• Korean Journal of Radiology
• /
• 제24권3호
• /
• pp.235-246
• /
• 2023

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27-82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrast-enhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46-4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01-2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.

• Wind and Structures
• /
• 제18권6호
• /
• pp.633-650
• /
• 2014

The uncertainty of extreme wind speeds is one key contributor to the uncertainty of wind loads and their effects on structures. The probability distribution of annual extreme wind speeds may be characterized using a classical Gumbel Type distribution. The expression that establishes the relationship between the extreme wind speeds at different recurrence periods and the corresponding coefficients of variation is formulated, and its efficacy is validated. The coefficients of variation are calibrated to be about 0.125 and 0.184 according to defined Chinese and US design specifications, respectively. Based on the wind data of 54 cities in China, 49 meteorological stations in the US, 3 stations in Singapore, the coefficients span intervals of (0.1, 0.35), (0.08, 0.20) and (0.06, 0.14), respectively. For hurricanes in the US, the coefficients range approximately from 0.3 to 0.4. This convenient technique is recommended as one alternative tool for coefficient of variation analyses in the future revisions of related codes. The sensitivities of coefficients of variation for 49 meteorological stations in the US are quantified and demonstrated. Some contradictions and incompatibilities can be clearly detected and illustrated by comparing the coefficients of variation obtained with different combinations of recurrence period wind data.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권16호
• /
• pp.6843-6848
• /
• 2014

Background: Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer. Methods: A total of 36 lung cancer patients with recurrence or metastasis were enrolled in this study. While 16 patients underwent magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography-computed tomography (PET-CT), 17 underwent MRI and CT, and 3 underwent MRI and PET-CT. Results: Each recurrence or metastasis showed decreased diffusion, which was easily recognized in DWI. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. Detection rate of DWI was significantly higher than that of CT (p=0.0244) but not significantly higher than that of PET-CT (p=0.22). When the optimal cutoff value of the apparent diffusion coefficient value was set as $1.70{\times}10^{-3}mm^2/sec$, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%. Conclusions: DWI is useful for detection of recurrence and metastasis of lung cancer.

• Korean Journal of Mathematics
• /
• 제30권3호
• /
• pp.433-442
• /
• 2022

Let N^(q) be an arithmetic table of a negative exponent polynomial with q-commuting variables. We study sequential properties of diagonal sums of N^(q). We first device a q-coefficient table $\hat{N}$ of N^(q), find sequences of diagonal sums over $\hat{N}$, and then retrieve the findings of $\hat{N}$ to N^(q). We also explore recurrence rules of s-slope diagonal sums of N^(q) with various s and q.

• 대한토목학회논문집
• /
• 제31권4B호
• /
• pp.361-367
• /
• 2011

하천 정비 및 하천 복업사업의 기준유량이 되는 하도형성유량 산정은 안정하도 설계시 반드시 선행되어야 하는 것이다. 국내의 경우 하도형성유량 산정방법에 대한 연구가 많이 수행되지 않아 특정패턴을 도출하기가 어려운 실정이다. 국내하천의 경우 외국의 주요하천과 비교하여 하상계수가 크게 나타나는 특성으로 인해 외국사례를 국내에 적용하기에 어려움이 있다. 따라서 현재 구하도 복원이 진행 되고 있거나 계획되어 있는 만경강, 청미천, 함평천을 대상으로 하도형성유량 산정을 위해 만제유량, 특정 재현기간별 유량, 유효유량을 산정해보고 각각의 상호관계를 분석하여 하상계수가 큰 국내하천에 적용 가능한 하도형성유량을 제안하고자 한다. 만제유량은 대상유역의 지형자료를 이용한 HEC-RAS 모의를 통해 산정하였으며 특정 재현기간별 유량과 유효유량은 대상구간의 유량, 하상토, 유사 자료를 이용하여 산정하였다. 산정결과 하상계수가 큰 하천에서는 유효유량이 만제유량보다 크게 나타났으며 하상계수와 관련하여 특정 재현기간별 유량은 일관성 있는 특징이 없는 것으로 나타났다.

• 대한족부족관절학회지
• /
• 제23권4호
• /
• pp.159-165
• /
• 2019

Purpose: This study investigated the recurrence rate after performing hallux valgus correction using scarf and Akin osteotomy, and also identified the correlation and cut-off values of both the preoperative and postoperative radiographic parameters as risk factors for the recurrence of hallux valgus. Materials and Methods: We reviewed 87 hallux valgus patients (122 feet) who received scarf and Akin osteotomy from January 2007 to August 2015. The clinical outcomes were evaluated using the visual analogue scale (VAS) and American Orthopaedic Foot and Ankle Society (AOFAS) scores. The radiological outcome measures included the hallux valgus angle (HVA), intermetatarsal angle (IMA), and distal metatarsal articular angle (DMAA) as determined on the serial weight bearing radiographs. Recurrence was defined as more than 20 degrees of HVA noted on the final follow-up radiograph. Those radiological factors associated with recurrence were evaluated and analyzed. Results: The mean follow-up duration was 20.6 months (12.0~46.5 months) and the mean age was 44 years (13~80 years). The VAS and AOFAS scores were significantly improved at the time of the final follow-up (7.0 to 2.0, p<0.001; 78.0 to 92.0, p<0.001; respectively). Significant corrections in the HVA, IMA, and DMAA were obtained (p<0.001). Eleven (9.0%: 11/122) cases experienced recurrent hallux valgus deformity. The postoperative IMA, DMAA and HVA showed significant moderate to strong correlation with HVA at the final follow-up (Pearson correlation coefficient: 0.44, 0.70, and 0.88, respectively; p<0.001). Postoperative HVA>16.7 degrees, postoperative DMAA>13.9 degrees, and postoperative IMA>8.2 degrees showed statistically significant correlation with radiological recurrence at the last follow-up, and the odds ratio of each variable was high in order. Conclusion: Our radiographic results indicated that postoperative HVA>16.7 degrees, postoperative DMAA>13.9 degrees, and postoperative IMA>8.2 degrees can be risk factors for hallux valgus recurrence. These risk factors may be helpful for modifying surgical procedures and preventing the recurrence of hallux valgus.

• Korean Journal of Radiology
• /
• 제23권11호
• /
• pp.1078-1088
• /
• 2022

Objective: To develop and validate a model using radiomics features from apparent diffusion coefficient (ADC) map to diagnose local tumor recurrence in head and neck squamous cell carcinoma (HNSCC). Materials and Methods: This retrospective study included 285 patients (mean age ± standard deviation, 62 ± 12 years; 220 male, 77.2%), including 215 for training (n = 161) and internal validation (n = 54) and 70 others for external validation, with newly developed contrast-enhancing lesions at the primary cancer site on the surveillance MRI following definitive treatment of HNSCC between January 2014 and October 2019. Of the 215 and 70 patients, 127 and 34, respectively, had local tumor recurrence. Radiomics models using radiomics scores were created separately for T2-weighted imaging (T2WI), contrast-enhanced T1-weighted imaging (CE-T1WI), and ADC maps using non-zero coefficients from the least absolute shrinkage and selection operator in the training set. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of each radiomics score and known clinical parameter (age, sex, and clinical stage) in the internal and external validation sets. Results: Five radiomics features from T2WI, six from CE-T1WI, and nine from ADC maps were selected and used to develop the respective radiomics models. The area under ROC curve (AUROC) of ADC radiomics score was 0.76 (95% confidence interval [CI], 0.62-0.89) and 0.77 (95% CI, 0.65-0.88) in the internal and external validation sets, respectively. These were significantly higher than the AUROC values of T2WI (0.53 [95% CI, 0.40-0.67], p = 0.006), CE-T1WI (0.53 [95% CI, 0.40-0.67], p = 0.012), and clinical parameters (0.53 [95% CI, 0.39-0.67], p = 0.021) in the external validation set. Conclusion: The radiomics model using ADC maps exhibited higher diagnostic performance than those of the radiomics models using T2WI or CE-T1WI and clinical parameters in the diagnosis of local tumor recurrence in HNSCC following definitive treatment.

• Wind and Structures
• /
• 제37권2호
• /
• pp.117-131
• /
• 2023

Korea Design Standard (KDS) will be updated with two major revisions on the assessment of wind load and performance-based wind design (PBWD). Major changes on the wind load assessment are the wind load factor and basic wind speed. Wind load factor in KDS is reduced from 1.3 to 1, and mean recurrence interval (MRI) for basic wind speed increases from 100 years to 500 years considering the reduction of wind load factor. Additional modification is made including pressure coefficient, torsional moment coefficient and spectrum, and aeroelastic instability. Combined effect of the updates of KDS code on the assessment of wind load is discussed with the case study on the specified sites and building. PBWD is newly added in KDS code to consider the cases with various target performance, vortex-induced vibration, aeroelastic instability, or inelastic behavior. Proposed methods and target performance for PBWD in KDS code are introduced.

• 상하수도학회지
• /
• 제23권5호
• /
• pp.599-608
• /
• 2009

This manuscript covers the results of field investigation and lab-scale experiments to design a double-layered biofilter system to control urban storm runoff. The biofilter system consisted of a coarse soil layer (CSL) for filtration and fine soil layer (FSL) for adsorption and biological degradation. The variations of flow rate and water quality of runoff from a local expressway were monitored for seven storm events. Laboratory column experiments were performed using seven kinds of soil and mulch to maximize pollutants removal. The site mean concentration (SMC) of storm runoff from the drainage area (runoff coefficient: 0.92) was measured to be 203 mg/L for SS, 307 mg/L for $TCOD_{Cr}$, 12.3 mg/L for TN, 7.3 mg/L for ${NH_4}^+-N$, and 0.79 mg/L for TP, respectively. This study employed a new design concept, to cover the maximum rainfall intensity with one month recurrence interval. Effective storms for last ten years (1998-2007) in seoul suggested the design rainfull intensity to be 8.8 mm/hr Single layer soil column showed the maximum removal rate of pollutants load when the uniformity coefficient of CSL was 1.58 and the silt/clay contents of FSL was virtually 7%. The removal efficiency during operation of double layer soil column was 98% for SS and turbidity, 75% for TCODCr, 56% for ${NH_4}^+-N$, 87% for TP, and 73-91% for heavy metals. The hydraulic conductivity of the soil column, 0.023 cm/sec, suggested that the surface area of the biofilter system should be about 1% of the drainage area to treat the rainfall intensity of one month recurrence interval.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권15호
• /
• pp.6425-6428
• /
• 2014

Background: Prostatic adenocarcinoma is one of the main causes of cancer death, and its timely diagnosis and preventing its progression dramatically helps improve life indexes. Given the high disease recurrence rate, today, research is more inclined toward exploring causes of recurrence and development, and innovation of modern treatment methods. Several studies have explored over-expression of human epidermal growth factor receptor 2 (HER-2/neu) in prostatic cancer so far, with different results. Thus, it was decided to investigate HER-2/neu overexpression in patients with prostatic adenocarcinoma in Iran. Materials and Methods: A sample size of 40 patients with prostate cancer entered the study, using a cross-sectional, non-randomized sampling method. Parameters studied included patient age at surgery, Gleason score, serum prostatic specific antigen (PSA) before surgery, and positive sample rate after immunohistochemical staining to investigate HER-2/neu overexpression. Results: In terms of HER-2/neu receptor staining rate, of 40 slides, 16 (40%) scored 0, 13 (32.5%) 1+, 7 (17.5%) 2+, and 4 (10%) 3+. In total 27.5% of slides showed HER-2/neu overexpression. In terms of age, an inverse correlation was found (-0.181), but without significance (p=0.263). In terms of serum PSA, the correlation coefficient was 0.449 (p=0.004). With respect to Gleason score, the coefficient was 0.190 (p=0.240). Conclusions: In this study, HER-2/neu overexpression occurred in 27.5% of prostate cancer cases, which is a relatively high figure, compared to similar studies elsewhere. While, we failed to reveal any relationship between HER-2/neu expression status with progression and prognosis of disease, it was demonstrated that the serum PSA level was significantly higher in cases with increased receptor expression.