• Archives of Pharmacal Research
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• v.1 no.1
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• pp.41-54
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• 1978

Aspirin is one of the oldest synthetic drugs and remains the most widely used medical agent. It is a household remedy effective in treating such common ailments as headache, minor muscular pain and fever. Aspirin is the drug choice for rheumatic fever and arthritis which some five million Americans suffer. Lately it has been established by double-blind and randomized clinical studies that regular aspirin intake reduces the incidence of mild strokes and heart attackes.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.38-38
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• 2003

The electrical properties of neurons are produced by the coordinated activity of ion channels (Hille, 1992). $K^{+}$ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance $Ca^{2+}$-activated $K^{+}$ (S $K_{Ca}$ ) channels are involved in modulating the slow component of afterhyperpolarization (AHP) (Kohler et al., 1996). Here we examine whether rat type 2 S $K_{Ca}$ (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intraburst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15, Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic S $K_{Ca}$ channels play an important role in regulating the filing pattern and the shape of the action potential.ntial.

• Journal of the Korean Institute of Educational Facilities
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• v.17 no.2
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• pp.3-12
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• 2010

The purpose of this study was to provide the planning guideline for the multi-purposed classroom in the elementary school and middle school using questionnaire and user participation method. As the user participation method, the design workshop in the study contains participation techniques, community action planning, and participation game. The design workshop used the design kit as a communication tool. Four user groups, selected from teachers and child in the elementary school and middle school, to be reconstructed, participated in a design workshop with design kit, and each group produced their own plans. The result of this study is as follows; (1) Teachers wanted multi-purposed classroom to be used by two classes. (2) The size of the multi-purposed classroom was preferred 1.5 times(30 py.) of the regular classroom. (3) By considering the characteristics of students it was required the open space in elementary, but required it to be separated from the regular classroom in middle school. (4) Through the analysis, we could grasp the processes that the users' needs were practically applied to design. Our design workshop method should be hereafter modified and advanced, but showed the usefulness in many aspects.

• Clinical and Experimental Reproductive Medicine
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• v.25 no.1
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• pp.93-102
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• 1998

Normal and abnormal follicular growth and steroidogenesis depend on gonadotropins as well as intraovarian peptides, which may mediate or potentiate gonadotropin action. Inhibin also affect follicular development and steroidogenesis and may play a role in dominant follicle selection and follicular atresia. Therefore, we studied the differences of serum inhibin, gonadotropin and androgen levels in the women with only the ultrasound findings and no disorder, and polycystic ovary (PCO) with ovulatory disturbance. We prospectively analysed forty-three women with PCO. The diagnosis of PCO was based on typical appearance of the ovaries on TVS. Twelve women with regular menstrual cycle and normal ovarian morphology were selected as control. Basal levels of inhibin, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol $(E_2)$, testosterone (T), androstenedione (ADD), dehydroepiandrosterone-sulfate (DS), prolactin and TSH in serum were determined. There were significant differences in basal LH levels and LH/FSH ratio between the control and the women with PCO. The basal levels of inhibin and $E_2$ in the oligo-amenorrheic PCO (N=34) were significantly higher than those in the control. There was higher negative correlation between the inhibin and T levels in the oligo-amenorrheic PCO, but, not in the regular cycling PCO. Also, there was higher positive correlation between the LH and T levels in the oligo-amenorrheic PCO, but not in the regular cycling PCO. These data presume that the initial event of PCO is elevated pituitary LH secretion. Elevated levels of LH may down-regulate LH receptors on granulosa cells and also cause hypertrophy of the thecal layer. High level of androgen secreted by the hypertrophied thecal layer may stimulate inhibin secretion from granulosa cells and can be converted to estrogen by extraovarian tissues and could serve to augment pituitary sensitivity to GnRH with a resultant secretion of more LH than FSH. Inhibin may inhibit FSH action on granulosa cell in the PCO follicle, impairing follicular development and dominant follicle selection resulted in ovulatory disturbance.

• International Journal of Vascular Biomedical Engineering
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• v.3 no.1
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• pp.23-29
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• 2005

We developed a three dimensional cardiac tissue model based on human cardiac cell and mono-domain approximation for action potential propagation. The human myocyte model proposed by ten Tusscher et al. (TNNP model) (2004) for cell electrophysiology and a mono-domain method for electric wave propagation are used to simulate the cardiac tissue propagation mechanism using a finite element method. To delineate non-homogeneity across cardiac tissue layer, we used three types of cardiac cell models. Ansiotropic effect of action potential propagation is also considered in this study. In this 3D anisotropic cardiac tissue with three cell layers, we generated a reentrant wave using S1-S2 protocol. Computational results showed that the reentrant wave was affected by the anisotropic properties of the cells. To test the reentrant wave under pathological state, we simulated a hypertopic model with non-excitable fibroblasts in stochastic manner. Compared with normal tissue, the hypertropic tissue result showed another center of reentrant wave, indicating that the wave pattern can be more easily changed from regular with a concentric focus to irregular multi-focused reentrant waves in case of patients with hypertrophy.

• Journal of Korean Academy of Nursing
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• v.34 no.5
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• pp.791-800
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• 2004

Purpose: This study was to investigate the characteristics and related factors of breast cancer screening and repeat screening, and to propose nursing interventions to increase the rate of breast cancer screening and repeat screening. Method: Study subjects was 236 women residing in the community, teachers and nurses who were older than 45 were recruited. Data was collected with self administered questionnaires from July 1st to August 31st, 2003 and analysed using SPSS/WIN 10.0 with $X^2$test, t-test, and stepwise multiple logistic regression at a significant level of =.05. Result: The breast cancer screening rate was 57.2%, and repeat screening rate was 15.3%. With the multiple logistic regression analysis, factors associated with mammography screening were age and perceived barriers of action, and factors related to the repeat mammography screening were education level and other cancer screening experience. Conclusion: Based on the results, we recommend the development of anintervention program to decrease the perceived barrier of action, to regard mammography as an essential test in regular check-up, and to give active advertisement and education to the public to improve the rates of breast cancer screening and repeat screening.

• Journal of Korean Academy of Nursing
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• v.34 no.5
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• pp.801-808
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• 2004

Purpose: This study was aimed to identify the effect of self-foot reflexology on the relief of premenstrual syndrome and dysmenorrhea in high school girls. Method: Study subjects was 236 women residing in the community, teachers and nurses who were older than 45 were recruited. Data was collected with self administered questionnaires from July 1st to August 31 st, 2003 and analysed using SPSS/WIN 10.0 with Xtest, t-test, and stepwise multiple logistic regression at a significant level of =.05. Result: The breast cancer screening rate was 57.2%, and repeat screening rate was 15.3%. With the multiple logistic regression analysis, factors associated with mammography screening were age and perceived barriers of action, and factors related to the repeat mammography screening were education level and other cancer screening experience. Conclusion: Based on the results, we recommend the development of an intervention program to decrease the perceived barrier of action, to regard mammography as an essential test in regular check-up, and to giveactive advertisement and education to the public to improve the rates of breast cancer screening and repeat screening.

• Research in Community and Public Health Nursing
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• v.15 no.3
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• pp.408-418
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• 2004

This study aims to provide useful basic materials for planning the Health Improvement Program and Policy for men aged 20 40. This study investigated 889 subjects, and at each corresponding age, who were collected among the trainers at the Civil Defense Training Institute in K-ku, Incheon City. The data collection period lasted from April to July of 2003. I revised and complemented the measurement tool for the Health Improvement Life Style developed by Jung Eun-Kyung. For analysis of the acquired data. I used SPSS11.0 program. The study shows that the Health Improvement Action of a group of middle aged men averaged 2.80, and 0.44 point out of 5. According to the results found during the analysis of the generic characters of differences in behaviors of Health Improvement. It was revealed that there were significant differences in age, regular exercise and health interest, stress management, self-concept as well as degrees of interest in health, and education level. According to monthly income levels, regular exercise and degrees of self-concept degrees were significantly different from each other. According to marital status. balanced diet and regular exercise were related to each other. According to religion, balanced diet, stress management degree, self concept degree, and degrees of interest in health, significant differences were shown. Based on the earlier mentioned results, we should pay attention to act more, rather than merely recognize the development of the health improvement program of our regional community. Also, it is necessary to find out the cause, which lowers men's interest in health.

• Journal of Agricultural Extension & Community Development
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• v.15 no.4
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• pp.659-681
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• 2008

The purpose of this study is to empirically analyze factors that influence farm managers' intentions to use an agricultural farm management information systems. It focused on "LFcenter System," a leading information system operated by the Rural Development Administration for farm management. Participants of this study are classified into two groups: a group of leading farm managers and a group fo regular farm managers. A total of 192 survey samples on users' intentions are collected; 85 samples from leading farm managers and 107 from regular farm managers. The theoretical background of this study is developed based on Theory of Reasoned Action(TRA), Technology Acceptance Model(TAM), Diffusion of Innovation(DOI), Social Cognitive Theory(SCT), and Theory of Planned Behavior(TPB). Partial Least Squares(PLS) method is used to test a proposed Structural Equation Model(SEM), including nine hypotheses. The differences between two groups are investigated using Smith-Satterthwait test. The findings from this study are: First of all, in terms of average comparison of most variables used in this study, a group of leading farm managers shows higher value that the other group in most cases. Second, hypothesis tests how that "subjective norms", "goal to study", "perceived usefulness", "perceived enjoyment", and "intention to use" significantly influence the intention to use an agricultural management information system in the group of leading farm managers. However, "subjective norms", "goal to study", "perceived ease of use", "perceived usefulness", "perceived enjoyment", and "intention to use" turned out to significantly influence the intention to use an agricultural management information system in the group of regular farms managers. Based on the results of Smith-Satterthwait test, compared with a group of leading farms managers, the impact of "goal to study" on "intention to use" is significantly stronger. On the other hand, in the group of leading farms managers, "perceived usefulness" and "perceived enjoyment" turned out to be main drivers of "intention to use."

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.2
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• pp.81-90
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• 2000

The types of $K^+$ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary $GH_3$ cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031 $(5\;{\mu}M)$ to $GH_3$ cells hardly affected SAP activities. On the other hand, the main $GH_3$ stimulator thyrotropin-releasing hormone (TRH) still produced its dual effects (transient hyperpolarization and later increase in SAP frequency) in the presence of TEA. However, addition of $BaCl_2$ (2 mM) in the presence of TEA completely blocked SAP repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type $Ca^{2+}$ channel was blocked by nicardipine $(10\;{\mu}M).$ These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in $GH_3$ cells.