• Journal of Pharmaceutical Investigation
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• 제17권2호
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• pp.75-78
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• 1987

The release rate of heparin from monolithic devices composed of raffinose, ${\beta}-cyclodextrin$, polyethylene oxide (Mw 20,000, PEO), and hydrophobic polyether urethane (biomer) was investigated. Water soluble raffinose, ${\beta}-cyclodextrin$, and PEO blended into the biomer provided a controlled release of heparin. The release rate of heparin could be controlled by the content of raffinose, ${\beta}-cyclodextrin$, and PEO in the devices. The mechanism of release rate increased by the raffinose, ${\beta}-cyclodextrin$, and PEO may result from the formation of channels and pores in the biomer matrices following the swelling and the change in the physical structure of polymer net work. Hydrophobic polyurethane containing raffinose, ${\beta}-cyclodextrin$, and PEO can provide a hydrophilic antithrombogenic material for prolonged release of heparin.

• 약학회지
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• 제31권5호
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• pp.286-295
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• 1987

The relationship between in vitro release and in vivo bioavailability of acetaminophen from suppositories was investigated. Effect of glycyrrhizin on the drug release and rectal absorption in rats was also examined. Suppositories containing 25mg of acetaminophen were prepared with Wecobee FS (fatty base) or PEG (water-soluble base) bases. The release from the suppositories were determined with USP rotating basket dissolution apparatus and with the suppository release tester. The temperature of the dissolution medium was very critical for the dissolution of acetaminophen from Wecobee FS suppositories. The bioavailability of acetaminophen was calculated from the plasma concentration-time curve after rectal administration of the suppositories to the rats. There were no significant differences in AUC following rectal administration of Wecobee FS and PEG suppositories, but the release and absorption from the Wecobee FS suppositories were faster than those from PEG suppositories. The dissolution rate obtained by the suppository release tester was better correlated with in vivo absorption rate constant than that by the USP dissolution apparatus. It suggests that the partitioning between rectal fluid and suppository base is the rate-limiting step in the rectal absorption of acetaminophen from suppositories. Glycyrrhizin was found not to affect in vitro dissolution and rectal absorption of acetaminophen.

• 한국연소학회지
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• 제19권4호
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• pp.49-55
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• 2014

Design criterion for the size of micro Pt-catalytic combustor is investigated in terms of heat release rate. One-dimensional plug flow model is applied to determine the surface reaction constants using the experimental data at stoichiometric butane-air mixture. With these reaction constants, the mass fraction of butane and heat release rate predicted by the plug flow model are in good agreement with the experimental data at the combustor exit. The relationship between the size of micro catalytic combustor and mixture flowrate is introduced in the form of product of two terms-the effect of fuel conversion efficiency, and the effect of chemical reaction rate and mass transfer rate.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.645-650
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• 1998

The dual drug-loaded alginate beads simultaneously containing drug in inner and outer layers were prepared by dropping plain (single-layered) alginate beads into $CaCl_2$ solution. The release characteristics were evaluated in simulated gastric fluid for 2 h followed by intestinal fluids thereafter for 12 h. The surface morphology and cross section of dual drug-loaded alginate beads was also investigated using scanning electron microscope (SEM). The poorlv water-soluble ibuprofen was chosen as a model drug. The surface of single-layered and dual drug-loaded alginate beads showed very crude and roughness, showing aggregated particles, surface cracks and rough crystals. The thickness of dual drug-loaded alginate beads surrounded by outer layer was ranged from about 57 to 329mcm. The distinct chasm between inner and outer layers was also observed. In case of single-layered alginate bead, the drug was not released in gastric fluid but was largely released in intestinal fluid. However, the release rate decreased as the reinforcing $Eudragit^{\circledR}$ polymer contents increased. When the plasticizers were added into polymer, the release rate largely decreased. The release rate of dual drug-loaded alginate beads was stable in gastric fluid for 2 h but largely increased when switched in intestinal fluid. The drug linearly released for 4 h followed by another linear release thereafter, showing a distinct biphasic release characteristics. There was a difference in the release profiles between single-layered and dual drug-loaded alginate beads due to their structural shape. However, this biphasic release profiles were modified by varying formulation compositions of inner and outer layer of alginate beads. The release rate of dual drug-loaded alginate beads slightly decreased when the outer layer was reinforced with $Eudragit^{\circledR}$ RS1OO polymers. In case of dual drug-loaded alginate beads with polymer-reinforced outer layer only, the initial amount of druc released was low but the initial release rate (slope) was higher due to more swellable inner cores when compared to polymer-reinforced inner cores. The current dual drug-loaded alginate beads may be used to deliver the drugs in a time dependent manner.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2003년도 추계학술대회 논문집(III)
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• pp.295-300
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• 2003

Experimental comparison was done for measuring Heat Release Rate and Smoke Production Rate of electric motor car's interior panels using cone calorimeter. Radiative heat flux of $50kW/m^2$ was used to simulate the condition of fully developed fire case in the tests. It was observed that Heat Release Rate and Smoke Production Rate curves were shown differently according to interior materials. From experiment's results we can deduce that materials having higher rate of heat release smolder more smoke. It needs to establish fire risk propensity of each material and to set up the standards urgently.

• Archives of Pharmacal Research
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• 제28권9호
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• pp.1092-1096
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• 2005

Huperzine A-loaded microspheres composed of poly(D,L-lactide-co-glycolide) were prepared by an O/w emulsion solvent evaporation method. The characterization of the microspheres such as drug loading, size, shape and release profile was described. The in vitro release in the initial 7 days was nearly linear with $10\%$ released per day. Thereafter drug release rate became slow gradually and about $90\%$ drug released at day 21. The in vitro release rate determined by dialysis bag method had a good correlation with the in vivo release rate. Huperzine A aqueous solution was intramuscularly injected (i.m.) at 0.4mg/kg and microspheres were intra­muscularly injected at 8.4 mg eq huperzine A/kg in rats. The maxium plasma concentration $(C_{max})$ after i.m. microspheres was only $32\%$ of that after i.m. solution. Drug in plasma could be detectd until day 14 and about $5\%$ of administered dose was residued at the injection site at day 14. The relative bioavailability of huperzine A microspheres over a period of 14 days was $94.7\%$. Inhibition of acyecholinesterase activity (AchE) in rat's cortex, hippocampus and striatum could sustain for about 14 days. In conclusion, huperzine A-loaded microspheres possessed a prolonged and complete drug release with significant inhibition of AchE for 2 weeks in rats.

• Archives of Pharmacal Research
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• 제9권4호
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• pp.193-199
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• 1986

The release of heparin from monolithic devices composed of different ratios of polythylene oxide (PEO MW 20,000) and hydrophobic polydimethylsiloxane or polyurethane was investigated. Water soluble PEO blended into the polymers provided a controlled release of heparin. The release rate of heparin could be controlled by varying the content of PEO. The heparin release rate from the devices increased as the content of PEO in the devices increased. The release mechanism may be associated with the creation of pore of domain through the devices following the swelling and the change in the physical structure of the polymer network. Hydrophobic polydimethylsiloxanes and polyurethanes containing PEO can provide an antith rombogenic material for prologed release of heparin from blended system.

• Journal of Advanced Marine Engineering and Technology
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• 제28권7호
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• pp.1063-1071
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• 2004

Accurate heat release analysis of cylinder pressure data is important for evaluating performance in the development of diesel engine However, traditional single zone first law heat release model(SZM) has significant limitations due to the simplified assumption of uniform charge and neglecting local temperature inside cylinder during combustion process. In this study. heat release rate based on single zone heat release model has been evaluated by comparison with computational analysis results using Fire code which is based on multi-dimensional model(MDM). To overcome limitations due to simplicity of single zone assumption. especially the influence of specific heat ratio on gross heat release has been esteemed and newly suggested were the equation $\gamma$= $\gamma$(${T/T}_{max}$) which describes the variations of gases thermodynamic properties with mean temperature and maximum mean temperature inside cylinder Single zone heat release model applied with this equation is shown to give very good results over whole range of operating conditions when compared with computational analysis results based on multi-dimensional model.

• 대한기계학회논문집
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• 제17권9호
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• pp.2172-2180
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• 1993

Under general loadings, including body forces, crack-face tractions and thermal loading, the energy release rate equation for a two-dimensional cracked body is presented. Defining the virtual crack extension as the variation of the geometry, the equation is directly derived by a shape design sensitivity of the potential energy. Although the form of the derived energy release rate equation is different from other researchers's results, the three example show that the former is exactly the same as the latter. However, the final integral equation do not involve the derivative of the displacement on the crack surface and crack tip region, thereby improving the numerical accuracy in the computation of the energy relase rate. Moreover, as it was derived from the governing equation including non-linear elasticity without special assumptions, the energy release rate of a elasto-plastic fracture can be obtained and any numerical stress analysis method can be applied.

• 한국화재소방학회논문지
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• 제17권3호
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• pp.26-30
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• 2003

본 논문은 화재발생시 열감지기가 오동작하는 특성을 열방출률(Heat Release Rate : HRR)을 이용하여 경계값을 정량적으로 나타내고 그 경계값을 기준으로 감지기의 오동작 영역을 분석하였다. Crib 형태의 목재를 가지고 small-scale의 화재실험을 통하여 화재감지기의 동작시간 등을 측정하였고 이를 이용하여 화재감지기가 동작하는 순간의 HRR을 계산하였다. 화재실험으로부터 얻은 변수를 가지고 화재감지기가 오동작하는 HRR의 경계값을 계산한 결과 정온식 감지기는 20.24 kW 차동식 감지기는 13.59 kW로 나타났다.