• Journal of Ginseng Research
• /
• v.42 no.4
• /
• pp.476-484
• /
• 2018

Background: Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well known for enhancing vital energy and immune capacity and for inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory disorders. This study was conducted to establish the therapeutic potential of ginseng saponins on the lung inflammatory response. Methods: From Korean Red Ginseng, 11 ginsenosides (Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, and Rh2) were isolated. Their inhibitory potential and action mechanism were evaluated using a mouse model of lung inflammation, acute lung injury induced by intranasal lipopolysaccharide administration. Their anti-inflammatory activities were also examined in lung epithelial cell line (A549) and alveolar macrophage (MH-S). Results: All ginsenosides orally administered at 20 mg/kg showed 11.5-51.6% reduction of total cell numbers in bronchoalveolar lavage fluid (BALF). Among the ginsenosides, Rc, Re, Rg1, and Rh2 exhibited significant inhibitory action by reducing total cell numbers in the BALF by 34.1-51.6% (n = 5). Particularly, Re showed strong and comparable inhibitory potency with that of dexamethasone, as judged by the number of infiltrated cells and histological observations. Re treatment clearly inhibited the activation of mitogen-activated protein kinases, nuclear factor-${\kappa}B$, and the c-Fos component in the lung tissue (n = 3). Conclusion: Certain ginsenosides inhibit lung inflammatory responses by interrupting these signaling molecules and they are potential therapeutics for inflammatory lung diseases.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2001.11a
• /
• pp.176-180
• /
• 2001

There are several factors causing re-work in CMP process such as improper polish time calculation by operator, removal rate decline of the polisher, unstable in-suit pad conditioning, slurry supply module problem and wafer carrier rotation inconsistency. And conclusively those fundimental reason for the re-work rate increasement is mainly from the cycle time delay between wafer polish and post measurement. Therefore, Wafer thickness measurement in wet condition could be able to remove those improper process conditions which may happen during the process in comparison with the conventional dried wafer measurement system and it can be able to reduce the CMP process cycle time. CMP scrap reduction by overpolish, re-work rate reduction, thickness control efficiency also can be easily achieved. CMP Equipment manufacturer also trying to develop integrated system which has multi-head & platen, cleaner, pre & post thickness measure and even control the polish time from the calculated removal rate of each polishing head by software. CMP re-work problem such as over & under polish by target thickness may result in the cycle time delay. By reducing those inefficient factors during the process and establish of the automatic process control, CLC system need to be adopted to maximize the process performance. Wafer to Wafer Polish Time Feed Back Control by measuring the wafer right after the polish shorten the polish time calculation for the next wafer and it lead to the perfect Post CMP target thickness control capability. By Monitoring all of the processed the wafer, CMP process will also be stabilize itself.

• The KIPS Transactions:PartC
• /
• v.12C no.4 s.100
• /
• pp.535-542
• /
• 2005

This paper proposes an on-demand ad hoc routing protocol, Node Density Based Routing (NDBR), which enhances the routing performance applying a new method to establish alternate patlis. It is important to reserve alternate paths for the route from source to destination in mobile ad hoc networks that are susceptible to failure due to the movement or the power exhaustion of mobile nodes. NDBR aims to establish a route that contains more alternate paths toward the destination by involving intermediate nodes with relatively more adjacent nodes in a possible route, and introduces a new routing criterion called 'node density.' This approach can localize the effects of route failures, and reduce control traffic overhead and route reconfiguration time by enhancing the reachability to the destination node without source-initiated route re-discoveries at route failures. This paper describes the route setup procedure using node density and the route re-configuration procedures employing alternate path information at the intermediate nodes. We show the performance of our routing schemes through a series of simulations using the Network Simulator 2 (ns-2).

• Restorative Dentistry and Endodontics
• /
• v.24 no.4
• /
• pp.639-646
• /
• 1999

The dental care delivery system and the dental specialty system have a very close relationship each other. Compared to Korea. Western European countries with predominant public sector in dental service have recognized merely 2 or 3 dental specialties, while North American countries with predominant private sector, 8 or 9 ones. It is desirable to adopt the dental specialty system as soon as possible in Korea to encourage scientific development in various dental specialties and qualitative advance in dental service. We, however, have to establish equitable dental care delivery system which can use limited dental resources efficiently as follows. 1. clarifying the different roles in assignments between general dentists and specialists by the amendment of the related laws such as the Medical Act and establishing the organic patient-referral system. 2. adopting the dental specialty system and expanding personnel and equipments so that the dental college hospitals, especially dental divisions of general hospitals, night function as secondary care facilities with specialties. 3. determining the size of dental specialists according to the national needs for dental specialized service's, whose number is to be not more than 10% of the total dentists. 4. transferring the function of accredating dental specialists to the efficient, self-controlled professional organization such as the Korean Dental Association rather than putting it under the governmental control. 5. conducting a comprehensive review of specialty education and practice for re-recognition, and maintaining competence of specialists by re-accredating them periodically. I expect this article to contribute to further discussion about the dental specialty system in Korea in productive and practical way. I am sure that we can Establish this system in the near future when people in every walks of life-the academic circle, the press, the authority concerned, consumer groups and the Korean Dental Association-take part in the discussion with special concern.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.13 no.5
• /
• pp.39-48
• /
• 2003

AAA(Authentication, Authorization, Accounting) protocol is a framework that propose functions of AAA on multiple networks and platforms. AAA protocol is extending from previous RADIUS protocol to Diameter protocol. There are some Diameter applications for variety purpose. Diameter CMS Application makes Diameter messages more secure by using PKI. Diameter CMS Application establish DSA(Diameter Security Association) for end to end security. However the Application has some problems to establish DSA(Diameter Security Association), which can make Diameter system unstable. If one system lose DSA information for some system error - for example, reboot -, the secure communication between two nodes may not be possible. At the application such as MIP, even user registration can't be done. In this paper, we propose a mechannism for DSA re-establishment, and also show the result of the implementation.

• The Journal of Information Systems
• /
• v.29 no.4
• /
• pp.25-43
• /
• 2020

Purpose The purpose of this study is to gradually increase the use of O2O services in recent years. It is a part of our daily lives, and accommodation/leisure is a part of the growing use of O2O services. Based on various prior research related to O2O service, the Commission intends to establish the justification and necessity of empirical research and to establish the relationship between O2O service impact factors and practical value, customer satisfaction and reuse intention. Design/methodology/approach This study analyzed what factors affected the intention of re-use of domestic accommodation O2O services. This research model was proposed based on the preceding research paper, and reliability, diversity, economics, leisure, safety and personalization were used as independent variables, practical value and customer satisfaction are parameters, and reuse intent is composed of dependent variables. Within the last year, users of domestic accommodation applications were selected as users who used domestic accommodation applications more than once, and data of domestic accommodation application users were analyzed using the SPSS 25.0 and AMOS 20.0 programs. Findings The results of this study show that economic efficiency, safety and personalization have significant effects on practical values in the relationship between O2O service impact factors and their impact on practical values. On the other hand, reliability, diversity and leisure were found to have no significant impact on practical values. In terms of O2O service impact factors and their impact on customer satisfaction, leisure and safety have significant effects on customer satisfaction. On the other hand, reliability, diversity, economics, and individualization have shown no significant impact on customer satisfaction. Practical values, parameters, customer satisfaction, and re-use intent, which are dependent variables, were also shown to have significant effects on practical values and customer satisfaction in the relationship.

• Health Policy and Management
• /
• v.28 no.3
• /
• pp.294-300
• /
• 2018

The development and management of epidemiology intelligence service (EIS) officer with more specialized competence to cope with and prepare for health threats, including pandemic of emerging and re-emerging infectious diseases, is a high priority policy issue in Korea. First of all, we need to establish the training goal of EIS officer. It is necessary to establish manpower training and management system with at least three tiers including quantitative and qualitative targets. Second, at least 50% of all EIS officer must secure a physician and secure expertise and competence for epidemic. Third, for the ultimate purpose of EIS officer, the establishment of a public health expert should expand the scope of epidemiologist's work to health and medical care, occupational environment, and various disasters. Fourth, it is essential to expand the epidemiologist training and education program to the level of advanced countries. Especially, the training course should be expanded at least twice of current times. Fifth, it is necessary to independently install and operate the 'EIS Officer Training Center' as a mid- and long-term goal. Stewardship and governance are secured with the organization, personnel, etc. that can fully manage the planning, management, and evaluation of the EIS system. In the future, it will be necessary to establish a systematic and phased operational base of education and training programs for EIS officer, and establish a sustainable implementation system for strategy development. In addition, it is urgent to revise the guidelines for training public health professionals and strengthening competencies, and for establishing professional educational institutions.

• Food Science and Preservation
• /
• v.9 no.3
• /
• pp.332-337
• /
• 2002

This study was undertaken in order to compare reflux extraction(RE) and microwave-assisted extraction(MAE) in extraction efficiency and establish optimum microwave extraction conditions in obtaining Ligularia fischeri extracts. A considerable reduction in extraction time was accomplished by MAE. When 70% methanol 50% methanol 70% ethanol, or 50% ethanol was used, MAE extract contained equal levels of soluble solid and total polyphenol as obtained by RE. The optimum microwave-assisted extraction conditions for Ligularia fischeri were achieved by 120∼150 watts of microwave energy and 4∼8 minutes of extraction time. No significant changes were found in antioxidant activity with DPPH scavenging method over the variation of microwave energy or extraction time. The use of diluted methanol or ethanol improved soluble solid content(30%), total polyphenol content(2.7%) and antioxidant activity(68%).

• Korean Journal of Adult Nursing
• /
• v.27 no.2
• /
• pp.156-169
• /
• 2015

Purpose: This study identified the reasons why tuberculosis (TB) patients withhold treatment in a bid to develop a assessment scale to select patients who needs nursing intervention in the early stage and decrease the risk of discontinuation of treatment. Sample: There were two samples. A sample of 191 patients with TB and having primary treatment and a second sample of N who were under re-treatment Methods: The study design included qualitative and quantitative methods. Qualitative data were collected from in-depth interviews of TB patients under re-treatment. The quantitative data were collected from 191 patients with TB under primary treatment. Results: Exploratory factor analysis revealed 11 factors explaining 69.6% of total variance. These factors were categorized into four subgroups. A depression scale was used to establish concurrent validity. The depression scale had a positive relationship (r=54) with the discontinuing of primary treatment. The internal consistency reliability for the four subgroups was over .84. The confidence coefficient was Cronbach's ${\alpha}$ .95. The final scale was a self-reported four Likert scale including 50 items. Conclusion: Reliability and validity was established for the scale and the scale can be used to examine the risk of treatment discontinuation for TB. The scale is an important resource for nursing interventions in identifying and treating high risk clients.

• Bulletin of the Korean Mathematical Society
• /
• v.57 no.4
• /
• pp.1003-1031
• /
• 2020

We consider the following Dirichlet initial boundary value problem with a gradient absorption and a nonlocal source $$\frac{{\partial}u}{{\partial}t}-div({\mid}{\nabla}u{\mid}^{p-2}{\nabla}u)={\lambda}u^k{\displaystyle\smashmargin{2}{\int\nolimits_{\Omega}}}u^sdx-{\mu}u^l{\mid}{\nabla}u{\mid}^q$$ in a bounded domain Ω ⊂ ℝ^N, where p > 1, the parameters k, s, l, q, λ > 0 and µ ≥ 0. Firstly, we establish local existence for weak solutions; the aim of this part is to prove a crucial priori estimate on |∇u|. Then, we give appropriate conditions in order to have existence and uniqueness or nonexistence of a global solution in time. Finally, depending on the choices of the initial data, ranges of the coefficients and exponents and measure of the domain, we show that the non-negative global weak solution, when it exists, must extinct after a finite time.