• The Korean Journal of Pharmacology
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• v.32 no.2
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• pp.159-168
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• 1996

To determine the regulatory mechanism of phenylethanolamine N-methyltransferase (PNMT) in the adrenal gland and in central nervous system, we observed the change of enzyme activity and mRNA level of PNMT in the adrenal gland, the brain stem, and hypothalamus of rats, which were injected with two neuroleptic agents(reserpine and haloperidol ). Reserpine depleting catecholamines in presynaptic vesicle increased PNMT activities in the adrenal gland and the brain stem to 150% of the control in time-dependent manner, but not in the hypothalamus. Haloperidol blocking dopamine receptor decreased PNMT activities in the adrenal gland and the hypothalamus, but not in the brain stem. Thus, the results indicate that catecholamines inhibit synthesis of epinephrine in the brain stem and the adrenal gland, and that dopamine stimulates synthesis of epinephrine in the hypothalamus and the adrenal gland. In addition, since the change of mRNA levels were nearly in accordance with the change of activities, the transcriptional regulation of PNMT is considered the mechanism of the regulation of epinephrine neuron.

• Environmental and Resource Economics Review
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• v.11 no.3
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• pp.345-375
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• 2002

The purpose of this paper is to measure the change of the production efficiency which may happen when environmental regulation incurs technological constraint in the process of production, and to compute the opportunity cost of pollution reduction with the lost products based on the change of efficiency. The patterns of production technoloy in the paper are divided into the technologies of strong disposability and weak disposabilty to grasp the effect of the technological constraint due to the environmental regulation. The endowment of the technolgical constraints in the process of production is considered to bring the greatest restriction on firm's production. When the environmental efficiencies of Korean regional manufactures were measured with linear programming model, the lost products related with the constraint of production technology that environmental regulation incurred, was average 148.1 billion dollar per year(5.87% of one year overall products) for total manufactures in 1991~1998. The ratio of the lost products for total products was spread from 0.78% to 1l.08%. The average lost products of 15 regions were changed from 4.66% to 18.35% of total products. Generally the environmental efficiency index of regional manufactures being decreased continuously since 1991, it is estimated that the environmental performance of Korean manufactures has been more and more deteriorating.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.203-203
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• 2016

The linkage between climate change and water security, i.e., the response of water resource to the future climate change, have been of great concern to both scientific community and policy makers. In this study, the impact of future climate on water resources in Yellow River Basin in North of China has been investigated using the Coupled Land surface and Hydrology Model System (CLHMS) and IPCC AR5 projected future climate change in the basin. Firstly, the performances of 14 IPCC AR5 models in reproducing the observed precipitation and temperature in China, especially in North of China, have been evaluated, and it's suggested most climate models do show systematic bias compared with the observation, however, CNRM-CM5、HadCM5 and IPSL-CM5 model are generally the best models among those 14 models. Taking the daily projection results from the CNRM-CM5, along with the bias-correction technique, the response of water resources in Yellow river basin to the future climate change in different emission scenarios have been investigated. All the simulation results indicate a reduction in water resources. The current situation of water shortage since 1980s will keep continue, the water resources reduction varies between 28 and 23% for RCP 2.6 and 4.5 scenarios. RCP 8.5 scenario simulation shows a decrease of water resources in the early and mid 21th century, but after 2080, with the increase of rainfall, the extreme flood events tends to increase.

• Journal of Korean Society of Transportation
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• v.12 no.4
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• pp.99-118
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• 1994

This study is designed to evaluate the effectiveness of TDM as a peak-period trip reduction strategy. This effort uses as a case study, the implementation of Regulation XV (REGXV) in Southern California, the most ambitious and far reaching employer-based ridesharing program implemented to date. This study explores the program effectiveness in terms of three aspects ; employee travel behavior changes after implementating Regulation XV, TDM programs offered by employers subjects to Regulation XV, and causal relationship between employee travel behavior changes and employer-based TDM programs. The study finds that Regualtion XV has a small, but statistically significant positive impact on AVR change. Popular incentives used by employers are less costly and easy to implement rather than to be effective. The increase in AVR is associated with increases of carpools promoted by strong incentives such as monetary subsides. A large number of indirect incentive programs are not effective. The study concludes that employers need to invest heavily on strong incentives, rather than on proposing diverse incentives, to comply with REGXV.

• BMB Reports
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• v.46 no.6
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• pp.289-294
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• 2013

To maintain cellular homeostasis against the demands of the extracellular environment, a precise regulation of kinases and phosphatases is essential. In cell cycle regulation mechanisms, activation of the cyclin-dependent kinase (CDK1) and cyclin B complex (CDK1:cyclin B) causes a remarkable change in protein phosphorylation. Activation of CDK1:cyclin B is regulated by two auto-amplification loops-CDK1:cyclin B activates Cdc25, its own activating phosphatase, and inhibits Wee1, its own inhibiting kinase. Recent biological evidence has revealed that the inhibition of its counteracting phosphatase activity also occurs, and it is parallel to CDK1:cyclin B activation during mitosis. Phosphatase regulation of mitotic kinases and their substrates is essential to ensure that the progression of the cell cycle is ordered. Outlining how the mutual control of kinases and phosphatases governs the localization and timing of cell division will give us a new understanding about cell cycle regulation.

• Journal of the Korea Institute of Building Construction
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• v.8 no.4
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• pp.87-93
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• 2008

With an increased use of alternative aggregate due to exhaustion of quality aggregate resources, the amount of used crushed aggregates have been increased and as a result, development of admixture materials has also been improved and its amount of use is increasing from day to day in order to secure quality in concrete. Accordingly, the purpose of this study is to make concrete of good quality by using chemical admixture developed in this study by replacement rate of fine aggregate. At first, susceptibility, compressive strength ratio and length change ratio in both fresh and hardened concrete were evaluated according to corresponding regulation. As for high performance related regulation, APC NO.3 and PC series were going to rule, and as for AE agent regulation, replacement ratio of fine aggregate of high performance chemical admixture was 10:0 and other chemical admixture met quality regulation for AE agent.

• Journal of Korean Physical Therapy Science
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• v.28 no.3
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• pp.1-10
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• 2021

Background: The purpose of this study is to investigate the effect of the online team project based learning on problem-solving, cooperative self-efficacy, and cooperative self-regulation of college students. Design: Single group pre-post design. Methods: The online team project based learning was conducted for a total of 92 college students for 8 weeks. A survey was conducted on problem-solving ability, cooperative self-efficacy, and cooperative self-regulation. In the online team project-based class, two projects were performed. It consists of video lectures and real-time video conferencing. Through the real-time video conference, the project was carried out based on discussion among learners and feedback was provided. Results: There was a significant difference in the change in problem-solving ability compared to before learning (p<0.05). As a result of the evaluation of cooperative self-efficacy, there was a significant difference (p<0.05). There was a significant differences in cooperative self-regulation compared to before learning (p<0.05). Conclusion: The online team project-based learning are effective in improving learners' problem-solving ability, cooperative self-efficacy, and cooperative self-regulation.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.3
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• pp.181-186
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• 2012

Fenofibrate is a selective peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) activator and is prescribed to treat hyperlipidemia. The mechanism through which $PPAR{\alpha}$ agonists reduce food intake, body weight, and adiposity remains unclear. One explanation for the reduction of food intake is that fenofibrate promotes fatty acid oxidation and increases the production of ketone bodies upon a standard experimental dose of the drug (100~300 mg/kg/day). We observed that low-dose treatment of fenofibrate (30 mg/kg/day), which does not cause significant changes in ketone body synthesis, reduced food intake in Long-Evans Tokushima (LETO) rats. LETO rats are the physiologically normal controls for Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are obese and cholecystokinin (CCK)-A receptor deficient. We hypothesized that the reduced food intake by fenofibrate-treated LETO rats may be associated with CCK production. To investigate the anorexic effects of fenofibrate in vivo and to determine whether CCK production may be involved, we examined the amount of food intake and CCK production. Fenofibrate-treated OLETF rats did not significantly change their food intake while LETO rats decreased their food intake. Treatment of fenofibrate increased CCK synthesis in the duodenal epithelial cells of both LETO and OLETF rats. The absence of a change in the food intake of OLETF rats, despite the increase in CCK production, may be explained by the absence of CCK-A receptors. Contrary to the OLETF rats, LETO rats, which have normal CCK receptors, presented a decrease in food intake and an increase in CCK production. These results suggest that reduced food intake by fenofibrate treatment may be associated with CCK production.

• Journal of Climate Change Research
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• v.5 no.4
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• pp.331-338
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• 2014

The continued efforts to reduce GHG emission by international cooperation and each country are in progress. As part of these efforts, Korea's ETS is enforced in 2015. This was the time to make strategies for each company to respond Korea's ETS. This study was performed to suggest a draft of basic strategies for electronic component industry in current Korea's ETS stage are as follows; - Analyzing the nature of electronic component industry - Identifying needs for corresponding ETS of electronic component industry - Analyzing basic countermeasures for each stage of ETS - Suggesting drafts of basic strategies for electronic component industry in current Korea's ETS stage The result of this study, the current stage of Korea's ETS is moving from implementation of the scheme become determined and prepare the minimum corresponding to direct corresponding to the regulation and market change. Electronic component industry has many GHG emission growth(or change) factor, and it will be make electronic component industry as a buyer when Korea's ETS is enforced. Korea's ETS will be clearly act as a regulation rather than new business for electronic component industry. Therefore, identifying the Korea's ETS as a regulation is resonable strategy for corresponding the scheme. The basic strategies of electronic component industry th responding Korea's ETS are as follows; - Building internal organization and decision-making system before enforcement the Korea's ETS - Establishing internal basic corresponding strategies according to carbon price forecast scenarios - Considering the energy consumption and GHG emissions in design phase and preparing the global ETS market in mid or long term.

• Environmental Analysis Health and Toxicology
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• v.23 no.1
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• pp.53-62
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• 2008

In the present study, the concentration levels of polychlorinated biphenyls (or PCBs) in the environments in Korea are estimated based on some measured data in Korea, in comparison with the data from the other countries. Even though PCBs were banned as electrical fluids in 1970s in Korea, PCBs are still detected in the environment. PCBs levels in Korea are greatly lower than those in other countries, which are gradually decreased as well. However, the measured data are not sufficient in both numbers and quality, to estimate the average PCBs levels in Korea. The regulation limit on polychlorinated biphenyls (or PCBs) is 2mg/kg (ppm), which is too low compared to 50 ppm of many other countries including U.S. With this strict regulation, there are many problems expected, for example, in the analysis of PCBs in the transformers using in the field as well as the safe treatment of PCBs. The risk assessment on the PCBs in the environment is surely necessary prior to the change in the limit. Also the PCBs concentration monitoring in the environmental media (i.e. air, water, soil and sediment) and exposure assessment will be essential for the accurate risk assessment. If the PCB-waste guideline maintain as 2 ppm after 10 years, the excess cancer risk of PCBs exposure by ambient air, drinking water and soil was $10^{-8}$. But if the guideline mitigate as 50 ppm after 10 years, the cancer risk was increased by $10^{-7}$. The ecological risk quotient by regulation change was not exceed '1'.