• Journal of Pharmaceutical Investigation
• /
• 제20권1호
• /
• pp.13-18
• /
• 1990

Hydrocortisone (HC) sustained-release suppositories were prepared by using a solid matrix of methacrylic acid-methacrylic acid methyl ester copolymer $(Eudragit\;L_{100}^{R}:\;EL)$ as a poorly water soluble carrier and polyethylene glycole 1540 (PEG) as an water soluble carrier. HC release rate was controlled by complexation with ${\beta}-cyclodextrin$ $({\beta}-CyD)$ which was confirmed by X-ray diffractometry, IR-spectroscopy and differential scanning calorimetry. Release rate of HC from the EL-PEG matrix suppositories decreased with increase of EL contents. The release rale from $HC-{\beta}-CyD$ complex decreased in the following order: $HC-{\beta}-CyD/PEG$ > HC/PEG > $HC-{\beta}-CyD/EL_{10%}-PEG$ > $HC/EL_{10%}-PEG$ > $HC-{\beta}-CyD/EL_{15%}-PEG$ > $HC/EL_{15%}-PEG$ > $HC-{\beta}-CyD/EL_{20%}-PEG$ > $HC/EL_{20%}-PEG$. The crystallinity of HC in polymer matrix was identified using X-ray diffractometer and the surface of matrix suppositories after release test was examined by scanning electron microscopy. The sustained release of HC from these matrix suppositories was attributed to the network structure of EL.

• Archives of Pharmacal Research
• /
• 제16권1호
• /
• pp.43-49
• /
• 1993

The polyvinyl alcohol (PVA) hydrogel containing 1-methy-2-pymolidinone (MP) and sorbitol was preapred by the freeze and thaw method. The release rate of indomethacin from PVA hydrogel was used as a criterion for deciding the optimum formula of hydrogel using the computer optimization technique. The hydrogel of optimum formula was composed of PVA (10 w/v%), MP (0 w/v%) and sorbitol (40 w/v%) and the release rate of indomethacin was 1.981$\mu$g/ml$\cdot{min}^{1/2}$.

• Journal of Pharmaceutical Investigation
• /
• 제26권1호
• /
• pp.13-22
• /
• 1996

Poly(D,L-lactic acid) (PLA) microspheres containing alprazolam(APZ) were prepared by a solvent-emulsion evaporation method and their release patterns were investigated in vitro. Various batches of microspheres with different size and drug content were obtained by changing the ratio of APZ to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like APZ crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decrease in the molecular weight of PLA. The release rate of APZ for long-acting injectable delivery system in vitro, which would aid in predicting in vitro release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.

• Restorative Dentistry and Endodontics
• /
• 제23권2호
• /
• pp.701-709
• /
• 1998

Many dental composites are Bis-GMA based resin which diluted with the more fluid monomer triethylenglycol dimethacrylate(TEGDMA). TEGDMA is often present in exess so that some quantity remains unreacted following photo-initiated polymerization. TEGDMA is a component of some resin composites which contributes to their cytotoxicity. The presence of dentin between resin composite and pulp space reduce the cytotoxicity in vitro. The root system from extrcted human third molar was removed and then a circular occlusal cavity 4mm in diameter was prepared, leaving a remaining dentinal thickness to the roof of the pulpal chamber within the range 1.0-1.5mm. Dentine was treated with 37% phosphoric acid prior to Z 100 placement without using bonding resin(group 1). In group 2, SMP(Scotchbond Multi Purpose) primer, bonding resin prior to Z 100 placement were applied sequently. In group 3, moulds with internal dimensions 4mm diameter by 2mm depth were used to contain the composite alone with an equvalent mass on tooth model, and then they were immersed directly into water. The purpose of this study is to evaluate the release rate and quantity of TEGDMA with or without the application of bonding resin. Both release rate and total cumulative amount of TEGDMA for the three groups were determined using reversed-phase HPLC at times up to 10 days. The results were as follows: 1. All experimental groups showed the highest rate of release was in the first sample period(0-4.32 min) and the rate of release declined exponentially thereafter. 2. The maximum release rate and total cumulative account of TEGDMA in the tooth model of group 1 and group 2 with the use of SMP bonding resin were reduced however ther were no significant differences between these groups(P>0.05). 3. In the first sample period(0-4.32 min), the rate of release of TEGDMA from composite resin in group 3 immersed directly into water was significantly higher than that in group 1 and group 2 of tooth model(P<0.05). Conclusively, TEGDMA diffusion from Z 100 resin was not effectively prevented by the presence of dentin in spite of using the SMP bonding resin.

• 한국화재소방학회논문지
• /
• 제22권2호
• /
• pp.104-107
• /
• 2008

산소소모법을 이용한 화재발열량 측정장치를 구성하고 대표적인 주택가연물(침대, 책상, 냉장고, 장롱)에 대하여 화재 발열량을 측정하였다. 발열량 측정 결과 최대 발열량은 각각 냉장고 1MW, 책상 0.8MW, 장롱 4.2MW, 침대 0.4MW로 나타났으며, 특히 냉장고와 장롱의 경우 화재성장속도가 상대적으로 빨라 위험요인이 큰 것으로 나타났다.

• 한국산학기술학회논문지
• /
• 제21권11호
• /
• pp.349-356
• /
• 2020

ISO 9705 룸코너 시험을 통해 복합소재 고체 가연물의 화재발생시 발생되는 열방출률을 측정하고 화재성장율을 계산하여 Fire Dynamics Simulator (FDS)에서 제공하는 열방출률 예측 모델을 사용자가 시험을 통해 얻어진 질량 소모율을 직접 입력하고 점화원에 의해 가연물의 표면 온도가 점화 온도에 도달하게 되면 정해진 연료를 소모하게 됨으로써 열방출률이 계산되는 단순 모델 (Simple model)과 질량 소모율을 직접 계산하는 방식으로 고체 가연물의 온도를 계산하고 고체 가연물의 열분해율을 조절하여 직접 열방출률을 계산하는 열분해 모델 (Pyrolysis model)로 구분하고 각각의 열방출률 모델에 필요한 입력 인자를 적용하여 동일한 조건에서 밀폐된 구획 환경에 따라 FDS 전산 해석을 수행하였다. 복합소재 고체 가연물로는 PU 폼과 PP, 철재로 대부분 구성되어있는 영화관 의자를 선정하였다. 동일한 조건에서 밀폐된 구획 환경에 따라 각각의 열방출률 예측 모델을 해석한 결과, 밀폐된 구획에서 단순 모델을 통해 예측된 열방출률과 화재성장율이 열분해 모델을 이용하는 경우에 비해 다소 과예측되는 것을 확인 할 수 있었다.

• International Journal of Concrete Structures and Materials
• /
• 제18권3E호
• /
• pp.213-219
• /
• 2006

Modified singular fracture process zone(S-FPZ) model is proposed in this paper to determine a fracture criterion for continuous crack propagation in concrete. The investigated fracture properties of the proposed fracture model are strain energy release rate at a micro-crack tip and the relationship between crack closure stress(CCS) and crack opening displacement(COD) in the FPZ. The proposed model can simulate the actual fracture energy of experimental results fairly well. The results of the experimental data analysis show that specimen geometry and loading condition did not affect the CCS-COD relation. However, the strain energy release rate is a function of not only specimen geometry but also crack extension. The strain energy release rate remained constantly at the minimum value up to the crack extension of 25 mm, and then it increased linearly to the maximum value. The maximum fracture criterion occurred at the peak load for specimens of large size. The fracture criterion remained at the maximum value after the peak load. The variation of the fracture criterion is caused by micro-cracking and micro-crack localization. The fracture criterion of strain energy release rate can simply be the size effect of concrete fracture, and it can be used to quantify the micro-cracking and micro-crack localizing behavior of concrete.

• Journal of Pharmaceutical Investigation
• /
• 제16권1호
• /
• pp.12-17
• /
• 1986

Etilefrine hydrochloride was microencapsulated with ethylcellulose by phase separation method to develop a sustained release dosage form. The results of dissolution test carried out with various microcapsules showed that the drug release was decreased with increasing the particle size of microcapsules at a constant core to wall ratio, and with decreasing the core to wall ratio. Also ethylcellulose 50 cps and fast stirring rate (900 rpm) was better in decreasing the drug release than ethylcellulose 22 cps and slow stirring rate (300 rpm), respectively.

• 오토저널
• /
• 제4권2호
• /
• pp.58-68
• /
• 1982

It is well known to diesel engineers that the heat release pattern is one of the most important factors affecting engine performance. Thorough research in heat release pattern has materially helped the progress in high-speed diesel engine development . This paper is based on the research conducted at KAIST and Daewoo Heavy Industry last year. The purpose of this paper is to determine the heat release pattern in combustion chamber of MAN M type, the famous low-noise engine. Thermodynamic cycle simulation was performed using Whitehous-Way's heat release pattern with modified coefficients and Annand's heat transfer model. Instantaneous temperature and pressure of gas in cylinder could be determined by the numerical solution of simultaneous equation of mass conservation, equation of energy conservation, and state equation of ideal gas. Calculated results were compared with measured values in some details emphasizing upon the factors affecting rate of heat release. The agreement was fairly good and revealed why M type should have lower burning velocity at the early part of combustion in spite of high injection rate. Additional results by parametric studies were given in relation to fuel injection conditions for further application to engine development.

• 한국정밀공학회지
• /
• 제20권7호
• /
• pp.193-200
• /
• 2003

The energy release rate for an interface crack in pseudo-isotropic dissimilar materials was obtained by the eigenfunction expansion method using the two-term William's type complex stress function. The complex stress function for pseudo-isotropic materials must be different from that for anisotropic materials. The energy release rate for an interface crack in pseudo-isotropic dissimilar materials was analyzed numerically by RWCIM. The results obtained were verified by comparing the other worker's results and discussed.