• Journal of Radiation Protection and Research
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• v.36 no.4
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• pp.230-236
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• 2011

As a way of improving social receptivity of using radiation, this study looked into the difference of understanding the need of using radiation in various fields between students majoring in radiation and non-radiation related studies, who will influence public opinion in the long term. This study also provides data needed for developing efficient strategies for projects promoting the public's awareness of using radiation. Of the students in the 79 schools sampled, 24%(177) were in 4 year colleges and 146 were junior colleges in educational statistics service (http://cesi.kedi.re.kr) In November 2010 1,945 students were selected as a sample, and they were given surveys on the need of using radiation in different fields. As a result, both between students majoring in radiation and non-radiation related studies showed a high level of understanding the need for radiation in the medical field and showed a low level of understanding of the need for radiation in the agricultural field. In all 6 fields of radiation use, students majoring in radiation related studies showed higher levels of understanding for the need to use radiation than students majoring in radiation and non-radiation related studies. In each field, male students and those who have experience medical radiation and relevant education had higher level of understanding. This shows we need to improve the understanding of the cases of female students and those who have not had experiences with medical radiation and to provide relevant education through various kinds of information. The characteristics of the groups that are shown in the results of this study are considered to be helpful for efficiently for project promoting the public's awareness of using radiation.

• The Journal of the Korea Contents Association
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• v.12 no.11
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• pp.49-57
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• 2012

Recently as the user experience's importance has been emphasized, there has been many tries of various research methodology in order to understand the user. Specially, as the political investigation method's user understanding method based on the statistical analysis so far has encountered a limit, there has been a continuous tendency to try to introduce a humanitarian or cultural anthropological methodology. As part of this effort, there has been many tries of various approach methods of the Ethnography which is the cultural anthropological typical research methodology, but among those the Diary Study Method is mentioned as one of the effective methodologies. Therefore this thesis applies the Diary Study Method to the notebook PC bundle SW's attitude research and tries a deep rooted research about the user attitude. Also centered to the project of understanding the notebook PC bundle SW's user receptivity. it shows a specific example of the Diary Study applied to the user understanding. Through this process, we will examine the summary about the Ethnography research method, and will discuss an effective research methodology by through the process of analyzing and deducting the user inclination by applying and designing the Diary Study to the project. That is to say, it was progressed by actually applying the research methodology through a specific case, with the purpose of breaking away from the textbook discussion and progress with an application aspect discussion. Through the current research, we will verify an active user-inclined process about the user's notebook PC SW, and it is expected to be useful in establishing a SW UX strategy and distribution related to the bundle software.

• Clinical and Experimental Reproductive Medicine
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• v.47 no.2
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• pp.114-121
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• 2020

Objective: Despite extensive research on implantation failure, little is known about the molecular mechanisms underlying the crosstalk between the embryo and the maternal endometrium, which is critical for successful pregnancy. Profilin 1 (PFN1), which is expressed both in the embryo and in the endometrial epithelium, acts as a potent regulator of actin polymerization and the cytoskeletal network. In this study, we identified the specific role of endometrial PFN1 during embryo implantation. Methods: Morphological alterations depending on the status of PFN1 expression were assessed in PFN1-depleted or control cells grown on Matrigel-coated cover glass. Day-5 mouse embryos were cocultured with Ishikawa cells. Comparisons of the rates of F-actin formation and embryo attachment were performed by measuring the stability of the attached embryo onto PFN1-depleted or control cells. Results: Depletion of PFN1 in endometrial epithelial cells induced a significant reduction in cell-cell adhesion displaying less formation of colonies and a more circular cell shape. Mouse embryos co-cultured with PFN1-depleted cells failed to form actin cytoskeletal networks, whereas more F-actin formation in the direction of surrounding PFN1-intact endometrial epithelial cells was detected. Furthermore, significantly lower embryo attachment stability was observed in PFN1-depleted cells than in control cells. This may have been due to reduced endometrial receptivity caused by impaired actin cytoskeletal networks associated with PFN1 deficiency. Conclusion: These observations definitively demonstrate an important role of PFN1 in mediating cell-cell adhesion during the initial stage of embryo implantation and suggest a potential therapeutic target or novel biomarker for patients suffering from implantation failure.

• Journal of Digital Convergence
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• v.19 no.10
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• pp.453-467
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• 2021

In this study, the autoregressive cross-lagged model was applied to verify the longitudinal correlation between the three factors and the pattern of changes over time in the mother's cultural adaptation type, the multicultural acceptability of multicultural adolescents, and national identity. For the study, longitudinal data from the 2nd, 4th, 6th, and 8th years of the MAPS tracked from the 5th grade of elementary school to the 2nd grade of high school were used for analysis. As a result of the analysis, all four types of mother's acculturation were analyzed to have a significant longitudinal effect over time. The four types of mothers' cultural adaptation were analyzed to have a longitudinal mediating effect on the relationship between the national identity of multicultural youth. Based on these analysis results, it is necessary to provide a continuous acculturation support program. In order to have a sense of belonging and solidarity with the country, it was suggested that education to increase multicultural receptivity should be carried out in parallel.

• Journal of the Korea Convergence Society
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• v.12 no.9
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• pp.239-250
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• 2021

This study has been conducted to identify the theoretical understanding of cultural competence by systematically reviewing national and international quantitative studies on 'nurses' and 'nursing students' cultural competence dimensions. A literature search was conducted over approximately three months from June to August 2020, targeting academic journals and dissertations published from January 1, 2010, to December 31, 2019. Literature extraction was conducted according to the PRISMA guidelines, and 67 papers from a total of 1,175 were selected for the systematic literature review. As a result, the most commonly measured component was cultural perception, other dimensions included cultural knowledge, cultural skills, cultural sensitivity, cultural encounter, cultural attitude, cultural behavior, cultural longings and cultural receptivity, cultural experience, cultural security, cultural ethics, cultural beliefs, cultural practice, motivation and curiosity, cultural emotions and empathy. Therefore, in order to improve the cultural competency of nurses and nursing students, it is necessary to seek consensus and a multifaceted approach that is essential in each society based on various components.

• The Korean Journal of Woman Psychology
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• v.15 no.2
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• pp.259-283
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• 2010

The present study was conducted to examine the effect of attitude, subjective norm, and perceived behavior control in explaining multicultural receptive behavior intention as well as multicultural receptive behavior, i.e., test the theory of planned behavior(Ajzen, 1991), to investigate the role of Korean social identity in the prediction of multicultural receptive behavior, and to investigate the role of stereotype and prejudice(i.e. attitude about object) in the prediction of multicultural receptive behavior. A sample of 505 undergraduate participated in the survey. The results from stepwise regression analyses indicated that the multicultural receptive intention was explained 47.4% by the theory of planned behavior, while multicultural receptive behavior was explained 61.1% by this theory. When the Korean social identity, stereotype and prejudice were added into the stepwise regression analysis, the variance was increased to 51.8% for multicultural receptive intention and 65.9% for multicultural receptive behavior. Furthermore, the influence of the Korean social identity on multicultural receptive intention/behavior was weak, but the influence of the stereotype on multicultural receptive behavior was strong. Finally the implications and limitations of the present study as well as the future directions of this area were discussed.

• Development and Reproduction
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• v.6 no.2
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• pp.105-110
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• 2002

Numerous hormones are involved in the regulation of reproduction. Among them, estrogen and progesterone are the most important ovarian steroid hormones regulating female fertility. On the other hand, diverse stressors impede female receptivity and fertility. Since norepinephrine(NE) and epinephrine(E) are released from the adrenal during stress, it might play a role in stress-induced disruptions of fEmale reproductive parameters. The present study was performed to analyze the changes in adrenal catecholaminergic activities in cycling rats. The tissue content and secretion level of catecholamines were determined by high performance liquid chromatography coupled with electrochemical detector(HPLC-ECD). Adrenomedullary content of norepinephrine(NE) was increased on proestrus stage (59.47 $\pm$ 6.86 ug/gland), peaked on diestrus I stage(65.22 $\pm$ 5.99 ug/gland), and was nadir on diestrus II stage(41.63 $\pm$ 1.33 ug/gland). The highest E content was observed on proestrus stage(361.86 $\pm$ 15.58 ug/gland) while the lowest level was on diestrus II stage(285.58 $\pm$ 12.25 ug/gland). In addition to these observations, a significant reduction of the NE : E ratio was observed (1 : 4.81 on diestrus I vs 1 : 6.13～7.02 on other stages). In vitro secretion of adrenal NE and E was increased on proestrus stage, peaked on estrus stage, and decreased on diestrus II stage. Interestingly, the NE : E ratio in conditioned media was significantly increased on estrus stage (1 : 3.32 vs 1 : 2.34～2.65 on other stages. The biosynthesis of NE and E is mediated by tyrosine hydroxylase(TH) and phenylethanolamine-N-methyltransferase(PNMT) which acts conversion of tyrosine into DOPA and NE into E, respectively. These finding demonstrated that sex steroids, during setrous cycle, seem to be able to modify the adrenal catecholamines biosynthesis and secretion with stage-specific manner by modulation of the enzyme activities.

• Clinical and Experimental Reproductive Medicine
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• v.27 no.1
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• pp.31-37
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• 2000

This study was designed to identify the ultrastructural changes of mouse endometrium during peri-implantation period and obtain the fundamental information for the establishment of 3-dimensional culture system of mouse endometrial cells in vitro. The used female ICR mice ($6{\sim}8$ wks) were conducted on pregnant. The biopsies were obtained from whole uterus at cycle day 1 (D1) and day 5 (D5) after hCG injection and mating. The biopsies materials were fixed 2.5% glutaraldehyde and 1% osmium tetroxide. Subsequently, for observation using light and transmission electron microscopy (LM and TEM), they were dehydrated and embedded in Epon and the embedded biopsies were sectioned and stained. For scanning electron microscopy (SEM), the fixed specimens were dehydrated, dried and coated with gold. 1) For LM, the biopsied materials at D5 (late secretory phase) were appeared the extended stromal layer by increased connective tissues and the fully developed endometrial glands and vessels compared with D1 (early secretory phase). 2) For TEM, the mouse endometrium was consisted of 3-layers, a simple polarized columnar epithelial cells, basement membrane and stromal cells. At D5, the distribution of microvilli, endoplasmic reticulum, Golgi body, lipid and glycogen deposits, secretory granules and surface area of basement membrane were increased. 3) For SEM, the degree of folding and microvilli of surface of mouse epithelial cells was became more and more according to the process of secretory phase, and at D5, implantation time of mouse, the appearance of pinopodes as a specific marker of uterine receptivity was found. The uterine pinopodes of mouse were found in narrow sites at the luminal surface, irregularity and appeared the different stages in the same sample. Therefore, these results indicated that the mouse endometrium was experienced dramatic morphological changes during peri-implantation period.

• Development and Reproduction
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• v.13 no.1
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• pp.1-11
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• 2009

Implantation itself is governed by an array of endocrine, paracrine and autocrine modulators, of embryonic and maternal origin. Window of implantation is the unique temporal and spatial expression of factors allows the embryo to implant via signaling, appositioning, attachment, and invasion in a specific time frame of $2{\sim}4$ days. When the embryo has arrived in the uterine cavity, a preprogrammed sequence of events occurs, which involves the production and secretion of a multitude of biochemical factors such as cytokines, growth factors, and adhesion molecules by the endometrium and the embryo, thus leading to the formation of a receptive endometrium. Cytokines such as LIF, CSF-1, and IL-1 have all been shown to play important roles in the cascade of events that leads to implantation. Integrin, L-selectin ligands, glycodelin, mucin-1, HB-EGF and pinopodes are involved in appositioning and attachment. The embryo also produces cytokines and growth factors (ILs, VEGF) and receptors for endometrial signals such as LIF, CSF-1, IGF and HB-EGF. The immune system and angiogenesis play an important role. The usefulness of these factors to assess endometrial receptivity and to estimate the prognosis for pregnancy in natural and artificial cycles remains to be proven. Integrins, pinopodes, glycodelin and LIF (from biopsies) are promising candidates; from uterine flushings, glycodelin and LIF are also candidates. The ideal serum marker is not available, but VEGF, glycodelin and CSF have some clinical implications. Further evaluation that includes larger groups of infertile women and fertile controls are needed to elucidate whether their presence in plasma, flushing fluid, or endometrial samples can be used as some kind of a screening tool to assess endometrial function and prognosis for pregnancy before and after artificial reproductive therapy. A better understanding of their function in human implantation may lead to therapeutic intervention, thereby improving the success rate in reproduction treatment. New molecular techniques are becoming available for measuring both embryonic and endometrial changes prior to and during implantation. The use of predictive sets of markers may prove to be more reliable than a single marker. Ultimately, the aim is to use these tools to increase implantation in artificial cycles and consequently improve live-birth rates.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.3
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• pp.243-251
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• 2005

Objective: Low-dose aspirin have been proposed to improving endometrial receptivity and pregnancy rate in COH-IVF by increasing endometrial perfusion. However, the effect of low-dose aspirin in COH-IVF could be negligible because there have been large quantity of other important factors responsible for changing endometrial perfusion accompanied by COH procedure. In contrast, in frozen-thawed embryo transfer cycles which were not accompanied by COH procedure, the effects of low-dose aspirin in endometrial blood flow seems to be more certain than in COH-IVF cycles. In this study, we analyzed the effect of low-dose aspirin treatment on implantation and pregnancy rates in patients undergoing frozen-thawed embryo transfer Methods: From January 2003 to December 2003, total 264 cycles from 264 patients who attended infertility clinic at Samsung Cheil Hospital were enrolled in this study. All cases included in this study, embryos were frozen and thawed at the pronuclear stage and three days after incubation, at least 2 or more good quality embryos were transferred into uterus. In study group, low dose aspirin (100 mg/day) was administrated from the first or second date of menstrual day to 9 days after embryo transfer. On the other hand, control group did not take any medicine except estradiol valerate for endometrial priming. Several variables including implantation and pregnancy rates were compared in both groups. After then, each groups were stratified by endometrial thickness checked at embryo transfer (ET) day such as (28 mm versus <8 mm) and same variables above described were compared between study and control groups. Results: The mean age, infertility duration, endometrial thickness at embryo transfer day and mean number of transferred embryo were not significantly different in both groups. Also, implantation rates (study group: 15.8%, control group: 20.5%) and pregnancy rate (study group: 45.1%, control group: 43.5%) were not significantly different between two groups. (p>0.05) After we analyzed same variables stratified by endometrial thickness checked at embryo transfer day, we could not found any significant difference between study and control groups. Conclusions: Low-dose aspirin treatment seems to have no advantage of improving implantation and pregnancy rates in patients undergoing frozen-thawed embryo transfer.