• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권3호
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• pp.295-305
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• 2021

Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.

• Wind and Structures
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• 제35권1호
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• pp.55-66
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• 2022

Tall buildings are often subjected to steady and unsteady forces due to external wind flows. Measurement and mitigation of these forces becomes critical to structural design in engineering applications. Over the last few decades, many approaches such as modification of the external geometry of structures have been investigated to mitigate wind-induced load. One such proven geometric modification involved the rounding of sharp corners. In this work, we systematically analyze the impact of rounded corner radii on the reducing the flow-induced loading on a square cylinder. We perform 3-Dimensional (3D) simulations for high Reynolds number flows (Re=1 × 105) which are more likely to be encountered in practical applications. An Improved Delayed Detached Eddy Simulation (IDDES) method capable of capturing flow accurately at large Reynolds numbers is employed in this study. The IDDES formulation uses a k-ω Shear Stress Transport (SST) model for near-wall modelling that prevents mesh-induced separation of the boundary layer. The effects of these corner modifications are analyzed in terms of the resulting variations in the mean and fluctuating components of the aerodynamic forces compared to a square cylinder with no geometric changes. Plots of the angular distribution of the mean and fluctuating coefficient of pressure along the square cylinder's surface illustrate the effects of corner modifications on the different parts of the cylinder. The windward corner's separation angle was observed to decrease with an increase in radius, resulting in a narrower and longer recirculation region. Furthermore, with an increase in radius, a reduction in the fluctuating lift, mean drag, and fluctuating drag coefficients has been observed.

• Tribology and Lubricants
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• 제38권6호
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• pp.255-260
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• 2022

This research presents tetrahedral amorphous (ta-C) coating on the artificial tooth for improving the durability and functionality (esthtics, foreign body of tooth) by filtered cathodic vacuum arc (FCVA). A differentiated coating method is required for a ta-C coating on polymer owing to the low melting point of the polymer, inter-facial adhesion, low friction, and non-conductivity. Herein, ta-C coating is applied below 50℃, and the potential difference of the carbon plasma drawn to the substrate was controlled by applying a positive duct bias voltage without using a substrate bias voltage. Consequently, the ta-C coating with a thickness of 70nm using the duct bias condition of 20V with the highest plasma intensity satisfies the esthetics of the artificial tooth and had a 5B level of inter-facial adhesion. In addition, the composite hardness of ta-C/polymer is 380 MPa, and correlations with esthetics, sp³ bonding, and mechanical properties. The friction coefficient (CoF) of the ta-C coating in a water-lubricated environment is 0.07, showing a six-fold reduction in CoF compared with that of a polymer.

• Journal of Information Technology Applications and Management
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• 제28권6호
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• pp.97-116
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• 2021

Due to the decrease in the school-age population and government regulations, universities have made great efforts to secure their own competitiveness. In particular, the selection of universities with financial support based on the recent evaluation of the Ministry of Education has become a major concern enough to affect the existence of the university itself. This paper extracts three-year data from 124 major private universities nationwide, and quantitatively analyzes the variables of major universities selected as self-improvement universities, competency reinforcement universities, and universities with limited financial support. As a result of estimating the selection of self-powered universities using the ordered logit model by hierarchically inputting 12 variables, student competitiveness in the metropolitan area (1.318^**), Educational Restitution Rate (4.078^***), University operation expenditure index rate (1.088^***) values were found. Significant positive coefficient values were found in the admission enrollment rate (45.98^***) and the enrollment rate (13.25^***). As a result of analyzing the marginal effects, the increase in the rate of reduction of education costs has always been positive in the selection of self-powered universities, but it was observed that the rate of increase decreases in areas of increase of 150% or more. On the contrary, the probability of becoming a Em-powered university was negative in all sectors, but on the contrary, it was analyzed that marginal effects increased at the same time point. On the other hand, the employment rate of graduates was not able to find direct significance with the result of the selection of Self powered universities. Through this paper, it is expected that each university will analyze the possibility and shortcomings of the selection of Self powered universities in policy making, and in particular, the risk of dropout of selection for the vulnerable field can be predicted using marginal effects. It can be used as major research data for both university evaluators, university officials and students.

• Geomechanics and Engineering
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• 제31권5호
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• pp.505-518
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• 2022

This study introduces soil resistance multipliers at locations encompassed by the zone of influence of the helix plate to consider the added lateral resistance provided to the helical pile. The zone of influence of a helix plate is a function of its diameter and serves as a boundary condition for the modified soil resistance springs. The concept is based on implementing p-multipliers as a reduction factor for piles in group action. The application of modified p-y springs in the analysis of helical piles allows for better characterization and understanding of the lateral behavior of helical piles, which will help further the development of design methods. To execute the proposed method, a finite difference program, HPCap (Helical Pile Capacity), was developed by the authors using Matlab. The program computes the deflection, shear force, bending moment, and soil resistance of the helical pile and allows the user to freely input the value of the zone of influence and Ω (a coefficient that affects the value of the p-multiplier). Results from ten full-scale lateral load tests on helical piles embedded at depths of 3.0 m with varying shaft diameters, shaft thicknesses, and helix configurations were analyzed to determine the zone of influence and the magnitude of the p-multipliers. The analysis determined that the value of the p-multipliers is influenced by the ratio between the pile embedment length and the shaft diameter (D_p), the effective helix diameter (D_h-D_p), and the zone of influence. Furthermore, the zone of influence is recommended to be 1.75 times the helix diameter (D_h). Using the numerical analysis method presented in this study, the predicted deflections of the various helical pile cases showed good agreement with the observed field test results.

• Journal of Electrochemical Science and Technology
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• 제14권1호
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• pp.75-84
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• 2023

The accumulation of spent carbide (YG8), not only pollutes the environment but also causes waste of tungsten, cobalt and other rare metal resources. To better address this issue, we proposed a combined electrochemical separation process of low-temperature aqueous solution and high-temperature molten salt for tungsten and cobalt. H₂WO₄ was obtained from spent carbide in an aqueous solution, and we calcined it to obtain WO₃, which was used as a raw material to obtain tungsten by using molten salt electrodeposition. The influence of the current efficiency and the electrochemical behavior of the discharge precipitation of W(VI) were also studied. The calcination results showed that the morphology of WO₃ was regular and there were no other impurities. The maximum current efficiency of 82.91% was achieved in a series of electrodeposition experiments. According to XRD and SEM analysis, the recovered product was high purity tungsten, which belongs to the simple cubic crystal system. In the W(VI) reduction mechanism experiments, the electrochemical process of W(VI) in NaCl-Na₂WO₄-WO₃ molten salt was investigated using linear scanning voltammetry (LSV) and chronoamperometry in a three-electrode system. The LSV showed that W(VI) was reduced at the cathode in two steps and the electrode reaction was controlled by diffusion. The fitting results of chronoamperometry showed that the nucleation mechanism of W(VI) was an instantaneous nucleation mode, and the diffusion coefficient was 7.379×10^-10 cm²·s^-1.

• 스마트미디어저널
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• 제12권5호
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• pp.28-35
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• 2023

본 연구에서는 음성감정인식의 적용 가능성과 실용성 향상을 위해 적은 수의 파라미터를 가지는 새로운 경량화 모델 RoutingConvNet(Routing Convolutional Neural Network)을 제안한다. 제안모델은 학습 가능한 매개변수를 줄이기 위해 양방향 MFCC(Mel-Frequency Cepstral Coefficient)를 채널 단위로 연결해 장기간의 감정 의존성을 학습하고 상황 특징을 추출한다. 저수준 특징 추출을 위해 경량심층 CNN을 구성하고, 음성신호에서의 채널 및 공간 신호에 대한 정보 확보를 위해 셀프어텐션(Self-attention)을 사용한다. 또한, 정확도 향상을 위해 동적 라우팅을 적용해 특징의 변형에 강인한 모델을 구성하였다. 제안모델은 음성감정 데이터셋(EMO-DB, RAVDESS, IEMOCAP)의 전반적인 실험에서 매개변수 감소와 정확도 향상을 보여주며 약 156,000개의 매개변수로 각각 87.86%, 83.44%, 66.06%의 정확도를 달성하였다. 본 연구에서는 경량화 대비 성능 평가를 위한 매개변수의 수, 정확도간 trade-off를 계산하는 지표를 제안하였다.

• 한국터널지하공간학회 논문집
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• 제11권2호
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• pp.189-198
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• 2009

현재 국내 외에서는 유류 지하 비축 공동, 식품 저장 공동 등과 같은 지하구조물 건설에 대한 관심이 증가하고 있다. 이러한 지하공동의 안정성을 평가할 때 형상비나 굴착면적을 비롯하여 지하공동이 굴착될 암반의 절리 발달 상태는 매우 중요하다. 따라서 본 연구는 형상비가 지하공동의 안정성에 미치는 영향을 안전율 중심으로 분석하였다 이를 위해 양호한 암반 내에 시공되는 공동의 네 가지의 형상비를 가정하고, 토피고, 측압계수, 절리의 간격, 강도 및 방향을 달리하여 민감도 분석을 실시하였다. 공동의 안정성은 강도감소기법을 이용하여 수치해석에 의해 얻은 안전율을 사용하여 평가되었다. 본 논문은 향후 불연속면을 포함한 암반에 시공되는 지하공동 설계 및 안정성 평가에 도웅이 될 수 있을 것으로 기대된다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.75-75
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• 2022

Traditional agriculture mostly focused on activity in the field, but current agriculture faces problems such as reduction of agricultural inputs, labor shortage and so on. Accordingly, traditional agricultural experiments generally considered the simple treatment effects, but current agricultural experiments need to consider the several and complicate treatment effects. To analyze such several and complicate treatment effects, data collection has the first priority. Remote sensing is a quite effective tool to collect information in agriculture, and recent easier availability of UAVs (Unmanned Aerial Vehicles) enhances the effectiveness. LAI (Leaf Area Index) is one of the most important information for evaluating the condition of crop growth. In this study, we utilized UAV with multispectral camera to evaluate plant-based LAI of sweetcorn in a small-scale field experiment and discussed the feasibility of a new experimental design to analyze the several and complicate treatment effects. The plant-based SR measured by UAV showed the highest correlation coefficient with LAI measured by a canopy analyzer in 2018 and 2019. Application of linear mix model showed that plant-based SR data had higher detection power due to its huge number of data although SR was inferior to evaluate LAI than the canopy analyzer. The distribution of plant-based data also statistically revealed the border effect in treatment plots in the traditional experimental design. These results suggest that remote sensing with UAVs has the advantage even in a small-scale experimental plot and has a possibility to provide a new experimental design if combined with various analytical applications such as plant size, shape, and color.

• 한국음향학회지
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• 제43권1호
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• pp.49-59
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• 2024

최근 환경규제가 강화되고 고유가 문제로 인하여 전기차 시장이 점차 커지고 있으며 또한 내연기관 자동차에서도 엔진의 Noise, Vibration, Harshness(NVH) 관련 소음이 저감되고 외부에서 유입되는 소음의 차폐 기술이 발전됨에 따라 Buzz, Squeak, Rattle(BSR) 이음의 민감도가 증가하는 추세이다. 본 연구에서는 자동차의 Panoramic Curved Display(PCD)에서 발생하는 Stick-slip 이음과 고분자 플라스틱의 표면에너지 및 극성 성분과의 상관관계에 대하여 분석하였다. 극성 고분자 소재인 Acrylonitrile Butadiene Styrene(ABS)와 PolyCarbonate-Acrylonitrile Butadiene Styrene(PC-ABS)를 대상으로 컴파운드 소재를 제작하여 평가하였다. 결과적으로 고분자 플라스틱의 극성성분이 3.86 mN/m 이상일 때 Stick-slip 거동이 발생하였으며, 시간에 따른 마찰 거동에서 absolute transition slope가 증가할수록 Stick-slip의 이음 가능성이 증가하고 마찰계수의 값 차이가 클수록 Stick-slip 이음의 세기가 증가하였다.