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http://dx.doi.org/10.14348/molcells.2016.0137

Brain Reward Circuits in Morphine Addiction  

Kim, Juhwan (Center for Neuroscience, Brain Science Institute)
Ham, Suji (Center for Neuroscience, Brain Science Institute)
Hong, Heeok (Department of Medical Science, Konkuk University School of Medicine)
Moon, Changjong (Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University)
Im, Heh-In (Center for Neuroscience, Brain Science Institute)
Publication Information
Molecules and Cells / v.39, no.9, 2016 , pp. 645-653 More about this Journal
Abstract
Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate's innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles of reward-related brain regions. Given the accumulated findings, a recent, emerging trend in morphine research is that of examining the dynamics of neuronal interactions in brain reward circuits under the influence of morphine action. In this review, we highlight recent findings on the roles of several reward circuits involved in morphine addiction based on pharmacological, molecular and physiological evidences.
Keywords
addiction; morphine; opiate; reward circuits; withdrawal symptom;
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