• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4369-4376
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• 2015

Background: To investigate in-vitro antagonistic effect of low-dose liquiritigenin on gemcitabine-induced capillary leak syndrome (CLS) in pancreatic adenocarcinoma via inhibiting reactive oxygen species (ROS)-mediated signalling pathways. Materials and Methods: Human pancreatic adenocarcinoma Panc-1 cells and human umbilical vein endothelial cells (HUVECs) were pre-treated using low-dose liquiritigenin for 24 h, then added into gemcitabine and incubated for 48 h. Cell viability, apoptosis rate and ROS levels of Panc-1 cells and HUVECs were respectively detected through methylthiazolyldiphenyl-tetrazoliumbromide (MTT) and flow cytometry. For HUVECs, transendothelial electrical resistance (TEER) and transcellular and paracellular leak were measured using transwell assays, then poly (ADP-ribose) polymerase 1 (PARP-1) and metal matrix proteinase-9 (MMP9) activity were assayed via kits, mRNA expressions of p53 and Rac-1 were determined through quantitative polymerase chain reaction (qPCR); The expressions of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and PARP-1 were measured via western blotting. Results: Low-dose liquiritigenin exerted no effect on gemcitabine-induced changes of cell viability, apoptosis rate and ROS levels in Panc-1 cells, but for HUVECs, liquiritigenin ($3{\mu}M$) could remarkably elevate gemcitabine-induced decrease of cell viability, transepithelial electrical resistance (TEER), pro-MMP9 level and expression of ICAM-1 and VCAM-1 (p<0.01). Meanwhile, it could also significantly decrease gemcitabine-induced increase of transcellular and paracellular leak, ROS level, PARP-1 activity, Act-MMP9 level, mRNA expressions of p53 and Rac-1, expression of PARP-1 and apoptosis rate (p<0.01). Conclusions: Low-dose liquiritigenin exerts an antagonistic effect on gemcitabine-induced leak across HUVECs via inhibiting ROS-mediated signalling pathways, but without affecting gemcitabine-induced Panc-1 cell apoptosis. Therefore, low-dose liquiritigenin might be beneficial to prevent the occurrence of gemcitabine-induced CLS in pancreatic adenocarcinoma.

• 마이크로전자및패키징학회지
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• 제29권4호
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• pp.21-27
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• 2022

저렴한 전도성 흑연을 인쇄전자 공법으로 유연 압력 센서를 개발하였다. 유연 압력 센서는 의료, 게임, AI 등 미래 산업에 활용될 소재로 각광받고 있다. 유연 압력 센서용 인쇄전극을 다양한 전기-기계적 특성을 평가한 결과 최대인장률 20%, 30°의 인장/굽힘, 간이 맥박 시험에서 일정한 저항 변화율을 보였다. 이렇게 검증이 완료된 전극을 시뮬레이션하여 더 적합한 matrix 패턴을 설계하였다. Serpentine 패턴을 활용하여 matrix 패턴 제작과 인캡슐레이션을 동시에 진행할 수 있는 공정을 활용하였다. 인쇄된 흑연 전극의 한쪽 면에 접착력 증가를 위한 O₂ 플라즈마 표면처리하고, 90°회전시켜, 라미네이션 공정을 통해 2개의 전극을 하나로 제작하였다. 이렇게 제작된 matrix 패턴을 인체의 손목 맥박 위치에 부착하여 실측을 진행한 결과 남녀 상관없이 일정한 저항 변화율을 보였다.

• 한국식생활문화학회지
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• 제21권3호
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• pp.311-318
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• 2006

This study aims to investigate the quality characteristics of breads with the addition of sweet pumpkin powder. Farinogram showed that the absorption rate of the dough decreased, the development time and stability became shortened, and the degree of attenuation tended to be grown along with increasing the amount of pumpkin powder. From the amylogram, it was found that the gelatinization starting temperature and the maximum viscosity of pumpkin powder added dough seemed to be decreased as the amount of pumpkin powder was increased. Extensogram showed that there was a decrease in the degree of extension of the dough added with increasing the amount of pumpkin powder, while an increase in the degree of resistance and resistance/extensibility. The lightness (L value) and redness (a value) of bread was found to be decreased with increasing the amount of pumpkin powder, while the yellowness (b value) increased. In terms of the dough texture, for which the hardness, cohesiveness and gumminess of the dough were measured, there were no significant differences between groups, while the dough added with 8.0% pumpkin powder showed a significant decrease in the elasticity. The results of sensory evaluation showed that the highest score of color (p<0.05) and taste (p<0.05) were obtained from the bread added with 6.0% and 8.0% pumpkin powder, while the highest score of texture in control and 3.0% pumpkin bread. In addition, the highest score of flavor (p<0.05) and overall acceptance (p<0.05) were observed in bread added with 6.0% pumpkin powder. Upon the results of this study, it was assumed that the development of food products using pumpkin are prospective in response to health-oriented consumers.

• Structural Engineering and Mechanics
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• 제83권4호
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• pp.551-561
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• 2022

In this paper, the effect of fire conditions according to ISO 834 standard on the behavior of carbon fibre-reinforced plastic (CFRP) reinforced steel beams coated with gypsum-based mortar has been investigated numerically. To study the efficiency of these beams, 3D coupled temperature-displacement finite element analyzes have been conducted. Mechanical and thermal characteristics of three different parts of composite beams, i.e., steel, CFRP plate, and fireproof coating, were considered as a function of temperature. The interaction between steel and CFRP plate has been simulated employing the adhesion model. The effect of temperature, CFRP plate reinforcement, and the fireproof coating thickness on the deformation of the beams have been analyzed. The results showed that within the first 120 min of fire exposure, increasing the thickness of the fireproof coating from 1 mm to 10 mm reduced the maximum temperature of the outer surface of the steel beam from 380℃ to 270℃. This increase in the thickness of the fireproof layer decreased the rate of growth in the temperature of the steel beam by approximately 30%. Besides excellent thermal resistance and gypsum-based mortar, the studied fireproof coating method could provide better fire resistance for steel structures and thus can be applied to building materials.

• Elastomers and Composites
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• 제54권1호
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• pp.54-60
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• 2019

The rapid development of the automobile industry is an important factor that led to the dramatic development of synthetic rubber. The tread part of tire that comes in direct contact with the road surface is related to the service life of the tire. Rubber compounds used in tire treads are often blended with SBR (styrene-butadiene rubber) and BR (butadiene rubber) to satisfy physical property requirements. However, when two or more kinds of rubber are blended, phase separation and silica dispersion problems may occur due to non-uniform mixing of the rubber. Therefore, in this study, we synthesized an SBR copolymer with the same composition as that of a typical SBR/BR blend compound by controlling butadiene content during ESBR (emulsion styrene-butadiene rubber) synthesis. Subsequently, silica filled compounds were manufactured using the synthesized ESBR, and their mechanical properties, dynamic viscoelasticity, and crosslinking density were compared with those of the SBR/BR blended compound. When the content of butadiene was increased in the silica filled compound, the cure rate accelerated due to an increased number of allylic positions, which typically exhibit higher reactivity. However, the T-2 compound with increased butadiene content by synthesis less likely to show an increase in crosslink density due to poor silica dispersion. In addition, the T-3 compound containing high cis BR content showed high crosslink density due to its monosulfide crosslinking structure. Because of the phase separation, SBR/BR blend compounds were easily broken and showed similar $M_{100%}$ and $M_{300%}$ values as those of other compounds despite their high crosslink density. However, the developed blend showed excellent abrasion resistance due to the high cis-1,4 butadiene content and low rolling resistance due to the high crosslink density.

• Nuclear Engineering and Technology
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• 제52권12호
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• pp.2789-2802
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• 2020

Small Modular Reactors (SMRs) are attracting wide attention due to their outstanding performance, extensive studies have been carried out for lead-based fast reactors (LFRs) that cooled with Lead or Lead-bismuth (LBE), and small modular natural circulation LFR is one of the promising candidates for SMRs and LFRs development. One of the challenges for the design small modular natural circulation LFR is to master the natural circulation thermal-hydraulic performance in the reactor primary circuit, while the natural circulation characteristics is a coupled thermal-hydraulic problem of the core thermal power, the primary loop layout and the operating state of secondary cooling system etc. Thus, accurate predicting the natural circulation LFRs thermal-hydraulic features are highly required for conducting reactor operating condition evaluate and Thermal hydraulic design optimization. In this study, a thermal-hydraulic analysis code is developed for small modular natural circulation LFRs, which is based on several mathematical models for natural circulation originally. A small modular natural circulation LBE cooled fast reactor named URANUS developed by Korea is chosen to assess the code's capability. Comparisons are performed to demonstrate the accuracy of the code by the calculation results of MARS, and the key thermal-hydraulic parameters agree fairly well with the MARS ones. As a typical application case, steady-state analyses were conducted to have an assessment of thermal-hydraulic behavior under nominal condition, and several parameters affecting natural circulation were evaluated. What's more, two characteristics parameters that used to analyze natural circulation LFRs natural circulation capacity were established. The analyses show that the core thermal power, thermal center difference and flow resistance is the main factors affecting the reactor natural circulation. Improving the core thermal power, increasing the thermal center difference and decreasing the flow resistance can significantly increase the reactor mass flow rate. Characteristics parameters can be used to quickly evaluate the natural circulation capacity of natural circulation LFR under normal operating conditions.

• Korean Chemical Engineering Research
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• 제46권2호
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• pp.286-290
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• 2008

고분자전해질 연료전지는 $60{\sim}80^{\circ}C$ 운전 온도에서 개질 가스에 약간의 일산화탄소만 있어도 백금 표면에 CO가 강하게 흡착하여 촉매기능을 방해한다. 본 연구에서는 일산화탄소를 산화시키기 위해 Ru/C 층(CO 필터)을 Pt/C 층과 가스 확산층(GDL) 사이에 위치 시켰다. Ru/C 필터는 PEMFC anode가 좋은 CO 내성을 갖게 했으나 Ru/C 필터 두께로 인한 물질전달 저항과 전하 전달 저항증가에 의한 단위전지 성능저하가 0.6 V에서 약 10% 있었다. 고분자막의 열화는 PEMFC 수명을 단축시키는 주요 원인이 되고 있다. 막 내구성은 전극의 촉매 종류에 영향을 받을 수 있다. 가속실험결과 Ru/C 촉매가 불소유출 속도를 향상시킴을 보임으로써 Ru/C 촉매 첨가가 PEMFC 수명을 단축시킬 수 있음을 보였다.

• 한국화재소방학회논문지
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• 제26권6호
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• pp.72-77
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• 2012

콘크리트-강재 합성보가 고온에 노출된 경우 콘크리트는 강재를 피복하여 온도상승을 지연시키거나 보 내부의 수열용량을 높이는 역할을 한다. 한편 재료 간 일체화로 부재의 강도가 보완되기 때문에 일반적으로 단순 강재 보 보다 합성보의 내화성능이 유리하게 나타난다. 합성보에서 외부에 노출된 강재의 온도상승은 부재 단면의 형상 및 강재의 노출정도와 직접 관련하게 된다. 본 연구에서는 합성보와 일반철골보에 내화인정을 받은 내화뿜칠재를 동일 두께로 피복하여 표준화재조건의 내화실험을 실시하고, 그 결과로 나타난 강재의 온도이력과 단면형상계수와의 관계를 비교 분석하였다. 강재 온도 측정결과와 부재별 단면형상계수의 상관관계를 살펴본 결과 상관성이 매우 높은 것으로 나타났다. 이 결과는 부재의 내화성능에 영향을 미치는 명확한 조건에 의해 비교우위의 성능예측이 가능한 경우 부재별 개별 인정 없이 표준구조 인정을 통한 보편적인 사용이 가능할 수 있음을 시사한다.

• 상하수도학회지
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• 제34권3호
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• pp.183-190
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• 2020

Although membrane bio-reactor (MBR) has been widely applied for wastewater treatment plants, the membrane fouling problems are still considered as an obstacle to overcome. Thus, many studies and commercial developments on mitigating membrane fouling in MBR have been carried out. Recently, high voltage impulse (HVI) has gained attention for a possible alternative technique for desalting, non-thermal sterilization, bromate-free disinfection and mitigation of membrane fouling. In this study, it was verified if the HVI could be used for mitigation of membrane fouling, particularly the internal pore fouling in MBR. The HVI was applied to the fouled membrane under different conditions of electric fields (E) and contact time (t) of HVI in order to investigate how much of internal pore fouling was reduced. The internal pore fouling resistance (R_f) after HVI induction was reduced as both E and t increased. For example, R_f decreased by 19% when the applied E was 5 kV/cm and t was 80 min. However, the R_f decreased by 71% as the E increased to 15 kV/cm under the same contact time. The correlation between E and t that needed for 20% of R_f reduction was modeled based on kinetics. The model equation, E^1.54t = 1.2 × 10³ was obtained by the membrane filtration data that were obtained with and without HVI induction. The equation states the products of En and t is always constant, which means that the required contact time can be reduced in accordance with the increase of E.

• 한국지열·수열에너지학회논문집
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• 제10권4호
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• pp.15-24
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• 2014

This study conducted a computational fluid dynamics(CFD) analysis to find an appropriate diameter or sectional area of air ducts and fluid pipes which have an electromagnetic pulse(EMP) shied to protect indoor electronic devices in special buildings like military fortifications. The result shows that the optimized outdoor air intake size can be defined with either the ratio of the maximum air velocity in the supply duct to the air intake size, or the shape ratio of indoor supply diffuser to the outdoor air intake. In the case of water channel, the fluid velocity at EMP shield with the identical size of the pipe, decreases by 25% in average due to the resistance of the shield. The enlargement of diameter at the shield, 2 step, improves the fluid flow. It illustrated that the diameter of downstream pipe size is 1step larger than the upstream for providing the design flow rate. The shield increases friction and resistance, in the case of oil pipe, so the average flow velocity at the middle of the shield increase by 50% in average. In consideration of the fluid viscosity, the oil pipe should be enlarged 4 or 5 step from the typical design configuration. Therefore, the fluid channel size for air, water, and oil, should be reconsidered by the engineering approach when EMP shield is placed in the middle of channel.