• Molecules and Cells
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• 제39권12호
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• pp.898-908
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• 2016

Despite recent groundbreaking advances in multiple myeloma (MM) treatment, most MM patients ultimately experience relapse, and the relapse biology is not entirely understood. To define altered gene expression in MM relapse, gene expression profiles were examined and compared among 16 MM patients grouped by 12 months progression-free survival (PFS) after autologous stem cell transplantation. To maximize the difference between prognostic groups, patients at each end of the PFS spectrum (the four with the shortest PFS and four with the longest PFS) were chosen for additional analyses. We discovered that integrin-${\alpha}8$ (ITGA8) is highly expressed in MM patients with early relapse. The integrin family is well known to be involved in MM progression; however, the role of integrin-${\alpha}8$ is largely unknown. We functionally overexpressed integrin-${\alpha}8$ in MM cell lines, and surprisingly, stemness features including $HIF1{\alpha}$, VEGF, OCT4, and Nanog, as well as epithelial mesenchymal transition (EMT)-related phenotypes, including N-cadherin, Slug, Snail and CXCR4, were induced. These, consequently, enhanced migration and invasion abilities, which are crucial to MM pathogenesis. Moreover, the gain of integrin-${\alpha}8$ expression mediated drug resistance against melphalan and bortezomib, which are the main therapeutic agents in MM. The cBioPortal genomic database revealed that ITGA8 have significant tendency to co-occur with PDGFRA and PDGFRB and their mRNA expression were up-regulated in ITGA8 overexpressed MM cells. In summary, integrin-${\alpha}8$, which was up-regulated in MM of early relapse, mediates EMT-like phenotype, enhancing migration and invasion; therefore, it could serve as a potential marker of MM relapse and be a new therapeutic target.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권3호
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• pp.218-224
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• 2011

Purpose: The purpose of this study is to evaluate the post-operative skeletal stability after surgical correction of patients with mandibular prognathism by bilateral sagittal split ramus osteotomy (BSSRO) and to evaluate the horizontal relapse tendency after the surgery. Methods: Twenty-six patients with Class III dental and skeletal malocclusion were selected for this retrospective study. Fifteen of them underwent BSSRO for mandibular setback and eleven of them underwent two-jaw surgery (Lefort I and BSSRO). In each patient, lateral cephalometric radiographs were taken pre-operatively, post-operatively within 1 week, and post-operatively after eight months. After tracing of the cephalometric radiographs, various parameters were measured. The analyses were done by linear measurement to evaluate the change in position of hard tissue B point, pogonion and mandibular plan angle by examination on lateral cephalograms. Results: The horizontal relapse rate was 27.1% at B point and 31.6% at pogonion in patients who underwent BSSRO. The horizontal relapse rate of the group where the amount of correction exceeded 10 mm was 25.69% at B point. Conclusion: There were no statistical differences on the magnitude of setback and direction of rotation of the mandible in mandibular stability. There were also no statistical differences between single mandibular surgery and two-jaw surgery for mandibular stability.

• 대한치과교정학회지
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• 제34권4호
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• pp.313-324
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• 2004

본 연구에서는 성장기 골격성 III급 부정 교합 한자의 치료 전 측모 두부방사선 계측사진에서 얻을 수 있는 골격성, 치성 분석을 통하여 안정군과 재발군을 구별하여 주는 요소를 찾아보아 III급 부절 교합의 치료시 안정성을 고려한 치료 선택에 도움을 주고자 하였다 고정식 교정 장치를 통한 전치부 반대 교합 혹은 절단 교합의 골격성 III급 부정 교합 치료 후 최소 1년 동안 안정된 결과를 보인 안정군 33명과 관찰 기간 동안 절단 교합 이하의 수평 피개를 보인 재발군 22명을 연구 대상으로 하여 비교하였으며 t-test를 시행하여 다음과 같은 결론을 얻었다. 1. 건후방적 골격 형태보다는 수직적 형태, 특히 AB-maxillo-mandibular triangle내의 수직적 형태가 III급 부정 교합치료의 예후에 주요한 결정 인자로 나타났다. 수직 각도 계측 항목에 의한 안정군과 재발군간의 비교에서 유의성 있는 차이를 보인 항목은 AB-MP, ODI로 나타났다(P<0.01). 수직 비율 계측 항목에서도 MP-P/AL, PP-P/AL항목이 유의성 있는 차이를 보였다(P<0.05). 2. 재발의 경향은 교합 평면 특히. 하악 교합 평면이 전하방으로 급경사를 이룰수록 증가했다. 친합 평면 경사도와 관련된 계측 항목에 의한 안정군과 재발군간의 비교에서 OP(L)-PP, OP-PP, AB-OP(L), Wits appraisal항목이 유의성 있는 차이를 보였다(P<0.05). 본 연구는 전후방 부조화가 아닌 골격성, 치성 수직 부조화가 재발을 예측하는 적절한 기준이 됨을 시사하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권6호
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• pp.407-420
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• 2003

Purpose : The purpose of this study was to analyse the facial changes and factors contributing to then after bilateral sagittal split ramus osteotomy of mandibular prognathism. Materials and Methods : Forty patients with Class III dental and skeletal malocclusion who were treated with bilateral sagittal split ramus osteotomy were reviewed. Frontal and lateral cephalometric radiographs were taken preoperatively, immediate postoperatively and more than six months postoperatively in each patient. After tracing the cephalometric radiographs, various parameters were measured. Results : 1. Gonial angle at postoperative two days was decreased about $10.4^{\circ}$ than preoperatively and gonial angle at postoperative six months was increased about $6.8^{\circ}$ than postoperative two days. So, gonial angle at postoperative six months was decreased about $3.6^{\circ}$ than preoperative gonial angle. 2. Facial height postoperative two days was decreased about 0.8mm than preoperatively and facial height at postoperative six months was decreased about 0.7mm than postoperative two days. So, facial height at postoperative six months was decreased about 1.5mm than preoperative facial height. 3. Mandibular width postoperative two days was decreased about 1.0mm than preoperatively and mandibular width at postoperative six months was increased about 1.8mm than postoperative two days. So, mandibular width at postoperative six months was decreased about 2.8mm than preoperative mandibular width. 4. Amount of set back and mandibular plane angle were not influencing on relapse degree. Conclusion : It is thought that bilateral sagittal split ramus osteotomy in mandibular prognathic patients is effective to improve long face and steep gonial angle. More prudent operation and careful postoperative management is required to maintain stable face postoperatively. Further research for soft tissue changes and factors which are related with relapse is needed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권1호
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• pp.28-38
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• 2010

The factors influencing the relapse and recurrence of skeletal deformity after the orthognathic surgery include various factors such as condylar deviation, the amount of mandibular set-back, stretching force by the soft tissues and muscles around the facial skeleton. The purpose of this report is to recognize and analyze the possible factors of reoperation after orthognathic surgery, due to early relapses. Six patients underwent reoperation after the orthognathic surgeries out of 110 patients from 2006 to 2009 were included in this study. In most cases, clincal signs of the insufficient occlusal stability, anterior open bite, and unilateral shifting of the mandible were founded within 2 weeks postoperatively. Although elastic traction was initiated in every case, inadequate correction made reoperation for these cases inevitable. The chief complaints of five cases were the protruded mandible combined with some degree of asymmetric face and in the other one case, it was asymmetric face only. Various factors were considered as a major cause of post-operative instability such as condylar sagging, counter-clockwise rotation of the mandibular segment, soft tissue tension related with asymmetrical mandibular set-back, preoperatively existing temporomandibular disorder (TMD), poor fabrication of the final wafer, and dual bite tendency of the patients.

• 대한치과교정학회지
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• 제26권3호
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• pp.267-279
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• 1996

교정치료는 치료 후의 분석이 이루어져야 그 성공여부를 평가받을 수 있다. 왜냐하면 교정치료는 환자자신의 고유한 균형을 변화시켜 또 다른 균형을 설정해가는 과정이기 때문이다. 그러나 1급이나 2급 부정교합에 비해 3급 부정교합 환자에 대한 연구는 미비하였다. 이 연구는 일반적인 교정치료시와 보정기간 중에는 어떠한 변화과정을 겪으며, 이들 중 재발 양상을 나타내는 요소에 대하여 치료 전의 골격형태와 치료기간 중 변화량과의 상관관계를 알아보고자 시행하였다. 초진시의 Heilman dental age가 IIIB이상이며 1년 6개월이상의 보정기간이 경과한 24명 을 대상으로 하여 치료기간과 보정기간 중에 각항목의 변화량을 비교하고 이중 복귀현상을 나타낸 항목에 대한 상관관계를 분석하여 다음과 같은 결론을 얻었다. 1. FH plane에 대한 교합평면의 각과 하악평면의 각, 그리고 하악평연에 대한 하악 전치의 각은 치료기간중의 변화가 보정기간 중에 치료전의 상태로의 복귀현상을 나타내었으며 이중 교합평면각과 하악 전치의 치축항목은 치료기간중의 변화량과 역상관 관계를 나타내었다. 2. 치료 종료시 교합평면의 상방변위가 보정기간 중에 원래의 형태로 복귀하려는 경향을 보였으며 이는 치료기간 중에 변위량과 비례하여 나타났으나 기저골에 대한 상하악 대구치의 경사는 치료기간중의 변화량이 보정기간에 일정하게 유지되었다. 3. 보정기간 중의 하악평면각은 치료기간 중의 하악의 후하방 회전량이 클수록 감소하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제18권4호
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• pp.594-606
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• 1996

저자는 하악골의 측방 변위를 보이는 악안면 비대칭증례에서 이하두정방사선규격사진과 정모두부방사선규격사진을 이용하여 두개부 형태와 악안면부의 비대칭성과의 상호 관련성을 조사하여 다음과 같은 결론을 얻었다. 1. 이하두정방사선규격사진에서 하악골의 편위정도는 평균 $-3.12{\pm}3.80$ 이며 절대치의 평균은 $2.50{\pm}2.82$ 이였다. 2. 이하두정방사선규격사진에서 비편위측과 편위측에 대한 유의성 검정에서 통계적인 유의성은 없었으나(p>0.05), 그 차이의 평균은 전두부(Y10, Y9, Y8, Y7, Y6)에서는 편위측이 상대적으로 더 크고, 측두부(Y5, Y-1, Y-2, Y-3, Y-4, Y-5, Y-6)에서는 비편위측이 상대적으로 더 크게 나타났다. 3. 정모두부방사선규격사진에서 술전의 하악골의 평균 편위는 $1.3983{\pm}3.521$ 이며 절대치의 평균은 $3.95{\pm}2.85$ 이였다. 4. 정모두부방사선규격사진에서 수술에 의한 변화량 (PT2A-PT1A) 에 대한 재발량(PTLA-PT2A)의 상관관계분석에서 수술에 의한 이동량이 많을 수록 재발이 많은 것으로 나타났다(p<0.05). 5. 이하두정방사선규격사진에서 하악골 편위정도에 대하여 두개관 형태(비변위-변위차이)에 대한 상관관계분석에서 통계적인 유의성은 없었으나(P>0.05), 변위가 클수록 전두부에서는 비변위측이, 후두부에서는 변위측이 더 큰 경향을 보였다. 6. 정모두부방사선사진상에서 하악골의 변위 정도에 대한 두개관(비변위-변위)과의 상관관계 분석에서 Y4(P<0.05), Y3, Y2, Yl, 0, Y-1, Y-2, Y-4, Y-6(P<0,01), Y-5(p<0.001) 등의 위치에서 하악골의 변위 정도가 클수록 비변위측이 더 큰 것으로 나타났다. 7. 정모두부방사선사진상에서 하악골 재발에 대한 두개관(비변위-변위)과의 상관관계분석에서는 통계적인 유의성이 없었으나(P>0.05), 측두부에서는 비변위-변위 차이가 클수록 재발이 많은 경향을 보였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권6호
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• pp.404-412
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• 2012

Purpose: The purpose of this study was to evaluate postsurgical facial hard tissue stability after orthognathic surgery with/without posterior impaction in skeletal class III malocclusion patients, and to evaluate the horizontal relapse tendency, according to changes in anteroposterior discrepancy and occlusal planes. Methods: Ninety patients, who had undergone orthognathic surgery in Pusan National University Dental Hospital, were enrolled in this study. Three main groups were classified as follows: Thirty patients underwent mandibular setback bilateral sagittal split ramus osteotomy (BSSRO) only (BSSRO group, BG); another thirty patients underwent mandibular setback BSSRO and Le Fort I osteotomy with posterior impaction (posterior impaction group, PG); and another thirty patients underwent mandibular setback BSSRO and Le Fort I osteotomy without posterior impaction (non-posterior impaction group, NPG). Preoperative (T0), immediate postoperative (T1) and six-month follow-up period (T2) lateral cephalograms were taken, and various parameters were measured. The analyses were done by linear and angular measurements between T0-T1 and T1-T2, to evaluate postsurgical facial hard tissue stability. Results: Mean horizontal relapse rates were distributed from 11.81% to 19.08%, and there were significant postsurgical changes (0.52 mm~2.44 mm) at the B point in all 3 groups. But, there were no statistical differences on relapse rate among BG, PG and NPG patients. Conclusion: In this study, the postsurgical stabilities of BSSRO and Le Fort I osteotomy with/without posterior impaction in skeletal class III malocclusion patients were acceptable. There were no significant statistical differences in mandibular stability according to changes in anteroposterior discrepancy and occlusal planes.

• Molecules and Cells
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• 제39권9호
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• pp.645-653
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• 2016

Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate's innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles of reward-related brain regions. Given the accumulated findings, a recent, emerging trend in morphine research is that of examining the dynamics of neuronal interactions in brain reward circuits under the influence of morphine action. In this review, we highlight recent findings on the roles of several reward circuits involved in morphine addiction based on pharmacological, molecular and physiological evidences.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권2호
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• pp.152-161
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• 2007

This study was conducted to patients visited oral maxillo-facial surgery, KNUH and the purpose of the study was to assess skeletal and dento-alveolar stability after surgical-orthodontic correction treated by skeletal Class III malocclusion patients with open bite versus non-open bite. This retrospective study was based on the examination of 40 patient, 19 males and 21 females, with a mean age 22.3 years. The patients were divided into two groups based on open bite and non-open bite skeletal Class III malocclusion patients. The cephalometric records of 40 skeletal Class III malocclusion patients (open bite: n = 18, non-open bite: n = 22) were examined at different time point, i.e. before surgery(T1), immediately after surgery(T2), one year after surgery(T3). Bilateral sagittal split ramus osteotomy was performed in 40 patients. Rigid internal fixation was standard method used in all patient. Through analysis and evaluation of the cephalometric records, we were able to achieve following results of post-surgical stability and relapse. 1. There was no significant statistical differences between open bite and non-open bite with skeletal Class III malocclusion patients in maxillary occlusal plane angle of pre-operative stage(p>0.05). 2. Mean vertical relapses of skeletal Class III malocclusion patients with open bite were $0.02{\pm}1.43mm$ at B point and $0.42{\pm}1.56mm$ at Pogonion point. In skeletal Class III malocclusion patients with non-open bite, $0.12{\pm}1.55mm$ at B point and $0.08{\pm}1.57mm$ at Pogonion point. There was no significant statistical differences between open bite and non-open bite with skeletal Class III malocclusion patients in vertical relapse(p>0.05). 3. Mean horizontal relapses of skeletal Class III malocclusion patients with open bite were $1.22{\pm}2.21mm$ at B point and $0.74{\pm}2.25mm$ at Pogonion point. In skeletal Class III malocclusion patients with non-open bite, $0.92{\pm}1.81mm$ at B point and $0.83{\pm}2.11mm$ at Pogonion point. There was no significant statistical differences between open bite and non-open bite with skeletal Class III malocclusion patients in horizontal relapse(p>0.05). 4. There were no significant statistical differences between open bite and non-open bite with skeletal Class III malocclusion patients in post-surgical mandibular stability(p>0.05). and we believe this is due to minimized mandibular condylar positional change using mandibular condylar positioning system and also rigid fixation using miniplate 5. Although there was no significant relapse tendency observed at chin points, according to the Pearson correlation analysis, the mandibular relapse was influenced by the amount of vertical and horizontal movement of mandibular set-back(p=0.05, r>0.304).