• Journal of the Korean Geographical Society
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• v.41 no.6 s.117
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• pp.701-713
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• 2006

This study considers the case when a district with a high development possibility is set up as a regulation region. Initial assumption is that there would be regulation resistance in and around the regulation region. Pyeongchang is taken as a study areas, performing necessary analysis of environment regulation and regulation resistance based upon spatial analysis with the use of GIS. The research proceeding steps are as follows. After examining Pyeongchang present environment regulation state, environment regulation map is constructed, and classification of Pyeongchang's relatively development possibility level map is made. Using this regulation map and development possibility level map, relative regulation resistance level is measured. The results that the rates of Pyeongchang environment regulation region in its present state was higher than Namhan river basin's regulation region rates. Also, overlapping a high development possibility level region with an environment regulation region, the analysis results give reasons to expect high level of regulation resistance in Doam-myeon and Jinbu-myeon in small town units. The analysis of Pyeongchang new buildings locations with regard to environment regulation showed intensive distribution in the regulation region with high development possibility level and adjacent areas (about 66% of new buildings are distributed within 500m range from regulation region). Such results show that the local administration and existing environment regulation policy, not capable of offering direct benefit to the population, are having immanent problems in environment sustainable development and connected with it environment harm causation.

• Molecules and Cells
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• v.38 no.8
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• pp.705-714
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• 2015

We investigated the role of HDAC3 in anti-cancer drug-resistance. The expression of HDAC3 was decreased in cancer cell lines resistant to anti-cancer drugs such as celastrol and taxol. HDAC3 conferred sensitivity to these anti-cancer drugs. HDAC3 activity was necessary for conferring sensitivity to these anti-cancer drugs. The down-regulation of HDAC3 increased the expression of MDR1 and conferred resistance to anti-cancer drugs. The expression of tubulin ${\beta}3$ was increased in drug-resistant cancer cell lines. ChIP assays showed the binding of HDAC3 to the promoter sequences of tubulin ${\beta}3$ and HDAC6. HDAC6 showed an interaction with tubulin ${\beta}3$. HDAC3 had a negative regulatory role in the expression of tubulin ${\beta}3$ and HDAC6. The down-regulation of HDAC6 decreased the expression of MDR1 and tubulin ${\beta}3$, but did not affect HDAC3 expression. The down-regulation of HDAC6 conferred sensitivity to taxol. The down-regulation of tubulin ${\beta}3$ did not affect the expression of HDAC6 or MDR1. The down-regulation of tubulin ${\beta}3$ conferred sensitivity to anti-cancer drugs. Our results showed that tubulin ${\beta}3$ serves as a downstream target of HDAC3 and mediates resistance to microtubule-targeting drugs. Thus, the HDAC3-HDAC6-Tubulin ${\beta}$ axis can be employed for the development of anti-cancer drugs.

• Korean Journal of Exercise Nutrition
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• v.15 no.4
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• pp.153-161
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• 2011

The maintenance of skeletal muscle mass is very important for the prevention of life style-related diseases and the improvement of quality of life. It is well-known that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. It has been reported that many molecules are involved in the regulation of protein synthesis in response to resistance exercise and nutrition. Understanding the molecular mechanisms regulating muscle protein synthesis is crucial for the development of appropriate interventions. The role of intracellular signaling pathways through the mammalian target of rapamycin (mTOR), a serine/threonine protein kinase in the regulation of muscle protein synthesis, has been extensively investigated for these years. Control of protein synthesis by mTOR is mediated through phosphorylation of downstream targets that modulate translation initiation and elongation step. In contrast, upstream mediators regulating mTOR and protein synthesis in response to resistance exercise and amino acid still needed to be determined. In this brief review, we discuss the current progress of intracellular mechanisms for exercise- and amino acid-induced activation of mTOR pathways and protein synthesis in skeletal muscle.

• Journal of the Korea Institute of Building Construction
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• v.22 no.6
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• pp.673-680
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• 2022

Modular construction is recognized as a construction method with various advantages, such as shortening the construction duration, achieving quality control through factory production, ease of maintenance, and reduced construction costs due to reduced weight of materials. However, despite efforts by the modular industry and government to activate modular construction, it has rarely been established in the domestic market. Currently, there are technical limitations to the modular construction fire resisting technology applied to general buildings. The lack of access to modular construction fire resistance regulation is considered a major factor. In this study, the current status and problems with modular construction fire resistance regulation, a significant hindrance factor, were considered to activate modular construction. This study is intended to present a direction for institutional improvement in modular construction fire resistance and a direction for research and development.

• Proceedings of the KGS Conference
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• 2006.06a
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• pp.140-142
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• 2006

• Journal of the Korean Solar Energy Society
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• v.31 no.4
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• pp.80-86
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• 2011

Investigation of the effective soil thermal conductivity(k) is the first step in designing the ground loop heat exchanger(borehole) of a geothermal heat pump system. Another important factor is the borehole thermal resistance($R_b$). Thermal response tests offer a good method to determine the ground thermal properties for the total heat transport in the ground. This is done by supplying a constant heat power into a borehole heat exchanger. There are two methods to supply a constant heat power. One is to employ the electricity provided by Korea Electric Power Corporation(KEPCO). The other is to use electricity generated by a generator. In this study, the power supply regulation was found to reduce when the electricity generated by the generator was used. This is because the generator evaluated with the power supply characteristically reduces the power supply regulation between an overload and a complex using. But it sometimes occurs a power supply regulation in In-situ thermal response test. In this case getting of k,$R_b$ requires delay times and restored normal state. However, the effect of the delay times and restored normal state on the soil thermal conductivity and borehole thermal resistance is very small. Therefore it is possible to use a generally accepted delay times and restored normal state in the analysis. In this work, it is also shown that an acceptable range of ${\Delta}k$, ${\Delta}R_b$ for normal state and regulation state might be approximately 0.01-0.16W/m k, and -0.004-0.007m K/W, respectively. Thus, restored normal state of power supply regulation is valuable to recommend.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.58 no.4
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• pp.597-601
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• 2009

Green car such as a hybrid electrical vehicle and fuel cell vehicle is developed as a commercial target. UN/ECE/WP29 is developing GTR of HFCV and establishing the regulation and standard of electrical safety by ELSA. The regulation and standard about Electrical safety of vehicle are prescribed in ISO, UN/ECE, FMVSS, Japanese Attachment and so on, in case of insulation resistance is referred to keep more than 100/Vdc, 500/Vac. However, accurate method to measure insulation resistance agreeable to structure of vehicle does not exist now, it is actually that correctness of measurement drops according to the feature of battery and fuel cell stack. In this paper, the method to measure insulation resistance for protection against electrical shock by direct contact or indirect contact in Green Car will be indicated by making a comparison between the insulation measurement in standard of electrical safety and the experiment results for HEV and HFCV.

• Archives of Pharmacal Research
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• v.22 no.1
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• pp.1-8
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• 1999

Transforming growth factor-$\beta$ (TGF-$\beta$) is the prototypical multifunctional cytokine, participating in the regulation of vital cellular activities such as proliferation and differentiations as well as a number of basic physiological functions. The effects of TGF-$\beta$ are critically dependent on the expression and distribution of a family of TGF-$\beta$ receptors, the TGF-$\beta$ types I, II, and III. It is now known that a wide variety of human pathology can be caused by aberrant expression and function of these receptors. the coding sequence of the type II receptor (RII) appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. By virtue of its key role in the regulation of cell proliferation, TGF-$\beta$ RII should be considered as a tumor suppressor gene. High levels of mutation in the TGF-$\beta$ RII gene have been observed in a wide range of primarily epithelial malignancies, including colon and gastric cancer. It appears likely that mutation of the TGF-$\beta$ RII gene may be a very critical step in the pathway of carcinogenesis.

• Endocrinology and Metabolism
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• v.31 no.1
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• pp.1-6
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• 2016

Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need for the development of novel pharmacological interventions that can target excessive fat accumulation and decreased muscle mass and/or strength. Adipokines, bioactive molecules derived from adipose tissue, are involved in the regulation of appetite and satiety, inflammation, energy expenditure, insulin resistance and secretion, glucose and lipid metabolism, and atherosclerosis. Recently, there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Novel discoveries and research into these organokines (adipokines, myokines, and hepatokines) may lead to the development of promising biomarkers and therapeutics for cardiometabolic disease. In this review, I summarize recent data on these organokines and focus on the role of adipokines, myokines, and hepatokines in the regulation of insulin resistance, inflammation, and atherosclerosis.

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.297-298
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• 2009