• Journal of Pharmaceutical Investigation
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• v.17 no.3
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• pp.111-126
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• 1987

Methyl methacrylate-butyl methacrylate copolymer (MMBM)-dibutyl phthalate (DBP) films were investigated as a potential topical drug delivery system for the controlled release of nitrofurazone. The kinetic analysis of release data indicated that drug release followed a diffusion-controlled granular matrix model, where the quantity released per unit area is proportional to the square root of time. DBP of several hydrophobic plasticizers selected was found to give the highest release of nitrofurazone. However, hydrophilic plasticizers such as propylene glycol and polyethylene glycol 400 had no controlled release properties and acceptable film formation. The effects of changes in film composition, drug concentration, film thickness, pH of release medium, and temperature on the in vitro release of nitrofurazone were analyzed both theoretically and experimentally. The release rate constant (k') was found to be proportional to DBP content, pH, and the temperature of release medium, but independent of film thickness, and drug concentration in a range of 0.1-0.4% by weight. The linear relationship was found to exist between the log k' and DBP content. The release of nitrofurazone from MMBM-DBP (8:2) films was found to be an energy-linked process. Two energy terms were calculated ; the activation energy for matrix diffusion was 13.45 kcal/mole, and the heat of drug crystal solvation was 27.26-29.34 kcal/mole. Observation of scanning electron micrographs and microscopic photographs showed that the incorporation of DBP in films increased markedly the particle size of nitrofurazone dispersed in the film matrix, comparing with the fine dispersion of nitrofurazone in pure MMBM film alone.

• Korean Journal of Pharmacognosy
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• v.46 no.1
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• pp.38-43
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• 2015

Ligularia stenocephala has a wide range of types of constituents with various pharmacological properties. Here in this study, we examined the effect of methanolic extract of L. stenocephala (MLS) on the lifespan and stress tolerance using Caenorhabditis elegans model system. We found that lifespan of wild-type worms was significantly lengthened in the presence of MLS in a dose dependent manner. MLS also elevated the tolerance of worms against osmotic, heat shock, and oxidative stress. We also demonstrated in vivo antioxidant capacity of MLS by checking intracellular reactive oxygen species levels as well as antioxidant enzyme activities such as catalase and superoxide dismutase. We further investigated several aging-related factors, including pharyngeal pumping rate and body length. Here, we showed that MLS exerts longevity effect independent of both factors. In addition, body movement of aged worms was significantly elevated, suggesting MLS could enhance healthspan as well as lifespan.

• Radiation Oncology Journal
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• v.36 no.2
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• pp.95-102
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• 2018

Purpose: To evaluate the prognostic value of $^{18}F$-fluorodeoxyglucose positron-emission tomography (FDG PET) with computed tomography (CT) before and during radiotherapy (RT) in patients with head and neck cancer. Methods: Twenty patients with primary head and neck squamous cell carcinoma were enrolled in this study, of whom 6 had oropharyngeal cancer, 10 had hypopharyngeal cancer, and 4 had laryngeal cancer. Fifteen patients received concurrent cisplatin and 2 received concurrent cetuximab chemotherapy. FDG PET/CT was performed before RT and in the 4th week of RT. The parameters of maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor were measured, and the prognostic significance of each was analyzed with the Cox proportional hazards model. Results: Higher TLG (>19.0) on FDG PET/CT during RT was a poor prognostic factor for overall survival (OS) (p = 0.001) and progression-free survival (PFS) (p = 0.007). In the multivariate analysis, TLG during RT as a continuous variable was significantly associated with OS and PFS rate (p = 0.023 and p = 0.016, respectively). Tumor response worse than partial remission at 1 month after RT was another independent prognostic factor for PFS (p = 0.024). Conclusions: Higher TLG of the primary tumor on FDG PET/CT during RT was a poor prognostic factor for OS and PFS in patients with head and neck cancer.

• 한국연소학회:학술대회논문집
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• 1998.10a
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• pp.139-154
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• 1998

Under certain circumstance, premixed turbulent flame can be treated as wrinkled thin laminar flame and its motion in a hydrodynamic flow field has been investigated by employing G-equation. Past studies on G-equation successfully described certain aspects of laminar flame propagation such as effects of stretch on flame speed. In those studies, flames were regarded as a passive interface that does not influence the flow field. The experimental evidences, however, indicate that flow field can be significantly modified by the propagation of flames through the volume expansion of burned gas. In the present study, a new method to be used with G -equation is described to include the effect of volume expansion in the flame dynamics. The effect of volume expansion on the flow field is approximated by Biot-Savart law. The newly developed model is validated by comparison with existing analytical solutions of G -equation to predict flames propagating in hydrodynamic flow field without volume expansion. To further investigate the influence of volume expansion, present method was applied to initially wrinkled or planar flame propagating in an imposed velocity field and the average flame speed was evaluated from the ratio of flame surface area and projected area of unburned stream channel. It was observed that the initial wrinkling of flame cannot sustain itself without velocity disturbance and wrinkled structure decays into planar flame as the flame propagates. The rate of decay of the structure increased with volume expansion. The asymptotic change in the average burning speed occurs only with disturbed velocity field. Because volume expansion acts directly on the velocity field, the average burning speed is affected at all time when its effect is included. With relatively small temperature ratio of 3, the average flame speed increased 10%. The combined effect of volume expansion and flame stretch is also considered and the result implied that the effect of stretch is independent of volume release.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.9
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• pp.103-112
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• 1999

In this paper, a speaker-independent isolated world recognition system for a car navigation system is implemented using a general digital signal processor. This paper presents a method combining SNR normalization with RAS as a noise processing method. The semi-continuous hidden markov model is adopted and TMS320C31 is used in implementing the real-time system. Recognition word set is composed of 69 command words for a car navigation system. Experimental results showed that the recognition performance has a maximum of 93.62% in case of a combination of SNR normalization and spectral subtraction, and the performance improvement rate of the system is 3.69%, Presented noise processing method showed good speech recognition performance in 5dB SNR in car environment.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.36.2-37
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• 2016

We study the long-term radio variability of 43 radio bright AGNs by exploiting the data base of the University of Michigan Radio Astronomy Observatory (UMRAO) monitoring program. The UMRAO database provides high quality lightcurves spanning 25 - 32 years in time at three observing frequencies, 4.8, 8, and 14.5 GHz. We model the periodograms (temporal power spectra) of the observed lightcurves as simple power-law noise (red noise, spectral power $P(f){\propto}f^{-{\beta}}$ using Monte Carlo simulations, taking into account windowing effects (red-noise leak, aliasing). The power spectra of 39 (out of 43) sources are in good agreement with the models, yielding a range in power spectral index (${\beta}$) from ${\approx}1$ to ${\approx}3$. We find a strong anti-correlation between ${\beta}$ and the fractal dimension of the lightcurves, which provides an independent check of the quality of our modelling of power spectra. We fit a Gaussian function to each flare in a given lightcurve to obtain the flare duration. We discover a correlation between ${\beta}$ and the median duration of the flares. We use the derivative of a lightcurve to obtain a characteristic variability timescale which does not depend on the assumed functional form of the flares, incomplete fitting, and so on. We find that, once the effects of relativistic Doppler boosting on the observed timescales are corrected, the variability timescales of our sources are proportional to the black hole mass to the power of ${\alpha}=1.70{\pm}0.49$. We see an indication for AGNs in different regimes of accretion rate, flat spectrum radio quasars and BL Lac objects, having different scaling relations with ${\alpha}{\approx}1$ and ${\approx}2$, respectively. We find that modelling the periodograms of four of our sources requires the assumption of broken powerlaw spectra. From simulating lightcurves as superpositions of exponential flares we conclude that strong overlap of flares leads to featureless simple power-law periodograms of AGNs at radio wavelengths in most cases (The paper is about to be submitted to ApJ).

• Korean Journal of Health Education and Promotion
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• v.26 no.2
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• pp.1-13
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• 2009

Objectives: This study identified how personal characteristics, family environment, governmental policy for the prevention and cessation of smoking might influence on adolescent smoking. Methods: This study used data from the 2006 Korea Youth Risk Behavior Web-based Survey of 71,404 middle school and high school students, giving a response rate of 90.9%. We selected 61,508 adolescents subjects of the final analysis without missing data on independent variables and dependent variables which are used in this study. This study used $\chi^2$ tests and logistic regression models. Variables were added to the regression model in three groups using a hierarchical approach.Results: Adolescents were significantly more likely to become current smokers if they were boys, were in a higher grade, and had lower academic achievement. Adolescents experiencing stress and depression were associated with increased risk of current smoking. Adolescents with single parents or students of non-living with parents comparing with students of living with parents showed the high possibility of smoking. Lower father's education was associated with increased likelihood of current smoking. Adolescents who were exposed to smoking at home were more likely to smoke. Adolescents without contacting with the antismoking media campaign was associated with increased likelihood of current smoking. Conclusion: Promoting antismoking media campaigns targeted at adolescent is required, and the smoking prevention education which are proper for subjects are required. Proper plans which could decrease the exposure of secondhand smoking should be established.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.59-70
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• 2013

As people invest most of their asset in real estate, there is high interest in changing in housing and real estate prices in the future for a digital economy. Various variables are affecting the housing and real estate market. Among them, four variables : households, productive population, interest rate and index price are chosen and analyzed representatively. This study is aimed to build decision model of apartment prices in Seoul empirically. From the analysis result the stock index is the only variable which is significant statistically to apartments in Seoul. From this study, the households and productive population show the same direction as shown in the previous studies before but not significant statistically. Among the independent variables, the stock index is chosen as a major variable of determinant of Seoul apartment price. From the result of the research, prediction of stock market should be preceded to forecast the movement of housing and real estate market in the future.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.5
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• pp.477-483
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• 2015

In this paper, Euler-Bernoulli beam theories(EB-beam) are used, and Fast Fourier Transformation(FFT) analysis is then employed to extract their natural frequencies using both analytical approach and Co-rotational plane beam(CR-beam) EDISON program. EB-beam is used to analyze a spring-mass system with a single degree of freedom. Sinusoidal force with various frequencies and constant magnitude are applied to tip of each beam. After the oscillatory tip response is observed in EB-beam, it decreases and finally converges to the so-called 'steady-state.' The decreasing rate of the tip deflection with respect to time is reduced when the forcing frequency is increased. Although the tip deflection is found to be independent of the excitation frequency, it turns out that time to reach the steady state response is dependent on the forcing frequency.

• Journal of the Korean Chemical Society
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• v.40 no.9
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• pp.640-648
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• 1996

Crosslinked chitosan was prepared from chitin after reaction with epichlorohydrin followed by deacetylation at C2-position. Epidermal releasing polymeric matrix was prepared after swelling crosslinked chitosan with distilled water and adding silver sulfadiazine and glycerine as a plasticiser. The release behavior of silver sulfadiazine from polymeric matrix was studied in pH 7.4 phosphate buffer solution by varing the drug content, glycerine concentration, and the thickness of the matrix. The drug release time was delayed by increasing the content of silver sulfadiazine and the thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant(K) of release rate was independent upon the matrix thickness, but was proportional to the content of drug or glycerine of crosslinked chitosan matrix. These results indicated that chitosan matrix showed some potential as a drug delivery system for transdermal therapeutic application.