• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.37 no.12
• /
• pp.1201-1208
• /
• 2009

Dome stretching tests and tension tests were performed to evaluate the formability of a copper alloy used for manufacturing the regenerative cooling chamber. The test specimens were prepared to investigate the effect of heat treatment and direction of specimens on the formability. The test results show that forming limit values are increased by the heat treatment of the material but the variation of the forming limit values by manufacturing direction is negligible compared to the heat treatment effect, and forming limit values are also different according to the test methods. These results indicate that the high temperature heat treatment of the material before bulging is a very important process to deform the inner cylindrical structure of the regenerative cooling chamber into a nozzle shape by the bulging process without necking or fracture and the test methods also have a great effect on a evaluation of the formability. The forming limit diagram obtained in this study would be utilized to the design of regenerative cooling chamber nozzles.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.23 no.6
• /
• pp.769-777
• /
• 1999

This paper presents models for the dynamic simulation of a regenerative gas turbine and describes dynamic behaviors of a small regenerative engine. A quasi-steady model is introduced where the inertia of the working fluid is assumed to be negligible compared with the mechanical inertia of the rotating shaft. Based on this quasi-steady model, the transient model for the heat exchanger is employed to simulate the unsteady heat exchange in the recuperator. The effect of the thermal inertia of the recuperator metal on transient behaviors is analyzed by comparing the predicted results of the transient and steady state heat exchanger models. For several load change modes such as sudden increase, decrease and periodic variation, engine dynamic characteristics are investigated by applying a fuel control logic for the constant shaft speed. It is found that the thermal inertia of the recuperator metal has a dominant effect on the whole engine dynamic behavior.

• Journal of the Korean Society of Combustion
• /
• v.8 no.1
• /
• pp.17-24
• /
• 2003

The conventional regenerative system has a high thermal efficiency as well as energy saving using the high preheated combustion air. in spite of these advantages, it can not avoid high nitric oxide emissions. Recently, flameless combustion has received much attention to solve these problems. In this research, numerical analysis is performed for flow-combustion phenomena in the self regenerative burner. In this analysis we used Fluent 6.0 code. the that is developed for commercial use, Methane gas is used as a fuel and two-step reaction model for methane and Zeldovich mechanism for NO generation are used. the velocity of the preheated combustion air is used as a parameter and we analyze the characteristics of flow-field, temperature distributions and NO emissions. Due to the increased recirculation rate, the maximum temperature of flame is significantly increased and NOx emissions is reduced.

• Journal of the Korean Society of Combustion
• /
• v.5 no.1
• /
• pp.99-108
• /
• 2000

Regenerative burner is a product of new combustion technology for realizing higher thermal efficiency and lower emissions, moreover utilizing very high preheated air temperature up to $1,000^{\circ}C$. In this study the experimental study was carried out to find out a combustion characteristics breaking the old combustion concept. From the variation of configuration of gas nozzle and hot test on the temperature distribution and NOx, CO, it was found out that the performance of regenerative burner was better than that of existing burner, mainly due to the effect of internal gas recirculation.

• 한국연소학회:학술대회논문집
• /
• 2002.11a
• /
• pp.97-104
• /
• 2002

The conventional regenerative system has a high thermal efficiency as well as energy saving using the high preheated combustion air. in spite of these advantages, it can not avoid high nitric oxide emissions. Recently, flameless combustion has received much attention to solve these problems. In this research, numerical analysis is performed for flow-combustion phenomena in the self regenerative burner. In this analysis we used Fluent 6.0 code. the that is developed for commercial use, Methane gas is used as a fuel and two-step reaction model for methane and Zeldovich mechanism for NO generation are used. the velocity of the preheated combustion air is used as a parameter and we analyze the characteristics of flow-field, temperature distributions and NO emissions. Due to the increased recirculation rate, the maximum temperature of flame is significantly increased and NOx emissions is reduced

• Medical Lasers
• /
• v.9 no.2
• /
• pp.134-141
• /
• 2020

The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

• Biomolecules & Therapeutics
• /
• v.28 no.5
• /
• pp.423-430
• /
• 2020

Telmisartan is an angiotensin-II receptor blocker and acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). Several studies have demonstrated that telmisartan ameliorates depression and memory dysfunction and reduces brain inflammation. We hypothesized that the beneficial effects of telmisartan on brain could be due to modulation of the blood-brain barrier (BBB) function. Here, we examined the effect of telmisartan on tumor necrosis factor alpha (TNF-α)-induced expression of intercellular adhesion molecule 1 (ICAM-1) which plays an important role in leukocyte transcytosis through the BBB. Telmisartan blocked TNF-α-induced ICAM-1 expression and leukocyte adhesion in U87MG human glioma cells but showed no effect on human brain microvascular endothelial cells. In U87MG cells, a PPAR antagonist, GW9662 did not block the effect of telmisartan on ICAM1 expression but rather potentiated. Moreover, GW9662 caused no change in TNF-α-induced ICAM-1 expression, suggesting no implication of PPARγ in the telmisartan effect. Further studies showed that telmisartan blocked TNF-α-induced activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and nuclear factorkappa B (NF-κB). In contrast, inhibitors of JNK, ERK1/2 and NF-κB but not p38, blocked ICAM-1 expression induced by TNF-α. Thus, our findings suggest that the beneficial effect of telmisartan is likely due to the reduction of astrocytic ICAM1 expression and leukocytes adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-κB activation and in the PPAR-independent manner. In conclusion, this study enhances our understanding of the mechanism by which telmisartan exerts the beneficial brain function.

• 한국신재생에너지학회:학술대회논문집
• /
• 2008.05a
• /
• pp.154-156
• /
• 2008

A prototype of the desiccant cooling system with a regenerative evaporative cooler was built and tested for the performance evaluation. The regenerative evaporative cooler is to cool a stream of air using evaporative cooling effect without an inc6rease in the humidity ratio. It is comprised of multiple pairs of dry and wet channels and the evaporation water is supplied only to the wet channels. By redirecting a portion of the air flown out of the dry channel into the wet channel, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature at the outlet end of the dry channels. Incorporating a regenerative evaporative cooler eliminates the need for deep dehumidification in the desiccant rotor that is necessary to achieve low air temperature in the system with a direct evaporative cooler. Subsequently, the regenerative evaporative cooler enables the use of low temperature heat source to regenerate the dehumidifier permitting the desiccant cooling system more beneficial compared with other thermal driven air conditioners. At the ARI condition with the regeneration temperature of $60^{\circ}C$, the prototype showed the cooling capacity of 4.4 kW and COP of 0.75.

• International Journal of Stem Cells
• /
• v.16 no.1
• /
• pp.44-51
• /
• 2023

Background and Objectives: DNA methyltransferases (Dnmts) play an important role in regulating DNA methylation during early developmental processes and cellular differentiation. In this study, we aimed to investigate the role of Dnmts in neural differentiation of embryonic stem cells (ESCs) and in maintenance of the resulting neural stem cells (NSCs). Methods and Results: We used three types of Dnmt knockout (KO) ESCs, including Dnmt1 KO, Dnmt3a/3b double KO (Dnmt3 DKO), and Dnmt1/3a/3b triple KO (Dnmt TKO), to investigate the role of Dnmts in neural differentiation of ESCs. All three types of Dnmt KO ESCs could form neural rosette and differentiate into NSCs in vitro. Interestingly, however, after passage three, Dnmt KO ESC-derived NSCs could not maintain their self-renewal and differentiated into neurons and glial cells. Conclusions: Taken together, the data suggested that, although deficiency of Dnmts had no effect on the differentiation of ESCs into NSCs, the latter had defective maintenance, thereby indicating that Dnmts are crucial for self-renewal of NSCs.

• The KSFM Journal of Fluid Machinery
• /
• v.16 no.5
• /
• pp.5-10
• /
• 2013

The regenerative pump is a kind of turbomachine which is capable of developing high pressure rise at relatively lower flow rates compared to the centrifugal and axial pumps. Although the efficiency of regenerative pumps is much lower than other turbomachines, still they have been widely used in many industrial applications for working at low specific speeds. There are some theoretical models to analysis the pump performance, however, the effect of the blade angle on the pump performance has not been covered in any model to date. In the present study, experimental study on the regenerative pump performance according to the impeller blade angle and its shape has been carried out. The straight radial blades with forward, backward and chevron blades which have inclined angles of $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$ were tested. The pump performance characteristics as the pressure head, efficiency were obtained depending on the flow rate for every impeller, and their results, expressed in appropriate non-dimensional coefficients, were compared and analysed in detail. From the experimental results, it was found that the pressure head and the efficiency depend strongly on the blade angles as well as the blade type. These experimental data has made it possible to better understand the effects of the blade angle on the pump performance, and widen the applicability of the current performance analysis and design models with including the effect of blade angles.