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Lifespan Extending Effects of Ligularia stenocephala  

Kim, Sang Hyun (College of Pharmacy, Woosuk University)
Im, Jun Sang (College of Pharmacy, Woosuk University)
Kim, Bong Seok (College of Pharmacy, Woosuk University)
Lim, Hyun Ju (College of Pharmacy, Woosuk University)
Oh, Jong Woo (College of Pharmacy, Woosuk University)
Park, Jin Suck (College of Pharmacy, Woosuk University)
Yoon, Young Jin (College of Pharmacy, Woosuk University)
Lee, Ha Na (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.1, 2015 , pp. 38-43 More about this Journal
Abstract
Ligularia stenocephala has a wide range of types of constituents with various pharmacological properties. Here in this study, we examined the effect of methanolic extract of L. stenocephala (MLS) on the lifespan and stress tolerance using Caenorhabditis elegans model system. We found that lifespan of wild-type worms was significantly lengthened in the presence of MLS in a dose dependent manner. MLS also elevated the tolerance of worms against osmotic, heat shock, and oxidative stress. We also demonstrated in vivo antioxidant capacity of MLS by checking intracellular reactive oxygen species levels as well as antioxidant enzyme activities such as catalase and superoxide dismutase. We further investigated several aging-related factors, including pharyngeal pumping rate and body length. Here, we showed that MLS exerts longevity effect independent of both factors. In addition, body movement of aged worms was significantly elevated, suggesting MLS could enhance healthspan as well as lifespan.
Keywords
Ligularia stenocephala; C. elegans; Lifespan extension; Stress tolerance;
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