• Journal of Pharmaceutical Investigation
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• 제27권3호
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• pp.213-217
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• 1997

The present sustained-release terfenadine-pseudoephedrine HCl dosage form was the core tablet composed of outer (fast-release) layer containing 60 mg of terfenadine and l0mg of pseudoephedrine HCl, and inner (sustained-release) layer containing 110 mg of pseudoephedrine HCl. The purpose of this study was to investigate the possibility of formulating the terfenadine-pseudoephedrine HCl double-layered tablet which was bioequivalent to the core tablet. Its sustained-release and fast-release layer were formulated with disintegrating agents and polymers, respectively, varying with their kinds and amounts. The comparative dissolution test of double-layered and core tablet was carried out at pH 1.2, 4.0 and 6.8, leading to select composite of double-layered tablet whose dissolution pattern was similar to that of core tablet. It was composed of fast-release layer containing 60mg of terfenadine. 10 mg of pseudoephedrine HCl, sodium bicarbonate, microcrystalline cellulose and sodium starch glycolate, and sustained-release layer containing 110 mg of pseudoephedrine HCl and ethylcellulose/hydroxypropyl methylcellulose) (110/30 mg/tablet).

• Journal of Pharmaceutical Investigation
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• 제23권4호
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• pp.213-216
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• 1993

${\kappa}-Carrageenan$, an anionic polysaccharide, was employed in tablet formulations and its function as a drug release sustaining agent was investigated. Tablets composed of ${\kappa}-carrageenan$ and hydroxypropyl methylcellulose were fabricated by using direct compression method. Lactose and sodium alginate were utilized as controls for ${\kappa}-carrageenan$. Drug release experiments performed at pHs 1.2 and 7.4 revealed that ${\kappa}-carrageenan$ retains pH-dependent sustained release effects due to its anionic characteristics. Also, the ionic interaction between ${\kappa}-carrageenan$ and drugs exerted significant affects on drug release kinetics. ${\kappa}-Carrageenan$ was found out to be a useful additive for sustained release tablet formulations.

• Journal of Pharmaceutical Investigation
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• 제18권4호
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• pp.169-174
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• 1988

The release of heparin from monolithic devices composed of different ratios of polyethylene oxide-polypropylene oxide (PEO-PPO) and hydrophobic polyurethane was investigated. The release rate of heparin could be controlled by varying the PEO-PPO content. The heparin release rate from the devices increased as the content of PEO-PPO in the devices increased. The release mechanism may be associated with creation of micro-channels and pores through the devices following the change in the physical structure of the polymer network. Hydrophobic polyurethane containing PEO-PPO can provide an antithrombogenic material for prolonged release of heparin from a heparin blended system.

• 약학회지
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• 제29권2호
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• pp.70-75
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• 1985

The influence of polyethylene glycol derivatives on heparin release from cylindrical monolithic type silicone segment devices was examined in physical saline solution. This water-soluble carrier caused the devices to absorb the water in aqueous media. The release rate of heparin from the devices was increased as molecular weight of polyethylene glycol was increased. Water soluble carrier incorporated into silitone segment devices permits controlled release of heparin that otherwise would be released extremly slowly from the polymer. Heparin released from the silicone segment containing polyethylene glycol showed the first-order kinetics. Without changing the release-pattern, the release rate of heparin could be controlled by varing molecular weight of polyethylene glycol, the water-soluble carrier and depleting polyethylene glycol on the outlayer of devices. The mechanism of release probably showed the creation of pore or microdomine through the devices secondary to the swelling.

• 방사성폐기물학회지
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• 제19권2호
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• pp.177-186
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• 2021

Radioactive materials from nuclear power facilities can be released into the atmosphere through various channels. Recently, the dispersion of radioactive materials has become critical issue in Korea after Kori Unit 1 and Wolsong Unit 1 were permanently shut down. In this study, annual atmospheric dispersion factors were compared based on the continuous release and purge release using the XOQDOQ computer program, a method for calculating atmospheric dispersion factors at commercial nuclear power stations. The meteorological data analyzed in this study was based on the Shin Kori nuclear power meteorological tower which has the largest operating nuclear power plants in Korea, for three years (from 2008 to 2010). The analysis results of the dispersion factor of the radioactive material release obtained using the XOQDOQ program showed that the difference between the continuous release and purge release was within two times. This study will be valuable helpful for revealing the uncertainty of the predictive atmospheric dispersion factor to achieve regulation.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.322.1-322.1
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• 2002

Lawsone methyl ether (LME. 2-methoxy-1, 4-naphthoquinone) is a natural compound found in balsaminaceae. In this study the effect of LME on the release of renal dipeptidase (RDPase) and alkaline phosphatase (APase) known as glycosylphosphatidylinositol (GPI) anchored proteins was examined from the renal proximal tubules. Compared with control, LME (0.5mM) increased RDPase release (218%) and APase release (135%). The increase of RDPase release by LME showed concentration-dependent effect but the release pattern of APase did not. (omitted)

• 항공우주시스템공학회지
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• 제15권4호
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• pp.1-6
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• 2021

The non-explosive holding and release mechanism is used to prevent damage to the mission component caused by explosives when the deployment structure for Cube Satellites is separated. However, among the several types available, the non-explosive holding and release mechanism system using nylon wires depend on the nylon wire knot method and tightening power of the worker. Therefore, in this study, we conducted experiments with the operation of a new holding and release mechanism system by conceptualizing the Boa System Dial, which can provide a constant tightening force regardless of worker proficiency and deploying a imitational solar panel. In this study, the process of binding and unbinding with constant tension was recorded while applying the novel non-explosive holding and release mechanism using the Boa System Dial proposed. In addition, required advances are indicated for the application of the proposed system to actual Cube Satellites.

• International Journal of Advanced Culture Technology
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• 제10권2호
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• pp.181-186
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• 2022

In this paper, we examine the shortening of the theatrical window whereby films play at theaters for 90 days as one of the most portentous issues that could reshape the Hollywood film industry. We first examine the windows system that protected the status of movie theaters and the studios' attempt to shorten the theatrical release to create a premium VOD window in response to the declining revenue of DVDs after 2007 and the rise of streaming services. We then look at some of the major disruptions in distribution COVID-19 brought about. We also explore the shortening of the theatrical release in the wake of the pandemic and shows the changes in the theatrical release, along with the expansion of streaming services, raise questions over the long-held primacy of the theatrical release and the definition of film with the theatrical release as its part. From this, we highlight Hollywood at the crossroads of major changes with its future less certain than ever before.

• 한국유기농업학회지
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• 제5권1호
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• pp.79-85
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• 1996

This experiment was carried out to investigate the effect of slow-release fertilizers on yield of radigh. Fertilizers were treated with CDU, MEISTER, Jobi Gohyungbok-hapbiryo, Kyungki Wonyebokbi 1ho, Kyungkibokbi Nojeok, Kyungki Jeonjakgo-hyungbokbi, Tradidtional manuring, and No maunring. Yields of radish were increased with slow-release fertilizers, CDU and MEISTER were effective to radish shoot, also. But analysis of chemical components of plants and soil were no difference. It was very effect to increase yields of radish, to reduce in number of supplementary manuring and laboring.

• 한국유기농업학회지
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• 제5권2호
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• pp.85-91
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• 1997

This experiment was carried out to investigate the effect of slow-release fertilizers on yield of lettuce. Fertilizers were treated with CDU, MEISTER, Jobi Gohyungbokhapbiryo, Kyungki Wonyebokbi 1ho, Kyungkibokbi Nojeok, Kyungki Jeonjakgohyungbokbi, Traditional manuring, and No manuring. Yields of Spinach was increased with slow-release fertilizers, also. But analysis of chemical components of plants and soil were no difference. It was very effect to increase yields of lettuce, to reduce in number of supplementary manuring and laboring.