• Korean Journal of Radiology
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• v.23 no.11
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• pp.1089-1101
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• 2022

Immunotherapy has revolutionized and opened a new paradigm for cancer treatment. In the era of immunotherapy and molecular targeted therapy, precision medicine has gained emphasis, and an early response assessment is a key element of this approach. Treatment response assessment for immunotherapy is challenging for radiologists because of the rapid development of immunotherapeutic agents, from immune checkpoint inhibitors to chimeric antigen receptor-T cells, with which many radiologists may not be familiar, and the atypical responses to therapy, such as pseudoprogression and hyperprogression. Therefore, new response assessment methods such as immune response assessment, functional/molecular imaging biomarkers, and artificial intelligence (including radiomics and machine learning approaches) have been developed and investigated. Radiologists should be aware of recent trends in immunotherapy development and new response assessment methods.

• Smart Structures and Systems
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• v.12 no.3_4
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• pp.415-426
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• 2013

Condition assessment and monitoring of bridges is critical for safe passenger travel, public transportation, and efficient freight. In monitoring, displacement measurement capability is important to keep track of performance of bridge, in part or as whole. One of the most important parts of a bridge is the expansion joint, which accommodates continuous cyclic thermal expansion of the whole bridge. Though expansion joint is critical for bridge performance, its inspection and monitoring has not been considered significantly because the monitoring requires long-term data using cost intensive equipment. Recently, a wireless smart sensor network (WSSN) has drawn significant attention for transportation infrastructure monitoring because of its merits in low cost, easy installation, and versatile on-board computation capability. In this paper, a rapid wireless displacement monitoring system, wireless hybrid sensor (WHS), has been developed to monitor displacement of expansion joints of bridges. The WHS has been calibrated for both static and dynamic displacement measurement in laboratory environment, and deployed on an in-service highway bridge to demonstrate rapid expansion joint monitoring. The test-bed is a continuous steel girder bridge, the Founders Bridge, in East Hartford, Connecticut. Using the WHS system, the static and dynamic displacement of the expansion joint has been measured. The short-term displacement trend in terms of temperature is calculated. With the WHS system, approximately 6% of the time has been spent for installation, and 94% of time for the measurement showing strong potential of the developed system for rapid displacement monitoring.

• The korean journal of orthodontics
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• v.52 no.3
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• pp.182-200
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• 2022

Objective: This study aims to examine the effectiveness of miniscrew assisted rapid palatal expansion (MARPE) treatment in late adolescents and adult patients using cone-beam computed tomography (CBCT). Methods: Literature search was conducted in five electronic databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) based on the PICOS keyword design focusing on MARPE. Out of the 18 CBCT screened outcomes, only nine parameters were sufficient for the quantitative meta-analysis. The parameters were classified into three main groups: 1) skeletal changes, 2) alveolar change, and 3) dental changes. Heterogeneity test, estimation of pooled means, publication bias, sensitivity analysis and risk of bias assessment were also performed. Results: Upon database searching, only 14 full-text articles were qualified from the 364 obtained results. Heterogeneity test indicated the use of the random-effects model. The pooled mean estimate were as follows: 1) Skeletal expansion: zygomatic width, 2.39 mm; nasal width, 2.68 mm; jugular width, 3.12 mm; and midpalatal suture at the posterior nasal spine and anterior nasal spine, 3.34 mm and 4.56 mm, respectively; 2) Alveolar molar width expansion, 4.80 mm; and 3) Dental expansion: inter-canine width, 3.96 mm; inter-premolar width, 4.99 mm and inter-molar width, 5.99 mm. The percentage of expansion demonstrated a skeletal expansion (PNS) of 55.76%, alveolar molar width expansion of 24.37% and dental expansion of 19.87%. Conclusions: In the coronal view, the skeletal and dental expansion created by MARPE was of the pyramidal pattern. MARPE could successfully expand the constricted maxilla in late adolescents and adult patients.

• Earthquakes and Structures
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• v.22 no.6
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• pp.609-623
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• 2022

To study the empirical seismic fragility of a reinforced concrete girder bridge, based on the theory of numerical analysis and probability modelling, a regression fragility method of a rapid fragility prediction model (Gaussian first-order regression probability model) considering empirical seismic damage is proposed. A total of 1,069 reinforced concrete girder bridges of 22 highways were used to verify the model, and the vulnerability function, plane, surface and curve model of reinforced concrete girder bridges (simple supported girder bridges and continuous girder bridges) considering the number of samples in multiple intensity regions were established. The new empirical seismic damage probability matrix and curve models of observation frequency and damage exceeding probability are developed in multiple intensity regions. A comparative vulnerability analysis between simple supported girder bridges and continuous girder bridges is provided. Depending on the theory of the regional mean seismic damage index matrix model, the empirical seismic damage prediction probability matrix is embedded in the multidimensional mean seismic damage index matrix model, and the regional rapid prediction matrix and curve of reinforced concrete girder bridges, simple supported girder bridges and continuous girder bridges in multiple intensity regions based on mean seismic damage index parameters are developed. The established multidimensional group bridge vulnerability model can be used to quantify and predict the fragility of bridges in multiple intensity regions and the fragility assessment of regional group reinforced concrete girder bridges in the future.

• Journal of the Korean Geotechnical Society
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• v.39 no.10
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• pp.27-39
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• 2023

To effectively manage flood risk, it is crucial to assess the stability of flood defense structures like levees under extreme flood conditions. This study focuses on the time-dependent probabilistic assessment of embankment slope stability when subjected to rapid water level drops. We integrate seepage analysis results from finite element analysis with slope stability analysis and employ Monte Carlo simulations to investigate the time-dependent behavior of the slope during rapid drawdown. The resulting probability of failure is used to develop fragility curves for the levee slope. Notably, the probability of slope failure remains low up to a specific water level, sharply increasing beyond that threshold. Furthermore, the fragility curves are strongly influenced by the rate of drawdown, which is determined through hydraulic analysis based on flood scenarios. Climate change has a significant impact on the stability of the water-side slope of the embankment due to water level fluctuations.

• The Journal of the Korea Contents Association
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• v.12 no.1
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• pp.68-79
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• 2012

Korea was followed by a rapid increase in road construction investment in late 1980s with the help of strong economic conditions. As a result of such investment, it will be expected that there must be a rapid increase in demand for maintenance or rehabilitation of the facilities after 2010. We are developing asset management information systems for enhancing user's satisfaction and innovating the facility management techniques within a limited budget. We suggested the assessment items for the Level of Service for tunnel facility's operation and maintenance(O&M), in this study. We have surveyed for the importance of assessment items by considering both user's viewpoints and facility management agency's viewpoints. We came to realize the relative importance of the items based on this survey using the Analytic Hierarchy Process(AHP) method proposed by Satty. The relative importance of assessment items in terms of the user's viewpoint was identified in descending order such as safety, mobility, accessibility, convenience, O&M efficiency, comfort, rural revitalization, environment, and information. Also, the importance of the items in terms of the management agency's viewpoint was identified in descending order such as safety, mobility, accessibility, environment, rural revitalization, convenience, O&M efficiency, information, and comfort. It means that safety of tunnel facilities is more important than mobility, although which is the basic function of the road facility, both in agency's and user's concern. Therefore, the agencies have to pay more attentions and efforts to ensure safety of tunnel facilities when they establish the investment plans for the tunnel facility O&M.

• Computers and Concrete
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• v.26 no.3
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• pp.203-211
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• 2020

Turkey is located in one of the most seismically active regions of in Europe. The majority of the population living in big cities are at high seismic risk due to insufficient structural resistance of the existing buildings. Such a seismic risk brings the need for a comprehensive seismic evaluation based on the risk analysis in Turkey. Determining the seismic resistance level of existing building stock against the earthquakes is the first step to reduce the damages in a possible earthquake. Recently in January 2020, the Elazig earthquake brought the importance of the issue again in the public. However, the excessive amount of building stock, labor, and resource problems made the implementation phase almost impossible and revealed the necessity to carry out alternative studies on this issue. This study aims for a detailed investigation of residential buildings in Antalya, Turkey. The approach proposed here can be considered an improved state of building survey methods previously identified in Turkey's Design Code. Antalya, Turkey's fifth most populous city, with a population over 2.5 Million, was investigated as divided into sub-regions to understand the vulnerability, and a threshold value found for the study area. In this study, 26,610 reinforced concrete buildings between 1 to 7 stories in Antalya were examined by using the rapid visual assessment method. A specific threshold value for the city of Antalya was determined with the second level examination and statistical methods carried out in the determined sub-region. With the micro zonation process, regions below the threshold value are defined as the priority areas that need to be examined in detail. The developed methodology can be easily calibrated for application in other cities and can be used to determine new threshold values for those cities.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.549-553
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• 2004

ATP bioluminescence system and impedance system were evaluated with the objective of reducing the time for microbial analysis of cosmetics formulations from 72 to 24 h. The meaningful correlation (at least $95\%$) was achieved when emulsion were artificially contaminated with low levels of different organisms, including Pseudomonas aeruinosa, Staphylococcus aureus, Escherichia coli and Ralstonia mannitolilytica. The standard agar plate method, ATP bioluminescence and impedance method were used for in this study. Successful evaluation and validation of automated systems has enabled the introduction of ATP bioluminescence and impedance method into routine use within the microbiology laboratory. This has provided a rapid assessment of product quality, resulting in faster throughput and resource maximization.

• International Journal of Aeronautical and Space Sciences
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• v.10 no.2
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• pp.134-139
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• 2009

Various modules are generally combined with one another in order to perform rotorcraft preliminary design and its optimization. At the stage of the preliminary design, analysis fidelity is less important than the rapid assessment of a design is. Most of the previous researchers attempted to implement sophisticated applications in order to increase the fidelity of analysis, but the present paper focuses on a rapid assessment while keeping the similar level of fidelity. Each small-sized module will be controlled by an externally-operated global optimization module. Results from each module are automatically handled from one discipline to another which reduces the amount of computational effort and time greatly when compared with manual execution. Automatically handled process decreases computational cycle and time by factor of approximately two. Previous researchers and the rotorcraft industries developed their own integrated analysis for rotorcraft design task, such as HESCOMP, VASCOMP, and RWSIZE. When a specific mission profile is given to these programs, those will estimate the aircraft size, performance, rotor performance, component weight, and other aspects. Such results can become good sources for the supplemental analysis in terms of stability, handling qualities, and cost. If the results do not satisfy the stability criteria or other constraints, additional sizing processes may be used to re-evaluate rotorcraft size based on the result from stability analysis. Trade-off study can be conducted by connecting disciplines, and it is an important advantage in a preliminary design study. In this paper among the existing rotorcraft design programs, an adequate program is selected for a baseline of the design framework, and modularization strategy will be applied and further improvements for each module be pursued.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.19 no.3
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• pp.171-181
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• 2009

This study was carried out to evaluate a musculoskeletal symptom and the work posture of the nurses in an operating room who have worked in the present department for more than one year. The job analysis of operating room nurses for ergonomic work posture analysis is divided into 14 tasks. On the basis of that, a survey research and ergonomic work posture analysis are also carried out. Among 41 operating room nurses of a cancer center in Kyonggi province who responded to the self-administered questionnaire, 20 nurses were observed and videorecorded to apply Rapid Entire Body Assessment(REBA) to ergonomic work posture analysis from April 16, 2007 to May 18, 2007. The results of analysis are as follows. The prevalence rate of musculoskeletal symptoms was 75.6% and its prevalence rates by part of the body are these followings; lower back and leg/foot 43.9%, shoulder 36.6%, neck 34.1%, hand/wrist/ finger 22.0%, arm/elbow 14.6%. In accordance with the results of ergonomic work posture analysis, 4 tasks that have a REBA score of 8 have high-risk levels and require an immediate management. It shows there is a significant correlation with overall musculoskeletal symptoms and objective workloads that are estimated by REBA. In conclusion, the work conditions of operating room nurses should be improved. It is also necessary that inappropriate work postures and ergonomic work conditions are improved to prevent musculoskeletal disorders of operating room nurses.