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http://dx.doi.org/10.7314/APJCP.2014.15.16.6843

Recurrence and Metastasis of Lung Cancer Demonstrate Decreased Diffusion on Diffusion-Weighted Magnetic Resonance Imaging  

Usuda, Katsuo (Department of Thoracic Surgery, Kanazawa Medical University)
Sagawa, Motoyasu (Department of Thoracic Surgery, Kanazawa Medical University)
Motomo, Nozomu (Department of Thoracic Surgery, Kanazawa Medical University)
Ueno, Masakatsu (Department of Thoracic Surgery, Kanazawa Medical University)
Tanaka, Makoto (Department of Thoracic Surgery, Kanazawa Medical University)
Machida, Yuichiro (Department of Thoracic Surgery, Kanazawa Medical University)
Maeda, Sumiko (Department of Thoracic Surgery, Kanazawa Medical University)
Matoba, Munetaka (Department of Radiology, Kanazawa Medical University)
Tonami, Hisao (Department of Radiology, Kanazawa Medical University)
Ueda, Yoshimichi (Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University)
Sakuma, Tsutomu (Department of Thoracic Surgery, Kanazawa Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6843-6848 More about this Journal
Abstract
Background: Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer. Methods: A total of 36 lung cancer patients with recurrence or metastasis were enrolled in this study. While 16 patients underwent magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography-computed tomography (PET-CT), 17 underwent MRI and CT, and 3 underwent MRI and PET-CT. Results: Each recurrence or metastasis showed decreased diffusion, which was easily recognized in DWI. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. Detection rate of DWI was significantly higher than that of CT (p=0.0244) but not significantly higher than that of PET-CT (p=0.22). When the optimal cutoff value of the apparent diffusion coefficient value was set as $1.70{\times}10^{-3}mm^2/sec$, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%. Conclusions: DWI is useful for detection of recurrence and metastasis of lung cancer.
Keywords
Lung cancer; recurrence; metastasis; diagnosis; magnetic resonance imaging; diffusion-weighted imaging;
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1 Blyth S, Blakeborough A, Peterson M, Cameron IC, Majeed AW (2008). Sensitivity of magnetic resonance imaging in the detection of colorectal liver metastases. Ann R Coll Surg Engl, 90, 25-8.   DOI   ScienceOn
2 Ceylan K, Taken K, Gecit I, et al (2010). Comparison of cystoscopy with diffusion-weighted magnetic resonance images used in the diagnosis and follow-up of patients with bladder tumors. Asian Pac J Cancer Prev, 11, 1001-4.
3 Fornasa F, Pinali L, Gasparini A, Toniolli E, Montemezzi S (2011). Diffusion-weighted magnetic resonance imaging in focal breast lesions. Analysis of 78 cases with pathological correlation. Radiol med, 116, 264-75.   DOI
4 Ghanem N, Uhl M, Brink I, et al (2005). Diagnostic value of MRI in comparison to scintigraphy, PET, MS-CT and PET/CT for the detection of metastases of bone. Eur J Radiol, 55, 41-55.   DOI   ScienceOn
5 Koike N, Cho A, Nasu K, et al (2009). Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions. World J gastroenterol, 15, 5805-12.   DOI
6 Le Bihan D, Breton E, Lallemand D, et al (1988). Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology, 168, 497-505.   DOI
7 Mori T, Nomori H, Ikeda K, et al (2008). Diffusion-weighted magnetic resonance imaging for diagnosing malignant pulmonary nodules/masses. Comparison with positron emission tomography. J Thoracic Oncol, 3, 358-64.   DOI   ScienceOn
8 Naiki T, Okamura T, Nagata D, et al (2011). Preoperative prediction of neurovascular bundle involvement of localized prostate cancer by combined T2 and diffusion-weighted imaging of magnetic resonance imaging, number of positive biopsy cores and Gleason score. Asian Pac J Cancer Prev, 12, 909-13.
9 Ohba Y, Nomori H, Mori T, et al (2009). Is diffusion-weighted magnetic resonance imaging superior to positron emission tomography with fludeoxyglucose F 18 in imaging non-small cell lung cancer? J Thorac Cardiovasc Surg, 138, 439-45.   DOI
10 Rakheja R, Chandarana H, DeMello L, et al (2013). Correlation between standardized uptake value and apparent diffusion coefficient of neoplastic lesions evaluated with whole-body simultaneous hybrid PET/MRI. Am J Roentgenol, 201, 1115-9.   DOI
11 Sorensen AG, Buonanno FS, Gonzalez RG, et al (1996). Hyperacute stroke. Evaluation with combined multisection diffusion-weighted and hemodynamically weighted echoplanar MR imaging. Radiology, 199, 391-401.   DOI
12 Szafer A, Zhong J, Gore JC (1995). Theoretical model for water diffusion in tissues. Magn Reson Med, 33, 697-712.   DOI
13 Tondo F, Saponaro A, Stecco A, et al (2011). Role of diffusionweighted imaging in the differential diagnosis of benign and malignant lesions of the chest-mediastinum. Radiol Med, 116, 720-33.   DOI
14 Takahara T, Imai Y, Yamashita T, (2004). Diffusion weighted whole body imaging with background body signal suppression (DWIBS). Technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med, 22, 275-82.
15 Takenaka D, Ohno Y, Matsumoto K, et al (2009). Detection of bone metastases in non-small cell lung cancer patients: comparison of whole-body diffusion-weighted imaging (DWI), whole-body MR imaging without and with DWI, whole-body FDG-PET/CT, and bone scintigraphy. J Magn Reson Imaging, 30, 298-308.   DOI
16 Tien RD, Felsberg GJ, Friedman H, Brown M, MacFall J (1994). MR imaging of high-grade cerebral gliomas. Value of diffusion-weighted echoplanar pluse sequences. AJR. 162, 671-7.   DOI   ScienceOn
17 Usuda K, Zhao XT, Sagawa M, et al (2011). Diffusion-weighted imaging is superior to PET in the detection and nodal assessment of lung cancers. Ann Thorac Surg, 91, 1689-95.   DOI
18 Usuda K, Sagawa M, Motono N, et al (2013). Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography in assessment of hilar and mediastinal lymph node in lung cancer. Ann Surg Oncol, 20, 1676-83.   DOI
19 Usuda K, Zhao XT, Sagawa M, et al (2013). Diffusion-weighted imaging (DWI) signal intensity and distribution represent the amount of cancer cells and their distribution in primary lung cancer. Clinical Imaging, 37, 265-72.   DOI   ScienceOn
20 Usuda K, Sagawa M, Motomo N, et al (2014). Diagnostic performance of diffusion weighted imaging of malignant and benign pulmonary nodules and masses. Comparison with positron emission tomography. Asian Pac J Cancer Prev, 15, 4629-35.   과학기술학회마을   DOI
21 Yamamura J, Salomon G, Buchert R, et al (2011). Magnetic resonance imaging of prostate cancer. Diffusion-weighted imaging in comparison with sextant biopsy. J Comput Assist Tomog, 35, 223-8.   DOI