• International Neurourology Journal
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• 제22권4호
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• pp.260-267
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• 2018

Purpose: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction. Methods: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into the sphincter complex of female NHPs with or without surgery-induced chronic urinary sphincter dysfunction (n=4/treatment condition). All monkeys had partial bone marrow transplantation with autologous lenti-green fluorescent protein (GFP) bone marrow cells prior to treatment. Labeled cells were identified, characterized and quantified using computer-assisted immunohistochemistry 6 months posttreatment. Results: GFP-labeled bone marrow cells (BMCs) were identified in the bone marrow and both BMCs and skMPCs were found in the urinary sphincter at 6-month postinjection. BMCs and skMPCs were present in the striated muscle, smooth muscle, and lamina propria/urothelium of the sphincter tissue. Sphincter injury increased the sphincter content of BMCs when analyzed 6-month postinjection. CXCL12 treatment, but not skMPCs, increased the number of BMCs in all layers of the sphincter complex (P<0.05). CXCL12 only modestly (P=0.15) increased the number of skMPCs in the sphincter complex. Conclusions: This dual labeling methodology now provides us with the tools to measure the relative number of locally injected cells versus bone marrow transplanted cells. The results of this study suggest that CXCL12 promotes mobilization of cells to the sphincter, which may contribute more to sphincter regeneration than injected cells.

• Journal of Electrical Engineering and Technology
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• 제9권6호
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• pp.1795-1804
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• 2014

Owing to the reduction in the peak power of a DC railway subsystem, many studies on energy storage system (ESS) applications have received attention. Each application focuses on improving the efficiency and addressing regulation issues by utilizing the huge regenerative energy generated by braking-phase vehicles. The ESS applications are widely divided into installation on a vehicle or in a substation, depending on the target system characteristics. As the main purpose of the ESS application is to reduce the peak power of starting-phase vehicles, an optimized ESS utilization can be achieved by the operating at the highest peak power section. However, the weight of an entire vehicle, including those of the passengers, continuously changes during operation; thus, considering the total power consumption and the discharging point is difficult. As a contribution to the various storage device algorithms, this study deals with ESS on board vehicles and introduces an ESS operating plan for peak-power reduction by investigating the weight of a train on a real-time basis. This process is performed using a train-performance simulator, and the simulation accuracy can be increased because the weight in each phase can be adopted in the simulation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권3호
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• pp.93-102
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• 2018

Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the healing of the alveolar socket following tooth extraction. The inappropriate removal of formed blood clots causes the undesirable phenomenon of alveolar osteitis (AO) or dry socket. In this review, we aimed to investigate whether enhanced angiogenesis contributes to a more effective prevention of AO. The potential pro- or anti-angiogenic activity of different materials used for the treatment of AO were evaluated. An electronic search was performed in the PubMed, MEDLINE, and EMBASE databases via OVID from January 2000 to September 2016 using the keywords mentioned in the PubMed and MeSH (Medical Subject Headings) terms regarding the role of angiogenesis in the prevention of AO. Our initial search identified 408 articles using the keywords indicated above, with 38 of them meeting the inclusion criteria set for this review. Due to the undeniable role of angiogenesis in the socket healing process, it is beneficial if strategies for preventing AO are directed toward more proangiogenic materials and modalities.

• 한국유체기계학회 논문집
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• 제15권5호
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• pp.32-36
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• 2012

The positive displacement pump and the regenerative pump are widely used in the range of low specific speed, $n_s{\leq}100$[rpm, m3/min, m]. The positive displacement pump is not suitable for miniaturization and operation in high rotational speed. The regenerative pump has a problem with large leakage flow and low efficiency. While the centrifugal pump has advantages of high efficiency, miniaturization and high rotational speed, efficiency drops sharply with decrease in specific speed. Therefore the purpose of this study is to design a new type of centrifugal pump that has advantages of centrifugal pumps in operation in low specific speed. The name of this new type of pump was called 'Pipe type centrifugal pump', since the flow path through the impeller is simple circular pipe. Due to the simple shape of impeller, the manufacturing process is simple and cost is low. There is strong jet flow at the outlet of the impeller. This jet induces flow path loss, meridional dynamic pressure loss and mixing loss. Large disk friction makes the efficiency be limitted in the range of low specific speed. Even though the loss and the low efficiency, 'Pipe type centrifugal pump' represents stable performance, affordable pressure ratio and efficiency better than that of other low specific speed pumps.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2017년도 제48회 춘계학술대회논문집
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• pp.643-646
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• 2017

탄화수소계열의 연료를 사용하는 액체로켓엔진에서 높은 열유속으로 인해 연소실 벽면이 구조적으로 손상 및 변형되는 것을 방지하기 위하여 연소실 벽면의 냉각은 필수적이다. 여러 가지 방법 중 연료를 냉각제로 사용 후 연소과정에 투입시키는 재생냉각 방식은 엔진 성능을 높여준다. 본 연구는 구리 단면적, 채널 내 유속, 채널에 가해지는 전류를 변화시켜 냉각제로 사용하는 케로신의 열전달 특성에 대해 알아보았다. 채널의 구리 단면적이 작을수록, 케로신의 유속이 빠를수록 대류 열전달이 빠르게 일어남을 알 수 있었다.

• 전자공학회논문지A
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• 제33A권5호
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• pp.212-221
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• 1996

A CMOS comparator is designed for low voltage and low power operations. The proposed comparator consists of a preadmplifier followed by a regenerative latch. The preasmplifier reduces the power consumption to a half with the power-down mode and the dynamic offsets of the latch, which is affected by each device mismatch, is statistically analyzed. The circuit is designed and simulated using a 0.8.mu.m n-well CMOS process and the dissipated power is 0.16mW at a 20MHz clock speed based on a 3V supply.

• Journal of the Korean Statistical Society
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• 제33권3호
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• pp.283-298
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• 2004

We present a trial solution approach to GI/M/l queues with generalized vacations. Specific types of generalized vacations we consider are N -policy and a combination of N-policy and exponential multiple vacations. Discussions about how to find trial solutions are given.

• 한국정밀공학회지
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• 제14권4호
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• pp.38-45
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• 1997

A new dynamic model for the cutting process inb the end milling process is developed. This model, which describes the dynamic response of the end mill, the chip load geometry including tool runout, the dependence of the cutting forces on the chip load, is used to predict the dynamic cutting force during the end milling process. In order to predict accurately cutting forces and tool vibration, the model which uses instantaneous specific cutting force, inclueds both regenerative effect and penetration effect, The model is verified through comparisons of model predicted cutting force with measured cutting force obtained from machining experiments.

• 생명과학회지
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• 제28권12호
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• pp.1455-1460
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• 2018

최근 들어 급속한 고령화 사회가 진행되고 있으며 이로 인해 골관절염과 골다공증 등의 퇴행성 골질환 환자수도 동반하여 증가하고 있다. 따라서 고령화에 따른 골관련 질환의 새로운 제어와 치료법 개발을 위해 성체줄기세포의 골세포 분화유도를 활용한 재생의학도 활발히 연구되고 있다. 또한 관련 연구에서 줄기세포의 분화과정에서 미토콘드리아의 산화적인산화가 중요하다고 알려지고 있다. 흥미롭게도 최근 연구에서 아스피린의 주성분인 salicylate가 동물세포의 미토콘드리아 생합성을 증진시키는 효과가 보고되었다. 그러나 성체줄기세포에서 salicylate가 골세포분화나 미토콘드리아 생합성을 유도할 수 있는지에 대한 연구결과는 미비한 실정이다. 본 연구에서는 인체 골막 유래의 성체줄기세포를 이용하여 골세포분화나 미토콘드리아 생합성에 대한 salicylate의 영향을 분석하였다. 골막 유래 성체줄기세포의 골세포 분화유도 과정에 동반한 salicylate 처리는 잘 알려진 골세포분화 표지자인 alkaline phosphatase의 활성을 증가시키는 결과를 본 연구에서 얻었다. 이러한 연구결과는 salicylate가 줄기세포로부터 골세포로의 분화를 조절할 수 있는 물질이 될 수 있음을 제시한다. 또한 이러한 골세포 분화과정에서 미토콘드리아 생합성도 salicylate 처리에 의해 증가됨이 관찰되었다. 따라서, 미토콘드리아 생합성이나 기능을 조절하는 물질이 성체줄기세포의 골세포 분화과정에도 영향을 줄 수 있으며, 이러한 물질이 골세포분화나 재생의학의 새로운 조절 물질로 응용될 수 있음을 제시한다.

• 한국기계가공학회지
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• 제12권2호
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• pp.27-33
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• 2013

In this study we analyzed the on-road driving performance of two parallel-type diesel-hybrid buses which have been driven in Daegu metropolitan area. A real-time on-board data logger was facilitated to measure the vehicle information such as vehicle speed, idle stop, state of charge of battery, and engine operating conditions. These diesel-hybrid buses ran as a commuter at Daegu Exco area and Dalsung industrial complex. The driving pattern in Exco area comprised more frequent idle stop and relatively lower speed than at Dalsung area, where comprised no idle stop. Due to those different driving patterns, the fuel economy at Dalsung showed $3.7\;km/{\ell}$, which is about 8% higher than that of Exco. The main causes of this come from the higher portion of regenerative braking and higher speed which moves to the operating points of diesel engine with a lower fuel consumption.