• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2011년도 춘계학술대회 논문집
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• pp.555-556
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• 2011

• 대한기계학회논문집
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• 제10권4호
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• pp.463-470
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• 1986

본 연구에서는 절삭공정 중 발생하는 공구의 접촉이탈 현상에 의하여 공작 물의 절삭된 표면중에 한회전 및 그 이전 회전에 절삭된 절삭면의 형상이 현재의 절삭 깊이에 영향을 미치는 다중재생효과(multiple regenerative effect)가 존재하는 선삭 작업에서 공구의 착탈현상을 고려한 비선형채터(nonlinear chatter)를 공작기계의 생 산성의 관점에서 절삭공정의 특성을 고려하여 해석하였으며, 수동제어기의 일종인 임 펙트댐퍼를 절삭공정에 응용하여 절삭작업중에 공작기계의 안정성향상 뿐만 아니라 생 산성의 증가효과를 규명하였다.아울러 댐퍼자체의 설계변수에 따른 채터 억제효과 를 고려하여 최적의 댐퍼를 설계하는 방법을 제시하였다.

• 전기학회논문지
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• 제59권12호
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• pp.2306-2313
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• 2010

This paper describes a model based fault detection algorithm for an Advanced ESC System which consists of Hydraulic Control Unit (HCU) with built-in wheel pressure sensors. Advanced ESC System can be used for various value-added functions such as Stop & Go Function and Regenerative Brake Function. Therefore, HCU must have a reliable fault detection. Due to the huge amount of sensor signals, existing specific sensor based fault detection of HCU cannot guarantee the safety of vehicle. However, proposed algorithm dose not require the sensors. When model based fault detection algorithm detects severe failures of the HCU, it warns the driver in advance to prevent accidents due to the failures. For this purpose, a mathematical model is developed and validated in comparison to actual data. Simulation results and data acquired from an actual system are compared with each other to obtain the information needed for the fault detection process.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2002년도 추계학술대회 논문집
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• pp.440-445
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• 2002

The characteristic equation for regenerative chatter loop including a delay element replaced by a rational function is presented by a linear differential-difference equation, accounting for the dynamics of the AMB controllers, the uncut chip thickness equation and the cutting process as well as the rigid spindle dynamics itself. The chatter stability analysis of a rigid milling spindle suspended by 5-axes active magnetic bearings(AMBs) is also performed to investigate the influences of the damping and stiffness coefficients of AMBs on the chatter free cutting conditions, as they are allowed to vary within the stable region formed by the AMB control gains. Several cutting tests varying the derivative gains of the AMB were performed to investigate the regenerative chatter vibrations, and it was concluded that the theoretical analysis results are in good consistency with the test results.

• Animal cells and systems
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• 제16권6호
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• pp.462-468
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• 2012

Urodeles including newt and salamander have remarkable regenerative capacity during the postembryonic life span. Some of the unique features are the formation of the well-developed wound epidermis and the active dedifferentiation process in the early phase of regeneration. These are regarded as key events for the successful regeneration since no further regenerative activity is possible without them. In this study, we investigated the role of retinoic acid (RA) in salamander limb regeneration by blocking RA synthesis using disulfiram, an inhibitor of aldehyde dehydrogenase that oxidizes retinal to RA. Disulfiram treatment resulted in delaying the limb regeneration processes via inhibition of wound epidermis formation and dedifferentiation process. When RA was administered after disulfiram treatment, the inhibitory effect of disulfiram was rescued. In addition, disulfiram treatment after the dedifferentiation stage resulted in the mild retardation of limb regeneration, suggesting that RA might also be involved in the blastema outgrowth. Furthermore, salamander MMP-9 gene expression was also inhibited by disulfiram treatment. Collectively, our findings indicate that endogenous RA may play an important role(s) in the early phase of limb regeneration by regulating the expression of molecules responsible for the modification of intracellular and extracellular environment during salamander limb regeneration.

• 한국추진공학회지
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• 제18권6호
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• pp.88-95
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• 2014

액체로켓 엔진 재생냉각챔버의 무게 감량을 위하여 내피에 스피닝 공정을 적용하였다. 스피닝 도중 실린더부와 노즐목부의 블랭크에 파손이 발생하였다. 이 문제를 극복하기 위해 맨드럴 및 블랭크 형상을 수정하였으며 이러한 수정을 통해 스피닝을 사용하여 내피를 제작할 수 있었다. 제작된 노즐목부 스피닝 시제품은 균열이나 네킹없이 성공적으로 벌징이 되어 연소기 제작에 적용할 수 있는 충분한 성형성을 확보한 것을 확인하였다.

• International Journal of Oral Biology
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• 제42권2호
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• pp.71-78
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• 2017

BMP-2 is a well-known TGF-beta related growth factor, having a significant role in bone and cartilage formation. It has been employed to promote bone formation in some clinical trials, and to differentiate mesenchymal stem cells into osteoblasts. However, it is difficult to obtain this protein in its soluble and active form. hBMP-2 is expressed as an inclusion body in the bacterial system. To continuously supply hBMP-2 for research, we optimized the refolding of recombinant hBMP-2 expressed in E. coli, and established an efficient method by using detergent and alkali. Using a heparin column, the recombinant hBMP-2 was purified with the correct refolding. Although combinatorial refolding remarkably enhanced the solubility of the inclusion body, a higher yield of active dimer form of hBMP-2 was obtained from one-step refolding with detergent. The refolded recombinant hBMP-2 induced alkaline phosphatase activity in mouse myoblasts, at $ED_{50}$ of 300-480ng/ml. Furthermore, the expressions of osteogenic markers were upregulated in hPDLSCs and hDPSCs. Therefore, using the process described in this study, the refolded hBMP-2 might be cost-effectively useful for various differentiation experiments in a laboratory.

• Journal of Periodontal and Implant Science
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• 제44권1호
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• pp.39-47
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• 2014

Purpose: Peri-implantitis, a clinical term describing the inflammatory process that affects the soft and hard tissues around an osseointegrated implant, may lead to peri-implant pocket formation and loss of supporting bone. However, this imprecise definition has resulted in a wide variation of the reported prevalence; ${\geq}10%$ of implants and 20% of patients over a 5- to 10-year period after implantation has been reported. The individual reporting of bone loss, bleeding on probing, pocket probing depth and inconsistent recording of results has led to this variation in the prevalence. Thus, a specific definition of peri-implantitis is needed. This paper describes the vast variation existing in the definition of peri-implantitis and suggests a logical way to record the degree and prevalence of the condition. The evaluation of bone loss must be made within the concept of natural physiological bony remodelling according to the initial peri-implant hard and soft tissue damage and actual definitive load of the implant. Therefore, the reason for bone loss must be determined as either a result of the individual osseous remodelling process or a response to infection. Methods: The most current Papers and Consensus of Opinion describing peri-implantitis are presented to illustrate the dilemma that periodontologists and implant surgeons are faced with when diagnosing the degree of the disease process and the necessary treatment regime that will be required. Results: The treatment of peri-implantitis should be determined by its severity. A case of advanced peri-implantitis is at risk of extreme implant exposure that results in a loss of soft tissue morphology and keratinized gingival tissue. Conclusions: Loss of bone at the implant surface may lead to loss of bone at any adjacent natural teeth or implants. Thus, if early detection of peri-implantitis has not occurred and the disease process progresses to advanced peri-implantitis, the compromised hard and soft tissues will require extensive, skill-sensitive regenerative procedures, including implantotomy, established periodontal regenerative techniques and alternative osteotomy sites.

• Journal of the Optical Society of Korea
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• 제7권3호
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• pp.160-164
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• 2003

Materials processing by ultrashort pulsed laser is actively being applied to micromachining technology due to its advantages with regard to non-thermal machining. In this study, materials processing with ultrashort pulses was studied by using the high repetition rate of a 800 nm Ti:sapphire regenerative amplifier. This revealed that the highly precise micromachining of metallic thin film and bulk glass with a minimal heat affected zone (HAZ) could be obtained by using near damage threshold energy. Grooves with diffraction limited sub-micrometer width were obtained with widths of 620 nm on Cr thin film and 800 nm on a soda-lime glass substrate. The machined patterns were investigated through SEM images. We also phenomenologically examined the influence of variations of parameters and proposed the optimal process conditions for microfabrication.

• 한국항공우주학회지
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• 제33권12호
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• pp.109-116
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• 2005

재생냉각형 액체로켓 연소기의 냉각채널 설계에 대한 탄-소성 구조설계를 수행하였다. 구조해석에 필요한 데이터를 얻기 위하여 여러 가지 온도에서 재생냉각 챔버 제작에 사용하는 구리합금의 단축인장시험을 수행하였다. 재료시험 결과 구리합금은 브레이징 공정 후에 연화되어 강도 값이 매우 저하되며 온도가 증가함에 따라 유동 응력 값이 더 작게 나타났다. 재료시험 데이터를 이용하여 냉각채널의 구조해석을 수행한 결과 채널 내부 냉각유체에 의한 내부압력보다 고온의 연소가스에 의한 열 하중에 의하여 채널의 변형이 심하게 발생함을 확인하였다. 따라서 기계적인 하중을 견딜 수 있는 한도 내에서 냉각채널의 두께를 감소시켜 열 하중을 최소화함으로서 연소기의 무게 감소, 냉각성능 향상, 그리고 구조적인 안정성을 향상시킬 수 있다는 것을 알 수 있었다.