• Title/Summary/Keyword: relative sensitivity factors

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Sensitivity Analysis of the Effect of Soil Ecological Quality Information in Selecting Eco-Friendly Road Route (토양생태 등급 정보가 친환경도로노선 선정에 미치는 영향에 관한 민감도 분석)

  • Ki, Dong-Won;Kang, Ho-Geun;Lee, Sang-Eun;Heo, Joon;Park, Joon-Hong
    • Journal of Soil and Groundwater Environment
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    • v.13 no.3
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    • pp.37-44
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    • 2008
  • Soil ecology has important roles in global ecosystems. However, soil ecological quality information is being ignored when assessing ecological impact of construction actions. And methods for classifying and assessing soil ecological quality have been very little established in comparison to those for animal and plant ecosystems. In this study, it was examined whether soil ecological quality information has influence on determining an eco-friendly route for a road construction project. For this, sensitivity analysis was systematically performed by varying the relative significance (weights) of soil ecological quality information among natural environmental and ecological factors. When the weight of soil ecological quality was greater than just 14%, the soil ecological quality information significantly influenced the determination of the eco-friendly routes for a specific road construction project. This demonstrates that soil ecological quality information has to be considered for more reliable environmental impact assessment, and also supports the validity of use of soil ecological quality information and its mapping technique in planning and siting of eco-friendly construction projects.

Simultaneous Determination of Tetracycline Antibiotics by 3-Phase Hollow Fiber-Liquid Phase Microextraction (HF-LPME) and HPLC-UV/Vis (3-상 속빈 섬유-액체상 미량추출법(HF-LPME)과 HPLC-UV/Vis을 이용한 Tetracycline류 항생제 동시분석)

  • Oh, Woong Kyo;Myung, Seung-Woon
    • Journal of the Korean Chemical Society
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    • v.58 no.6
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    • pp.535-542
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    • 2014
  • A simple and efficient preconcentration method was developed using three-phase liquid phase microextraction prior to HPLC-UV for simultaneous extraction and determination of tetracycline antibiotics (tetracycline, oxytetracycline, and chlortetracycline). The tetracycline antibiotics were separated simultaneously on a column ($C_8$, $3.0{\times}150mm$, $3{\mu}m$) with high selectivity and sensitivity using gradient elution. Under optimized conditions (extraction solvent, heptanal; pH of donor, 9.0; pH of acceptor, 1.0; stirring speed, 700 rpm; NaCl salt, 0%; and extraction time, 60 min), enrichment factors (EF) were between 5.6 and 22.3. The limit of detection (LOD) and limit of quantitation (LOQ) in the spiked urine matrix were in the concentration range of $0.08{\sim}0.8{\mu}g/mL$ and $0.4{\sim}1.6{\mu}g/mL$, respectively. The calibration curves were linear within the range of $0.1{\sim}32{\mu}g/mL$ with the square of the correlation coefficient being more than 0.995. The precision (as a relative standard deviation, RSD) and accuracy (as a relative recovery) within working range were 1.3~9.1% and 84~118%, respectively.

Vulnerability Assessment of the Air Pollution Using Entropy Weights : Focused on Ozone (엔트로피 가중치를 활용한 대기오염 취약성 평가 - 오존을 중심으로 -)

  • Lee, Sang-hyeok;Kang, Jung Eun;Bae, Hyun Joo;Yoon, Dong Keun
    • Journal of the Korean association of regional geographers
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    • v.21 no.4
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    • pp.751-763
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    • 2015
  • Both the selection of indicators and weights for them are critical issues in the vulnerability assessment. This study is to assess the air pollution vulnerability focused on ozone for 249 local jurisdictions using weights calculated by the entropy methodology and then examine the applicability of the methodology. We selected indicators for air pollution vulnerability assessment and standardized them. Subsequently, we calculated weights of each indicator using the entropy method and then integrated them into the vulnerability index. The exposure indicators consider meteorological and air pollution factors and the sensitivity of the local jurisdiction include variables on vulnerable areas and environments. The adaptive capacity contains socio-economic characteristics, health care capacities and air pollution managemental factors. The results show that Hwaseong-si, Gwangjin-gu, Gimpo-si, Gwangju-si, Gunpo-si are among the highest vulnerabilities based on the simple aggregation of indicators. And vulnerability-resilience (VRI) aggregation results indicates the similar spatial pattern with the simple aggregation outcomes. This article extends current climate change vulnerability assessment studies by adopting the entropy method to evaluate relative usefulness of data. In addition, the results can be used for developing customized adaptation policies for each jurisdiction reflecting vulnerable aspects.

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Simulation and Sensitivity Analysis of the Air Separation Unit for SNG Production Relative to Air Boosting Ratios (SNG 생산용 공기분리공정의 공기 재 압축비에 따른 민감도 분석)

  • Kim, Mi-yeong;Joo, Yong-Jin;Seo, Dong Kyun;Shin, Jugon
    • KEPCO Journal on Electric Power and Energy
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    • v.5 no.3
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    • pp.173-179
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    • 2019
  • Cryogenic air separation unit produces various gases such as $N_2$, $O_2$, and Ar by liquefying air. The process also varies with diverse production conditions. The one for SNG production among them has lower efficiency compared to other air separation unit because it requires ultrapure $O_2$ with purity not lower than 99.5%. Among factors that reduce the efficiency of air separation unit, power consumption due to compress air and heat duty of double column were representatives. In this study, simulation of the air separation unit for SNG production was carry out by using ASEPN PLUS. In the results of the simulation, 18.21 kg/s of at least 99.5% pure $O_2$ was produced and 33.26 MW of power was consumed. To improve the energy efficiency of air separation unit for SNG production, the sensitivity analysis for power consumption, purities and flow rate of $N_2$, $O_2$ production in the air separation unit was performed by change of air boosting ratios. The simulated model has three types of air with different pressure levels and two air boosting ratio. The air boosting ratio means flow rate ratio of air by recompressing in the process. As increasing the first air boosting ratio, $N_2$ flow rate which has purity of 99.9 mol% over increase and $O_2$ flow rate and purity decrease. As increasing the second air boosting ratio, $N_2$ flow rate which has purity of 99.9 mol% over decreases and $O_2$ flow rate increases but the purity of $O_2$ decreases. In addition, power consumption of compressing to increase in the two cases but results of heat duty in double column were different. The heat duty in double column decreases as increasing the first air boosting ratio but increases as increasing the second air boosting ratio. According to the results of the sensitivity analysis, the optimum air boosting ratios were 0.48 and 0.50 respectively and after adjusting the air boosting ratios, power consumption decreased by approximately 7% from $0.51kWh/O_2kg$ to $0.47kWh/O_2kg$.

Definition of Tumor Volume Based on 18F-Fludeoxyglucose Positron Emission Tomography in Radiation Therapy for Liver Metastases: An Relational Analysis Study between Image Parameters and Image Segmentation Methods (간 전이 암 환자의 18F-FDG PET 기반 종양 영역 정의: 영상 인자와 자동 영상 분할 기법 간의 관계분석)

  • Kim, Heejin;Park, Seungwoo;Jung, Haijo;Kim, Mi-Sook;Yoo, Hyung Jun;Ji, Young Hoon;Yi, Chul-Young;Kim, Kum Bae
    • Progress in Medical Physics
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    • v.24 no.2
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    • pp.99-107
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    • 2013
  • The surgical resection was occurred mainly in liver metastasis before the development of radiation therapy techniques. Recently, Radiation therapy is increased gradually due to the development of radiation dose delivery techniques. 18F-FDG PET image showed better sensitivity and specificity in liver metastasis detection. This image modality is important in the radiation treatment with planning CT for tumor delineation. In this study, we applied automatic image segmentation methods on PET image of liver metastasis and examined the impact of image factors on these methods. We selected the patients who were received the radiation therapy and 18F-FDG PET/CT in Korea Cancer Center Hospital from 2009 to 2012. Then, three kinds of image segmentation methods had been applied; The relative threshold method, the Gradient method and the region growing method. Based on these results, we performed statistical analysis in two directions. 1. comparison of GTV and image segmentation results. 2. performance of regression analysis for relation between image factor affecting image segmentation techniques. The mean volume of GTV was $60.9{\pm}65.9$ cc and the $GTV_{40%}$ was $22.43{\pm}35.27$ cc, and the $GTV_{50%}$ was $10.11{\pm}17.92$ cc, the $GTV_{RG}$ was $32.89{\pm}36.8$4 cc, the $GTV_{GD}$ was $30.34{\pm}35.77$ cc, respectively. The most similar segmentation method with the GTV result was the region growing method. For the quantitative analysis of the image factors which influenced on the region growing method, we used the standardized coefficient ${\beta}$, factors affecting the region growing method show GTV, $TumorSUV_{MAX/MIN}$, $SUV_{max}$, TBR in order. The result of the region growing (automatic segmentation) method showed the most similar result with the CT based GTV and the region growing method was affected by image factors. If we define the tumor volume by the auto image segmentation method which reflect the PET image parameters, more accurate and consistent tumor contouring can be done. And we can irradiate the optimized radiation dose to the cancer, ultimately.

Sensitivity Analysis of Surface Reflectance Retrieved from 6SV LUT for Each Channel of KOMPSAT-3/3A (KOMPSAT-3/3A 채널별 6SV 조견표의 지표반사도 민감도 분석)

  • Jung, Daeseong;Jin, Donghyun;Seong, Noh-Hun;Lee, Kyeong-Sang;Seo, Minji;Choi, Sungwon;Sim, Suyoung;Han, Kyung-Soo;Kim, Bo-Ram
    • Korean Journal of Remote Sensing
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    • v.36 no.5_1
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    • pp.785-791
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    • 2020
  • The radiance measured from satellite has noise due to atmospheric effect. Atmospheric correction is the process of calculating surface reflectance by removing atmospheric effect and surface reflectance is calculated by the Radiative Transfer Model (RTM)-based Look-Up Table (LUT). In general, studies using a LUT make LUT for each channel with the same atmospheric and geometric conditions. However, atmospheric effect of atmospheric factors do not react sensitively in the same channel. In this study, the LUT for each channel of Korea Multi-Purpose SATellite (KOMPSAT)-3/3A was made under the same atmospheric·geometric conditions. And, the accuracy of the LUT was verified by using the simulated Top of Atmosphere radiation and surface reflectance in the RTM. As a result, the relative error of the surface reflectance in the blue channel that sensitive to the aerosol optical depth was 81.14% at the maximum, and 42.67% in the NIR (Near Infrared) channel.

Evaluation of DNA Double Strand Breaks in Human and Mouse Lymphocyte Following ${\gamma}-Irradiation$ (${\gamma}-Ray$ 조사에 따른 사람의 정상임파구와 마우스 정상임파구의 DNA Double Strand Break 발생율에 대한 비교분석)

  • Kim Tae Hwan;Kim Sung Ho;Chung In Yong;Cho Chul Koo;Ko Kyung Hwan;Yoo Seong Yul
    • Radiation Oncology Journal
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    • v.11 no.2
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    • pp.219-225
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    • 1993
  • The evaluation of radiation-induced DNA double strand breaks (DSB) was made following irradiation of human lymphocytes, murine lymphocytes and EL-4 leukemia cells over a wide dose range of $^{60}Co\;{gamma}-rays.$ In lipopolysaccharide (LPS) or phytohemagglutinin (PHA)-stimulated murine lymphocytes, the slopes of the stand scission factor (SSF) revealed that lymphocytes with LPS increased DNA DSB formation by a factor of 1.432 (p<0.005). Furthermore, strand break production was relatively inefficient in the T lymphocytes compared to the B lymuhocytes. And EL-4 leukemia cells were found to form significantly more DNA DSB to a greater extent than normal lymphocytes (p<0.005). The in vitro studies of the intrinsic radiosensitivity between human lymphocytes and murine lymphocytes showed similar phasic kinetics. However, murine lymphocytes were lower in DNA DSB formation and higher in the relative radiation dose of 10 percent DNA strand breaks at 3.5 hours following ${gamma}-irradiation$ than human lymphocytes. Though it is difficult to interpret these results, these differences may be result from environmental and genetic factors. From our data, if complementary explanations for this difference will be proposed, the differences in the dose-effect relationship for the induction of DSB between humans and mice must be related to interspecies variations in the physiological condition of the peripheral blood in vitro and not to differences in the intrinsic radiation sensitivity of the lymphocytes. These results can be estimated on the basis of dose-effect correlation enabling the interpretation of clinical response and the radiobiological parameters of cytometrical assessment.

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The gene expression programming method to generate an equation to estimate fracture toughness of reinforced concrete

  • Ahmadreza Khodayari;Danial Fakhri;Adil Hussein, Mohammed;Ibrahim Albaijan;Arsalan Mahmoodzadeh;Hawkar Hashim Ibrahim;Ahmed Babeker Elhag;Shima Rashidi
    • Steel and Composite Structures
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    • v.48 no.2
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    • pp.163-177
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    • 2023
  • Complex and intricate preparation techniques, the imperative for utmost precision and sensitivity in instrumentation, premature sample failure, and fragile specimens collectively contribute to the arduous task of measuring the fracture toughness of concrete in the laboratory. The objective of this research is to introduce and refine an equation based on the gene expression programming (GEP) method to calculate the fracture toughness of reinforced concrete, thereby minimizing the need for costly and time-consuming laboratory experiments. To accomplish this, various types of reinforced concrete, each incorporating distinct ratios of fibers and additives, were subjected to diverse loading angles relative to the initial crack (α) in order to ascertain the effective fracture toughness (Keff) of 660 samples utilizing the central straight notched Brazilian disc (CSNBD) test. Within the datasets, six pivotal input factors influencing the Keff of concrete, namely sample type (ST), diameter (D), thickness (t), length (L), force (F), and α, were taken into account. The ST and α parameters represent crucial inputs in the model presented in this study, marking the first instance that their influence has been examined via the CSNBD test. Of the 660 datasets, 460 were utilized for training purposes, while 100 each were allotted for testing and validation of the model. The GEP model was fine-tuned based on the training datasets, and its efficacy was evaluated using the separate test and validation datasets. In subsequent stages, the GEP model was optimized, yielding the most robust models. Ultimately, an equation was derived by averaging the most exemplary models, providing a means to predict the Keff parameter. This averaged equation exhibited exceptional proficiency in predicting the Keff of concrete. The significance of this work lies in the possibility of obtaining the Keff parameter without investing copious amounts of time and resources into the CSNBD test, simply by inputting the relevant parameters into the equation derived for diverse samples of reinforced concrete subject to varied loading angles.

Coronary Computed Tomography Angiography for the Diagnosis of Vasospastic Angina: Comparison with Invasive Coronary Angiography and Ergonovine Provocation Test

  • Jiesuck Park;Hyung-Kwan Kim;Eun-Ah Park;Jun-Bean Park;Seung-Pyo Lee;Whal Lee;Yong-Jin Kim;Dae-Won Sohn
    • Korean Journal of Radiology
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    • v.20 no.5
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    • pp.719-728
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    • 2019
  • Objective: To investigate the diagnostic validity of coronary computed tomography angiography (cCTA) in vasospastic angina (VA) and factors associated with discrepant results between invasive coronary angiography with the ergonovine provocation test (iCAG-EPT) and cCTA. Materials and Methods: Of the 1397 patients diagnosed with VA from 2006 to 2016, 33 patients (75 lesions) with available cCTA data from within 6 months before iCAG-EPT were included. The severity of spasm (% diameter stenosis [%DS]) on iCAGEPT and cCTA was assessed, and the difference in %DS (Δ%DS) was calculated. Δ%DS was compared after classifying the lesions according to pre-cCTA-administered sublingual nitroglycerin (SL-NG) or beta-blockers. The lesions were further categorized with %DS ≥ 50% on iCAG-EPT or cCTA defined as a significant spasm, and the diagnostic performance of cCTA on identifying significant spasm relative to iCAG-EPT was assessed. Results: Compared to lesions without SL-NG treatment, those with SL-NG treatment showed a higher Δ%DS (39.2% vs. 22.1%, p = 0.002). However, there was no difference in Δ%DS with or without beta-blocker treatment (35.1% vs. 32.6%, p = 0.643). The significant difference in Δ%DS associated with SL-NG was more prominent in patients who were aged < 60 years, were male, had body mass index < 25 kg/m2, and had no history of hypertension, diabetes, or dyslipidemia. Based on iCAG-EPT as the reference, the per-lesion-based sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of cCTA for VA diagnosis were 7.5%, 94.0%, 60.0%, 47.1%, and 48.0%, respectively. Conclusion: For patients with clinically suspected VA, confirmation with iCAG-EPT needs to be considered without completely excluding the diagnosis of VA simply based on cCTA results, although further prospective studies are required for confirmation.