• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9241-9247
• /
• 2014

Background: Rs31489 in the cleft lip and palate transmembrane1-like gene (CLPTM1L) has been identified to be associated with lung cancer through genome-wide association studies (GWAS). However, some recent replication studies yielded inconclusive results. Thus, we undertook this study to investigate the precise effect of rs31489 on lung cancer susceptibility. Materials and Methods: A hospital-based case-control study in 1,673 Chinese subjects (611 individuals with lung cancer and 1,062 controls) and a meta-analysis among 32,199 subjects (16,364 cases and 15,835 controls) were performed in this study. Results: In our case-control study, rs31489 was inversely associated with lung cancer (AC versus CC: OR=0.68, 95%CI=0.52-0.88; additive model: OR=0.68, 95%CI=0.54-0.85; dominant model: OR=0.65, 95%CI =0.51-0.84). Stratification analysis by smoking status showed a significant association and strong genetic effect in non-smokers but not in smokers. Our meta-analysis further confirmed the association, although with significant heterogeneity contributed by study design and source of controls, as shown by stratified analysis. Sensitive and cumulative analyses both indicated robust stability of our results. In addition, there was no observable publication bias in our meta-analysis. Conclusions: Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.

• 한국정보통신학회논문지
• /
• 제6권8호
• /
• pp.1292-1296
• /
• 2002

본 논문에서는 CFB 구조에 기반한 마이크로스트립 라인을 이용하여 커플링 개수가 3개인 가변 대역통과 필터를 제안한다. 바이어스 전압을 증가시키면 강유전체의 실효 유전율($\varepsilon$eff)이 감소하고, 감소된 실효 유전율은 중심 주파수를 높은 값으로 이동시킨다 설계된 필터는 $\varepsilon$eff이 13～10에 걸쳐, 반사 손실이 10 dB 이상, 삽입손실이 3.5 dB 이하, 3-dB 대역폭이 1.18 GHz 이하, 중심 주파수는 25.4 GHz에서 28.8 GHz까지 이동하므로 가변성은 3.4 GHz에 달하는 특성을 보인다. 필터의 크기는 7.0 mm ${\times}$ 5.0 mm ${\times}$ 0.5 mm이다.

• Journal of Power Electronics
• /
• 제17권1호
• /
• pp.222-231
• /
• 2017

In this paper, a new architecture for a cost-effective power conditioning systems (PCS) using a single-sourced asymmetric cascaded H-bridge multilevel inverter (MLI) for photovoltaic (PV) applications is proposed. The asymmetric MLI topology has a reduced number of parts compared to the symmetrical type for the same number of voltage level. However, the modulation index threshold related to the drop in the number of levels of the inverter output is higher than that of the symmetrical MLI. This problem results in a modulation index limitation which is relatively higher than that of the symmetrical MLI. Hence, an extra voltage pre-regulator becomes a necessary component in the PCS under a wide operating bias variation. In addition to pre-stage voltage regulation for the constant MLI dc-links, another auxiliary pre-regulator should provide isolation and voltage balance among the multiple H-bridge cells in the asymmetrical MLI as well as the symmetrical ones. The proposed PCS uses a single-ended DC-DC converter topology with a coupled inductor and charge-pump circuit to satisfy all of the aforementioned requirements. Since the proposed integrated-type voltage pre-regulator circuit uses only a single MOSFET switch and a single magnetic component, the size and cost of the PCS is an optimal trade-off. In addition, the voltage balance between the separate H-bridge cells is automatically maintained by the number of turns in the coupled inductor transformer regardless of the duty cycle, which eliminates the need for an extra voltage regulator for the auxiliary H-bridge in MLIs. The voltage balance is also maintained under the discontinuous conduction mode (DCM). Thus, the PCS is also operational during light load conditions. The proposed architecture can apply the module-integrated converter (MIC) concept to perform distributed MPPT. The proposed architecture is analyzed and verified for a 7-level asymmetric MLI, using simulation results and a hardware implementation.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2004년도 춘계학술대회 논문집 디스플레이 광소자분야
• /
• pp.193-197
• /
• 2004

The organic light emitting diode (OLED) is proposed as the novel source in the microchip because it has ideal merits (various wavelengths, thin-film structure and overall emitting) for the integration. In this paper, we fabricated the finger-type pin photodiodes for fluorescence detection and the advanced microchip with OLED integrated pn the microchannel. The finger-type in the diode design extended the depletion region and reduced the internal resistance about 31.2% than rectangular-type. The photodiodes had a 100pA leakage current and a 8720 sensitivity $(I_{Light}/I_{Dark})$ at -1 V bias. The interference filter with 32 layers ($SiO_2$, $TiO_2$) was directly deposited on the photodiode. The OLED was fabricated on the ITO coated glass and was bonded with LOC. The application of thin-film OLED increased the excitation efficiency and simplified the integration process extremely. The prototype device of this application had a superior sensitivity of 100nM-LOD in the fluorescence detection.

• 동서간호학연구지
• /
• 제26권1호
• /
• pp.1-16
• /
• 2020

Purpose: The purpose of this study was to evaluate the effectiveness of non-pharmacologic interventions for chronic nonspecific low back pain (CLBP) in adults aged 18-64 years. Methods: We searched for potentially relevant randomized controlled trials and non-randomized controlled trials through five Korean electronic databases (i.e., Korean Studies Information Service System, Research Information Sharing Service, Korean Medical Database, KoreaMed, and National Assembly Library) published from January 2010 to May 2019. Two investigators independently selected the studies based on the criteria and assessed risk of bias in the included studies. We estimated the effect size of interventions using Comprehensive Meta Analysis 3.3. Results: Of 10,151 studies, 26 studies met the inclusion criteria and 15 studies were included in the meta-analysis. Exercise reduced low back pain (Hedges's g=-1.53, 95% CI: -2.22 to -0.85) and pain-related disabilities (Hedges's g=-0.92, 95% CI: -1.40 to -0.45). We found that taping was effective in decreasing low back pain (Hedges's g=-1.12, 95% CI: -1.51 to -0.73) and pain-related disabilities (Hedges's g=-0.50, 95% CI: -0.93 to -0.07). Manual therapy yielded a marginally significant reduction in low back pain (Hedges's g=-2.32, 95% CI: -4.64 to 0.00), the therapy was not effective in decreasing pain-related disabilities. Conclusion: Although there was little evidence for the effectiveness of manual therapy in adults with CLBP, exercise and taping were effective to relieve pain and pain-related disabilities. Based on these findings, we suggest the development of non-pharmacologic interventions or a nursing intervention protocol for the CLBP management. Also, nurses should consider implementation of effective non-pharmacologic interventions for CLBP.

• 한국전자파학회논문지
• /
• 제7권1호
• /
• pp.53-60
• /
• 1996

본 논문에서는 hybrid기법을 이용하여 무궁화 위성의 상향 주파수인 14.0-14.5 GHz에서 동작하는 위성 지구국용 8W 전력증폭기를 설계.제작하였다. 제작의 간편성 때문에 전체 전력 증폭기를 크게 구동 증폭부와 전력 증폭부의 두 부분으로 나누어 설계.제작하였다 또 각 부에 DC 전원 공급을 위 한 바이어스 회로부를 같은 하우정내에 장착하여 무게 및 부피를 최소화하였다 제작된 전력 증폭기는 500 MHz대역폭 내에서 소신호 이득이 $26\pm1dB$, 입.출력 반사손실이 각각 7dB와 12dB이상이었다. 14 GHz, 14.25 GHz와 14.5 GHz 주파수에 대해 ldB 압축접의 출력전력은 39.0-39.2 dBm으로서 설계시 목표로 했던 출력전력 8W를 상회하였다, 본 논문에서 제시한 SSPA 제작기법은 각종 radar 및 SCPC용 고출력 증폭기 설계 및 제작에도 적용할 수 있다.

• 대한의생명과학회지
• /
• 제20권1호
• /
• pp.43-47
• /
• 2014

To understand the effect of prenatal stress on sex-specific changes in embryonic and placental growth, a synthetic glucocorticoid (dexamethasone) was administered intraperitoneally at a dosage of 1 mg/kg body weight (BW) (Dex1) or 10 mg/kg BW (Dex10) to pregnant ICR mice at the gestational days 7.5, 8.5 and 9.5 post coitum (p.c.). Embryos and placentas were then harvested at days 11.5 and 18.5 p.c., and their body weight and size were measured following the determination of sex through PCR using Sry specific primers in tail tissues. As a result, female embryos presented reduced fetal body weight and size in Dex1- and Dex10-treated groups than those of control group at the embryonic day 11.5 p.c. Interestingly, the growth seems to be recovered at day 18.5 as there was no difference in growth between control and dexamethasone treated groups. In the case of males, Dex1 induced a decrease in fetal weight in day 11.5 and this pattern was maintained until day 18.5, whereas their growth was not affected by Dex10 treatment. Placental growth showed similar patterns to fetal growth in both sexes but the extent of reduction was not statistically significant in most cases. Placental weights in Dex1- and Dex10-treated group were decreased significantly in male only. The results imply that the effect of prenatal stress is largely sex dependent due to different strategies for growth and survival in a stressful environment.

• 척추신경추나의학회지
• /
• 제15권1호
• /
• pp.65-74
• /
• 2020

Objectives : This study aimed to evaluate the randomized controlled clinical trials (RCTs) analyzing the effectiveness of Chuna manual therapy (CMT) for benign prostatic hyperplasia (BPH). Methods : Among the literature published until May 2020, a literature search was carried out using 10 electronic databases using related keywords to identify all RCTs that applied CMT for the treatment of BPH. The Cochrane risk of bias tool was used to assess the methodological quality of each RCT. Results : Five RCTs met our inclusion criteria and were included in the analysis. These studies showed that CMT had no positive results compared to herbal medication. However, positive results were shown in terms of an increased efficacy rate, reduced international prostate symptom scores, and increased maximum flow rate when CMT was combined with acupuncture or herbal medication. Conclusions : Based on the analysis, this review has limited evidence of CMT being beneficial in the treatment of BPH. Therefore, further investigation is required using well-designed RCTs to support the effectiveness of CMT and to obtain higher evidence.

• 성인간호학회지
• /
• 제25권2호
• /
• pp.219-230
• /
• 2013

Purpose: This study is reviewed of the available literature to identify the evidence of the value of Kegel exercise programs as an intervention to decrease urinary incontinence and the improvement of the quality of life following a radical prostatectomy in localized prostate cancer. Methods: We searched studies of randomized controlled trials that utilized the Kegel exercise programs with patient with a radical prostatectomy. The review was conducted electronic bibliographic database of Ovid-Medline, Embase, Scopus, KoreaMed and NDSL, etc. Of 630 publications identified, seven studies that met the inclusion criteria, and all studies analyzed by meta-analysis. To ensure the quality of the studies, we used Cochrane's Risk of Bias. Results: Kegel exercise helped patient to achieve continence more quickly (after 1, 3, 6, 12 months) than men not using Kegel exercises. Especially, Kegel exercise significantly reduced the development of urinary incontinence at one month after prostatectomy. The effectiveness of Kegel exercise after prostatectomy was found to improve the quality of life at a significant level. Conclusion: Based on available evidence, Kegel exercise that nurses can teach improved the return to continence more than usual care in men with prostatectomy urinary incontinence.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제12권2호
• /
• pp.275-281
• /
• 2001

본 연구에서는 아동의 발달적 측면을 고려하면서, ADHD 아동의 정신 병리(우울, 불안, 공격성) 수준과 부적응적 인지 특성(인지 오류, 귀인 편파)의 관계를 탐색하였다. 병원을 내원하여 주진단이 ADHD인 40명의 아동과 아동의 어머니는 아동의 우울, 불안, 공격성과 부적응적인 인지 특성들을 평가하는 질문지를 작성하였다. 연구 결과, ADHD 아동의 우울과 불안, 공격성 수준과 부적응적 인지 특성은 유의미한 상관을 보이지 않았다. 연령은 우울증에 특징적인 부적응적인 귀인 특성인 부정적인 사건에 대한 내적 안정적 귀인 경향과 부적인 상관을 보였으며, 연령은 부정적인 사건에 대한 내적 안정적 귀인 경향에 유의미한 영향을 미쳤다. ADHD 아동은 연령이 높아짐에 따라 부정적인 사건에 대해 내부 귀인을 하는 경향이 줄어들었으며, 이들의 우울이나 불안 증상은 부적응적인 인지 특성과 관련되기보다는 그 당시에 직면한 스트레스 사건과 연관된 것일 가능성이 있겠다. 본 연구결과의 시사점과 제한점, 앞으로의 연구방향이 논의되었다.