• The korean journal of orthodontics
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• v.50 no.6
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• pp.391-400
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• 2020

Objective: Increased gingival elasticity has been implicated as the cause of relapse following orthodontic rotational tooth movement and approaches to reduce relapse are limited. This study aimed to investigate the effects of sulforaphane (SFN), an inhibitor of osteoclastogenesis, on gene expression in gingival fibroblasts and relapse after rotational tooth movement in beagle dogs. Methods: The lower lateral incisors of five beagle dogs were rotated. SFN or dimethylsulfoxide (DMSO) were injected into the supra-alveolar gingiva of the experimental and control group, respectively, and the effect of SFN on relapse tendency was evaluated. Changes in mRNA expression of extracellular matrix components associated with gingival elasticity in beagles were investigated by real-time polymerase chain reaction. Morphology and arrangement of collagen fibers were observed on Masson's trichrome staining of buccal gingival tissues of experimental and control teeth. Results: SFN reduced the amount and percentage of relapse of orthodontic rotation. It also decreased the gene expression of lysyl oxidase and increased the gene expression of matrix metalloproteinase (MMP) 1 and MMP 12, compared with DMSO control subjects. Histologically, collagen fiber bundles were arranged irregularly and were not well connected in the SFN-treated group, whereas the fibers extended in parallel and perpendicular directions toward the gingiva and alveolar bone in a more regular and well-ordered arrangement in the DMSO-treated group. Conclusions: Our findings demonstrated that SFN treatment may be a promising pharmacologic approach to prevent orthodontic rotational relapse caused by increased gingival elasticity of rotated teeth in beagle dogs.

• Restorative Dentistry and Endodontics
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• v.9 no.1
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• pp.101-106
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• 1983

It was the purpose of this study to investigate the fracture mode of dental amalgam by observing the crack propagation, and to relate this to the microstructure of the amalgam. Caulk 20th Century Regular, Caulk Spherical, Dispersalloy, and Tytin amalgam alloys were used for this study. After each amalgam alloy and Hg measured exactly by the balance was triturated by the mechanical amalgamator (Capmaster, S.S. White), the triturated mass was inserted into the cylindrical metal mold which was 4 mm in diameter and 12 mm in height and was pressed by the Instron Universal Testing Machine at the speed of 1mm/min with 120Kg. The specimen removed from the mold was stored in the room temperature for a week. This specimen was polished with the emery papers from #100 to #200 and finally on the polishing cloth with 0.06${\mu}Al_2O_3$ powder suspended in water. The specimen was placed on the Instron testing machine in the method similar to the diametral tensile test and loaded at the crosshead speed of 0.05mm/min. The load was stopped short of fracture. The cracks on the polished surface of specimen was examined with scanning electron microscope (JSM-35) and analyzed by EPMA (Electron probe microanalyzer). The following results were obtained. 1. In low copper lathe-cut amalgam, the crack went through the voids and ${\gamma}_2$ phase, through the ${\gamma}_1$ phase around the ${\gamma}$ particles. 2. In low copper spherical amalgam, it was observed that the crack passed through the ${\gamma}_2$ and ${\gamma}_1$ phase, and through the boundary between the ${\gamma}_1$ and ${\gamma}$ phase. 3. In high copper dispersant (Dispersalloy) amalgam, the crack was found to propagate at the interface between the ${\gamma}_1$ matrix and reaction ring around the dispersant (Ag-Cu) particles, and to pass through the Ag-Sn particles. 4. In high copper single composition (Tytin) amalgam, the crack went through the ${\gamma}_1$ matrix between ${\eta}$ crystals, and through the unreacted alloy particle (core).

• The KIPS Transactions:PartA
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• v.9A no.3
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• pp.271-280
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• 2002

In this paper, the input-output interconnection method of the multiple-valued signal processing circuit using Perfect Shuffle technique and Kronecker product is discussed. Using this method, the circuit design method of the multiple-valued Reed-Muller Expansions (MRME) which can process the multiple-valued signal easily on finite fields GF$(p^m)$ is presented. The proposed input-output interconnection methods show that the matrix transform is an efficient and the structures are modular. The circuits of multiple-valued signal processing of MRME on GF$(p^m)$ design the basic cells to implement the transform and inverse transform matrix of MRME by using two basic gates on GF(3) and interconnect these cells by the input-output interconnection technique of the multiple-valued signal processing circuits. The proposed multiple-valued signal processing circuits that are simple and regular for wire routing and possess the properties of concurrency and modularity are suitable for VLSI.

• Journal of Mechanical Science and Technology
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• v.19 no.5
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• pp.1072-1079
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• 2005

Conceptual design is the first step in the overall process of product design. Its intrinsic uncertainty, imprecision, and lack of information lead to the fact that current conceptual design activities in engineering have not been computerized and very few CAD systems are available to support conceptual design. In most of the current intelligent design systems, approach of principle synthesis, such as morphology matrix, bond graphic, or design catalogues, is usually adopted to deal with the concept generation, in which optional concepts are generally combined and enumerated through function analysis. However, as a large number of concepts are generated, it is difficult to evaluate and optimize these design candidates using regular algorithm. It is necessary to develop a new approach or a tool to solve the concept generation. Generally speaking, concept generation is a problem of concept synthesis. In substance, this process of developing design candidate is a combinatorial optimization process, viz., the process of concept generation can be regarded as a solution for a state-place composed of multi-concepts. In this paper, genetic algorithm is utilized as a feasible tool to solve the problem of combinatorial optimization in concept generation, in which the encoding method of morphology matrix based on function analysis is applied, and a sequence of optimal concepts are generated through the search and iterative process which is controlled by genetic operators, including selection, crossover, mutation, and reproduction in GA. Several crucial problems on GA are discussed in this paper, such as the calculation of fitness value and the criteria for heredity termination, which have a heavy effect on selection of better concepts. The feasibility and intellectualization of the proposed approach are demonstrated with an engineering case. In this work concept generation is implemented using GA, which can facilitate not only generating several better concepts, but also selecting the best concept. Thus optimal concepts can be conveniently developed and design efficiency can be greatly improved.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.9
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• pp.34-40
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• 2005

In present study, a two dimensional unsteady Navier-Stokes solver has been developed using the Diagonalized ADI (DADI) method and implicit dual time stepping method. The jacobian matrices in steady state Navier-Stokes equations are introduced from inviscid flux terms. The implicit treatment of artificial dissipation terms results in a block penta-diagonal matrix system and it becomes a scalar penta-diagonal matrix by diagonalization. In steady state equations about fictitious time, a new residual including a real time derivative term is introduced. From a converged solution about fictitious time, a real time unsteady solution can be obtained, which is called 'implicit dual time stepping method'. For code validation, an oscillating flat plate, a regular Karman vortices past a circular cylinder and shock buffeting around a bicircular airfoil problems are numerically solved. And they are compared with a theoretical solution, experiments and other researcher's computations.

• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.179-189
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• 2000

Clebopride malate(Cm) is a new benzamide drug which has a potent central antidopaminergic activity possessing antiemetic and anxiolytic properties. A purpose of this study was to assess the feasibility of formulating sustained release preparation by dispersing a drug in hydrophilic polymeric matrices and double layered tablets(DLT), using HPMC, carbopol, PEO, PVP/VA and other polymers as a rate controlling barrier. The matrix and DLT showed optimum dissolution pattern up to 8 hours and the contents of polymer were optimized at 30% level in this preparation. After an oral administration in beagle dog, Cm concentration was determined by use of GC-ECD and pharmacokinetic parameters were calculated by Vallner's method. The AUC of DLT showed similar results and the duration of action was increased 55% compared to that of regular release dosage form. The calculated absorption rate effectiveness(ARE) and controlled release effectiveness(CRE) for DLT increased 50% compared to that of matrix, the overall effectiveness(E) of this product appears to be about 70%. in vivo effectiveness test, DLT showed significant differences from control on antiemetic action of Cm. In consequence, it was possible to conclude that double layered tablet might be a good candidate for the sustained release dosage forms.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.26 no.2
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• pp.33-44
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• 1996

This study was for comparing healing patterns and effects between with odontogenic and nonodontogenic tissues on the defected mandible. Experimental bone defects that measured 3 mm in diameter were created on the mandibular body of guinea pig by removal of bone with the use of trephine burs and bone defects were grafted with Biogran(Orthovita Co., U.S.A.) and covered with Dura Mata(Pfrimmer-Viggo GmbH Co., Germany). Guinea pigs were serially terminated by fours on the 3 days, the 1 week, the 2 weeks, the 3 weeks, the 4 weeks, and the 5 weeks after experiment, and the mandibular body was removed and fixed with 10％ neutral formalin. They were decalcified and embedded in paraffin as using the usual methods. The specimen sectioned and stained with hematoxylin and eosin and toluidine blue. They were observed with a light microscope and a polarizing microscope. The obtained results were as follows : 1. Defected bone was healed fast from the odontogenic tissues in early stage of the experiment. 2. The arrangement of the bone matrix was relatively regular in the bone from the nonodontogenic tissues, but irregular in the bone from the odontogenic tissues. 3. Compact bone has started to be resorbed and changed to the pattern of matrix bone tissue from 3 weeks after experiment.

• Journal of the East Asian Society of Dietary Life
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• v.20 no.5
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• pp.823-835
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• 2010

The research aimed to measure the efficiency of using multi stores in a foodservice company using by DEA (data envelopment analysis) which is a new management science technique. The study also attempted to identify relevant variables affecting DEA efficiency in order to suggest methods for improving efficiency. The data were collected from 148 contract foodservice operations, which were operated in similar fashion in October 2009. The DEA efficiency was calculated as an output-oriented BCC Model. Sales, and CSI (customer satisfaction index) were used as output variables whereas food cost, labor cost, and management expense were used as input variables to calculate the DEA efficiency. Operation process variables of the unit consisted of the were consist of ratio of regular employee, ratio of housekeeper, meal counts, meal price, food cost per meal, contract period, number of menu items, forecasting accuracy, order accuracy, inventory turnover, use of processed food, deviation of food cost, number of new menus, and number of events. According to the BCC score and profitability, units were classified into four groups: High efficiency-high profitability (HEHP), High efficiency-low profitability (HELP), Low efficiency-high profitability (LEHP), and Low efficiency-low profitability (LELP). The HEHP group contained 54 units, which mostly contracted management fee type and had a high meal price. The units were also very large and, served three meals. Twenty of the units were operated with high labor cost: most of these were factories and hospitals. The LEHP group contained 20 units, that were mainly office stores of large scale and medium price. Fifty-four LELP group had a low meal price. A high performance group must have high efficiency, profitability, and satisfaction. The BCC score was over 0.969, the meal price was over 4,116 won, the food cost was over 2,077 won, and meal counts per month were over 10,212 meals.

• Steel and Composite Structures
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• v.52 no.3
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• pp.343-356
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• 2024

This paper presents an analytical solution for correctly predicting the Lateral-Torsional Buckling critical moment of simply supported castellated beams, the solution covers uniformly distributed loads combined with compressive loads. For this purpose, the castellated beam section with hexagonal-type perforation is treated as an arrangement of double "T" sections, composed of an upper T section and a lower T section. The castellated beam with regular openings is considered as a periodic repeating structure of unit cells. According to the kinematic model, the energy principle is applied in the context of geometric nonlinearity and the linear elastic behavior of materials. The differential equilibrium equations are established using Galerkin's method and the tangential stiffness matrix is calculated to determine the critical lateral torsional buckling loads. A Finite Element simulation using ABAQUS software is performed to verify the accuracy of the suggested analytical solution, each castellated beam is modelled with appropriate sizes meshes by thin shell elements S8R, the chosen element has 8 nodes and six degrees of freedom per node, including five integration points through the thickness, the Lanczos eigen-solver of ABAQUS was used to conduct elastic buckling analysis. It has been demonstrated that the proposed analytical solution results are in good agreement with those of the finite element method. A parametric study involving geometric and mechanical parameters is carried out, the intensity of the compressive load is also included. In comparison with the linear solution, it has been found that the linear stability underestimates the lateral buckling resistance. It has been confirmed that when high axial loads are applied, an impressive reduction in critical loads has been observed. It can be concluded that the obtained analytical solution is efficient and simple, and offers a rapid and direct method for estimating the lateral torsional buckling critical moment of simply supported castellated beams.

• Computers and Concrete
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• v.12 no.3
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• pp.337-349
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• 2013

Traditional concrete is effectively an insulator in the dry state. However, conductive concrete can attain relatively high conductivity by adding a certain amount of electronically conductive components in the regular concrete matrix. The main purpose of this study is to investigate the electrical and thermal properties of conductive concrete with various graphite contents, specimen dimensions and applied voltages. For this purpose, six different mixtures (the control mixtures and five conductive mixtures with steel fibers of 2% by weight of coarse aggregate and graphite as fine aggregate replacement at the levels of 0%, 5%, 10%, 15% and 20% by weight) were prepared and concrete blocks with two types of dimensions were fabricated. Four test voltage levels, 48 V, 60 V, 110 V, and 220 V, were applied for the electrical and thermal tests. Test results show that the compressive strength of specimens decreases as the amount of graphite increases in concrete. The rising applied voltage decreases electrical resistivity and increases heat of concrete. Meanwhile, higher electrical current and temperature have been obtained in small size specimens than the comparable large size specimens. From the results, it can be concluded that the graphite contents, applied voltage levels, and the specimen dimensions play important roles in electrical and thermal properties of concrete. In addition, the superior electrical and thermal properties have been obtained in the mixture adding 2% steel fibers and 10% graphite.