• Title/Summary/Keyword: rejection

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Research on public sentiment of the post-corona new normal: Through social media (SNS) big data analysis (포스트 코로나 뉴노멀에 대한 대중감성 연구: 소셜미디어(SNS) 빅데이터 분석을 통해)

  • Ann, Myung-suk
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.2
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    • pp.209-215
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    • 2022
  • In this study, detailed factors of public sentiment toward the 'post-corona new normal' were examined through social media big data sentiment analysis. Thus, it is to provide basic data to preemptively cope with the post-COVID-19 era. For data collection and analysis, the emotional analysis program of 'Textom', a big data analysis program, was used. The data collection period is one year from October 5, 2020 to October 5, 2021, and the collection channels are set as blogs, cafes, Twitter, and Facebook on Daum and Naver. The original data edited and refined a total of 3,770 collected texts from this channel were used for this study. The conclusion is as follows. First, there is a high level of interest and liking for the 'post-corona new normal'. In other words, it can be seen that optimism such as daily recovery, technological growth, and expectations for a new future took the lead at 77.62%. Second, negative emotions such as sadness and rejection are 22.38% of the total, but the intensity of emotions is 23.91%, which is higher than the ratio, suggesting that these negative emotions are intense. This study has a contribution to the detailed factor analysis of the public's positive and negative emotions through big data analysis on the 'post-corona new normal'.

Relationship between DNA mismatch repair and CRISPR/Cas9-mediated knock-in in the bovine β-casein gene locus

  • Kim, Seung-Yeon;Kim, Ga-Yeon;You, Hyeong-Ju;Kang, Man-Jong
    • Animal Bioscience
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    • v.35 no.1
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    • pp.126-137
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    • 2022
  • Objective: Efficient gene editing technology is critical for successful knock-in in domestic animals. RAD51 recombinase (RAD51) gene plays an important role in strand invasion during homologous recombination (HR) in mammals, and is regulated by checkpoint kinase 1 (CHK1) and CHK2 genes, which are upstream elements of RAD51 recombinase (RAD51). In addition, mismatch repair (MMR) system is inextricably linked to HR-related pathways and regulates HR via heteroduplex rejection. Thus, the aim of this study was to investigate whether clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9)-mediated knock-in efficiency of human lactoferrin (hLF) knock-in vector in the bovine β-casein gene locus can be increased by suppressing DNA MMR-related genes (MSH2, MSH3, MSH6, MLH1, and PMS2) and overexpressing DNA double-strand break (DSB) repair-related genes (RAD51, CHK1, CHK2). Methods: Bovine mammary epithelial (MAC-T) cells were transfected with a knock-in vector, RAD51, CHK1, or CHK2 overexpression vector and CRISPR/sgRNA expression vector to target the bovine β-casein gene locus, followed by treatment of the cells with CdCl2 for 24 hours. After 3 days of CdCl2 treatment, the knock-in efficiency was confirmed by polymerase chain reaction (PCR). The mRNA expression levels of DNA MMR-related and DNA DSB repair-related genes were assessed by quantitative real-time PCR (RT-qPCR). Results: Treatment with CdCl2 decreased the mRNA expression of RAD51 and MMRrelated genes but did not increase the knock-in efficiency in MAC-T cells. Also, the overexpression of DNA DSB repair-related genes in MAC-T cells did not significantly affect the mRNA expression of MMR-related genes and failed to increase the knock-in efficiency. Conclusion: Treatment with CdCl2 inhibited the mRNA levels of RAD51 and DNA MMR-related genes in MAC-T cells. However, the function of MMR pathway in relation to HR may differ in various cell types or species.

The Importance of Employee's Perceptions When Conducting a Company's CSR Strategy : The Concept of 'Authenticity' (조직의 CSR 전략 이행과정에서 직원 인식 중요성 : '진정성' 개념을 바탕으로)

  • Jung, Ji-Young;Kim, Sang-Joon
    • Korean small business review
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    • v.43 no.4
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    • pp.27-57
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    • 2021
  • How does authenticity influence the process that conducts a company's CSR Strategy? Authenticity, an internal/external alignment condition that an employee feels in relation to an organization, means the decision on how true and beneficial to employees through their experiences, such as thoughts and emotions. Also, it can be understood as a process of meaning formation between the organization's strategy to conduct CSR and the perception of employees conducting CSR. To prove the relation between authenticity and CSR clearly, we used various techniques like Text Mining, Topic Modeling and Semantic network analysis about O corporation's 657 review data, from 2015 to 2021. As a result of the analysis, we find out the special issues and types. The analysis shows that the issue concerning the 'external image' is the biggest characteristic of authenticity perception in other conditions. Furthermore, the types of authenticity perception evaluations are largely divided into acceptance and rejection, in detail, five categories. This study indicates that organizations should consider both external and internal conditions when establishing CSR strategies. In addition, it is necessary to be an interactive circular relationship between the organization and employee, collecting and reflecting employee's perceptions. Finally, this study proposes ways to overcome problems related to interaction.

European Experience in Implementing Innovative Educational Technologies in the Field of Culture and the Arts: Current Problems and Vectors of Development

  • Kdyrova, I.O.;Grynyshyna, M.O.;Yur, M.V.;Osadcha, O.A.;Varyvonchyk, A.
    • International Journal of Computer Science & Network Security
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    • v.22 no.5
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    • pp.39-48
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    • 2022
  • The main purpose of the work is to analyze modern innovative educational practices in the field of culture and art and their effectiveness in the context of the spread of digitalization trends. The study used general scientific theoretical methods of analysis, synthesis, analogy, comparative, induction, deduction, reductionism, and a number of others, allowing you to fully understand the pattern of modern modernization processes in a long historical development and demonstrate how the rejection of the negativity of progress allows talented artists to realize their own potential. The study established the advantages and disadvantages of involving innovative technologies in the educational process on the example of European experience and outlined possible ways of implementing digitalization processes in Ukrainian institutions of higher education, formulated the main difficulties encountered by teachers and students in the use of technological innovation in the pandemic. The rapid development of digital technologies has had a great impact on the sphere of culture and art, both visual, scenic, and musical in all processes: creation, reproduction, perception, learning, etc. In the field of art education, there is a synthesis of creative practices with digital technologies. In terms of music education, these processes at the present stage are provided with digital tools of specially developed software (music programs for composition and typing of musical text, recording, and correction of sound, for quality listening to the whole work or its fragments) for training programs used in institutional education and non-institutional learning as a means of independent mastering of the theory and practice of music-making, as well as other programs and technical tools without which contemporary art cannot be imagined. In modern stage education, the involvement of video technologies, means of remote communication, allowing realtime adjustment of the educational process, is actualized. In the sphere of fine arts, there is a transformation of communicative forms of interaction between the teacher and students, which in the conditions of the pandemic are of two-way communication with the help of information and communication technologies. At this stage, there is an intensification of transformation processes in the educational industry in the areas of culture and art.

Covalent Organic Framework Based Composite Separation Membrane: A Review (공유 유기 골격체 기반 복합 분리막 : 고찰)

  • Jeong Hwan Shim;Rajkumar Patel
    • Membrane Journal
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    • v.33 no.4
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    • pp.149-157
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    • 2023
  • Covalent organic frameworks (COFs) have shown promise in various applications, including molecular separation, dye separation, gas separation, filtration, and desalination. Integrating COFs into membranes enhances permeability, selectivity, and stability, improving separation processes. Combining COFs with single-walled carbon nanotubes (SWCNT) creates nanocomposite membranes with high permeability and stability, ideal for dye separation. Incorporating COFs into polyamide (PA) membranes improves permeability and selectivity through a synthetic interfacial strategy. Three-dimensional COF fillers in mixed-matrix membranes (MMMs) enhance CO2/CH4 separation, making them suitable for biogas upgrading. All-nanoporous composite (ANC) membranes, which combine COFs and metal-organic framework (MOF) membranes, overcome permeance-selectivity trade-offs, significantly improving gas permeance. Computational simulations using hypothetical COFs (hypoCOFs) demonstrate superior CO2 selectivity and working capacity relevant for CO2 separation and H2 purification. COFs integrated into thin-film composite (TFC) and polysulfonamide (PSA) membranes enhance rejection performance for organic contaminants, salt contaminants, and heavy metal ions, improving separation capabilities. TpPa-SO3H/PAN covalent organic framework membranes (COFMs) exhibited superior desalination performance compared to traditional polyamide membranes by utilizing charged groups to enable efficient desalination through electrostatic repulsion, suggesting their potential for ionic and molecular separations. These findings highlight COFs' potential in membrane technology for enhanced separation processes by improving permeability, selectivity, and stability. In this review, COF applied for the separation process is discussed.

Content-based Korean journal recommendation system using Sentence BERT (Sentence BERT를 이용한 내용 기반 국문 저널추천 시스템)

  • Yongwoo Kim;Daeyoung Kim;Hyunhee Seo;Young-Min Kim
    • Journal of Intelligence and Information Systems
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    • v.29 no.3
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    • pp.37-55
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    • 2023
  • With the development of electronic journals and the emergence of various interdisciplinary studies, the selection of journals for publication has become a new challenge for researchers. Even if a paper is of high quality, it may face rejection due to a mismatch between the paper's topic and the scope of the journal. While research on assisting researchers in journal selection has been actively conducted in English, the same cannot be said for Korean journals. In this study, we propose a system that recommends Korean journals for submission. Firstly, we utilize SBERT (Sentence BERT) to embed abstracts of previously published papers at the document level, compare the similarity between new documents and published papers, and recommend journals accordingly. Next, the order of recommended journals is determined by considering the similarity of abstracts, keywords, and title. Subsequently, journals that are similar to the top recommended journal from previous stage are added by using a dictionary of words constructed for each journal, thereby enhancing recommendation diversity. The recommendation system, built using this approach, achieved a Top-10 accuracy level of 76.6%, and the validity of the recommendation results was confirmed through user feedback. Furthermore, it was found that each step of the proposed framework contributes to improving recommendation accuracy. This study provides a new approach to recommending academic journals in the Korean language, which has not been actively studied before, and it has also practical implications as the proposed framework can be easily applied to services.

Changes of Kidney Injury Molecule-1 Expression and Renal Allograft Function in Protocol and for Cause Renal Allograft Biopsy (이식신 계획생검 및 재생검에서 Kidney Injury Molecule-1 표현과 이식신 기능 변화)

  • Kim, Yonhee;Lee, A-Lan;Kim, Myoung Soo;Joo, Dong Jin;Kim, Beom Seok;Huh, Kyu Ha;Kim, Soon Il;Kim, Yu Seun;Jeong, Hyeon Joo
    • Korean Journal of Transplantation
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    • v.28 no.3
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    • pp.135-143
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    • 2014
  • Background: Kidney injury molecule-1 (KIM-1) is known as a good ancillary marker of acute kidney injury (AKI) and its expression has also been observed in acute rejection and chronic graft dysfunction. We tested usefulness of KIM-1 as an indicator of acute and chronic renal graft injury by correlating KIM-1 expression with renal graft function and histology. Methods: A total of 133 zero-time biopsies and 42 follow-up biopsies obtained within 1 year posttransplantation were selected. Renal tubular KIM-1 staining was graded semiquantitatively from 0 to 3 and the extent of staining was expressed as the ratio of KIM-1 positive/CD10 positive proximal tubules using Image J program. Results: KIM-1 was positive in 39.8% of zero-time biopsies. KIM-1 positive cases were predominantly male and had received grafts from donors with older age, deceased donors, and poor renal function at the time of donation, compared with KIM-1 negative cases. KIM-1 expression showed correlation with delayed graft function and acute tubular necrosis. In comparison of KIM-1 expression between stable grafts (n=23) and grafts with dysfunction (n=19) at the time of repeated biopsy, the intensity/extent of KIM-1 staining and renal histology at zero-time did not differ significantly between the two groups. Histologically, KIM-1 expression was significantly increased with both acute and chronic changes of glomeruli, tubules and interstitium, peritubular capillaritis, and arteriolar hyalinosis. Conclusions: KIM-1 can be used as an ancillary marker of AKI and a nonspecific indicator of acute inflammation and tubulointerstitial fibrosis. However, KIM-1 expression at zero-time is not suitable for prediction of long-term graft dysfunction.

Persuasive Impact of Native Advertising for Social Issues: Focusing on Source of Native Advertising and Consumer Tendency for Ethical Consumption (기업의 사회적 메시지를 담은 네이티브 광고 효과 연구)

  • Yu, Eunah;Choi, Jieun
    • Journal of Service Research and Studies
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    • v.13 no.2
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    • pp.24-40
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    • 2023
  • As the aversion to advertising grows, native advertising has gained significant attention as a means to counteract this rejection. Native advertising is designed to seamlessly blend with other content on the page where they are displayed. They mimic the overall design and presentation of the platform, providing a natural exposure to consumers. Many companies utilize native advertising, but there is not much academic research on this topic. Therefore this study aims to examine the effectiveness of native advertising for social issues. The study looked at two types of native advertising: ads created by a company and ads sponsored by a company. Results suggested that consumers showed more positive attitudes towards a company's ads if they were sponsored by the company rather than created by the company. This study argued that this effect would be more pronounced for consumers who tended to buy ethically. To verify these hypotheses an online experiment was conducted revealing that on average consumers displayed the same attitude toward a company whether the native advertising was created or sponsored by a company. However, it was also discovered that consumers with a tendency for ethical consumerism formed more positive attitudes toward companies when the company sponsored native advertising as opposed to having created it. In practice, this study suggests how companies can improve the effectiveness of native advertising, such as implementing native advertising as a sponsor and being transparent about their advertising to appeal to consumers with high ethical consumption tendencies. This study expands the scope of research in areas related to native adverting and corporate social responsibilities.

The Political Recognition Surrounding Candlelight Rally and Taegeukgi Rally: A Big Data Analytics on Online News Comments (촛불 집회와 태극기 집회를 둘러싼 정국 인식: 온라인 뉴스 댓글에 대한 빅데이터 분석)

  • Kim, ChanWoo;Jung, Byungkee
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.8 no.6
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    • pp.875-885
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    • 2018
  • This study analyzed the major issues of the Candlelight Rally and Taegukgi Rally registered in news comments of the politics section of the portal site from October 24, 2016 to March 19, 2017. We examined the political recognition of the two rallies with the Named Entity Recognition. The main analytical items are the responsibility for impeachment, the subject and method of settlement, and other major issues. As a result of the analysis, the comments of the Candlelight Rally focused on the impeachment support and the legal penalties of the regime ministers, and insisted on resolving the political situation through the next election after impeachment. The comments of the Taegukgi Rally focused on the rejection of the impeachment to maintain the regime and insisted on rejecting the impeachment of the Constitutional Court. The conflicts between the group that supported Candlelight Rallis and the group that supported Taegukgi rallies are predicted to last at least for the time being (Park Geun-hye's trial period) after the presidential election. After the impeachment of the President and replacement of the regime this conflict will develop into the confrontation between the pursuit of liquidation and new politics and the attempt to influence the trial of Park Geun-hye. Therefore, the efforts to integrate society in the aftermath are necessary.

Understanding of Yon-Ko-Jeon Culture : The Phenomenon of Women's Alienation in Yon-Ko-Jeon (연고전 문화 읽기: 연고전과 여성 소외현상)

  • Bae, Jae-yoon;Won, Young-shin
    • 한국체육학회지인문사회과학편
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    • v.55 no.4
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    • pp.85-107
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    • 2016
  • By examining the constitutive characteristics of Yon-Ko-Jeon and analyzing the lived meanings and experiencing essence of students, this study details the students' awareness, responses, and strategies with regards to the phenomenon of women's alienation from Yon-Ko-Jeon. Students from the two colleges were divided into two groups- one which was aware of women's alienation from Yon-Ko-Jeon, and another group that was unaware of such a phenomenon. Students without awareness tended to perceive the alienation of women from Yon-Ko-Jeon as a natural phenomenon. On the other hand, the members who had awareness tended to see it as a phenomenon that was either justified, unequal, or in need of change. In the latter group, those who saw women's alienation as a justified phenomenon responded with tolerance and adopted a bystander strategy. Conversely, those who saw it as an unequal phenomenon responded with rejection and instead chose to adopt anti-/alternative Yon-Ko-Jeon strategies. The last group, which perceived women's alienation as a phenomenon in need of change, adopted correcting responses as well as intercollegiate solidarity and cooperation strategies. A generalization of the findings reveals that the students' experiencing essence of the phenomenon extends from critical thinking to awareness, response, and strategy in a step-by-step and sequential process. Through this study, it was found that the students' experiencing essence all follow a continuous thinking pattern, as illustrated in the diagram provided.