• 대한한방소아과학회지
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• 제21권3호
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• pp.189-203
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• 2007

Objectives The prognosis, recurrence rate and treatment of febrile seizure were studied through the research of recent western medicine and Chinese oriental medicine paper. Methods Recent western medicine paper of internal and external and chinese oriental medicine paper from 1999 to 2007 were investigated. Results and Conclusions The prognosis of febrile seizure was good in most cases, but children with febrile seizure who developed epilepsy range between 2 and 10%. The risk factors developed epilepsy including complex febrile seizure, focal and prolonged seizure, pre-existing neurodevelopmental abnormalities and recurrent febrile seizure. Recurrence rate of febrile seizure ranges between 30 and 50% was high. The risk factors can be predicted by their age at first febrile seizure happened, family medical history of febrile seizure and epilepsy, complex febrile seizure, and neurodevelopmental abnormalities. However, the most important factor of those is the age when they have first febrile seizure. Diazepam or Lorazepam was administrated for a child with prolonged seizure but only Diazepam was used for reducing recurrence of febrile seizurein febrile illness. However, there were some side effects such as lethargy, ataxia, and irritability. The study of chinese oriental medicine demonstrates that the acupuncture and venesection were used for seizure attack and reduced of recurrences and second attack. To reduce recurrence of febrile seizure, herbal medicine was also used for febrile illness or after seizure attack within a certain period of time, so reduce the recurrence, frequency of seizure and febrile illness. The most of herbs in prescription were used for removing heat and toxic meterials(淸熱解毒), extinguishing wind and to stopping the convulsion(熄風止痙)

• Annals of Clinical Neurophysiology
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• 제4권1호
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• pp.16-20
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• 2002

Background and Objective : Epileptic seizures are frequent complication of lobar hemorrhage. We investigated the factors affecting development of epilepsy following spontaneous lobar ICH. Methods : From January 1986 to July 1999, 114 patients were admitted to Chungnam National University Hospital with spontaneous lobar ICH. We analyzed 75 patients. Excluded were no follow-up(8 patients) and patients died within few days(31 patients). All the patient was followed up at least two years aside from two patients who underwent epileptic seizure and died five and eight months later each. Medical history was obtained through medical record and by telephone interview. Statistical analyses were performed using Chi-square test, Student's t - test, Fisher's exact test. Results : Seizure occurred in 19 patients. As three patients had previous history of seizures, 16 patients(22.2%) showed first onset early- and late-seizures. Early seizure occurred in 14 patients(19.4%). Three out of 14 were heavy alcoholics. Five patients developed late recurrent seizure 61 days to 800 days after the early seizure. Late seizure with no acute seizure occurred in two patients. The types of seizure were diverse as generalized tonic clonic seizure(10), partial seizure with secondary generalization(5), and complex partial seizure(1). The common risk factors for lobar ICH were hypertension(HT), arteriovenous malformation(AVM), and excessive use of alcohol. We could not find any causes in 23 patients. Although size of hematoma, age of onset, sex, incidence of HT or AVM were not different between patients with seizure and without seizure, the history of excessive alcohol drinking was more frequent in patients with seizure. Five patients with late recurrent seizure had ICH involving temporal area. Conclusions : This study suggests that the risk of seizure in patients with lobar ICH was increase in chronic alcoholics and patient with late recurrent seizure had ICH frequently involving temporal area.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1036-1039
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• 2003

Sandifer 증후군은 식도의 역류와 관련되어 음식섭취 후 비특이적인 경련과 자세를 취하게 되는 증후군으로서 증상이 경미할 경우 진단이 지연될 수도 있고 여러 신경학적인 질환과 근골격계의 이상과 감별을 위해 과도한 진단과정이 진행될 수도 있다. 저자들은 흡인성 폐렴과 수유 후 무호흡, 비전형적인 경련을 주소로 한 환아에서 Sandifer 증후군을 의심하고 조기에 진단하여 치료한 1례를 보고하는 바이다.

• 대한한의학회지
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• 제17권2호
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• pp.394-404
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• 1996

Epilepsy is a chronic cerebral. disease resulting from a variety of factors, which is a syndrome with chief complaint of recurrent seizure caused by abnormal electrical discharge of cerebral nerve cell, while the clinical result showed that epilepsia occurs more frequently in pediatrics. A Child having the chief complaint of recerrent vomiting for 2 months undergone the brain and abdominal C.T, MRI, and gastric endoscopy, when the child was normal. While vomiting gas too serious to administer a medicine, a cyclic vomiting repeated with its discontinuation for 2-3 days after continuation for 10 days. As a result, the child visited the ambulatorium of our hospital and then was hospitalized and treated over two times, when there was a remarkably improvement. There was no any particular complaint for 1 year and 2 months, then, the child complained moderate headache. For thjs reason, we performed again electroencephalography, when there appeared in epilepsia opinion. Since then, we have experienced a case of autonomic nervous seizure which was significantly improved by anticonvulsant, and a therapy by using the phlegm resolvents and central stimulants for treating epilepsy(豁痰醒腦治癎法) as an oriental medicine. Therefore, it is to report both treatment view of oriental medicine and analysis on Oriental and Western medical literatures.

• Journal of Korean Neurosurgical Society
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• 제57권4호
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• pp.298-302
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• 2015

This case report describes the symptoms and clinical course of a 35-year-old female patient who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first presentation the patient complained about recurrent nasal discharge of clear fluid which had begun some weeks earlier. She also reported that three months earlier she had for the first time suffered from a generalized seizure. In a first therapeutic attempt an endoscopic endonasal approach to the sphenoid sinus was performed. An attempt to randomly seal the suspicious area failed. After frontotemporal craniotomy, it was possible to localize the encephalocele and the underlying bone defect. The herniated brain tissue was resected and the dural defect was closed with fascia of the temporalis muscle. In summary, the combination of recurrent rhinorrhea and a first-time seizure should alert specialists of otolaryngology, neurology and neurosurgery of a temporo-sphenoidal encephalocele as a possible cause. Treatment is likely to require a neurosurgical approach.

• 전기전자학회논문지
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• 제22권4호
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• pp.1175-1179
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• 2018

본 논문에서는 뇌파 신호를 이용하여 환자의 경련을 감지하는 순환 CNN (Convolutional Neural Networks)을 제안한다. 제안 된 방법은 뇌파 신호의 스펙트럼 특성과 전극의 위치를 보존하기 위해 영상으로 데이터를 매핑하여 처리하였다. 스펙트럼 전처리 과정을 거친 후 CNN에 입력하고 공간 및 시간 특성을 웨이블릿 변환(wavelet transform)없이 추출하여 발작을 검출하였다. 여기에 사용된 보스턴 매사추세츠 공과 대학 (Boston Massachusetts Institute of Technology, CHB-MIT) 아동 병원의 데이터셋 결과는 시간당 0.85의 민감도와 90 %의 위양성 비율 (FPR)을 보였다.

• Clinics in Shoulder and Elbow
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• 제12권1호
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• pp.98-101
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• 2009

목적: 본 증례 보고는 드물게 보고되고 있는 간질 발작과 동반된 견관절 전방 불안정성에서 발견되는 골병변을 기술하고 고빈도의 재발 요인을 파악하고자 하였다. 대상 및 방법: 저자들은 전간 발작과 동반된 2례의 재발성 전방 탈구를 경험하였으며 본 증례 통하여 일반적인 재발성 견관절 탈구에 준하여 치료하면서 정기적으로 경과를 관찰하였다. 결과: 본 두 증례에서 수술의 경과는 전간 발작의 조절 여부에 따라 경과가 결정됨을 알 수 있었다. 즉 간질 조절이 잘된 환자에서는 안정성을 유지할 수 있었으나 발작이 조절되지 않은 전방 불안정성의 경우 결국 재발성 탈구가 유발되게 되었다. 결론: 전간 발작과 동반된 견관절 불안정성에서 재발 방지를 위해서는 경련 조절이 필수적인 인자임을 인지하게 되었다.

• Korean Journal of Anesthesiology
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• 제71권6호
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• pp.483-485
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• 2018

A 34-year-old man who previously underwent a craniotomy due to oligodendroglioma was admitted with a diagnosis of recurrent brain tumor. An awake craniotomy was planned. Approximately 15 minutes after completing the scalp nerve block, his upper torso suddenly moved and trembled for 10 seconds, suggesting a generalized clonic seizure. He recovered gradually and fully in 55 minutes without any neurological sequelae. The emergency computed tomography scan revealed a localized fluid collection and small intracerebral hemorrhage nearby in the temporoparietal cortex beneath the skull defect. He underwent surgery under general anesthesia at 8 hours after the seizure and was discharged from the hospital after 10 days. This report documents the first case of generalized seizure that was caused by the accidental intracerebral injection of local anesthetics. Although the patient recovered completely, the clinical implications regarding the scalp infiltration technique in a patient with skull defects are discussed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제10권2호
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• pp.202-205
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• 2007

저자들은 6세 된 남아에서 4년간의 반복적이고, 발작적인 복통의 원인을 규명하던 중 만성 복통의 타 기질적 질환들이 배제되고, 뇌파 검사의 이상 소견과 함께 항경련제의 사용에 증상의 극적인 소실을 보여 복성 간질로 진단된 1예를 경험하고 문헌 고찰과 함께 보고하는 바이다.

• Natural Product Sciences
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• 제23권1호
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• pp.40-45
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• 2017

Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs produce various side effects such as tolerance and sedation. Thus, there is a growing interest for alternative anticonvulsive drugs, preferably from natural or herbal sources. In this study, we evaluated the anticonvulsive effects of Rehmannia glutinosa (RG). The anticonvulsive effect of RG extract was evaluated using electroshock- and chemical-induced seizure tests in mice. To identify its probable mechanism of action, the effects of RG extract on $Cl^-$ influx was measured in vitro. We found that RG extract has anticonvulsive effects against electroshock-induced seizures, as indicated by an increased seizure threshold in mice. The RG extract also decreased the percentage of seizure responses induced by the GABAergic antagonist, pentylenetetrazole. These results suggest that the anticonvulsive effects of RG extract are mediated through a GABAergic mechanism. In support of this mechanism, our in vitro test showed that RG extract increases intracellular $Cl^-$ influx. Furthermore, RG extract did not show sedative and/or muscle relaxant effects in the open-field and rota-rod tests. Altogether, these results confirm that RG extract could be a herbal anticonvulsant and a potential alternative for clinical use.