• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회(2)
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• pp.1419-1419
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• 2005

• Molecules and Cells
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• 제41권5호
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• pp.390-400
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• 2018

Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioinformatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.

• BMB Reports
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• 제38권2호
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• pp.151-160
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• 2005

By a cDNA array representing 2308 signal transduction related genes, we studied the expression profiles of HeLa cells stably transfected by Hepatitis C virus nonstructural protein 4B (HCV-NS4B). The alterations of the expression of four genes were confirmed by real-time quantitative RT-PCR; and the aldo-keto reductase family 1, member C1 (AKR1C1) enzyme activity was detected in HCV-NS4B transiently transfected HeLa cells and Huh-7, a human hepatoma cell line. Of the 2,308 genes we examined, 34 were up-regulated and 56 were down-regulated. These 90 genes involved oncogenes, tumor suppressors, cell receptors, complements, adhesions, transcription and translation, cytoskeletion and cellular stress. The expression profiling suggested that multiple regulatory pathways were affected by HCV-NS4B directly or indirectly. And since these genes are related to carcinogenesis, host defense system and cell homeostatic mechanism, we can conclude that HCV-NS4B could play some important roles in the pathogenesis mechanism of HCV.

• 한국멀티미디어학회논문지
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• 제12권5호
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• pp.644-652
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• 2009

유비쿼터스 센서 네트워크(USN), 휴대 인터넷(WiBro), 무선식별 시스템(RFID) 등의 새로운 통신 환경이 현실화 되고 있다. 이에, 이러한 제약된 자원을 사용하는 통신 환경에서 보안과 프라이버시 보호를 보장하기 위해 mCrypton, HIGHT, SEA, PRESENT와 같은 경량 블록 암호들이 제안되었다. mCrypton은 Crypton의 경량화 버전으로 64-비트, 96-비트, 128-비트 키를 지원하는 64-비트 블록 암호이다. 본 논문에서는 mCrypton에 대한 첫 번째 분석 결과로서, 128-비트 키를 사용하는 8-라운드 mCrypton에 대한 연관키 렉탱글 공격을 제안한다. 이를 위해 7-라운드 연관키 렉탱글 구별자를 구성하기 위해 사용하는 두 개의 연관키 부정 차분 특성을 설명하고 이를 기반으로 8-라운드 mCypton에 대한 연관키 렉탱글 공격을 제안한다. 본 공격은 $2^{45.5}$의 데이터와 $2^{45.5}$의 시간 복잡도를 필요로 한다.

• 정보보호학회논문지
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• 제18권4호
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• pp.45-52
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• 2008

$K{\ddot{u}}c{\ddot{u}}k$은 eSTREAM 프로젝트에 제안된 스트림 암호인 Grain-v1에 대하여, 공격자에게 키스트림 수열이 주어지면 이를 1-비트 좌측 이동시킨 키스트림 수열을 생성할 수 있음을 보였다[5]. 본 논문에서는 [5]에서 제안된 공격을 확장하여 연관키 선택 Ⅳ 공격을 제안한다. 본 공격은 Grain-v1의 초기화 과정의 취약점을 이용하여 비밀키의 부분 정보를 획득하여 $2^{25.02}$개의 Ⅳ와 $2^{56}$의 시간 복잡도로 Grain-v1의 비밀키를 복구한다. 본 공격은 Grain-v1에 대한 첫 번째 키 복구 공격이다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2013년도 춘계학술발표대회
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• pp.507-510
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• 2013

Cloud computing is an emerging technology, which allows the user to fulfill his needs by outsourcing the resources. With the passage of time, cloud computing has become an essential part of our lives. But it still requires some sort of standardization, specially in terms of user's trust, privacy, and security related things. This study presents different types of cloud computing services and their working domains along with some key virtualization related issues that are encountered by the cloud service provider as well as the user. Those key issues, related with virtual network are discussed in this paper. This study provides a basis to work further on those issues, so that the key concerns are addressed as soon as possible and cloud computing could become standardized and more prevalent.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.775-780
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• 2014

Objectives: TCR-gamma-delta+T cells (${\gamma}{\delta}$ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of ${\gamma}{\delta}$ T cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. Methods: The association between ${\gamma}{\delta}$ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). Results:Immunohistochemistry showed decreased infiltration of ${\gamma}{\delta}$ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of ${\gamma}{\delta}$ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral ${\gamma}{\delta}$T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral ${\gamma}{\delta}$ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral ${\gamma}{\delta}$ T cells did not show independent prognostic value for either TTR or OS in HCC patients. Conclusions: Low counts of ${\gamma}{\delta}$ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.

• 한국통신학회:학술대회논문집
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• 한국통신학회 1991년도 추계종합학술발표회논문집
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• pp.155-158
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• 1991

In this paper, we investigate key issues and the CCITT activities related to the quality of service in the B-ISDN based on the ATM. We first clarify the relationships between the QOS(Quality of Service). NP(Network Performance), and GOS(Grade of Service). Using the GOS, network design and tuning method is suggested. Also, we examine the performance impairments and key NP parameters in ATM networks.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권9호
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• pp.3322-3347
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• 2021

Cloud Storage is the primary component of many businesses on cloud. Majority of the enterprises today are adopting a multicloud strategy to keep away from vendor lock-in and to optimize cost. Auditing schemes are used to ascertain the integrity of cloud data. Of these schemes, only the Provable Data Possession schemes (PDP) are resilient to key-exposure. These PDP schemes are devised using Public Key Infrastructure (PKI-) based cryptography, Identity-based cryptography, etc. PKI-based systems suffer from certificate-related communication/computational complexities. The Identity-based schemes deal with the exposure of only the auditing secret key (audit key). But with the exposure of both the audit key and the secret key used to update the audit key, the auditing process itself becomes a complete failure. So, an Identity-based PDP scheme with Parallel Key-Insulation is proposed for multiple cloud storage. It reduces the risk of exposure of both the audit key and the secret key used to update the audit key. It preserves the data privacy from the Third Party Auditor, secure against malicious Cloud Service Providers and facilitates batch auditing. The resilience to key-exposure is proved using the CDH assumption. Compared to the existing Identity-based multicloud schemes, it is efficient in integrity verification.

• Asian-Australasian Journal of Animal Sciences
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• 제28권10호
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• pp.1394-1406
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• 2015

The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats. Herein, a total of seven novel single nucleotide polymorphisms (SNPs) (SNP 1-7) within this gene were found in two well-known Chinese native goat breeds. Haplotypes structure analysis demonstrated that there were four haplotypes in Hainan black goat while seventeen haplotypes in Xinong Saanen dairy goat, and both breeds only shared one haplotype (hap1). Association testing revealed that the SNP2, SNP5, SNP6, and SNP7 loci were also found to significantly associate with growth-related traits in goats, respectively. Moreover, one diplotype in Xinong Saanen dairy goats significantly linked to growth related traits. These preliminary findings not only would extend the spectrum of genetic variations of the goat ATBF1 gene, but also would contribute to implementing marker-assisted selection in genetics and breeding in goats.