• 사상체질의학회지
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• 제22권4호
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• pp.65-76
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• 2010

1. Objectives The present study was designed to investigate the effect of Soyangin Hyeongbangdojeok-san(HBDJS) on acute cocaine-induced behavior effect and gene expression in the rat brain. 2. Methods Experimental animals were composed of saline(SAL), cocaine(COC), HBDJS + COC, HBDJS + SAL group. Rats received HBDJS(100, 200 mg/kg, p.o.) 1 h prior to cocaine hydrochloride(20 mg/kg, i.p.) treatment respectively. After cocaine injection, locomotor activity and rearing were measured in a rectangular container equipped with a video camera above the center of the floor for 60 min. In addiction, c-Fos expression in the rat brain was detected using immunohistochemistry 2 h after cocaine injection. And the effect of HBDJS on acute cocaine-induced pERK, pElk, pCREB upstream of c-Fos expression was detected using western blotting and immunohistochemistry 15 min after cocaine challenge. 3. Results The present results show that HBDJS at dose of 200 mg/kg attenuated cocaine-induced both locomotor activity and rearing. Also HBDJS at dose of 200 mg/kg significantly decreased c-Fos expression in the rat brain(nucleus accumebns and striatum). However HBDJS at dose of 200 mg/kg have no effect on cocaine-induced pERK, pCREB, pElK-1 expression. HBDJS is c-Fos expression through ERK-independent pathway. 4. Conclusions. These results suggest that HBDJS may be effective in suppressing the reinforcing effects of cocaine.

• 한국융합학회논문지
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• 제12권11호
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• pp.435-444
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• 2021

본 연구는 대학 및 대학원생을 대상으로 향유신념과 반추, 긍정정서의 관계를 확인함으로써, 긍정정서를 증진시킬 수 있는 방안을 실증적으로 제안하고자 하였다. 이를 위해 서울 소재 대학에 재학 중인 대학 및 대학원생 235명을 대상으로 향유신념, 반추, 긍정정서를 측정하는 질문지를 실시하였다. 구조방정식 모형분석을 실시한 결과, 대학 및 대학원생의 향유신념은 긍정정서에 긍정적인 영향을, 반추에는 부정적인 영향을 미쳤고, 반추는 긍정정서에 부정적인 영향을 끼쳤는데, 향유신념과 긍정정서의 정적 관계는 반추에 의해 부분 매개되는 것으로 나타났다. 본 연구의 결과는 긍정정서를 높이기 위한 향유하기 방략의 효과를 확인하는 동시에 그 기제를 밝혔다는 점에서 의의가 있다. 단순히 향유신념에 초점을 두는 것보다 긍정정서에 대한 반추의 영향력을 함께 고려할 때 더 효과적으로 긍정정서의 향상을 기대할 수 있을 것이다.

• Archives of Pharmacal Research
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• 제26권7호
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• pp.540-544
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• 2003

Morphine, an analgesic with significant abuse potential, is considered addictive because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. CPP is a useful method for the screening of morphine-induced psychological dependence. In the present study, we investigated the effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. Furthermore, we examined c-fos expression in the parietal cortex, piriform cortex, striatum, nucleus accumbens, and hippocampus of the morphine-induced CPP mouse brain. Treatment of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of c-fos was increased in the cortex, striatum, nucleus accumbens, and hippocampus of the morphine-induced CPP mouse brain. These increases of expression were inhibited by treatment with MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of c-fos expression in the mouse brain.

• 가정과삶의질연구
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• 제30권6호
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• pp.183-199
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• 2012

Since the Framework Act on Healthy Families came into effect in 2005, family policy has become a primary field of social policy, and 'family' has emerged as an important keyword for solving Korean society's various phenomena and problems. In order to seek practical plans for reforming social policy through family policy, this thesis has analyzed the transitional characteristics of Korean families in relation to where Korean families currently stand and the situation they are facing. This thesis has also reviewed the content of family policy in the master plan of healthy families, the starting point of the actual family policy, and other related policies. It also has analyzed the key content of child care support policy. From these various analyses and discussions, this thesis has emphasized "family care" as the keyword of family policy, family effect analysis as the means of reinforcing family perspective, and family integrity for policy effectiveness.

• Steel and Composite Structures
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• 제21권2호
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• pp.323-342
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• 2016

To study the effect of collar-plate reinforcement on the static strength of tubular T-joints under axial loading, fundamental research work is carried out from both experimental test and finite element (FE) simulation. Through experimental tests on 7 collar-plate reinforced and 7 corresponding un-reinforced tubular T-joints under axial loading, the reinforcing efficiency is investigated. Thereafter, the static strengths of the above 14 models are analyzed by using FE method, and it is found that the numerical results agree reasonably well with the experimental data to prove the accuracy of the presented FE model. Additionally, a parametric study is conducted to analyze the effect of some geometrical parameters, i.e., the brace-to-chord diameter ratio ${\beta}$, the chord diameter-to-chord wall thickness ratio $2{\gamma}$, collar-plate thickness to chord wall thickness ratio ${\tau}_c$, and collar-plate length to brace diameter ratio $l_c/d_1$, on the static strength of a tubular T-joint. The parametric study shows that the static strength can be greatly improved by increasing the collar-plate thickness to chord wall thickness ratio ${\tau}_c$ and the collar-plate length to brace diameter ratio $l_c/d_1$. Based on the numerical results, parametric equations are obtained from curving fitting technique to estimate the static strength of a tubular T-joint with collar-plate reinforcement under axial loading, and the accuracy of these equations is also evaluated from error analysis.

• 한국초전도ㆍ저온공학회논문지
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• 제5권3호
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• pp.15-19
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• 2003

For the purpose of standardization of the critical current measurement, it is meaningful to describe how $I_{c}$ will behave as the stress/strain level changes. In this study, strain dependencies of the critical current $I_{c}$ in Ag-alloy sheathed multifilamentary Bi(2212) and Bi(2223) superconducting tapes were evaluated at 77K, 0T. The external reinforcement was accomplished by soldering AgMgNi alloy tapes onto single or both sides of the sample. With the external reinforcement to the Bi(2212) tape, the strength of the tapes increased but the critical current at the strain free state, $I_{c0}$ decreased in some cases. The strain for onset of the $I_{c}$ degradation, $\varepsilon$$_{\irr}$, increased with an increase of the reinforcing volume and then saturated to a certain value. The effect of external reinforcement on the degradation of $I_{c}$ due to the bending strain in the Bi(2223) tape was also examined. Contrary to the expectation, it showed a significant $I_{c}$ degradation even at a small strain of 0.4 %. The observations of damage morphologies gave a good explanation to the $I_{c}$ behavior.c/ behavior.r.

• 조명전기설비학회논문지
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• 제23권1호
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• pp.36-40
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• 2009

콘크리트 전주는 배전선로 지지물로서 널리 사용되고 있다. 전주의 접지저항을 규정치 이내로 유지하기 위하여 동피복 접지봉을 포함한 여러 종류의 접지전극들이 사용되어 왔다. 전주 내부에는 철근이 들어있기 때문에 지중에 매설되는 전주 하단은 어느 정도 구조체접지극으로서 작용을 하게 된다. 본 논문에서는 전주 접지선으로 시험전류를 주입하면서 주입되는 전류와 금속 접지극으로 분류되는 전류를 각각 측정하였다. 이로써 전주 구조체로 분류되는 전류의 간접측정이 가능하였다. 측정결과에 근거하여 금속 접지극의 접지저항과 전주 구조체로 분류되는 전류크기 간의 상관관계를 분석하였다.

• 한국농공학회지
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• 제42권6호
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• pp.98-105
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• 2000

Recently, the construction method of high pressure jet-grouting is in wide-use, for the purpose of structure foundation ground, reinforcing of ground behind propped retaining walls and cut-off in order to perform safe construction of underground excavation work. This study was performed a serious of tests of field permeability and unconfined compressive strength upon ground improved established on the ground behind propped retaining walls and examined proper jet mechanism by changing the construction parameter value of high pressure jet-grouting. In addition, we got the conclusion like the followings as a result of inspecting the condition of earth pressure distribution and deformation, using elasto-plastic method and FEM. 1. In that characteristics of strength of ground improved, with the same condition of construction parameter, unconfined compressive strength of sand gravel is shown bigger than that of silty sand by about 1.6 times and cut-off effect is shown to have effect of reducing the permeability of original ground by about 10$^{-2}$ ~10$^{-3}$ cm/s. 2. As a result of analysis of figures of horizontal displacing quantity of propped retaining walls materials regarding before and after High pressure jet- grouting through FEM, the reducing quantity of 0.1~0.3mm in maximum horizontal displacement is shown.

• Earthquakes and Structures
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• 제9권4호
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• pp.699-718
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• 2015

The effect of reinforcing concrete members with high strength steel bars with yield strength up to 600 MPa on the overall seismic behavior of concrete moment frames was studied experimentally and numerically. Three geometrically identical plane frame models with two bays and two stories, where one frame model was reinforced with hot rolled bars (HRB) with a nominal yield strength of 335 MPa and the other two by high strength steel bars with a nominal yield strength of 600 MPa, were tested under simulated earthquake action considering different axial load ratios to investigate the hysteretic behavior, ductility, strength and stiffness degradation, energy dissipation and plastic deformation characteristics. Test results indicate that utilizing high strength reinforcement can improve the structural resilience, reduce residual deformation and achieve favorable distribution pattern of plastic hinges on beams and columns. The frame models reinforced with normal and high strength steel bars have comparable overall deformation capacity. Compared with the frame model subjected to a low axial load ratio, the ones under a higher axial load ratio exhibit more plump hysteretic loops. The proved reliable finite element analysis software DIANA was used for the numerical simulation of the tests. The analytical results agree well with the experimental results.

• Advances in concrete construction
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• 제10권4호
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• pp.319-332
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• 2020

The impacts of reinforcing concrete matrix with steel fibers, polypropylene fibers and recycled plastic fibers using different volume fractions of 0.15%, 0.5%, 1.5% and 2.5% on the compressive and tensile characteristics are experimentally investigated in the current research. Also, flexural behavior of plain concrete (PC) beams, shear performance of reinforced concrete (RC) beams and compressive characteristics of both PC and RC columns reinforced with recycled plastic fibers were studied. The experimental results showed that the steel fibers improved the splitting tensile strength of concrete higher than both the polypropylene fibers and recycled plastic fibers. The end-hooked steel fibers had a positive effect on the compressive strength of concrete while, the polypropylene fibers, the recycled plastic fibers and the rounded steel fibers had a negative impact. Compressive strength of end-hooked steel fiber specimen with volume fraction of 2.5% exhibited the highest value among all tested samples of 32.48 MPa, 21.83% higher than the control specimen. The ultimate load, stiffness, ductility and failure patterns of PC and RC beams in addition to PC and RC columns strengthened with recycled plastic fibers enhanced remarkably compared to non-strengthened elements. The maximum ultimate load and stiffness of RC column reinforced with recycled plastic fibers with 1.5% volume fraction improved by 21 and 15%, respectively compared to non-reinforced RC column.