• Title/Summary/Keyword: redundant methods

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Systems Pharmacological Analysis of Dichroae Radix in Anti-Tumor Metastasis Activity (시스템 약리학적 분석에 의한 상산의 암전이 억제 효과)

  • Jee Ye Lee;Ah Yeon Shin;Hak Koon Kim;Won Gun An
    • Herbal Formula Science
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    • v.31 no.4
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    • pp.295-313
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    • 2023
  • Objectives : While treatments for cancer are advancing, the development of effective treatments for cancer metastasis, the main cause of cancer patient death, remains insufficient. Recent studies on Dichroae Radix have revealed that its active ingredients have the potential to inhibit cancer metastasis. This study aimed to investigate the cancer metastasis inhibitory effect of Dichroae Radix using network pharmacological analysis. Methods : The active compounds of Dichroae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : In total, 25 active compounds and their 62 non-redundant targets were selected through the TCMSP database and analysis platform. The target genes underwent gene ontology and pathway enrichment analysis. The gene list applied to the gene ontology analysis revealed associations with various biological processes, including signal transduction, chemical synaptic transmission, G-protein-coupled receptor signaling pathways, response to xenobiotic stimulus, and response to drugs, among others. A total of eleven genes, including HSP90AB1, CALM1, F2, AR, PAKACA, PTGS2, NOS2, RXRA, ESR1, ESR2, and NCOA1, were found to be associated with biological pathways related to cancer metastasis. Furthermore, nineteen of the active compounds from Dichroae Radix were confirmed to interact with these genes. Conclusions : The results provide valuable insights into the mechanism of action and molecular targets of Dichroae Radix. Notably, Berberine, the main active ingredient of Dichroae Radix, plays a significant role in degrading AR proteins in advanced prostate cancer. Further studies and validations can provide crucial data to advance cancer metastasis prevention and treatment strategies.

Summarization of Korean Dialogues through Dialogue Restructuring (대화문 재구조화를 통한 한국어 대화문 요약)

  • Eun Hee Kim;Myung Jin Lim;Ju Hyun Shin
    • Smart Media Journal
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    • v.12 no.11
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    • pp.77-85
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    • 2023
  • After COVID-19, communication through online platforms has increased, leading to an accumulation of massive amounts of conversational text data. With the growing importance of summarizing this text data to extract meaningful information, there has been active research on deep learning-based abstractive summarization. However, conversational data, compared to structured texts like news articles, often contains missing or transformed information, necessitating consideration from multiple perspectives due to its unique characteristics. In particular, vocabulary omissions and unrelated expressions in the conversation can hinder effective summarization. Therefore, in this study, we restructured by considering the characteristics of Korean conversational data, fine-tuning a pre-trained text summarization model based on KoBART, and improved conversation data summary perfomance through a refining operation to remove redundant elements from the summary. By restructuring the sentences based on the order of utterances and extracting a central speaker, we combined methods to restructure the conversation around them. As a result, there was about a 4 point improvement in the Rouge-1 score. This study has demonstrated the significance of our conversation restructuring approach, which considers the characteristics of dialogue, in enhancing Korean conversation summarization performance.

Subsequence Matching Under Time Warping in Time-Series Databases : Observation, Optimization, and Performance Results (시계열 데이터베이스에서 타임 워핑 하의 서브시퀀스 매칭 : 관찰, 최적화, 성능 결과)

  • Kim Man-Soon;Kim Sang-Wook
    • The KIPS Transactions:PartD
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    • v.11D no.7 s.96
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    • pp.1385-1398
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    • 2004
  • This paper discusses an effective processing of subsequence matching under time warping in time-series databases. Time warping is a trans-formation that enables finding of sequences with similar patterns even when they are of different lengths. Through a preliminary experiment, we first point out that the performance bottleneck of Naive-Scan, a basic method for processing of subsequence matching under time warping, is on the CPU processing step. Then, we propose a novel method that optimizes the CPU processing step of Naive-Scan. The proposed method maximizes the CPU performance by eliminating all the redundant calculations occurring in computing the time warping distance between the query sequence and data subsequences. We formally prove the proposed method does not incur false dismissals and also is the optimal one for processing Naive-Scan. Also, we discuss the we discuss to apply the proposed method to the post-processing step of LB-Scan and ST-Filter, the previous methods for processing of subsequence matching under time warping. Then, we quantitatively verify the performance improvement ef-fects obtained by the proposed method via extensive experiments. The result shows that the performance of all the three previous methods im-proves by employing the proposed method. Especially, Naive-Scan, which is known to show the worst performance, performs much better than LB-Scan as well as ST-Filter in all cases when it employs the proposed method for CPU processing. This result is so meaningful in that the performance inversion among Nive- Scan, LB-Scan, and ST-Filter has occurred by optimizing the CPU processing step, which is their perform-ance bottleneck.

Assessment of System Reliability and Capacity-Rating of Composite Steel Box-Girder Highway Bridges (합성 강 상자형 도로교의 체계신뢰성 해석 및 안전도평가)

  • Cho, Hyo Nam;Lee, Seung Jae;Kang, Kyoung Koo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.13 no.2
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    • pp.51-59
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    • 1993
  • This paper develops practical and realistic reliability models and methods for the evaluation of system-reliability and system reliability-based rating of various types of box-girder bridge superstructures. The strength limit state model for box-girder bridges suggested in the paper are based on not only the basic flexural strength but also the strength interaction equations which simultaneously take into account flexure, shear and torsion. And the system reliability problem of box-girder superstructure is formulated as parallel-series models obtained from the FMA(Failure Mode Approach) based on major failure mechanisms or critical failure states of each girder. In the paper, an improved IST(Importance Sampling Technique) simulation algorithm is used for the system reliability analysis of the proposed models. This paper proposes a practical but rational approach for the evaluation of capacity rating in terms of the equivalent system-capacity rating corresponding to the estimated system-reliability index which is derived based on the concept of the equivalent FOSM(First Order Second Moment) form of system reliability index. The results of the reliability evaluation and rating of existing bridges indicate that the reserved reliability and capacity rating at system level are significantly different from those of element reliability or conventional methods especially in the case of highly redundant box-girder bridges.

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Immediate Nipple Reconstruction in Breast Reconstruction with TRAM Free Flap (횡복직근 유리피판을 이용한 유방재건술에서의 즉시 유두재건)

  • Kim, Jeong Tae;Kim, Chang Yeon;Cha, Ji Hun;Hwang, Weon Jung
    • Archives of Plastic Surgery
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    • v.32 no.1
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    • pp.76-84
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    • 2005
  • Immediate breast reconstruction in breast cancer patients is universalized and now with a wide variety of methods to choose from, we can select a breast reconstruction method according to the patient's condition. Among these methods, immediate breast reconstruction with TRAM free flap is the most commonly used. Nipple reconstruction is usually performed as a secondary procedure, reconstructed. Nipple is reconstructed with contralateral nipple composite graft or with local flap. Areola is reconstructed with skin graft and tattooing. Therefore, to reconstruct complete breast, two or more staged operations are needed and are troublesome to both the surgeon and the patient. If we could reconstruct breast mound and nipple at same time, we would reduce the operative stages and heighten the patient's satisfaction. The author performed delayed or immediate breast reconstruction with TRAM free flap and nipple reconstruction at the same time. If the TRAM flap was to situate in the whole of the breast or at the center of the breast mound, nipple was reconstructed with a local flap from the TRAM flap. If the TRAM flap was not situated in center of breast mound, nipple was reconstructed with a local flap from remnant breast skin. Immediate nipple reconstructions in breast reconstruction consisted total of 22 cases. Among these, delayed breast reconstruction were 5 cases and immediate breast reconstruction were 17 cases. According to patient's condition and mastectomy method, nipple reconstruction method was selected; nipple reconstruction with contralateral nipple composite graft(3 cases); nipple reconstruction with remnant breast skin(6 cases); nipple reconstruction from flap margin(10 cases); nipple reconstruction with prefabricated nipple on flap(3 cases). Malposition of the reconstructed nipple was the most common and serious complication(6 cases). The other complications were atrophy of the nipple(1 case), and necrosis(1 case). Reconstruction of the breast and nipple at the same time can reduce the need of a secondary operation and use remnant skin or redundant flap tissue maximally. On the other hand, it must be considered that position and shape of nipple could be deformed, because the nipple reconstruction is performed before the shape of reconstructed breast settles completely. Prudent attention is needed, because the danger of complication is higher than delayed nipple reconstruction.

A Study on the Improvement of the Quality Management in Apartment Construction Projects (공동주택 현장의 품질관리 개선에 관한 연구)

  • Moon Hyeon;Wang Ilkook;Chin Sangyoon
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • autumn
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    • pp.373-378
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    • 2001
  • In order to analyze the problems and improvement methods in the quality management of domestic apartment construction projects, this study derived the four barrier factors through relevant literature survey and interviews with construction practitioners. Among these four factors, which are 1) policies and regulations, 2) technologies, 3) human and organization, and 4) other miscellaneous aspects, the human and organization factor is the main focus of this survey and it was decomposed into perception, management system, education, and system on quality management according to the Taguchi's S/N theory to survey existing problems and suggest improvement methods for them. The survey on the quality perception showed that all the members need to cooperate actively, and CEO and chief construction managers should recognize the quality as the highest priority and act by themselves accordingly. The survey on the quality management showed that they need to reform their business process to reduce redundant tasks and miscommunications among participants. Quality education should be provided in a way that people at different management level can be educated differently with close relation to their practices. Quality systems should help corrective actions against quality problems at construction fields. Also with clear quality management implantation polices and objectives, the quality system should be established in order to support better communication among project stakeholders.

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Storage and Retrieval of XML Documents Without Redundant Path Information (경로정보의 중복을 제거한 XML 문서의 저장 및 질의처리 기법)

  • Lee Hiye-Ja;Jeong Byeong-Soo;Kim Dae-Ho;Lee Young-Koo
    • The KIPS Transactions:PartD
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    • v.12D no.5 s.101
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    • pp.663-672
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    • 2005
  • This Paper Proposes an approach that removes the redundancy of Path information and uses an inverted index, as an efficient way to store a large volume of XML documents and to retrieve wanted information from there. An XML document is decomposed into nodes based on its tree structure, and stored in relational tables according to the node type, with path information from the root to each node. The existing methods using path information store data for all element paths, which cause retrieval performance to be decreased with increased data volume. Our approach stores only data for leaf element path excluding internal element paths. As the inverted index is made by the leaf element path only, the number of posting lists by key words become smaller than those of the existing methods. For the storage and retrieval of U data, our approach doesn't require the XML schema information of XML documents and any extension of relational database. We demonstrate the better performance of on approach than the existing approaches within the scope of our experiment.

The Effects of Blanching Temperature and Cooking Methods on the Changes in Vitamin C of Potato (감자의 Vitamin C의 변화에 대한 Blanching 온도 및 조리 방법의 영향)

  • Chung, Hyoun-Mi;Lee, Gui-Ju
    • Korean Journal of Food Science and Technology
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    • v.21 no.6
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    • pp.788-794
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    • 1989
  • This study was attempted to investigate the effects of blanching temperature and cooking methods on the changes in the proportions of vitamin C of fresh potato and potatoes with different storage time. Sensory evaluation of fresh potato by different cooking methods was also conducted. The contents of residual ascorbic acid(AA) and total ascorbic acid(TAA) of fresh potato were maximum at $40^{\circ}C$ followed by rapid decrease at $50-65^{\circ}C$ while leached AA and TAA showed steady increase as the blanching temperature increased. Oxidized AA and dehydroascorbic acid(DHA) hydrolyzed increased at $50-65^{\circ}C$. From these results, it was considered that AA was lost mainly by oxidation up to $65^{\circ}C$ and leaching of AA was the major mode of loss above $65^{\circ}C$. In the case of potatoes stored for 1-4 weeks, they showed similar changes in the proportions of vitamin C as that of fresh potato. However, at $40^{\circ}C$ the content of residual TAA decreased and those of leached TAA and DHA hydrolyzed increased redundant during storage. At $65^{\circ}C$, the content of DHA hydrolyzed decreased The residual TAA of fresh potato by different cooking methods decreased in the order of pressure cooking (PC) > microwave cooking (MC)>boiling. Leached TAA were 49.5% and 36.4%, during boiling and MC, respectively. While DHA hydrolyzed were 22.3% and 4.2%, respectively Leached TAA and DHA hydrolyzed during PC were not determined. From these results, it was considered that AA was lost mainly by leaching during cooking. Residual TAA of stored potatoes by different cooking methods decreased during storage. But leached TAA and DHA hydrolyzed did not show any steady increase or decrease. Overall eating quality of fresh potato by different cooking methods decreased in the order of PC>MC>boiling(p<0.05).

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Comparison of Association Rule Learning and Subgroup Discovery for Mining Traffic Accident Data (교통사고 데이터의 마이닝을 위한 연관규칙 학습기법과 서브그룹 발견기법의 비교)

  • Kim, Jeongmin;Ryu, Kwang Ryel
    • Journal of Intelligence and Information Systems
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    • v.21 no.4
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    • pp.1-16
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    • 2015
  • Traffic accident is one of the major cause of death worldwide for the last several decades. According to the statistics of world health organization, approximately 1.24 million deaths occurred on the world's roads in 2010. In order to reduce future traffic accident, multipronged approaches have been adopted including traffic regulations, injury-reducing technologies, driving training program and so on. Records on traffic accidents are generated and maintained for this purpose. To make these records meaningful and effective, it is necessary to analyze relationship between traffic accident and related factors including vehicle design, road design, weather, driver behavior etc. Insight derived from these analysis can be used for accident prevention approaches. Traffic accident data mining is an activity to find useful knowledges about such relationship that is not well-known and user may interested in it. Many studies about mining accident data have been reported over the past two decades. Most of studies mainly focused on predict risk of accident using accident related factors. Supervised learning methods like decision tree, logistic regression, k-nearest neighbor, neural network are used for these prediction. However, derived prediction model from these algorithms are too complex to understand for human itself because the main purpose of these algorithms are prediction, not explanation of the data. Some of studies use unsupervised clustering algorithm to dividing the data into several groups, but derived group itself is still not easy to understand for human, so it is necessary to do some additional analytic works. Rule based learning methods are adequate when we want to derive comprehensive form of knowledge about the target domain. It derives a set of if-then rules that represent relationship between the target feature with other features. Rules are fairly easy for human to understand its meaning therefore it can help provide insight and comprehensible results for human. Association rule learning methods and subgroup discovery methods are representing rule based learning methods for descriptive task. These two algorithms have been used in a wide range of area from transaction analysis, accident data analysis, detection of statistically significant patient risk groups, discovering key person in social communities and so on. We use both the association rule learning method and the subgroup discovery method to discover useful patterns from a traffic accident dataset consisting of many features including profile of driver, location of accident, types of accident, information of vehicle, violation of regulation and so on. The association rule learning method, which is one of the unsupervised learning methods, searches for frequent item sets from the data and translates them into rules. In contrast, the subgroup discovery method is a kind of supervised learning method that discovers rules of user specified concepts satisfying certain degree of generality and unusualness. Depending on what aspect of the data we are focusing our attention to, we may combine different multiple relevant features of interest to make a synthetic target feature, and give it to the rule learning algorithms. After a set of rules is derived, some postprocessing steps are taken to make the ruleset more compact and easier to understand by removing some uninteresting or redundant rules. We conducted a set of experiments of mining our traffic accident data in both unsupervised mode and supervised mode for comparison of these rule based learning algorithms. Experiments with the traffic accident data reveals that the association rule learning, in its pure unsupervised mode, can discover some hidden relationship among the features. Under supervised learning setting with combinatorial target feature, however, the subgroup discovery method finds good rules much more easily than the association rule learning method that requires a lot of efforts to tune the parameters.

Metagenomic analysis of bacterial community structure and diversity of lignocellulolytic bacteria in Vietnamese native goat rumen

  • Do, Thi Huyen;Dao, Trong Khoa;Nguyen, Khanh Hoang Viet;Le, Ngoc Giang;Nguyen, Thi Mai Phuong;Le, Tung Lam;Phung, Thu Nguyet;Straalen, Nico M. van;Roelofs, Dick;Truong, Nam Hai
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.5
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    • pp.738-747
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    • 2018
  • Objective: In a previous study, analysis of Illumina sequenced metagenomic DNA data of bacteria in Vietnamese goats' rumen showed a high diversity of putative lignocellulolytic genes. In this study, taxonomy speculation of microbial community and lignocellulolytic bacteria population in the rumen was conducted to elucidate a role of bacterial structure for effective degradation of plant materials. Methods: The metagenomic data had been subjected into Basic Local Alignment Search Tool (BLASTX) algorithm and the National Center for Biotechnology Information non-redundant sequence database. Here the BLASTX hits were further processed by the Metagenome Analyzer program to statistically analyze the abundance of taxa. Results: Microbial community in the rumen is defined by dominance of Bacteroidetes compared to Firmicutes. The ratio of Firmicutes versus Bacteroidetes was 0.36:1. An abundance of Synergistetes was uniquely identified in the goat microbiome may be formed by host genotype. With regard to bacterial lignocellulose degraders, the ratio of lignocellulolytic genes affiliated with Firmicutes compared to the genes linked to Bacteroidetes was 0.11:1, in which the genes encoding putative hemicellulases, carbohydrate esterases, polysaccharide lyases originated from Bacteroidetes were 14 to 20 times higher than from Firmicutes. Firmicutes seem to possess more cellulose hydrolysis capacity showing a Firmicutes/Bacteroidetes ratio of 0.35:1. Analysis of lignocellulolytic potential degraders shows that four species belonged to Bacteroidetes phylum, while two species belonged to Firmicutes phylum harbouring at least 12 different catalytic domains for all lignocellulose pretreatment, cellulose, as well as hemicellulose saccharification. Conclusion: Based on these findings, we speculate that increasing the members of Bacteroidetes to keep a low ratio of Firmicutes versus Bacteroidetes in goat rumen has resulted most likely in an increased lignocellulose digestion.