• Asian Pacific Journal of Cancer Prevention
• /
• 제14권1호
• /
• pp.589-594
• /
• 2013

Background: Prospective cohort studies to determine cofactors with oncogenic HPV-infections for cervical cancer are very rare from developing countries and such data are limited to the few screening trials. Large screening trials provide such data as a by product. Some of the cases are prevented by screening and do not surface as invasive cancers at all. Also, pre-invasive lesions are detected almost entirely by screening. Screening causes selection bias if attendance in or effectiveness of screening is correlated with the risk factors. The aim of this study was to quantify the influence of screening on risk factors for cervical cancer. Materials and Methods: Our material stems from a rural cohort of 80,000 women subjected to a randomised screening trial. The effect of screening on the incidence of cervix cancer was estimated with reference to socio-demographic and reproductive risk factors of cervical cancer. We compared these risks with the incidence of cancer in the randomised control population by the same determinants of risk. Results: The results in the screening arm compared to the control arm showed that the women of low SES and young age were benefitting more than those of high SES and old age. The relative risk by age (30-39 vs 50-59) was 0.33 in the control arm and 0.24 in the screening arm. The relative risk by education (not educated vs educated) was 2.8 in the control arm and 1.8 in the screening arm. The previously married women did not benefit (incidence 113 and 115 per 100,000 women years in control vs screening arms) whereas the effect was substantial in those married (86 vs 54). Conclusions: The results in controls were consistent with the general evidence, but results in attenders and nonattenders of the screening arm showed that screening itself and self-selection in attendance and effectiveness can influence the effect estimates of risk factors. The effect of cervical cancer screening programmes on the estimates of incidence of cervical cancer causes bias in the studies on etiology and, therefore, they should be interpreted with caution.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권1호
• /
• pp.91-96
• /
• 2013

Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권8호
• /
• pp.3945-3951
• /
• 2016

Background: Whether concurrent chemotherapy treatment is superior to radiotherapy alone as an adjuvant regimen for postoperative cervical carcinoma with risk factors remains controversial. Materials and Methods: A literature search strategy examined Pubmed, Embase, the Cochrane Library, the China National Knowledge Internet Web, the Chinese Biomedical Database and the Wanfang Database. Article reference lists and scientific meeting abstracts were also screened. Controlled trials comparing concurrent chemoradiotherapy versus radiotherapy alone in postoperative cervical cancer were included. The methodological quality of non-randomized controlled trials was evaluated using the Newcastle-Ottawa Scale. Randomized controlled studies were evaluated with the Cochrane handbook. A meta-analysis was performed with RevMan 5.3. Results: A total of 1,073 patients from 11 clinical trials were analysed, with 582 patients in the concurrent chemoradiotherapy group and 491 patients in the radiotherapy group. Hazard ratios (HR) of 0.47 (95% CI 0.31-0.72) and 0.50 (95% CI 0.35-0.72) were observed for overall survival and progression-free survival, indicating a benefit from the additional use of concurrent chemotherapy. Subgroup analyses demonstrated that cervical cancer with high risk factors significantly benefitted from concurrent chemotherapy when examining overall survival (HR 0.44, 95% CI 0.28-0.67) and progression-free survival (HR 0.48, 95% CI 0.33-0.70), but patients with intermediate risk factors showed no benefit from concurrent chemotherapy in overall survival (HR 1.72, 95% CI 0.28-10.41) and progression-free survival (HR 1.09, 95% CI 0.19-6.14). No significant differences were observed for grade 3-4 anaemia (risk ratio (RR) 3.87, 95% CI 0.69-21.84), grade 3-4 thrombocytopenia (RR 3.04, 95% CI 0.88-10.58), grade 3-4 vomiting or nausea (RR 1.71, 95% CI 0.27-10.96), or grade 3-4 diarrhoea (RR 1.40, 95% CI 0.69-2.83). Significant differences were observed for grade 3-4 neutropenia in favour of the radiotherapy group (RR 7.23, 95% CI 3.94-13.26). Conclusions: In conclusion, concurrent chemoradiotherapy improves survival in postoperative cervical cancer with high risk factors but not in those with intermediate risk factors.

• 디지털융복합연구
• /
• 제16권3호
• /
• pp.415-422
• /
• 2018

현대 문명의 발달로 사람들은 편안한 생활을 영유하게 됐지만, 폭력적이고 자극적인 콘텐츠들도 쉽게 접하게 되었다. 현대 문명에서 벗어나 자연을 동경하는 자연친화 문화가 형성되고 있으며 이러한 문화를 영유아들이 쉽게 접하는 캐릭터에도 적용해 자연친화적 캐릭터를 만들고 발전시켜 나가야 한다. 본 논문에서는 자연친화적 캐릭터 개발사례를 보여주고 한국의 자연친화적 캐릭터 설정을 제시하여 다양한 자연친화적 캐릭터가 등장하도록 가이드 역할을 하는 것을 목적으로 한다. 유명한 국외 자연친화적 캐릭터 3가지 사례와 자연이 영유아에게 주는 영향을 선행 연구된 논문과 출간된 책을 참고하여 조사한다. 선행 연구를 통해 자연친화가 영유아의 정서와 생명존중에 긍정적인 영향을 준다는 것을 확인하였으며 자연친화적 캐릭터의 특징으로 1.그 나라의 자연환경을 배경으로 그려졌다. 2.자연보호와 사랑, 자연에서 노는 이야기로 많은 사람들의 사랑을 받아왔다. 이야기 설정으로 1.친구들과 숲 체험활동을 하는 이야기 2.놀이, 탐구, 해설 등 자연 관찰과 탐구의 이야기 3.풀, 꽃, 나무, 곤충 등의 한국의 자연환경으로 그려진 그림 4.생명 존중, 자연보호, 자연 사랑의 교육적, 철학적 이야기를 제시하였다. 본 논문을 통해 자연친화적 캐릭터가 널리 알려지는 계기가 되길 바라며 국내 캐릭터 산업이 다양한 분야로 확장되고 성장해 나가길 기대해 본다.

• 전자공학회논문지SC
• /
• 제46권5호
• /
• pp.8-14
• /
• 2009

음성 인식 연구에서 잡음이 있는 상태에서 음성 발음상의 시작점과 종단점을 찾는 것은 매우 중요하다. 기존 음성인식 시스템의 오차는 대부분 참고템플릿의 시작점과 종단점을 왜란이나 잡음으로 인해 자동적으로 찾지 못했을 경우 발생한다. 따라서 음성 신호상에서 필요 없는 부분을 제거할 수 있는 방법이 필요하다. 기존의 음성 종단점을 찾는 방법으로는 시간도메인 측정방법, 미세시간 에너지 분석, 영교차율 방법이 있다. 위의 방법들은 저주파 신호 노이즈의 영향에 정밀성을 보장을 못한다. 따라서 본 논문에서는 시간영역상에서 리야프노프 지수를 이용한 종단점 인식 알고리즘을 제안하였다. 기존의 방법들과의 비교를 통해 제안한 방법의 성능 우수성을 보였으며, 시뮬레이션 및 실험을 통해 잡음환경에서도 음성종단 인식이 가능함을 보였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9101-9105
• /
• 2014

Background: The purpose of this study was to compare the accuracy and effectiveness of automated breast volume scanning (ABVS) and hand-held ultrasound (HHUS) in the detection of breast cancer in a large population group with a long-term follow-up, and to investigate whether different ultrasound systems may influence the estimation of cancer detection. Materials and Methods: Institutional review board approval was obtained for this retrospective study, and informed consent was waived. From September 2010 to August 2011, a total of 1,866 ABVS and 3,700 HHUS participants, who underwent these procedures at our institute, were included in this study. Cancers occurring during the study and subsequent follow-up were evaluated. The reference standard was a combination of histology and follow-up imaging (${\geq}12months$). The recall rate, cancer detection yield, diagnostic accuracy, sensitivity, specificity, and positive (PPV) and negative (NPV) predictive values were calculated with exact 95% confidence intervals. Results: The recall rate was 2.57 per 1,000 (48/1,866) for ABVS and 3.57 per 1,000 (132/3,700) for HHUS, with a significant difference (p=0.048). The cancer detection yield was 3.8 per 1,000 for ABVS and 2.7 per 1,000 for HHUS. The diagnostic accuracy was 97.7% for ABVS and 96.5% for HHUS with statistical significance (p=0.018). The specificity of ABVS and HHUS were 97.8%, 96.7%, respectively (p=0.022). Conclusions: ABVS shows a comparable diagnostic performance to HHUS. ABVS is an effective supplemental tool for mammography in breast cancer detection in a large population.

• 지구물리와물리탐사
• /
• 제9권1호
• /
• pp.73-85
• /
• 2006

상시진동의 수직 성분에 대한 배열 관측은 상시진동이 대부분 레일리파의 기본 모드로 이루어졌다는 가정하에 지하 층서구조를 추정하기 위해 자주 수행된다. 자료획득, 처리 및 분석의 유용한 도구로서 공간 자기상관(SPAC) 방법이 많이 사용되는데 이는 실제로 M개의 원형 수진기 배열과 중앙의 하나 측점으로 이루어진다 (M 측점 원형 배열). 이 논문에서는 분석 효율 및 현장 노력의 관점에서 효율적인 자료획득을 위한 원형 배열에 필요한 측점의 최소 수에 대해 연구하였다. 이 연구에서는 먼저 M 무한대의 원형 배열을 위한 SPAC 계수들이 단지 Bessel 함수 J0(rk)(r은 반지름, k는 파수)로서 표현되는 SPAC 알고리듬의 이론적 배경을 재정리하였다. 두번째로 M 측점 원형 배열에 대해 상시진동 에너지장과 무관한 오차항을 포함하는 SPAC 계수들을 배열을 가로지르는 파의 방향에 한해 해석적으로 유도해 내고 수치적으로 이들 오차항들에 대해서 평가하였다. 주요 평가 결과들은: 1) 만약 SPAC 계수들이, 계수가 첫번째 최소값을 갖는 주파수까지 이용되면 다른 4-, 5-, 9-측점 배열들에 비교했을 때 3-측점 원형배열이 상시진동의 관측에 효율적이고 유리하다. 2) 나이퀴스트 파수가 유효한 SPAC 계수가 평가될 수 있는 주파수의 상한선을 결정하는데 가장 영향을 끼치는 요소이다.

• 대한암한의학회지
• /
• 제16권1호
• /
• pp.41-53
• /
• 2011

Background and Objectives: Iodine is an essential constituent of the thyroid hormones associated with the growth and development of humans and animals as an inorganic nutrition. This element may be accumulated in human blood, tissues and body through the intake of foodstuffs, a beverage, a nutritional supplement and a medicine, among others. The aim of the research is to find out a better medicinal stuff for the thyroid cancer patient who required a low level of iodine diet. Methods: Neutron activation analysis (NAA) used for the iodine analysis is one of nuclear analytical techniques using radiation and radioisotopes and very useful as sensitive analytical technique for performing both qualitative and quantitative multi-elemental non-destructive analysis of major, minor and trace components in variety of environmental and biological materials. In this study, iodine contents in ten kinds of oriental herb medicinal products, which is frequently used to cancer patients are determined by using instrumental neutron activation analysis (INAA) at the HANARO research reactor. The samples prescribed are manufactured as powdered form for taking medicine easily. The analytical quality control is performed to assure an uncertainty of the measurement and to compensate the measured data using a biological certified reference material, NIST SRM 1572, Citrus Leaves. The measured value is $1.89{\pm}0.35mg/kg$, and the relative error is 2.88%, and relative standard deviation is 19 % due to high counting error by small counts of gamma ray spectrum. The standard deviations for other elements such as Cl, K, Mn and Na were in the range of 2 to 8%. Result: The level of iodine contents of Biki-huan, Chungryong-huan and Chungcho-huan, samples detected is less than 6 mg/kg except Hangam Plus sample (more than 210 mg/kg) and six samples were not detected. Iodine in the samples of Shoxiho-tang, Shopunghualhyl-tang, Shocungryong-tang, Banhasaxim-tang, Insampaedox-san and Myunyuk Plus were not measured, but possible level of content can be estimated from the detection limits. In addition, the concentrations of some major elements like Cl, K, Mn, Na, in the samples were determined with the detection limits. Conclusions: Most of samples showed low iodine contents of less than 6 mg/kg but it turned out that most of testing samples can be used to classify the level of iodine diet samples considering the recommended low level of iodine diet 50 ${\mu}g$/day, and a better medicinal stuff for the thyroid cancer patient can be found.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7567-7573
• /
• 2015

Background: Catastrophic effects of mustard gas as a chemical warfare agent have always been a major problem for those exposed to this agent. In this meta-analysis it was tried to evaluate carcinogenesis, ocular, cutaneous and respiratory complications of mustard gas exposure among Iranians who had been exposed to this agent during the Iran-Iraq war. Materials and Methods: In this meta-analysis, the required data were collected using keywords "mustard gas", "sulfur mustard", "cancer", "neoplasm", "respiratory complications", "ocular complications", "lung disease", "chronic complication", "eye", "skin", "cutaneous complication", "carcinogenesis" and their combination with keywords "Iran", "Iranian", "prevalence", "mortality" and their Farsi equivalent terms from the databases of SID, Iranmedex, Magiran, Pubmed, Science Direct, Google Search engine, Gray Literature and Reference of References. To determine the prevalence of each complication and perform meta-analysis, CMA: 2 (Comprehensive Meta-Analysis) software with a randomized model was used. Results: Of the 542 articles found, 7 national articles, consistent with the aims of this study were selected. Meta-analysis of seven papers revealed that cancer risk, especially cancer of the respiratory system was elevated, so that the relative risk (RR) of cancer role of mustard gas was inconsistent from 2/1 to 4 in this survey. Also prevalence of delayed skin disorders due to sulfur mustard was 94.6%, pulmonary complications 94.5% and ocular complications 89.9%. The incidence of various cancers in victims exposed to mustard gas was 1.7% worldwide where the rate was 2.2% in Iranian victims of the Iraq-Iran war. Conclusions: Based on present study the prevalence of delayed mustard gas related cutaneous, pulmonary and ocular complications is above 90% and risk of carcinogenesis is higher in comparison to worldwide statistics. This may suggest need for long-term and persistent follow-up and rehabilitation procedures for populations exposed to this agent.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7749-7754
• /
• 2015

Background: Currently, cationic liposome has become the commonly used vehicles for gene transfection. Furthermore, one of the most significant steps in microRNAs expression studies is transferring microRNAs into cell cultures successfully. In this study we aim to approach the feasibility of transfection of cervical cancer cell lines mediated by liposome and to obtain the optimized transfection condition for cervical cancer cell lines. Materials and Methods: $Lipofectamine^{TM}2000$ as the carrier, miR-101 mimic was transfected into Hela cells and Siha cells. Using green fluorescent protein as reporter gene, to set different groups according to cell seeding density, the amount of miRNA, miRNA and the proportion of Liposomes, Whether to add serum into medium to study their impact on the liposomal transfection efficiency. Finally, MTT assay was used to analyze the relative minimal cell toxicity of liposome reagents. Results: The seeding density of Hela cell line and Siha are $1.5{\times}10^4$ (per well of 24 well plates), miRNA amount is 1ul of both, the ratio of miRNA and liposome is 1:0.5 of Hela cell line; 1:0.7 of Siha cell line respectively, after 24 hours we can get the highest transfection efficiency. Compared with serum medium, only Siha cells cultured with serum-free medium obtained higher transfection efficiency before transfection (P<0.01). MTT assay showed that according to the above conditions which has the lowest cytotoxicity. Conclusions: The method of Liposome to transfected is a suitable way and it can be an efficient reagent for miRNA delivery for Hela cells and Siha cells in vitro. It may serve as a reference for the further research or application.