• 한국실내디자인학회논문집
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• 제21권3호
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• pp.119-127
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• 2012

In correlation to the rapid growth of Korea's economy and increased international exchange, hotel architecture in Korea has likewise evolutionized in its own distinctive style. Since hotels accomodate foreign visitors, they should be representative of the local architecture in which they reside, to add to the experience of the regions culture. City hotels provide not only primary housing functions but also many different varieties of services. Furthermore, city hotels operate as a focal point for their local communities. Seoul announced special measures for the expansion of accommodations for foreign tourists, and a large number of hotel construction entities have consequently propagated. Unfortunately, the designs for most of these new hotels have failed to reflect their local cultural characteristics, with most having similar designs and programs. As Korea enters an era seeing ten million foreign tourists annually, progressive reform is especially necessary. Space marketing, which is based on strategies of cultural experience, is a crucial element to city boutique hotel planning. It must be applied to satisfy both the cultural needs of its local communities and well as to vitalize the local economy through development of cultural tourism. To date, there have been numerous studies on boutique hotels and space marketing. However, most of these studies are limited to interior designs and artistic trends rather than focusing on the unique architectural and public aspects of their respective cities. In this thesis, the overall aim and strategies of space marketing for the city boutique hotel are analyzed, and the elements of strategies are used for further case analysis. The purpose of this study is to find applicability of Korean boutique hotel development through the result of case studies. Also, this thesis aims to advocate space marketing for Korea's forthcoming boutique hotels, as a means to showcase its unique cultural assets as well as to advance its international appeal and competitiveness.

• 자원환경지질
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• 제28권5호
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• pp.469-480
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• 1995

Gravity and magnetic surveys were carried out to investigate the three-dimensional configuration and characteristics of the landfills at Nanjido waste disposal site. For terrain correction and three-dimensional density inversion of gravity data an algorithm, which calculates the gravity effect of a three-dimensional body by using the solid angle method, is developed. This algorithm has been proved to give more accurate terrain correction values for the small survey area having varied topography like Nanjido site as compared with widely used methods such as Hammer's method and multiquadric equation method. Density inversion of gravity anomaly data gives very useful information about the lateral and vertical variation of the landfills, which can be used to discriminate the kinds of wastes. The average density of filled materials appears to be $1.7\;g/cm^3$ which is much higher than the value $(0.8\;g/cm^3)$ estimated by Seoul City. The lateral variation of density shows high correlation with the pattern of ongoing depression of the landfills. The northern region of the landfill no. 1, which shows low density and high depression, is closely associated with the industrial waste and sludge filled area. The magnetic anomaly data provide information about relative concentration of magnetic materials, which is also very useful to investigate characteristics of the fills. Several high positive anomaly regions on the reduced-to-pole magnetic anomaly map are appeared to be associated with the industrial waste fills, but certain industrial waste fills show low negative anomalies. This kind of magnetic information can be used in selecting drilling locations over landfills away from buried metal products during the stabilization process.

• The Korean Journal of Physiology and Pharmacology
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• 제19권4호
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• pp.319-325
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• 2015

Among solute carrier proteins, the organic anion transporters (OATs) play an important role for the elimination or reabsorption of endogenous and exogenous negatively charged anionic compounds. Among OATs, SLC22A9 (hOAT7) transports estrone sulfate with high affinity. The net decrease of estrogen, especially in post-menopausal women induces rapid bone loss. The present study was performed to search the SNP within exon regions of SLC22A9 in Korean females with osteoporosis. Fifty healthy controls and 50 osteoporosis patients were screened for the genetic polymorphism in the coding region of SLC22A9 using GC-clamped PCR and denaturing gradient gel electrophoresis (DGGE). Six SNPs were found on the SLC22A9 gene from Korean women with/without osteoporosis. The SNPs were located as follows: two SNPs in the osteoporosis group (A645G and T1277C), three SNPs in the control group (G1449T, C1467T and C1487T) and one SNP in both the osteoporosis and control groups (G767A). The G767A, T1277C and C1487T SNPs result in an amino acid substitution, from synonymous vs nonsynonymous substitution arginine to glutamine (R256Q), phenylalanine to serine (F426S) and proline to leucine (P496L), respectively. The Km values and Vmax of the wild type, R256Q, P496L and F426S were 8.84, 8.87, 9.83 and $12.74{\mu}M$, and 1.97, 1.96, 2.06 and 1.55 pmol/oocyte/h, respectively. The present study demonstrates that the SLC22A9 variant F426S is causing inter-individual variation that is leading to the differences in transport of the steroid sulfate conjugate (estrone sulfate) and, therefore this could be used as a marker for certain disease including osteoporosis.

• International Journal of Industrial Entomology and Biomaterials
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• 제14권2호
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• pp.107-112
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• 2007

The mole crickets, Gryllotalpa, are insect pest distributed in the world. In Korea, G. orientalis was reported to occur, but previous ecological studies suggested the presence of two ecological types. To test this hypothesis, we sequenced a portion of mitochondrial (mt) genome from 48 G. orientali individuals collected over five Korean localities: Busan, Suwon, Okchon, Wonju, and Gangneung. From the sequence analysis, only two haplotypes were obtained, but the sequence divergence between the two haplotypes was 11 %, suggesting the presence of two distinct genetic groups in Korea. Although the population of Busan, Okchon, Wonju, and Gangneung was identified as a single haplotype, but that of Suwon was occupied by both hapotypes. Considering sequence divergence of other insect species occurring in Korea, the divergence estimate found between the two haplotypes seems to be too large to be considered as identical species. This result may suggest that the two differentiated haplotypes found in this study may reflect the previously reported two ecological types found in Suwon, Korea. To further understand the genetic divergence of the two phylogenetic groups, analysis of more variable regions of G. orientalis genome is required.

• Journal of Microbiology
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• 제41권1호
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• pp.46-51
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• 2003

RAD6 in yeast mediates postreplication DNA repair and is responsible for DNA-damage induced mutations. RAD6 encodes ubiquitin-conjugating enzyme that is well conserved among eukaryotic organisms. However, the molecular targets and consequences of their ubiquitination by Rad6 have remained elusive. In Aspergillus nidulans, a RAD6 homolog has been isolated and shown to be an allele of uvs). We screened a CDNA library to isolate UVSJ-interacting proteins by the yeast two-hybrid system. JIPA was identified as an interactor of UVSJ. Their interaction was confirmed in vitro by a GST-pull down assay. JIPA was also able to interact with mutant UVSJ proteins, UVSJl and the active site cysteine mutant UVSJ-C88A. The N- and the C-terminal regions of UVSJ required for the interaction with UVSH, a RAD18 homolog of yeast which physically interacts with Rad6, were not necessary for the JIPA and UVSJ interactions. About 1.4 kb jipA transcript was detected in Northern analysis and its amount was not significantly increased in response to DNA-damaging agents. A genomic DNA clone of the jipA gene was isolated from a chromosome I specific genomic library by PCR-sib selection. Sequence determination of genomic and cDNA of jipA revealed an ORF of 893 bp interrupted by 2 introns, encoding a putative polypeptide of 262 amino acids. JIPA has 33% amino acid sequence identity to TIP41 of Saccharomyces cerevisiae which negatively regulates the TOR signaling pathway.

• 한국환경복원기술학회지
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• 제22권4호
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• pp.35-45
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• 2019

The objective of this study is to analyze habitat distribution on tiger, wolf, and leopard in Joseonwangjosilok. Nowaday, we only come to meet these kind of animals at the historical records because of haman-induced habitat encroachment. Historically, extinct animal became an object of game by people. So, we try to get distribution information for restoration on historical extinct animals. We made distribution map by constructing 402 counts on tiger(350), leopard(51) and wolf(1) recordsfrom 14th to Early 20th century for study. Analyzing historical materials, criteria for data analysis took into account objectivity, location information, accuracy for extinct animals. We carried out location identification of animals by using geocoding comparing with geographical name of the Joseon Dynasty period, topographic map of time under the rule of Japanese imperialism, present place name and historical materials. Database items are constructed 20 types for example appearance year of animal, population, location, damage, etc. As a result of analysis for appearance regions, tigers were recorded in capital area of higher density population intensively, and also were frequently seen at Daegu, Andong etc. Leopard and wolf were founded at regionally Gyeonggi-do and Jinju with limitation, relatively seen a few number. The reason of the appearance records like this, tiger prefer game of open and water-front area in near human residential area, there are lots of historical records such as 'Hosang'(mourning someone who killed by Tiger) and hunting. But leopard and wolf inhabit rocky area and dense forest, the reason why they made a few contact with human. Results of this are expect to be applicable restoration research for extinct animal by providing for populations, habitat environments and distribution information.

• 한국기후변화학회지
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• 제2권4호
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• pp.269-281
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• 2011

전구 및 지역 기후 모델 결과를 분석하여 동아시아와 한반도 지역에 대해 상세한 지역기후의 변화를 전망한 연구를 소개하였다. 특히 IPCC 4차 평가 보고서의 배출 시나리오를 기반으로 국내 연구그룹이 산출한 한반도 지역기후 변화 전망을 소개하고 그 특성을 파악하였다. 배출 시나리오에 따라 강도의 차이가 다소 있지만 미래 한반도의 온난화 경향은 명확한 것으로 나타났다. 강수량의 경우 배출 시나리오와 시기에 따라 다소 상이한 변화 경향을 보이지만, 대부분의 연구에서 공통적으로 미래 집중호우의 발생 빈도와 강도가 증가하는 것으로 나타났다. 이와 같은 지역기후 변화로 인하여 고지대를 제외한 대부분의 남한지역이 아열대 기후구로 점차 변해갈 것으로 전망되며, 이로 인한 생태계와 계절의 변화가 야기될 것으로 예상된다.

• 한국기후변화학회지
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• 제7권1호
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• pp.49-57
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• 2016

In the present study, the time series of the number of days on which temperatures were not higher than $-5^{\circ}C$ in winter in Seoul was analyzed. The results showed a decreasing tendency until recently. Statistical change-point analysis was conducted to examine whether climate regime shifts existed in this time series. According to the results, the number of days on which temperatures were not higher than $-5^{\circ}C$ in winter in Seoul drastically decreased since 1988. Therefore, to find out the reason for the recent decrease in the number of days, differences between the means of large-scale environments in winder during 1988~2010 and those during 1974~1987 were analyzed. In all layers of the troposphere, anomalous anticyclones developed in regions around the Korean Peninsula and thus the Korean Peninsula was affected by westerlies or south-westerlies. This was associated with the recent a little further northward development of western North Pacific subtropical high. Therefore, environments good for warm and humid air to flow into the Korean Peninsula were formed. To examine whether relatively warm and humid air actually flowed into the Korean Peninsula recently, temperatures and specific humidity in all layers in the troposphere were analyzed and according to the results the Korean Peninsula showed warm and humid anomalies. In the analyses of sensible heat net flux and maximum temperatures at a height of 2 m that can be felt by humans, the East Asia Continent including the Korean Peninsula showed positive anomalies.

• 한국응급구조학회지
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• 제23권1호
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• pp.49-60
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• 2019

Purpose: This study was conducted to analyze job stress, ego-resilience, and results of the impact of event scale in order to verify the actual job stress of firefighters and provide baseline data for developing resolution programs. Methods: Data were collected via e-mail from 270 firefighters working at 119 safety centers and firehouses in the regions of Gyeonggi, Chungcheong, Busan, and Gyeongsang-do between the $1^{st}$ and $30^{th}$ of July, 2017. Results: Regarding gender differences in job stress, women ($2.16{\pm}0.65$) showed statistically significant job stress compared to men ($1.93{\pm}0.57$). As for the results of the incident impact of event scale statistically significant differences were observed (p=.001), and ego-resilience in men ($4.15{\pm}0.54$) was significantly higher than that in women ($3.79{\pm}0.75$) (p=.006). Depending on the work period, there were statistically significant differences (p=.000) in job stress, ego-resilience (p=.002), and impact of event scale (p=.000). Conclusion: Since job stress, ego-resilience, and results of the impact of event scale were closely related to dispatch frequency and work period of the firefighters, detailed and continuous stress management programs that consider these factors need to be developed.

• Infection and chemotherapy
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• 제50권4호
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• pp.357-361
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• 2018

While carbapenems are the drug of choice to treat extended-spectrum-${\beta}$-lactamase (ESBL)-producing strains, some alternative carbapenem-sparing regimens are suggested for antibiotic stewardship. We experienced a case of ciprofloxacin treatment failure for acute pyelonephritis caused by an apparently susceptible Escherichia coli. A 71-year-old woman presented the emergency department with fever for 7 days and bilateral flank pain for 2 days. The laboratory results and abdominopelvic computed tomography finding were compatible with acute pyelonephritis. During 3-day ciprofloxacin therapy, the patient remained febrile with persistent bacteremia. After the change in antibiotics to ertapenem, the patient's clinical course started to improve. ESBL-producing E. coli isolates were identified in all three consecutive blood samples. Pulsed-field gel electrophoresis (PFGE) patterns, serotypes, and sequence types showed the three isolates were derived from the identical strain. The isolates produced CTX-M-14 type ESBL belonging to the ST69 clonal group. Despite in vitro susceptibility, the failure was attributed to a gyrA point mutation encoding Ser83Leu within quinolone resistance-determining regions. This case suggests that ciprofloxacin should be used cautiously in the treatment of serious infections caused by ciprofloxacin-susceptible, ESBL-producing E. coli, even in acute pyelonephritis because in-vitro susceptibility tests could fail to detect certain genetic mutations.