• Journal of Digital Convergence
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• v.11 no.2
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• pp.175-182
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• 2013

In this paper, the simulation model of house price is presented on the basis of pricing mechanism between the demand and the supply of apartments in seoul. The algorithm of house price simulation model for calculating the rate of price over time includes feedback control theory. The feedback control theory consists of stock variable, flow variable, auxiliary variable and constant variable. We suggest that the future price of apartment is simulated using mutual interaction variables which are demand, supply, price and parameters among them. In this paper we considers three items which include the behavior of apartment price index, the size of demand and supply, and the forecasting of the apartment price in the future economic scenarios. The proposed price simulation model could be used in public needs for developing a house price regulation policy using financial and non-financial aids. And the quantitative simulation model is to be applied in practice with more specific real data and Powersim Software modeling tool.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.2
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• pp.17-32
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• 2013

Objectives: The purpose of this study was to investigate whether Lonicera japonica(LJ) could inhibit LPS-induced type I IFN production. Methods: To evaluate inhibitory effect of LJ on type I IFN, we examined type I IFN, IRF-1, 7 and IL-10 production on LPS-induced macrophages using real time RT-PCR. Next, we observed the interaction of type I IFN, IRF-1, 7 and IL-10 using IL-10 neutralizing antibody. Finally we examined the activation of STAT-1, 3 using western blot. Results: LJ inhibited Type I IFN expression of mRNA and increased IL-10 expression of mRNA. Also LJ inhibited the level of IRF-1, 7 mRNA and the nuclear translocation of IRF-3. Further more, LJ reduced the activation of STAT-1, 3 which are involved in continuous secretion of immune cytokines. Blockade of IL-10 action caused a significant reduction of type I IFN and IRF-1, 7 than LPS-induced LJ pretreatment. Conclusions: LJ inhibits LPS-induced production of type I IFN by IL-10. This study may provide a clinical basis for anti-inflammatory properties of LJ.

• Preventive Nutrition and Food Science
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• v.21 no.1
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• pp.62-67
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• 2016

Green tea (Camellia sinensis) is one of the most popular beverages in the world and has been acknowledged for centuries as having significant health benefits. (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea, and it has been reported to have health benefit effects. Peroxisome proliferator-activated receptor ${\gamma}$ coactivator $(PGC)-1{\alpha}$ is a crucial regulator of mitochondrial biogenesis and hepatic gluconeogenesis. The objective of this study was to investigate whether EGCG from green tea can affect the ability of transcriptional regulation on $PGC-1{\alpha}$ mRNA expression in HepG2 cells and 3T3-L1 adipocytes. To study the molecular mechanism that allows EGCG to control $PGC-1{\alpha}$ expression, the promoter activity levels of $PGC-1{\alpha}$ were examined. The $PGC-1{\alpha}$ mRNA level was measured using quantitative real-time PCR. The -970/+412 bp of $PGC-1{\alpha}$ promoter was subcloned into the pGL3-Basic vector that includes luciferase as a reporter gene. EGCG was found to up-regulate the $PGC-1{\alpha}$ mRNA levels significantly with $10{\mu}mol/L$ of EGCG in HepG2 cells and differentiated 3T3-L1 adipocytes. $PGC-1{\alpha}$ promoter activity was also increased by treatment with $10{\mu}mol/L$ of EGCG in both cells. These results suggest that EGCG may induce $PGC-1{\alpha}$ gene expression, potentially through promoter activation.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.5
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• pp.615-623
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• 2016

Angiopoietin-like protein 4 (ANGPTL4) is involved in a variety of functions, including lipoprotein metabolism and angiogenesis. To reveal the role of ANGPTL4 in fat metabolism of sheep, ovine ANGPTL4 mRNA expression was analyzed in seven adipose tissues from two breeds with distinct tail types. Forty-eight animals with the gender ratio of 1:1 for both Guangling Large Tailed (GLT) and Small Tailed Han (STH) sheep were slaughtered at 2, 4, 6, 8, 10, and 12 months of age, respectively. Adipose tissues were collected from greater and lesser omental, subcutaneous, retroperitoneal, perirenal, mesenteric, and tail fats. Ontogenetic mRNA expression of ANGPTL4 in these adipose tissues from GTL and STH was studied by quantitative real time polymerase chain reaction. The results showed that ANGPTL4 mRNA expressed in all adipose tissues studied with the highest in subcutaneous and the lowest in mesenteric fat depots. Months of age, tissue and breed are the main factors that significantly influence the mRNA expression. These results provide new insights into ovine ANGPTL4 gene expression and clues for its function mechanism.

• The Journal of Internal Korean Medicine
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• v.32 no.4
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• pp.487-496
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• 2011

Objectives : The aim of this study was to investigate the hepatoprotective effect of Soshiho-tang (SSH) in mouse primary liver cells against hydrogen peroxide ($H_2O_2$)-induced oxidative stress. We also elucidated the molecular mechanism of hepatoprotective effect by SSH. Methods : Cell viability, level of ALT, AST and LDH, intracellular ROS level, mRNA expression and activity of antioxidant enzymes were used to evaluate hepatoprotection of SSH against $H_2O_2$. Target gene expressions were analyzed by real-time PCR. Results : Pre-treatment with SSH for 1 hour prevented cytotoxicity against $H_2O_2$. $H_2O_2$-induced ROS level decreased under SSH pre-treatment. mRNA expression of GPx and SOD increased in SSH-treated cells. In addition, HSP72 and HSP40 gene expression were elevated under SSH-treatment. Conclusions : These results indicate that SSH protects mouse primary liver cells from $H_2O_2$-induced oxidative injury. This hepatoprotective activity of SSH is mediated by decreasing intracellular ROS and increasing antioxidant enzyme expression (GPx and SOD) and stress response protein (HSP72 and HSP40).

• Journal of IKEEE
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• v.12 no.4
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• pp.196-203
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• 2008

The IEEE 802.11e working group has announced a new distributed MAC(Medium Access Control) called EDCA(Enhanced Distributed Channel Access) to provide service differentiation among classified traffics. In comparison with the 802.11 legacy MAC, the EDCA provides QoS mechanism by differentiated channel access which is called AC(Access Category) to the frames with different priorities. In multimedia applications, however, the EDCA has some difficulties to achieve QoS throughput because of using fixed AC parameters and never considers overall throughputs, i.e. fairness, for classified services. In this paper, AC parameter control technique is proposed to achieve overall QoS throughputs with differentiated services. The proposed technique controls AC parameters dynamically in real time. Simulation is used to verify the technique and the simulation shows that QoS fairness is improved by 13% in throughput deviation in multimedia environments including voice, video and data service.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.4
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• pp.1854-1868
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• 2018

A wireless body-sensor network (WBSN) refers to a network-configured environment in which sensors are placed on both the inside and outside of the human body. The sensors are much smaller and the energy is more constrained when compared to traditional wireless sensor network (WSN) environments. The critical nature of the energy-constraint issue in WBSN environments has led to numerous studies on the reduction of energy consumption of WBSN sensors. The transmission-power-control (TPC) technique adjusts the transmission-power level (TPL) of sensors in the WBSN and reduces the energy consumption that occurs during communications. To elaborate, when transmission sensors and reception sensors are placed in various parts of the human body, the transmission sensors regularly send sensor data to the reception sensors. As the reception sensors receive data from the transmission sensors, real-time measurements of the received signal-strength indication (RSSI), which is the value that indicates the channel status, are taken to determine the TPL that suits the current-channel status. This TPL information is then sent back to the transmission sensors. The transmission sensors adjust their current TPL based on the TPL that they receive from the reception sensors. The initial TPC algorithm made linear or binary adjustments using only the information of the current-channel status. However, because various data in the WBSN environment can be utilized to create a more efficient TPC algorithm, many different types of TPC algorithms that combine human movements or fuse TPC with other algorithms have emerged. This paper defines and discusses the design and development process of an efficient TPC algorithm for WBSNs. We will describe the WBSN characteristics, model, and closed-loop mechanism, followed by an examination of recent TPC studies.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.9
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• pp.1802-1807
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• 2015

The cloud computing service provides physical IT resources to VM instances to users using virtual technique and the users pay cost of VM instances to service provider. The auction model based on cloud computing provides available resources of service provider to users through auction mechanism. The users bid spot instances to process their a job until its deadline time. If the bidding price of users is higher than the spot price, the user will be provided the spot instances by service provider. In this paper, we propose a new bidding strategy to minimize the total cost for job completion. Typically, the users propose bidding price as high as possible to get the spot instances and the spot price get high. we lower the spot price using proposed strategy and minimize the total cost for job completion. To evaluate the performance of our strategy, we compare the spot price and the total cost for job completion with real workload data.

• Korean Journal of Head & Neck Oncology
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• v.23 no.1
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• pp.21-25
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• 2007

Background：Squamous cell carcinoma(SCC)of the palatine tonsils represents approximately 15-23% of all intraoral SCC. The most frequently reported risk factors for oropharyngeal cancer are smoking and alcohol. In a recent overview of HPV and tonsillar squamous cell carcinoma(TC), 51% contained HPV DNA, and HPV-16 being the most frequent type. We aimed to clarify whether HPV directly effects on the oncogenesis and biologic behavior of TC by comparison with infection prevalence, and physical status of virus. Material and Method：We used HPV genotyping DNA chip(Biocore, Korea, Seoul) arrayed by multiple oligonucleotide probes of L1 sequence of 26 types of HPV and HPV genotypes are identified by fluorescence scanner. The copy numbers of HPV E2 and E6 open reading frames(ORF) were assessed using a TaqMan-based 5'-exonuclease quantitative real-time PCR assay. The ratio of E2 to E6 copy numbers was calculated to determine the physical status of HPV-16 viral gene. Results：We observed a significant difference in HPV prevalence between 52 TCs and 69 CFTs(73.1% vs. 11.6%), and most of the HPVs were type 16(87.2%)and non-episomal(94.1%) state. Conclusions：This study regarding HPV infection prevalence and mechanism in the largest population of palatine tonsillar squamous cell carcinoma with chronic follicular tonsillitis revealed significant difference pf HPV prevalence between TC and CFT. Most of HPV were 16 type and integrated or mixed, HPV-16 integration could be directly related to tonsillar carcinogenesis.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1545-1552
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• 2013

This study was conducted to investigate the effects of Trichostatin A (TSA) on cumulus expansion during mouse oocyte maturation. TSA treatment inhibited cumulus expansion and significantly reduced the cumulus expansion index (CEI) (p<0.05). To determine the underlying mechanism, the expression levels of several key factors that play crucial roles in cumulus expansion including components of extracellular matrix (ECM) (Has2, Ptgs2, Ptx3, and Tnfaip6) and Growth differentiation factor 9 (GDF9) were measured in control and TSA treated samples by real-time PCR. The effect of TSA on ERK phosphorylation (p-ERK1/2) in cumulus cells and GDF9 protein level in fully grown oocytes (FGOs) were detected by Western blotting. The expression levels of the ECM genes were significantly decreased (p<0.05) by TSA treatment while GDF9 expression did not response to TSA (p>0.05). TSA treatment blocked the activation of ERK1/2 (p<0.05) and had no significant effect on GDF9 protein expression (p>0.05). Collectively, these results suggested that TSA treatment altered ECM gene expression and blocked ERK1/2 activation to inhibit cumulus expansion in the mouse.