probabilistic model is proposed to describe the variability of arrest toughness due to the nonhomogeneity of material. For these models, experiments were conducted on the Carbon/Epoxy composite plates with various thickness using the impact hammer. The elastic work factor used in J-Integral is applicable to the evaluation of energy release rate. The fracture behavior can be described by crack arrest concept and the arrest toughness is independent of the delamination size. Additionally, a probabilistic characteristics of arrest toughness is well described by the Weibull distribution function. A variation of arrest toughness increases with specimen thickness.

• Journal of Advanced Marine Engineering and Technology
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• v.22 no.4
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• pp.490-497
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• 1998

An elast-biscoplastic finite element analysis is performed to investigate detailed growth behavior of creep cracks and the numerical results are compared with experimental results. The results of mesh translation method are compared with those of node release method. Load line displancement curve obtained from the crack growth analysis by mesh translation shows the improved results than that obtained from the crack growth by node release method when the secondary creep rate is only used as creep material property. The results of accounting for primary creep rate and instantaneous plasticity shows a good agreement with the experimental result.

• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.46-46
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• 2001

Evidence has suggested that an anion channel blocker, 4, 4'-diisothiocyanatostilbene-2, 2' disulfonic acid (DIDS) could trigger Ca release from skeletal sarcoplasmic reticulum (SR) by binding to a 30 kDa SR protein. Since the high molecular weight $Ca^{2＋}$ release channel (CRC)/ryanodine receptor (RyR) is the main SR protein that conducts $Ca^{2＋}$ efflux in skeletal muscles, the relationship between CRC and the 30kDa protein remains to be elucidated.(omitted)

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.637-642
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• 1996

This paper presents the analysis results for the core degradation processes and the fission product release of the PHEBUS FPT0 experiment using MELCOR1.8.3. The objective of this study is to assess models associated with the core damage and fission product behavior in MELCOR. The calculation results were much improved through sensitivity studies. Thermal/hydraulic behavior in the core and the circuit was well predicted under the intact core geometry. In non-eutectic model case. the UO$_2$ dissolution model in the MELCOR always showed such a tendency that the resulting dissolved UO$_2$ mass was small at the highly oxidized condition due to the model logic. Total H$_2$ generation mass was underpredicted because the stiffner was not modeled and the liner in the shroud was not allowed to be oxidized in MELCOR. Some difficulties were found in modeling the activation product were solved by manipulating the RN input associated with the initial fission product inventory. These problem were occurred because there are no control rod model in MELCOR. Generally the fission product release ratio showed a similar trend compared with the measured data except the activation product. which have no model to simulate in MELCOR.

• Journal of the Korean Society of Combustion
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• v.19 no.1
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• pp.29-38
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• 2014

This paper described an experimental investigations of combustion instability mode in a lean premixed dual swirl combustor for micro-gasturbine system. When such the instability occurs, a strong coupling between pressure oscillations and unsteady heat release excites a self-sustained acoustic wave which results in a loud, annoyed sound and may also lead a structural damage to the combustion chamber. The detailed period of flame behavior and heat release in combustion instability mode have been examined with high speed OH and CH-PLIF system and $CH^*$ chemiluminescence measurement, flame tomography with operated at 10 kHz and 6 kHz each. Experiment results suggest that unstable flame behavior has a specific frequency with 200 Hz and this frequency is accords with about 1/2 sub-harmonic of combustor resonance frequency, not fundamental frequency. This is very interesting phenomenon that have not reported yet from other previous works. Therefore, when a thermo-acoustic instability with Rayleigh criterion occurs, the fact that the period of heat release and flame behavior are different each other was proposed for the first time through this work.

• Polymer(Korea)
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• v.32 no.2
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• pp.103-108
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• 2008

Osmotic pellet, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic pellet with nifedipine as model drug and a mixture of cellulose acetate (CA) and Eudragit RS as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer (CA and Eudragit RS) and release media. Furthermore, we examined the nifedipine release behavior using sodium alginate as a potential membrane candidate. Osmotic pellet was obtained in the quantitative yield by fluidized bed coater. Osmotic pellet exhibited the round morphology and the size ranging $1500{\sim}1700{\mu}m$ in SEM. The nifedipine release decreased as the thickness of membrane layer (CA and Eudragit RS) increased. In addition, it observed that there is difference of release amount in between intestinal juice (pH 6.8) and gastric juice (pH 1.2). In the case of osmotic pellet coated with sodium alginate, nifedipine release behavior depended on the crosslinking of sodium alginate layer. In conclusion, we found that various membrane layers could control the release amount of nifedipine.

• Polymer(Korea)
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• v.29 no.3
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• pp.260-265
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• 2005

The initial burst of drug release is an important role in the controlled delivery of drug having hish toxicity and narrow therapeutic ranges. Nanosphere composed of monolayer could not achieve precisely controlled drug release because of the initial burst of drug on surface. In this study, double layered nanosphere was prepared for sustained drug delivery without initial burst. Double layered nanosphere composed of dextran and PLGA was fabricated by using conventional W/O/W double emulsion method. To control surface tension on the outer layer of nanospheres, PVA was used as a surfactant. Release behavior of dextran as model drug was observed as the $3{\times}1$mm wafers formed by compression mould in the deionized water for 7 days. Double layered nanosphere has sustained release behavior, in contast to single layered nanospheres. such as mechanical mixture and dextran nanospheres. Especially, nanosphere containing PVA $0.2\%$ has shown nearly the zero-order release profile. As a result of this study, double layered nanospheres has more sustained release profile of drug without the initial burst and the release behavior of dexoan on tile double layered nanospheres was controlled by the contents of PVA as a surfactant.

• International Journal of Concrete Structures and Materials
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• v.18 no.3E
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• pp.213-219
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• 2006

Modified singular fracture process zone(S-FPZ) model is proposed in this paper to determine a fracture criterion for continuous crack propagation in concrete. The investigated fracture properties of the proposed fracture model are strain energy release rate at a micro-crack tip and the relationship between crack closure stress(CCS) and crack opening displacement(COD) in the FPZ. The proposed model can simulate the actual fracture energy of experimental results fairly well. The results of the experimental data analysis show that specimen geometry and loading condition did not affect the CCS-COD relation. However, the strain energy release rate is a function of not only specimen geometry but also crack extension. The strain energy release rate remained constantly at the minimum value up to the crack extension of 25 mm, and then it increased linearly to the maximum value. The maximum fracture criterion occurred at the peak load for specimens of large size. The fracture criterion remained at the maximum value after the peak load. The variation of the fracture criterion is caused by micro-cracking and micro-crack localization. The fracture criterion of strain energy release rate can simply be the size effect of concrete fracture, and it can be used to quantify the micro-cracking and micro-crack localizing behavior of concrete.

• Macromolecular Research
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• v.11 no.5
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• pp.352-356
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• 2003

The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (M$_{w}$) and glass transition temperature (T$_{g}$) of PLGA decreased after gamma irradiation. The extent of M$_{w}$ reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.study.

• Macromolecular Research
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• v.16 no.3
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• pp.189-193
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• 2008

Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.